Skip to main content

Trinity College Dublin, The University of Dublin

Trinity Menu Trinity Search



You are here People

Maria Santos-Martinez
Assistant Professor, Pharmacy
Assistant Professor, Clinical Medicine

RESEARCH INTERESTS

Maria J. Santos-Martinez is a Spanish medical doctor specialist in Respiratory Medicine. Her research interests are mainly focused on blood platelets - cancer - nanoparticles and their interactions: Application of Quartz Crystal Microbalance with Dissipation (QCM-D) technology to platelets, cancer cells and nanomaterials. Platelet biology and pharmacology. Contribution of platelets to cancer progression (tumor invasion, angiogenesis and blood metastastasis). Nanoparticle-cell and nanoparticle-platelet interactions (Nanotoxicology). Interactions between nanoparticles developed for drug delivery, their targets and the potential barriers that they have to be overcome to exert their action.

FINANCIAL SUPPORT

Trinity College Dublin (Start-up grant); Intensive Care Society of Ireland; Merck Sharp Dome; Abb Vie ; Flight Attendant Medical Research Institute (FAMRI; Collaborator).

Biography

Dr Maria J Santos-Martinez is a medical doctor Specialist in Respiratory Medicine from the Universidad Autónoma de Barcelona (Spain). She started her training as basic researcher in The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases at UTHealth (University of Texas Health Science-Houston-USA) in 2004. In 2006 she moved to Ireland and defended her PhD in 2009 (Trinity College Dublin).

She was appointed as Assistant Professor (Ussher) in Nanopharmaceutical Drug Discovery (School of Pharmacy and Pharmaceutical Sciences & School of Medicine) in 2010.

Publications and Further Research Outputs

Peer-Reviewed Publications

Nam, L.; Coll, C.; Erthal, L.C.S.; de la Torre, C.; Serrano, D.; Martínez-Máñez, R.; Santos-Martínez, M.J.; Ruiz-Hernández, E., Drug delivery nanosystems for the localized treatment of glioblastoma multiforme, Materials, 11, (5), 2018, p779- Review Article, 2018 DOI

Inkielewicz-Stepniak I, Tajber L, Behan G, Zhang H, Radomski MW, Medina C, Santos-Martinez MJ, The Role of Mucin in the Toxicological Impact of Polystyrene Nanoparticles, Materials, 11, (5), 2018, p1 - 12 Journal Article, 2018 DOI

Keogh AP; Hante N; Santos-Martinez MJ; Kelly B; Rozas I. , 4. Exploring the polypharmacology of 2-amino imidazoline derivatives: Antiaggregatory activity in human platelets, Medicinal Chemistry Ireland Conference 2018, Dublin City University, Dublin, Ireland, June , 2018 Meeting Abstract, 2018

Umerska A, Paluch KJ, Santos-Martinez MJ, Corrigan OI, Medina C, Tajber L, 1. Freeze drying of polyelectrolyte complex nanoparticles: Effect of nanoparticle composition and cryoprotectant selection, International Journal of Pharmaceutics, 552, (1-2), 2018, p27 - 38 Journal Article, 2018 DOI

Larkin CM, Hante NK, Breen EP, Tomaszewski KA, Eisele S, Radomski MW, Ryan TA, Santos-Martinez MJ, Role of matrix metalloproteinases 2 and 9, toll-like receptor 4 and platelet-leukocyte aggregate formation in sepsis-associated thrombocytopenia., PloS one, 2018 Journal Article, 2018 DOI

Chan Guo Gin C; Lam C; Hante N; Keogh AP; Kelly B, Rozas I; Santos-Martinez MJ. , Effect of novel H2-receptor selective compounds on platelet aggregation, Pharmacology 2018, London, 18-20 December 2018, 2018 Meeting Abstract, 2018

Pharmacology of Haemostasis and Thrombosis in, Velazquez Farmacologia Basica y Clinica (19th Edition) , Ed. Medica Panamericana, 2018, [Santos-Martinez MJ; Radomski MW; Medina C.] Book Chapter, 2018

Larkin CM, Breen EP, Tomaszewski KA, Eisele S, Radomski MW, Ryan TA, Santos-Martinez MJ, Platelet microaggregation in sepsis examined by quartz crystal microbalance with dissipation technology., Platelets, 29, (3), 2018, p301 - 304 Journal Article, 2018 DOI

Radziwon-Balicka A, Lesyk G, Back V, Fong T, Loredo-Calderon EL, Dong B, El-Sikhry H, El-Sherbeni AA, El-Kadi A, Ogg S, Siraki A, Seubert JM, Jurasz P, Differential eNOS-signalling by platelet subpopulations regulates adhesion and aggregation., Cardiovascular research, 113, (14), 2017, p1719 - 1731 Journal Article, 2017 DOI

Cruz R; Bowe R; Santos-Martinez MJ; Tajber L, 3. Investigation of interactions of pegylated and non-pegylated itraconazole nanoparticles with mucin using quartz crystal microbalance with dissipation and dynamic light scattering, AAPS Annual Meeting and Exposition, San Diego, USA, 12-15 November, 2017 Meeting Abstract, 2017

Mugheirbi N, Zotova J, Umerska AM, Santos-Martinez MJ, Tajber L. , Novel surfactant-stabilized ciprofloxacin nanodispersions made by media milling; interactions with physiological barriers using quartz crystal microbalance with dissipation monitoring, AAPS Annual Meeting and Exposition, San Diego, USA, 12-15 November, 2017 Meeting Abstract, 2017

Larkin, C.M., Santos-Martinez, M.-J., Ryan, T., Radomski, M.W., Sepsis-associated thrombocytopenia, Thrombosis Research, 141, 2016, p11-16 Review Article, 2016 DOI

Samuel S., Santos-Martinez M., Medina C., Jain N., Radomski MW., Prina-Mello A., Volkov Y., CdTe quantum dots induce activation of human platelets: Implications for nanoparticle hemocompatibility, International Journal of Nanomedicine, 10, 2015, p2723-2734 Journal Article, 2015 DOI TARA - Full Text

Niska, K., Santos-Martinez, M.J., Radomski, M.W., Inkielewicz-Stepniak, I. , CuO nanoparticles induce apoptosis by impairing the antioxidant defense and detoxification systems in the mouse hippocampal HT22 cell line: protective effect of crocetin, Toxicology in vitro, 29, 2015, p663 - 671 Journal Article, 2015 DOI

Gaffney, A.M., Santos-Martinez, M.J., Satti, A., (...), Elia, G., Radomski, M.W. , Blood biocompatibility of surface-bound multi-walled carbon nanotubes, Nanomedicine: Nanotechnology, Biology, and Medicine, 11, (1), 2015, p39-46 Journal Article, 2015 DOI

Tomaszewski KA, Radomski MW, Santos-Martinez MJ. , Nanodiagnostics, Nanopharmacology and Nanotoxicology of Platelet - Vessel Wall Interactions., Nanomedicine (Lond.), 10, (9), 2015, p1451 - 1475 Review Article, 2015 DOI

Gaffney, A.M., Santos-Martinez, M.J., Satti, A., Major, T.C., Wynne, K.J., Gun'ko, Y.K., Annich, G.M., Elia, G., Radomski, M.W, Blood biocompatibility of surface-bound multiwall carbon nanotubes. , Nanomedicine: NBM Feature Article, 11, 2015, p39 - 46 Journal Article, 2015 DOI

Santos-Martinez, M.J., Tomaszewski, K., Medina, C., Bazou, D., Gilmer, J.F., Radomski, M.W. , Pharmacological characterization of nanoparticle-induced platelet microaggregation using quartz crystal microbalance with dissipation: comparison with light aggregometry, International Journal of Nanomedicine, 10, 2015, p5107 - 5119 Journal Article, 2015 DOI TARA - Full Text

Umerska A, Paluch KJ, Santos-Martinez MJ, Medina C, Corrigan OI, Tajber L, Chondroitin-based nanoplexes as peptide delivery systems--Investigations into the self-assembly process, solid-state and extended release characteristics., European Journal of Pharmaceutics and Biopharmaceutics, 93, 2015, p242 - 253 Journal Article, 2015 DOI TARA - Full Text

Umerska A, Paluch KJ, Santos-Martinez MJ, Corrigan OI, Medina C, Tajber L, Self-assembled hyaluronate/protamine polyelectrolyte nanoplexes: synthesis, stability, biocompatibility and potential use as peptide carriers, Journal of Biomedical Nanotechnology, 10, (12), 2014, p3658 - 3673 Journal Article, 2014 TARA - Full Text DOI

N Glezeva, M Santos-Martinez, C Watson, K Mcdonald, C Medina, J Gilmer, M Ledwidge, Inhibition of thromboxane pathways in monocytes impedes cell invasiveness, European Journal of Heart Failure, 16, 2014, pp208-209 Conference Paper, 2014

D'Arcy DM; Connell Y; Santos-Martinez MJ, 6. Clinically relevant dissolution testing: exploring albumin concentrations in testing of parenteral formulations, 10th Central European Symposium on Pharmaceutical Technology (CESPT) Conference, Portoro , Slovenija, 2014 Meeting Abstract, 2014

Santos-Martinez, M.J., Rahme, K., Corbalan, J.J., Faulkner, C., Holmes, J., Tajber, L., Medina, C., Radomski, M.W. , Pegylation increases platelet biocompatibility of gold nanoparticles. , Journal of Biomedical Nanotechnology, 10, 2014, p1004 - 1015 Journal Article, 2014 URL

Inkielewicz-Stepniak, I., Santos-Martinez, M.J., Medina, C., Radomski, M.W. , Pharmacological and toxicological effects of co-exposure of human gingival fibroblasts to silver nanoparticles and sodium fluoride, International Journal of Nanomedicine, 9, 2014, p1677 - 1687 Journal Article, 2014 TARA - Full Text

Radziwon-Balicka A, Santos-Martinez MJ, Corbalan JJ, O'Sullivan S, Treumann A, Gilmer JF, Radomski MW, Medina C, Mechanisms of platelet-stimulated colon cancer invasion: role of clusterin and thrombospondin 1 in regulation of the P38MAPK-MMP-9 pathway., Carcinogenesis, 35, (2), 2014, p324 - 332 Journal Article, 2014 TARA - Full Text

Lesniak, A., Salvati, A., Santos-Martinez, M.J., Radomski, M.W., Dawson, K.A., Aberg, C. , Nanoparticle adhesion to the cell membrane and its effect on nanoparticle uptake efficiency, Journal of American Chemical Society, 135, 2013, p1438 - 1444 Journal Article, 2013 DOI

Medina C, Harmon S, Inkielewicz I, Santos-Martinez MJ, Jones M, Cantwell P, Bazou D, Ledwidge M, Radomski MW, Gilmer JF., Differential Inhibition of Tumor Cell-Induced Platelet Aggregation by Nicotinate Aspirin Prodrug (ST0702) and Aspirin., British Journal of Pharmacology, 166, (3 ), 2012, p938 - 949 Journal Article, 2012 TARA - Full Text DOI

Umerska A, Paluch KJ, Inkielewicz-Stępniak I, Santos-Martinez MJ, Corrigan OI, Medina C, Tajber L., Exploring the assembly process and properties of novel crosslinker-free hyaluronate-based polyelectrolyte complex nanocarriers, International Journal of Pharmaceutics, 436, (1-2), 2012, p75 - 87 Journal Article, 2012 URL TARA - Full Text DOI

Wahab, A.; Rahayu, I; Wong, Siu Hai N.; Santos-Martinez, M J ; Boylan, F., Alkaloids from Choisya ternata and their human antiplatelet activity., Planta Medica, International Conference on Natural Products Research, New York, USA, 2012, 78, (11), 2012, pp1205- Conference Paper, 2012

Santos-Martinez, M.J., Inkielewicz-Stepniak, I., Medina, C., Rahme, K., D'Arcy, D., Holmes J.D., Zhang, H., Radomski, M.W, The use of quartz crystal microbalance with dissipation for studying nanoparticle-induced platelet aggregation. , International Journal of Nanomedicine, 7, 2012, p243 - 255 Journal Article, 2012 DOI

Harmon, S., Inkielewicz-Stepniak, I., Jones, M., Ledwidge, Santos-Martinez, M.J., Medina, C., Radomski, M.W., Gilmer, J.F, Mechanisms of aggregation inhibition by aspirin and nitrate-aspirin prodrugs in human platelets, Journal of Pharmacy and Pharmacology, 64, (1), 2012, p77 - 89 Journal Article, 2012 TARA - Full Text

Santos-Martinez, M.J., Prina-Mello, A., Medina, C., Radomski, M.W. , Analysis of platelet function: role of microfluidics and nanodevices, Analyst, 136, 2011, p5120 - 5126 Review Article, 2011 DOI TARA - Full Text

Bazou D, Santos-Martinez MJ, Medina C, radomski MW, Elucidation of flow-mediated tumour cell-induced platelet aggregation using an ultrasound standing wave trap, British journal of Pharmacology, 162, (7), 2011, p1577 - 1589 Journal Article, 2011 DOI

Medina C, Santos-Martinez MJ, Santana A, Paz-Cabrera MC, Johnston MJ, Mourelle M, Salas A, Guarner F., Transforming growth factor-beta type 1 receptor (ALK5) and Smad proteins mediate TIMP-1 and collagen synthesis in experimental intestinal fibrosis., The Journal of Pathology, 224, (4), 2011, p461 - 472 Journal Article, 2011 DOI

Santos-Martinez, MJ, Medina, C, Prina-Mello, A, Conroy, J, Samuels, SP, Volkov, Y, Radomski, MW, A nanoscale resolution assay of flow-induced platelet microaggregation, Kardiochirurgia i Torakochirurgia Polska, 7, (4), 2010, p365-375 Journal Article, 2010 URL

Jones, M., Inkielewicz, I., Medina, C., Santos-Martinzez, M.J., Radomski, M.W., Radomski, A., Lally, M.N., Moriarty, L.M., Gaynor, J., Carolan, C.G., Coyne, D., O'Byrne, P., Clancy, J.M., Gilmer, J.F. , Isosorbide-based aspirin prodrugs: integration of nitric oxide releasing groups. , Journal of Medicinal Chemistry, 52, (21), 2009, p6588-6598 Journal Article, 2009 DOI

Santos-Martinez MJ, A novel method for the measurement of flow-induced platelet activation at nanoscale resolution Level., TCD, 2009 Thesis, 2009

Santos-Martinez, M.J., Medina, C., Gilmer, J.F., Radomski, M.W. , Matrix metalloproteinases in platelet function: coming of age. , Thrombosis and Haemostasis, 6, (3), 2008, p514-516 Review, 2008 URL DOI

Gilmer JF, Inkielewicz I, Jones M, Radomski A, Medina C, Santos Martinez MW, Radomski MW, Clancy JM, In vitro activation and platelet inhibition effects of the first true aspirin and nitro-aspirin prodrugs, Bioorganic Medicinal Chemistry, IBC's 13th Annual World Congress " Drug Discovery and Development of Innovative Therapeutics" August 4-7th 2008. , 2008 Conference Paper, 2008

Santos-Martinez, M.J., Medina, C., Jurasz, P., Radomski, M.W. , Metalloproteinases in platelet function, Thrombosis Research, 121, (4), 2008, p535-542 Review Article, 2008 DOI URL

Santos-Martínez MJ, Medina C, Jurasz P, Radomski MW., Role of metalloproteinases in platelet function, Thrombosis Research, 121, 2008, p535 - 542 Review Article, 2008

Santos-Martinez MJ, Medina C, Booth J, Radomski W. , A novel method for the measurement of platelet aggregation under flow conditions using Nanobalance, All-Ireland Schools of Pharmacy Research Seminar , Royal College of Surgeons, 2007 , 2007 Oral Presentation, 2007

Jurasz, P., Santos-Martinez, M.J., Radomska, A., Radomski, M.W. , Development and pharmacological characterization of a novel, plasma-based angiogenesis assay, Kardiochirurgia i Torakochirurgia Polska, 4, (2), 2007, p126 - 130 Journal Article, 2007 URL

Medina, C., Santos-Martinez, M.J., Radomski, A., Corrigan, O.I., Radomski, M.W., Nanoparticles: pharmacological and toxicological significance, British Journal of Pharmacology, 150, 2007 Review Article, 2007 URL DOI TARA - Full Text

Medina, C., Jurasz, P., Santos-Martinez, M.J., Jeong, S.S., Mitzky, R., Chen, R., Radomski, M.W. , Platelet aggregation induced by Caco-2 cells: regulation by matrix metalloproteinase-2 and adenosine diphosphate, Journal of Pharmacology and Experimental Therapeutics, 317, (2), 2006, p739 - 745 Journal Article, 2006 TARA - Full Text URL DOI

Rosell A, Xaubet A, Agusti C, Castella J, Puzo C, Curull V, de Gracia J; RASTA study group., A NEW BAL FLUID INSTILLATION AND ASPIRATION TECHNIQUE: A MULTICENTER RANDOMIZED STUDY. , Respir Med. Mar;100(3):529-535., 2006 Journal Article, 2006 DOI

Alonso-Escolano, D., Medina, C., Cieslik, K., Radomski, A., Jurasz, P., Santos-Martinez, M.J., Jiffar, T., Ruvolo, P., Radomski, M.W, Protein Kinase C{delta} Mediates Platelet-Induced Breast Cancer Cell Invasion, Journal of Pharmacology and Experimental Therapeutics, 318, 2006, p372 - 380 Journal Article, 2006 URL DOI

D Alonso-Escolano, C Medina, K Cieslik, A Radomski, P Jurasz, MJ Santos-Martinez, P Ruvolo, MW Radomski, PKCä Mediates Platelet-Induced Breast Cancer Cell Invasion, Journal of Pharmacology Experimental therapeutics, 318, 2006, p373 - 380 Journal Article, 2006 TARA - Full Text

Jurasz, P., Santos-Martinez, M.J., A. Radomska, Radomski, M.W. , Generation of platelet angiostatin mediated by urokinase plasminogen activator: effects of angiogenesis, Journal of Thrombosis and Haemostasis, 4, (5), 2006, p1095 - 1106 Journal Article, 2006 DOI URL

Santos-Martínez MJ, Curull V, Blanco ML, Macià F, Mojal S, Vila J, Broquetas JM, [Lung cancer at a university hospital: epidemiological and histological characteristics of a recent and a historical series], Archivos de bronconeumologia, 2005 Journal Article, 2005

Jericó Alba C, Nogués Solán X, Santos Martínez MJ, Félez Flor M, Garcés Jarque JM, Mariñosa Marré M, Sanz Salvador X, [Legionella pneumophila pneumonia community epidemic outbreak in Barcelona: "The Barceloneta outbreak". Effect on the early diagnosis and treatment], Revista clinica espanola, 2004 Journal Article, 2004

María Molina-Molina, Joan Ramon Badia, Alejandra Marín-Arguedas, Antoni Xaubet, María José Santos, José María Nicolás, Miguel Ferrer, Antoni Torres, Características clínicas y pronóstico de los pacientes con fibrosis pulmonar que ingresan en cuidados intensivos por insuficiencia respiratoria. Análisis de 20 casos, Medicina Clínica, 121, (2), 2003, p63--67 Journal Article, 2003

Non-Peer-Reviewed Publications

Mugheirbi N; Zotova J; Umerska AM; Santos-Martinez MJ; Tajber L, 2. Novel surfactant-stabilized ciprofloxacin nanodispersions made by media milling; interactions with physiological barriers using quartz crystal microbalance with dissipation monitoring, AAPS Annual Meeting and Exposition, San Diego, USA, 12-15 November, 2017 Meeting Abstract, 2017

Santos-Martinez, M.J., Medina, C., Radomska, A., Radomski, M.W., Clinician-scientist: a hobby for few, career prospects for some and training for all practicioners? , 2005, 17-19 Report, 2005

Research Expertise

Description

Dr Santos-Martinez research interests are focused on platelet biology and pharmacology; nanoparticle-cell and nanoparticle-platelet interactions (Nanotoxicology/Biocompatibility of nanomaterials) and cancer. During her PhD studies she developed a novel method for measuring platelet aggregation using a Quartz Crystal Microbalance with Dissipation monitoring (QCM-D). This is a unique and very sensitive technology able to quantify and characterise surface-molecules-cells interactions at nanoscale. Her expertise on the use of QCM-D has been consolidated and she applies this technology for investigating 1) the effect of different compounds, nanomaterials and novel formulations on platelet function and 2)the interactions between nanoparticles developed for drug delivery, their targets and the potential barriers that they have to overcome to exert their action. In the field of cancer, her research is mainly focused on the contribution of platelets to cancer progression (tumor invasion, angiogenesis and blood metastasis).

Keywords

ANGIOGENESIS; Blood Platelets; CANCER; MATRIX METALLOPROTEINASES; Nanomedicine; nanotoxicology; Pulmonary Diseases; QUARTZ CRYSTAL MICROBALANCE

Recognition

Representations

Reviewer:PNAS; Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine); Critical Care Medicine, Thrombosis and Haemostasis

Awards and Honours

Dean's Research Initiatives Fund (Faculty of Health Sciences, TCD) 2015

Innovation Award CRANN 2010

Catalan Respiratory Medicine Association (FUCAP) 2003

Catalan Respiratory Medicine Association (SOCAP) 2003

Spanish Respiratory Medicine Association (SEPAR) 2002

Memberships

COST Action 17140 'Cancer nanomedicine - from the bench to the bedside'(NANO2CLINIC) 2018 – date

Irish Association of Pharmacologists (IAP) 2017 – date

Member and co-founder of the Spanish Research Society in Ireland 2016 – date

Spanish Respiratory Medicine Association (SEPAR) 2002 – date