Competencies & Equipment
- Drug design, synthesis, purification & characterisation
- Conventional and microwave synthetic technologies
- Combinatorial /Library design
- Drug discovery from Natural Products
- Structure-activity relationships
- Drug stability studies
- Mass spectrometry
- Molecular biology, including cloning
- Site-directed mutagenesis
- Reporter gene expression studies
- Genotyping, SNPs and VNTRs identification
- Mammalian cell culture (class 10,000 clean rooms)
- Protein-based assays
- Cellular-based assays including:
- Morphology
- Anti-proliferative /cytotoxic
- Cell cycle, migration
- Invasion
- Apoptosis /anoikis
- Tubule formation & angiogenesis
- Ex vivo: aortic ring assay of angiogenesis/vasculature
- In vivo xenograft models for efficacy, necrosis and tumour vasculature shutdown
- Quartz Crystal Microbalance with Dissipation (QCM-D)
- Nano-toxicology evaluation
- Tumour cell-induced platelet aggregation (TCIPA) analysis
- Exosomes isolation & characterisation
- Pre-formulation studies
- Solid state characterisation
- In vitro aerosol deposition characterisation
- Pharmaceutical processing methods:
- Milling
- Spray drying
- Freeze drying
- Compaction
- Thermal analysis infrared spectroscopy
- Powder X-ray diffraction
- Micromeritic properties analysis
- Nanoparticle characterisation
- Pharmacokinetic & pharmacodynamic studies
- Physicochemical characterisation salts, cocrystals, amorphous, polymeric APIs forms
- Spray drying
- Translational clinical trials (with ICORG and first-in-man through spinouts companies)
- Pharmacoeconomics
- IP disclosure & patent filing
Access to Core Facilities:
Class 10,000 cleanrooms for mammalian cell culture
Microarrays, qPCR
advanced microscopy (confocal microscopy, transmission & scanning electron microscopy)
Fluorescence-activated cell sorting (FACS)
NMR, X-Ray, MS
In vivo core
The School of Pharmacy and Pharmaceutical Sciences welcomes new partners and collaborators.
Please contact us at:
The School of Pharmacy & Pharmaceutical Sciences,
Panoz Institute,
Trinity College,
Dublin 2,
Ireland.
Head of School and Directors:
- Prof. John Gilmer, Head of School
- Assoc. Prof. Astrid Sasse, Director of Teaching and Learning (Undergraduate)
- Prof. Cristin Ryan, Director of Teaching and Learning (Postgraduate)
- Assoc. Prof. Lidia Tajber, Director of Research
- Helen Thornbury, School Administrative Manager