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Lidia Tajber
Associate Professor, Pharmacy

RESEARCH INTERESTS

Lidia Tajber is a pharmacist by qualification and gained her M. Pharm. degree (with first class honours) from Medical University of Silesia, Katowice, Poland. Her Master’s thesis focussed on dielectric spectroscopy investigations of biotechnological materials utilised in transplantology. As a postgraduate visiting student in Trinity College Dublin, prior to her doctoral studies, she concentrated on spectroscopic studies of macromolecules, e.g. liquid crystalline materials. She holds a PhD degree entitled “Investigations of physicochemical properties of spray dried drug-excipient composites directed to inhalable products” in Pharmaceutical Technology from Trinity College Dublin.

Prior to her appointment as a full-time lecturer in Pharmaceutics and Pharmaceutical Technology in 2007, she completed postdoctoral studies on the use of spray drying in the production of nanoporous microparticles. Her research interests involve two principal research themes: Preformulation and formulation aspects of solid pharmaceutical materials and Pharmaceutical systems at the nanoscale supported by Science Foundation Ireland, Enterprise Ireland, Irish Research Council, European Union and Trinity College. She has supervised (in past and at present) 16 PhD students, published 50 peer-review papers, contributed to around 70 international conference presentations and is also a co-inventor on a number of patent applications including “A method of producing porous microparticles” and “A polymeric nanoparticle”. She is currently involved in the Synthesis and Solid State Pharmaceuticals Centre (SSPC) pursuing research on advancing solid state formulations and pharmaceutical nanocrystals.

FINANCIAL SUPPORT

Science Foundation Ireland, Enterprise Ireland, Irish Research Council, European Union, Trinity College (Start-up grant), Ministry of Higher Education (Libya).

Biography

Lidia is currently employed as an Associate Professor in Pharmaceutics and Pharmaceutical Technology in the School of Pharmacy and Pharmaceutical Sciences. She first gained M. Pharm. degree from Medical University of Silesia, Katowice, Poland (with first class honours, best in class) and then pursued her Ph.D. degree in the School of Pharmacy, Trinity College Dublin (completed in 2005). She holds a postgraduate diploma in quality improvement and completed "Research leaders" training. Lidia has published 76 high quality peer-review papers and contributed to numerous international conference presentations. Her current h-index is 25. She is also a co-inventor on a number of patent applications including "A method of producing porous microparticles" and "A polymeric nanoparticle". In addition to being an active researcher, she contributes to undergraduate (Pharmaceutics and Pharmaceutical Technology module) and postgraduate (Preformulation, Formulation and Advanced Drug Delivery modules) teaching. She is part of the coordinating team for the MSc in Pharmaceutical Sciences course. Lidia's research activities fit with national policy objectives supporting the development and production of a highly educated and relevant workforce in demand by the pharmaceutical industry. She and her team have successfully participated in collaborative, multidisciplinary and industry-led research consortia (IDDN, SSPC, H2020 RISE) leading to high impact research, leveraging international funding and attracting talented people to Ireland. The ultimate objective of her work is to advance the pharmaceutical product design and manufacture to benefit the general public and enhance the quality of health.

Publications and Further Research Outputs

Peer-Reviewed Publications

Nanoparticle Tracking Analysis to Examine the Temperature-Induced Aggregation of Proteins in, editor(s)McManus, J.J. , Protein Self-Assembly: Methods and Protocols , New York, Humana Press, 2019, pp131 - 139, [Sladek S., McComiskey K., Healy A.M., Tajber L.] Book Chapter, 2019 DOI

McComiskey KPM, McDonagh AF, Tajber L, Isolation of Itraconazole Nanostructured Microparticles via Spray Drying with Rational Selection of Optimum Base for Successful Reconstitution and Compaction, AAPS PharmSciTech, 20, (5), 2019, p217- Journal Article, 2019 DOI

Wojnarowska Z, Zotowa J, Knapik-Kowalczuk J, Tajber L, Paluch M, Effect of electrostatic interactions on the relaxation dynamics of pharmaceutical eutectics, European Journal of Pharmaceutical Sciences, 134, 2019, p93 - 101 Journal Article, 2019 DOI

Wojnarowska Z, Tajber L, Paluch M, Density Scaling in Ionic Glass-Former Controlled by Grotthuss Conduction, Journal of Physical Chemistry B, 123, (5), 2019, p1156 - 1160 Journal Article, 2019 DOI

Mesallati H, Umerska A, Tajber L, Fluoroquinolone Amorphous Polymeric Salts and Dispersions for Veterinary Uses, Pharmaceutics, 11, (6), 2019, pE268- Journal Article, 2019 DOI

McComiskey K, Tajber L, Comparison of particle size methodology and assessment of nanoparticle tracking analysis (NTA) as a tool for live monitoring of crystallisation pathways, European Journal of Pharmaceutics and Biopharmaceutics, 130, 2018, p314 - 326 Journal Article, 2018 DOI

McComiskey KPM, Mugheirbi NA, Stapleton J, Tajber L., In Situ Monitoring of Nanoparticle Formation: Antisolvent Precipitation of Azole Anti-fungal Drugs., International Journal of Pharmaceutics, 543, (1-2), 2018, p201 - 213 Journal Article, 2018 DOI

McComiskey, K.P.M. and Mugheirbi, N.A. and Stapleton, J. and Tajber, L., In situ monitoring of nanoparticle formation: Antisolvent precipitation of azole anti-fungal drugs, International Journal of Pharmaceutics, 543, (1-2), 2018, p201-213 Journal Article, 2018 DOI

Inkielewicz-Stepniak, I. and Tajber, L. and Behan, G. and Zhang, H. and Radomski, M.W. and Medina, C. and Santos-Martinez, M.J., The role of mucin in the toxicological impact of polystyrene nanoparticles, Materials, 11, (5), 2018, p724- Journal Article, 2018 DOI TARA - Full Text

Wojnarowska Z, Smolka W, Zotova J, Knapik-Kowalczuk J, Sherif A, Tajber L, Paluch M, The Effect of Electrostatic Interactions on the Formation of Pharmaceutical Eutectics, Physical Chemistry Chemical Physics, 20, (43), 2018, p27361 - 27367 Journal Article, 2018 DOI

Sladek S, Kearney C, Crean D, Brama PAJ , Tajber L, Fawcett K, Labberte MC, Leggett B, Brayden DJ, Intra-articular delivery of a nanocomplex comprising salmon calcitonin, hyaluronic acid, and chitosan using an equine model of joint inflammation, Drug Delivery and Translational Research, 8, (5), 2018, p1421 - 1435 Journal Article, 2018 DOI

Wojnarowska Z, Paluch M, Tajber L, Role of intermolecular interactions in the formation of pharmaceutical eutectics, 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain, 19-22 March, 2018, 2018 Meeting Abstract, 2018

Bialek K, Wojnarowska Z, Tajber L, Formation of eutectic and multicomponent phases of propranolol, 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain, 19-22 March, 2018, 2018 Meeting Abstract, 2018

Paczkowska M, Bialek K, McDonagh A, Cielecka-Piontek J, Tajber L, Evaluation of physicochemical and tableting properties of rutin-cyclodextrin complexes, Acta Pharmaceutica Hungarica, 12th Central European Symposium on Pharmaceutical Technology and Regulatory Affairs, Szeged, Hungary, 20-22 September 2018, 88, (3), 2018, pp184 - 185 Conference Paper, 2018

Knapik-Kowalczuk J, Wojnarowska Z, Chmiel K, Rams-Baron M, Tajber L, Paluch M., Can Storage Time Improve the Physical Stability of Amorphous Pharmaceuticals with Tautomerization Ability Exposed to Compression? The Case of a Chloramphenicol Drug., Molecular Pharmaceutics, 15, (5), 2018, p1928 - 1940 Journal Article, 2018 DOI

Paczkowska M, Tajber L, Cielecka-Piontek J, Application of PAMPA gastrointestinal model to predict permeability of sumatriptan in free form and in system with cyclodextrin derivatives, Acta Pharmaceutica Hungarica, 12th Central European Symposium on Pharmaceutical Technology and Regulatory Affairs, Szeged, Hungary, 20-22 September 2018, 88, (3), 2018, pp194 - 195 Conference Paper, 2018

Inkielewicz-Stepniak I, Tajber L, Behan G, Zhang H, Radomski MW, Medina C, Santos-Martinez MJ, The Role of Mucin in the Toxicological Impact of Polystyrene Nanoparticles, Materials, 11, (5), 2018, p1 - 12 Journal Article, 2018 DOI

Umerska A, Paluch KJ, Santos-Martinez MJ, Corrigan OI, Medina C, Tajber L, Freeze drying of polyelectrolyte complex nanoparticles: Effect of nanoparticle composition and cryoprotectant selection, International Journal of Pharmaceutics, 552, (1-2), 2018, p27 - 38 Journal Article, 2018 DOI

Borges VRA, Tavares M, Silva JH, Tajber L, Boylan F, Ribeiro A, Nasciuti LE, Cabral L, Sousa VP, Development and characterization of poly(lactic-co-glycolic) acid nanoparticles loaded with copaiba oleoresin, Pharmaceutical Development and Technology , 23, (4), 2018, p343 - 350 Journal Article, 2018 DOI

Zotova J, Sherif A, Wojnarowska Z, Tajber L, Eutectic, deep eutectic and other multicomponent phases of lidocaine with dicarboxylic acids, 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain, 19-22 March, 2018, 2018 Meeting Abstract, 2018

Kozyra A, Mugheirbi NA, Paluch KJ, Garbacz G, Tajber L, Phase diagrams of polymer-dispersed liquid crystal systems of itraconazole - component immiscibility induced by molecular anisotropy, Molecular Pharmaceutics, 15, (11), 2018, p5192 - 5206 Journal Article, 2018 DOI

Sladek S, Healy AM, Tajber L, Thermally-induced aggregation behaviour of liquid protein formulations at low concentrations as determined by DLS and NTA, 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain, 19-22 March, 2018, 2018 Meeting Abstract, 2018

Wojnarowska, Z. and Smolka, W. and Zotova, J. and Knapik-Kowalczuk, J. and Sherif, A. and Tajber, L. and Paluch, M., The effect of electrostatic interactions on the formation of pharmaceutical eutectics, Physical Chemistry Chemical Physics, 20, (43), 2018, p27361-27367 Journal Article, 2018 DOI

Bialek K, Wojnarowska Z, Tajber L, Formation of eutectic and multicomponent phases of propranolol, 1st International Conference on Contemporary Pharmacy Challenges: Amorphous Pharmaceuticals and Biopharmaceuticals, Wisla, Poland, 9-11 September, 2018, 2018 Meeting Abstract, 2018

Bialek K, Wojnarowska Z, Tajber L, Formation and Characterisation of a New Salt, Di-Propranolol Sebacate, Chemical Crystallography @ Central Facilities, Belfast, NI, 31 October, 2018, 2018 Meeting Abstract, 2018

McComiskey K, Tajber L, Critical comparison of dynamic light scattering versus nanoparticle tracking analysis as particle sizing techniques and solid state monitoring for azole anti-fungal nanodispersions, AAPS Annual Meeting and Exposition, San Diego, USA, 12-15 November, 2017, 2017 Meeting Abstract, 2017

Dul M, Paluch KJ, Healy AM, Sasse A, Tajber L, Optimisation of the self-assembly process: production of stable, alginate-based polyelectrolyte nanocomplexes with protamine, Journal of Nanoparticle Research, 19, (6), 2017, p221 - 231 Journal Article, 2017 TARA - Full Text DOI

Mugheirbi N, O'Connell P, Serrano D, Healy AM, Taylor L, Tajber L, A comparative study on the performance of inert and functionalized spheres coated with solid dispersions made of two structurally related antifungal drugs, Molecular Pharmaceutics, 14, 2017, p3718 - 3728 Journal Article, 2017 DOI TARA - Full Text

Mesallati H, Umerska A, Paluch KJ, Tajber L, Amorphous polymeric drug salts as ionic solid dispersion forms of ciprofloxacin, Molecular Pharmaceutics, 14, 2017, p2209 - 2223 Journal Article, 2017 DOI TARA - Full Text

Svenja Sladek, Polymer-based polyelectrolyte nanocomplexes for oral and intra-articular peptide delivery, University College Dublin, 2017 Thesis, 2017

Mugheirbi N, Zotova J, Umerska AM, Santos-Martinez MJ, Tajber L, Novel surfactant-stabilized ciprofloxacin nanodispersions made by media milling; interactions with physiological barriers using quartz crystal microbalance with dissipation monitoring, AAPS Annual Meeting and Exposition, San Diego, USA, 12-15 November, 2017, 2017 Meeting Abstract, 2017

Hanah Mesallati, The production and characterization of fluoroquinolone amorphous solid dispersions, Trinity College Dublin, 2017 Thesis, 2017

McDonagh A, Brennan L, Tajber L, Investigation of the physical properties of drug-excipient tablets comprising powders produced by co-spray drying, AAPS Annual Meeting and Exposition, San Diego, USA, 12-15 November, 2017, 2017 Meeting Abstract, 2017

Mesallati H, Conroy D, Hudson S, Tajber L, Preparation and characterization of amorphous ciprofloxacin-amino acid salts, European Journal of Pharmaceutics and Biopharmaceutics, 121, 2017, p73 - 89 Journal Article, 2017 TARA - Full Text DOI

McComiskey K, Mugheirbi N, Stapleton J, Tajber L, In situ monitoring of azole anti-fungal nanoparticle formation, AAPS Annual Meeting and Exposition, San Diego, USA, 12-15 November, 2017, 2017 Meeting Abstract, 2017

Cruz R, Bowe R, Santos-Martinez MJ, Tajber L, Investigation of interactions of pegylated and non-pegylated itraconazole nanoparticles with mucin using quartz crystal microbalance with dissipation and dynamic light scattering, AAPS Annual Meeting and Exposition, San Diego, USA, 12-15 November, 2017, 2017 Meeting Abstract, 2017

Mesallati H, Tajber L, Polymer/amorphous salt solid dispersions of ciprofloxacin, Pharmaceutical Research, 34, (11), 2017, p2425 - 2439 Journal Article, 2017 DOI TARA - Full Text

Umerska A, Corrigan OI, Tajber L, Design of chondroitin sulfate-based polyelectrolyte nanoplexes: Formation of nanocarriers with chitosan and a case study of salmon calcitonin, Carbohydrate Polymers, 156, 2017, p276 - 284 Journal Article, 2017 DOI URL TARA - Full Text

Mugheirbi N, Tajber L, Taylor L, Investigations into the dissolution process of amorphous solid dispersions: an orthogonal approach utilizing high resolution imaging coupled with localized thermal analysis, AAPS Annual Meeting and Exposition, San Diego, USA, 12-15 November, 2017, 2017 Meeting Abstract, 2017

Mugheirbi NA, O'Connell P, Serrano DR, Healy AM, Taylor LS, Tajber L, A Comparative Study on the Performance of Inert and Functionalized Spheres Coated with Solid Dispersions Made of Two Structurally Related Antifungal Drugs, Molecular Pharmaceutics, 14, (11), 2017, p3718-3728 Journal Article, 2017 DOI

Mugheirbi, N.A. and Fleischer, K. and Tajber, L., A Rare Case of Mesomorphic Behavior-Molecular Reorientation of Itraconazole Liquid Crystal Induced by a Hygrothermal Treatment, Crystal Growth and Design, 16, (3), 2016, p1329-1336 Journal Article, 2016 DOI

Naila Mugheirbi , Engineering of itraconazole nano- and micro-particles with improved pharmaceutical performance, Trinity College Dublin, 2016 Thesis, 2016

Mugheirbi NA, Umerska A, Tajber L, Trojan microparticles containing ciprofloxacin nanoparticles produced via media milling, 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Glasgow, UK, 4-7 April, 2016, 2016 Meeting Abstract, 2016

Knapik J, Wojnarowska Z, Grzybowska K, Tajber L, Mesallati H, Paluch K, Paluch M, Molecular dynamics and physical stability of amorphous nimesulide drug and its binary drug-polymer systems, Molecular Pharmaceutics, 13, (6), 2016, p1937 - 1946 Journal Article, 2016 DOI TARA - Full Text

Wlodarski K, Tajber L, Sawicki W., Physicochemical properties of direct compression tablets with spray dried and ball milled solid dispersions of tadalafil in PVP-VA, European Journal of Pharmaceutics and Biopharmaceutics, 109, 2016, p14 - 23 Journal Article, 2016 TARA - Full Text DOI

Mesallati H, Conroy D, Tajber L, Preparation of amorphous solid dispersions of the zwitterionic drug ciprofloxacin with amino acids, 51st AAPS Arden Conference, Baltimore, USA, 18-20 April, 2016, 2016 Meeting Abstract, 2016

Wlodarski K, Tajber L, Sawicki W, Direct compression of amorphous spray dried and ball milled tadalafil/PVP-VA solid dispersions, 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Glasgow, UK, 4-7 April, 2016, 2016 Meeting Abstract, 2016

Mugheirbi N, Fleischer K, Tajber L, A rare case of mesomorphic behavior-molecular reorientation of itraconazole liquid crystal induced by a hygrothermal treatment, Crystal Growth and Design, 16, (3), 2016, p1329 - 1336 Journal Article, 2016 TARA - Full Text DOI

Serrano DR, Mugheirbi NA, O'Connell P, Leddy N, Healy AM, Tajber L, Impact of substrate properties on the formation of spherulitic films: a case study of salbutamol sulfate, Crystal Growth and Design, 16, (7), 2016, p3853 - 3858 Journal Article, 2016 DOI URL TARA - Full Text

Mesallati H, Mugheirbi NA, Tajber L, Two faces of ciprofloxacin: investigation of proton transfer in solid state transformations, Crystal Growth and Design, 16, (11), 2016, p6574 - 6585 Journal Article, 2016 DOI TARA - Full Text

McDonagh A, Tajber L, The crystallisation of active pharmaceutical ingredients onto excipient surfaces using a spray dryer, 12th International Workshop on Crystal Growth of Organic Materials CGOM, Leeds, UK, 26-20 June, 2016, 2016 Meeting Abstract, 2016

McComiskey K, Mugheirbi N, Tajber L, In situ monitoring of kinetics of azole anti-fungal nanoparticle formation, AAPS Annual Meeting and Exposition, Orlando, USA, 25-29 October, 2015, 2015 Meeting Abstract, 2015

Dul M, Paluch KJ, Kelly H, Healy AM, Sasse A, Tajber L, Self-assembled carrageenan/protamine polyelectrolyte nanoplexes-Investigation of critical parameters governing their formation and characteristics., Carbohydrate Polymers, 123, 2015, p339 - 349 Journal Article, 2015 TARA - Full Text DOI

Wlodarski K, Sawicki W, Haber K, Knapik J, Wojnarowska Z, Paluch M, Lepek P, Hawelek L, Tajber L, Physicochemical properties of tadalafil solid dispersions - Impact of polymer on the apparent solubility and dissolution rate of tadalafil., European Journal of Pharmaceutics and Biopharmaceutics, 94, 2015, p106 - 115 Journal Article, 2015 DOI

Knopp MM, Tajber L, Tian Y, Olesen NE, Jones DS, Kozyra A, Löbmann K, Paluch K, Brennan CM, Holm R, Healy AM, Andrews GP, Rades T, Comparative study of different methods for the prediction of drug-polymer solubility, Molecular Pharmaceutics, 12, (9), 2015, p3408 - 3419 Journal Article, 2015 TARA - Full Text DOI

Amaro MI, Tajber L, Corrigan OI, Healy AM, Co-spray dried carbohydrate microparticles: crystallisation delay/inhibition and improved aerosolization characteristics through the incorporation of hydroxypropyl-ß-cyclodextrin with amorphous raffinose or trehalose, Pharmaceutical Research, 32, (1), 2015, p180 - 195 Journal Article, 2015 TARA - Full Text DOI

Amaro MI, Tewes F, Gobbo O, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Formulation, stability and pharmacokinetics of sugar-based salmon calcitonin-loaded nanoporous/nanoparticulate microparticles (NPMPs) for inhalation., International Journal of Pharmaceutics, 483, (1-2), 2015, p6 - 18 Journal Article, 2015 DOI

Mugheirbi L, Tajber L, Unusual isomorphic intergrowth of itraconazole induced by tuning recrystallization conditions, AAPS Annual Meeting and Exposition, Orlando, USA, 25-29 October, 2015, 2015 Meeting Abstract, 2015

Wlodarski K, Sawicki W, Kozyra A, Tajber L, Physical stability of solid dispersions with respect to thermodynamic solubility of tadalafil in PVP-VA., European Journal of Pharmaceutics and Biopharmaceutics, 96, 2015, p237 - 246 Journal Article, 2015 TARA - Full Text DOI

Brennan C, A. Giles A, Amaro MI, Tajber L, Andrews GP, Healy AM, Film Casting as a Screening Technique in the Selection of API-Polymer Compositions for Amorphous Solid Dispersion Production via Spray Drying, Controlled Release Society Annual Meeting 2015, Edinburgh, UK, 26-29 July, 2015, 2015 Meeting Abstract, 2015

Mugheirbi NA, Tajber L, Crystal habits of itraconazole microcrystals: unusual isomorphic intergrowths induced via tuning recrystallization conditions, Molecular Pharmaceutics, 12, (9), 2015, p3468 - 3478 Journal Article, 2015 DOI TARA - Full Text

Umerska A, Paluch KJ, Santos-Martinez MJ, Medina C, Corrigan OI, Tajber L, Chondroitin-based nanoplexes as peptide delivery systems--Investigations into the self-assembly process, solid-state and extended release characteristics., European Journal of Pharmaceutics and Biopharmaceutics, 93, 2015, p242 - 253 Journal Article, 2015 TARA - Full Text DOI

Sladek S, Eskander M, Tajber L, Brayden DJ, Size exclusion chromatography: a useful method to determine peptide loading of nanoparticles, 42nd Annual Meeting & Exposition of the Controlled Release Society, Edinburgh, Scotland, 26-29 July, 2015, 2015 Meeting Abstract, 2015

Amaro, M.I. and Tajber, L. and Corrigan, O.I. and Healy, A.M., Co-Spray dried carbohydrate microparticles: Crystallisation delay/inhibition and improved aerosolization characteristics through the incorporation of hydroxypropyl-β-cyclodextrin with amorphous raffinose or trehalose, Pharmaceutical Research, 32, (1), 2015, p180-195 Journal Article, 2015 DOI

Wlodarski K, Sawicki W, Tajber L, Paluch M, Is thermodynamic solubility of tadalafil in Kollidon® VA 64 the key parameter affecting physical stability of the amorphous solid dispersion?, 1st European Conference on Pharmaceutics: Drug Delivery, Reims, France, 13-14 April, 2015, 2015 Meeting Abstract, 2015

Mugheirbi NA, Tajber L, Mesophase and size manipulation of itraconazole liquid crystalline nanoparticles produced via quasi nanoemulsion precipitation., European Journal of Pharmaceutics and Biopharmaceutics, 96, 2015, p226 - 236 Journal Article, 2015 TARA - Full Text DOI

Knapik J, Wojnarowska Z, Grzybowska K, Jurkiewicz K, Tajber L, Paluch M, Molecular dynamics and physical stability of coamorphous ezetimib and indapamide mixtures, Molecular Pharmaceutics, 12, (10), 2015, p3610 - 3619 Journal Article, 2015 TARA - Full Text DOI

Sladek S, Eskander M, Tajber L, Brayden DJ, Hyaluronate-based polyelectrolyte nanocomplexes as a potential oral peptide delivery formulation, Crossing Biological Barriers - Advances in Nanocarrier Design for Targeted Drug Delivery (DECHEMA), Dresden, Germany, 9-11 November, 2015, 2015 Meeting Abstract, 2015

Mesallati H, Tajber L, Production of binary amorphous salt solid dispersions of ciprofloxacin, AAPS Annual Meeting and Exposition, Orlando, USA, 25-29 October, 2015, 2015 Meeting Abstract, 2015

Mugheirbi L, Tajber L, Mesophase and size manipulation of itraconazole liquid crystalline nanoparticles produced via quasi nano-emulsion precipitation, AAPS Annual Meeting and Exposition, Orlando, USA, 25-29 October, 2015, 2015 Meeting Abstract, 2015

Wojnarowska Z, Paluch KJ, Shoifet E, Schick C, Tajber L, Knapik J, Wlodarczyk P, Grzybowska K, Hensel-Bielowka S, Verevkin SP, Paluch M, Molecular origin of enhanced proton conductivity in anhydrous ionic systems., Journal of the American Chemical Society, 137, (3), 2015, p1157 - 1164 Journal Article, 2015 DOI

Kozyra A, Paluch KJ, Tajber L, Application of theoretical and practical approaches in the prediction of itraconazole-polymer miscibility for the design of solid dispersions, AAPS Annual Meeting and Exposition, Orlando, USA, 25-29 October, 2015, 2015 Meeting Abstract, 2015

Grossjohann C, Serrano DR, Paluch KJ, O'Connell P, Vella-Zarb L, Manesiotis P, Mccabe T, Tajber L, Corrigan OI, Healy AM, Polymorphism in sulfadimidine/4-aminosalicylic acid cocrystals: solid-state characterization and physicochemical properties., Journal of Pharmaceutical Sciences, 104, (4), 2015, p1385 - 1398 Journal Article, 2015 DOI

Kozyra A, Colgan DA, Paluch KJ, Tajber L, Ionic liquids of lidocaine with dicarboxylic acids, 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Lisbon, Portugal, 31 March-3 April, 2014 Meeting Abstract, 2014

Healy AM, Amaro MI, Paluch KJ, Tajber L, Dry powders for oral inhalation free of lactose carrier particles, Advanced Drug Delivery Reviews, 75, 2014, p32 - 52 Review Article, 2014 DOI TARA - Full Text

Wlodarski K, Sawicki W, Paluch KJ, Tajber L, Grembecka M, Hawelek L, Wojnarowska Z, Grzybowska K, Talik E, Paluch M, The influence of amorphization methods on the apparent solubility and dissolution rate of tadalafil., European Journal of Pharmaceutical Sciences, 62, 2014, p132 - 140 Journal Article, 2014 DOI

Umerska A, Corrigan OI, Tajber L, Intermolecular interactions between salmon calcitonin, hyaluronate, and chitosan and their impact on the process of formation and properties of peptide-loaded nanoparticles., International Journal of Pharmaceutics, 477, (1-2), 2014, p102 - 112 Journal Article, 2014 TARA - Full Text DOI

Mugheirbi N, Paluch KJ, Tajber L, Heat induced evaporative antisolvent nanoprecipitation of itraconazole, 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Lisbon, Portugal, 31 March-3 April, 2014 Meeting Abstract, 2014

Stojkovic A, Tajber L, Paluch KJ, Djuric Z, Parojcic J, Corrigan OI, Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution., Acta Pharmaceutica, 64, (1), 2014, p77 - 88 Journal Article, 2014 DOI

Mugheirbi NA, Tajber L, Evaporative antisolvent precipitation of enteric itraconazole nanoparticles, UK and Ireland Controlled Release Society Symposium, Cork, Ireland, 31 March-3 April, 2014 Meeting Abstract, 2014

StojkoviÄ , A. and Tajber, L. and DjuriÄ , Z. and Corrigan, O.I. and ParojÄ iÄ , J., In vitro simulation of drug interaction: Ciprofloxacin/zinc chloride, Journal of Drug Delivery Science and Technology, 24, (2), 2014, p229-233 Journal Article, 2014 DOI

Mugheirbi NA, Paluch KJ, Tajber L, Heat induced evaporative antisolvent nanoprecipitation (HIEAN) of itraconazole., International Journal of Pharmaceutics, 471, (1-2), 2014, p400 - 411 Journal Article, 2014 TARA - Full Text DOI

Mugheirbi N, Tajber L, Tailoring itraconazole crystal habits-impact of solvent and polymer effect, AAPS Annual Meeting and Exposition, San Diego, USA, 2-6 November, 2014, 2014 Meeting Abstract, 2014

Sladek S, Tajber L, Brayden DJ, Self-assembling hyaluronate-based polyelectrolyte nanocomplexes for oral insulin delivery, 41st Annual Meeting & Exposition of the Controlled Release Society, Chicago, USA, 13-16 July, 2014 , 2014 Meeting Abstract, 2014

Umerska A, Paluch KJ, Santos-Martinez MJ, Corrigan OI, Medina C, Tajber L, Self-assembled hyaluronate/protamine polyelectrolyte nanoplexes: synthesis, stability, biocompatibility and potential use as peptide carriers, Journal of Biomedical Nanotechnology, 10, (12), 2014, p3658 - 3673 Journal Article, 2014 DOI TARA - Full Text

Joanne Crean, The optimisation, characterisation and platelet compatibility of polymeric nanocarriers loaded with NSAIDs, Trinity College Dublin, 2014 Thesis, 2014

Santos-Martinez MJ, Rahme K, Corbalan JJ, Faulkner C, Holmes JD, Tajber L, Medina C, Radomski MW, Pegylation increases platelet biocompatibility of gold nanoparticles., Journal of Biomedical Nanotechnology, 10, (6), 2014, p1004 - 1015 Journal Article, 2014 DOI

Brennan C, Tian Y, Paluch KJ, Tajber L, Andrews G, Healy AM, Drug-polymer thermodynamic phase diagrams in the selection of optimal API-polymer compositions for amorphous solid dispersions, AAPS Annual Meeting and Exposition, San Diego, USA, 2-6 November, 2014, 2014 Meeting Abstract, 2014

Paluch KJ, Wojnarowska Z, Żeglinski J, Knapik J, Paluch M, Healy AM, Tajber L, The role of thermodynamic and kinetic fragility in the stabilisation of amorphous nimesulide composites, 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Lisbon, Portugal, 2014 Meeting Abstract, 2014

Wojnarowska Z, Paluch KJ, Shoifet E, Schick C, Tajber L, Knapik J, Wlodarczyk P, Grzybowska K, Hensel-Bielowka S, Verevkin SP, Paluch M, Crystal structure of lidocaine succinate, Refcode ROYWIN, CCDC Number 935179, CCDC, https://www.ccdc.cam.ac.uk/, 2013 Dataset, 2013 DOI

Curtin V, Amharar Y, Hu Y, Erxleben A, McArdle P, Caron V, Tajber L, Corrigan OI, Healy AM, Investigation of the capacity of low glass transition temperature excipients to minimize amorphization of sulfadimidine on comilling., Molecular Pharmaceutics, 10, (1), 2013, p386 - 396 Journal Article, 2013 DOI

Paluch KJ, McCabe T, Müller-Bunz H, Corrigan OI, Healy AM, Tajber L, Formation and physicochemical properties of crystalline and amorphous salts with different stoichiometries formed between ciprofloxacin and succinic acid, Molecular Pharmaceutics, 10, (10), 2013, p3640 - 3654 Journal Article, 2013 DOI TARA - Full Text

Maria Dul, Engineering a novel insulin delivery system , Trinity College Dublin, 2013 Thesis, 2013 URL

Tewes F, Paluch KJ, Tajber L, Gulati K, Kalantri D, Ehrhardt C, Healy AM, Steroid/mucokinetic hybrid nanoporous microparticles for pulmonary drug delivery, European Journal of Pharmaceutics and Biopharmaceutics, 85, (3), 2013, p604 - 613 Journal Article, 2013 TARA - Full Text DOI

Wojnarowska Z, Paluch KJ, Shoifet E, Schick C, Tajber L, Knapik J, Wlodarczyk P, Grzybowska K, Hensel-Bielowka S, Verevkin SP, Paluch M, Crystal structure of lidocaine phosphate, Refcode ROYWOT, CCDC Number 935178, CCDC, https://www.ccdc.cam.ac.uk/, 2013 Dataset, 2013 DOI

Wojnarowska Z, Kolodziejczyk K, Paluch KJ, Tajber L, Grzybowska K, Ngai KL, Paluch M, Decoupling of conductivity relaxation from structural relaxation in protic ionic liquids and general properties., Physical Chemistry Chemical Physics, 15, (23), 2013, p9205 - 9211 Journal Article, 2013 DOI

Dul M, Kelly H, Sasse A, Tajber L, Formulation and in vitro characterisation of polymeric nanoparticulate carrier systems for oral delivery of insulin, 5th World Conference on Drug Absorption, Transport and Delivery: Clinical Significance and Regulatory Impact, Uppsala, Sweden , 24-26 June, 2013, 2013 Meeting Abstract, 2013

Stefano Bianco, The effect of processing on the solid state characteristics of selected sulphonamides and their sodium salts, alone and as drug-salt composites, Trinity College Dublin, 2013 Thesis, 2013 URL

Anita Umerska, Formulation and characterisation of polyelectrolyte complex nanoparticles for the delivery of salmon calcitonin, Trinity College Dublin, 2013 Thesis, 2013 URL

Maria Ines Amaro, Development of salmon calcitonin (sCT) nanoporous/nanoparticulate microparticles for pulmonary delivery, Trinity College Dublin, 2013 Thesis, 2013 URL

de Sousa VP, Crean J, de Almeida Borges VR, Rodrigues CR, Tajber L, Boylan F, Cabral LM, Nanostructured systems containing babassu (Orbignya speciosa) oil as a potential alternative therapy for benign prostatic hyperplasia., International Journal of Nanomedicine, 8, 2013, p3129 - 3139 Journal Article, 2013 TARA - Full Text DOI

Christine Grossjohann, Pharmaceutical cocrystals: a contribution to fundamental studies addressing solubility, dissolution, formation and characterisation, Trinity College Dublin, 2013 Thesis, 2013 URL

Salt Forms: Pharmaceutical Aspects in, editor(s)James Swarbrick , Encyclopedia of Pharmaceutical Technology, CRC Press, 2013, pp3041 - 3051, [Corrigan OI, Tajber L] Book Chapter, 2013 DOI

Caron V, Hu Y, Tajber L, Erxleben A, Corrigan OI, McArdle P, Healy AM, Amorphous solid dispersions of sulfonamide/Soluplus® and sulfonamide/PVP prepared by ball milling., AAPS PharmSciTech, 14, (1), 2013, p464 - 474 Journal Article, 2013 DOI

Hu Y, MacFhionnghaile P, Caron V, Tajber L, Healy AM, Erxleben A, Formation, physical stability and quantification of process induced disorder in cryo-milled samples of a model polymorphic drug, Journal of Pharmaceutical Sciences, 102, (1), 2013, p93 - 103 Journal Article, 2013 DOI

Paluch KJ, Tajber L, Corrigan OI, Healy AM, Impact of alternative solid state forms and specific surface area of high-dose, hydrophilic active pharmaceutical ingredients on tabletability, Molecular Pharmaceutics, 10, (10), 2013, p3628 - 3639 Journal Article, 2013 URL

Wojnarowska Z, Grzybowska K, Hawelek L, Dulski M, Wrzalik R, Gruszka I, Paluch M, Pienkowska K, Sawicki W, Bujak P, Paluch KJ, Tajber L, Markowski J, Molecular dynamics, physical stability and solubility advantage from amorphous indapamide drug., Molecular Pharmaceutics, 10, (10), 2013, p3612 - 3627 Journal Article, 2013 DOI

Bianco S, Tewes F, Tajber L, Caron V, Corrigan OI, Healy AM, Bulk, surface properties and water uptake mechanisms of salt/acid amorphous composite systems, International Journal of Pharmaceutics, 456, (1), 2013, p143 - 152 Journal Article, 2013 DOI TARA - Full Text

Curtin V, Amharar Y, Gallagher KH, Corcoran S, Tajber L, Corrigan OI, Healy AM, Reducing mechanical activation-induced amorphisation of salbutamol sulphate by co-processing with selected carboxylic acids, International Journal of Pharmaceutics, 456, (2), 2013, p508 - 516 Journal Article, 2013 TARA - Full Text DOI

Evelyn O'Shea, Investigation of the solid-state, powder flow and tabletability properties of comminuted active pharmaceutical ingredients, Trinity College Dublin, 2013 Thesis, 2013

Ryan SM, McMorrow J, Umerska A, Patel HB, Kornerup KN, Tajber L, Murphy EP, Perretti M, Corrigan OI, Brayden DJ, An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis., Journal of Controlled Release, 167, (2), 2013, p120 - 129 Journal Article, 2013 DOI

Crean J, Corrigan OI, Tajber L, Exploring hydrophobic drug interaction with polyelectrolyte complex nanoparticles, 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Istanbul, Turkey, 19-22 March, 2012, 2012 Meeting Abstract, 2012

Paluch KJ, Tajber L, Corrigan OI, Healy AM, Impact of process variables on the micromeritic and physicochemical properties of spray dried porous microparticles - Part I. Introduction of a new Morphology Classification System, Journal of Pharmacy and Pharmacology, 64, (11), 2012, p1570 - 1582 Journal Article, 2012 DOI TARA - Full Text

Bianco S, Tewes F, Tajber L, Caron V, Corrigan OI, Healy AM, Bulk and surface properties and water uptake mechanisms of salt/acid amorphous composite systems, 10th International Workshop on Crystal Growth of Organic Materials CGOM, Limerick, Ireland, 11-14 June, 2012, 2012 Meeting Abstract, 2012

Curtin V, Amharar Y, Hu Y, McArdle P, Erxleben A, Caron V, Tajber L, Corrigan OI, Healy AM, Investigation of the capability of crystalline dicarboxylic acids to minimize amorphization of sulfadimidine on co-milling, AAPS Annual Meeting and Exposition, Chicago, USA, 14-18 October, 2012, 2012 Meeting Abstract, 2012

Ní Ógáin O, Tajber L, Corrigan OI, Healy AM, Spray drying from organic solvents to prepare nanoporous/nanoparticulate microparticles (NPMPs) of protein:excipient composites designed for oral inhalation, Journal of Pharmacy and Pharmacology, 64, (9), 2012, p1275 - 1290 Journal Article, 2012 TARA - Full Text DOI

Amharar Y, Tajber L, Corrigan OI, Healy AM, Mechanical activation of crystalline APIs by dry blending, 10th International Workshop on Crystal Growth of Organic Materials CGOM, Limerick, Ireland, 11-14 June, 2012, 2012 Meeting Abstract, 2012

Paluch KJ, McCabe T, Müller-Bunz H, Corrigan OI, Healy AM, Tajber L, Crystal structure of ciprofloxacin succinate, Refcode QABTOF, CCDC Number 870867, CCDC, https://www.ccdc.cam.ac.uk/, 2012 Dataset, 2012 DOI

Amharar Y, Tajber L, Corrigan OI, Healy AM, Amorphisation of crystalline APIs by dry mixing, AAPS Annual Meeting and Exposition, Chicago, USA, 14-18 October, 2012, 2012 Meeting Abstract, 2012

Mori A, Oleszycka E, Sharp FA, Coleman M, Ozasa Y, Singh M, O'Hagan DT, Tajber L, Corrigan OI, McNeela EA, Lavelle EC, The vaccine adjuvant alum inhibits IL-12 by promoting PI3 kinase signaling while chitosan does not inhibit IL-12 and enhances Th1 and Th17 responses., European Journal of Immunology, 42, (10), 2012, p2709 - 2719 Journal Article, 2012 DOI

Grossjohann C, Paluch KJ, Coakley N, Tajber L, Corrigan OI, Healy AM, Investigating the potential for reaction crystallization on spray-drying sulfadimidine with aromatic carboxylic acids, AAPS Annual Meeting and Exposition, Chicago, USA, 14-18 October, 2012, 2012 Meeting Abstract, 2012

Grossjohann C, Eccles KS, Maguire AR, Lawrence SE, Tajber L, Corrigan OI, Healy AM, Characterisation, solubility and intrinsic dissolution behaviour of benzamide:dibenzyl sulfoxide cocrystal, International Journal of Pharmaceutics, 422, (1-2), 2012, p24-32 Journal Article, 2012 TARA - Full Text DOI

Paluch KJ, Tajber L, Corrigan OI, Healy AM, Assessment of compactibility performance of spray dried, amorphous and excipient-free, large surface area nanoporous microparticles, 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Istanbul, Turkey, 19-22 March, 2012, 2012 Meeting Abstract, 2012

Crean J, Paluch KJ, Corrigan OI, Tajber L, The solid state of hydrophobic drugs in polyelectrolyte nanoplexes, 10th International Workshop on Crystal Growth of Organic Materials CGOM, Limerick, Ireland, 11-14 June, 2012, 2012 Meeting Abstract, 2012

Paluch KJ, Amaro MI, Tajber L, Corrigan OI, Healy AM, Impact of process variables on the micromeritic and physicochemical properties of spray dried microparticles - Part II. Physicochemical characterisation of spray dried materials, Journal of Pharmacy and Pharmacology, 64, (11), 2012, p1583 - 1591 Journal Article, 2012 TARA - Full Text DOI

Paluch KJ, McCabe T, Müller-Bunz H, Corrigan OI, Healy AM, Tajber L, Crystal structure of ciprofloxacin succinate, Refcode QABTUL, CCDC Number 870866, CCDC, https://www.ccdc.cam.ac.uk/, 2012 Dataset, 2012 DOI

Paluch KJ, Tajber L, Adamczyk B, Corrigan OI, Healy AM, A novel approach to crystallisation of nanodispersible microparticles by spray drying for improved tabletability, International Journal of Pharmaceutics, 436, (1-2), 2012, p873 - 876 Journal Article, 2012 URL DOI

Dul M, Kelly H, Tajber L, Development of a new nanoparticulate system for the oral delivery of insulin, AAPS Annual Meeting and Exposition, Chicago, USA, 14-18 October, 2012, 2012 Meeting Abstract, 2012

Amaro MI, Gobbo O, Tewes F, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Characterisation and pharmacokinetic studies of salmon calcitonin:sugar nanoporous/nanoparticulate microparticles (NPMPs) for pulmonary delivery, 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Istanbul, Turkey, 19-22 March, 2012, 2012 Meeting Abstract, 2012

Paluch KJ, Tajber L, Adamczyk B, Corrigan OI, Healy AM, Continuous crystallisation by spray drying to produce nanocrystalline microparticle (NCMP) powders with enhanced tabletability performance, AAPS Annual Meeting and Exposition, Chicago, USA, 14-18 October, 2012, 2012 Meeting Abstract, 2012

Bianco S, Caron V, Tajber L, Corrigan OI, Nolan LM, Hu Y, Healy AM, Modification of the solid state nature of sulfathiazole and sulfathiazole sodium by spray drying, AAPS PharmSciTech, 13, (2), 2012, p647 - 660 Journal Article, 2012 DOI

Umerska AM, Inkielewicz-Stepniak I, Corrigan OI, Medina C, Tajber L, Redispersibility studies on freeze-dried hyaluronic acid/chitosan polymeric nanoparticles, 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Istanbul, Turkey, 19-22 March, 2012, 2012 Meeting Abstract, 2012

Grossjohann C, Tajber L, Corrigan OI, Healy AM, Co-grinding and co-spray drying: alternative approaches to the formation of cocrystals, 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Istanbul, Turkey, 19-22 March, 2012, 2012 Meeting Abstract, 2012

Gad S, Tajber L, Corrigan OI Healy AM, Preparation and characterisation of novel spray dried nano-structured para-aminosalicylic acid particulates for pulmonary delivery: impact of ammonium carbonate on morphology, chemical composition and solid state, Journal of Pharmacy and Pharmacology, 64, (9), 2012, p1264 - 1274 Journal Article, 2012 DOI TARA - Full Text

O'Shea E, Tajber L, Corrigan OI, Healy AM, Comminution of sulfathiazole polymorphs, 10th International Workshop on Crystal Growth of Organic Materials CGOM, Limerick, Ireland, 11-14 June, 2012, 2012 Meeting Abstract, 2012

Grossjohann C, Tajber L, Corrigan OI, Healy AM, Physicochemical properties, solubility and dissolution of a cocrystal composed of two amphoteric components, 10th International Workshop on Crystal Growth of Organic Materials CGOM, Limerick, Ireland, 11-14 June, 2012, 2012 Meeting Abstract, 2012

Paluch KJ, McCabe T, Mueller-Bunz H, Corrigan OI, Healy AM, Tajber L, Supersaturation of drug in aqueous media obtained by transformation of ciprofloxacin succinate hydrate, AAPS Annual Meeting and Exposition, Chicago, USA, 14-18 October, 2012, 2012 Meeting Abstract, 2012

Curtin V, Corcoran S, Hu Y, McArdle P, Erxleben A, Caron V, Tajber L, Corrigan OI, Healy AM, The capability of glutaric acid excipient to improve the crystallinity of sulfadimidine and salbutamol sulphate upon co-milling, 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Istanbul, Turkey, 19-22 March, 2012, 2012 Meeting Abstract, 2012

Paluch KJ, Tajber L, Adamczyk B, Corrigan OI, Healy AM, Continuous crystallisation of nanodispersible microparticles by spray drying for improved tableting, 10th International Workshop on Crystal Growth of Organic Materials CGOM, Limerick, Ireland, 11-14 June, 2012, 2012 Meeting Abstract, 2012

Paluch KJ, McCabe T, Mueller-Bunz H, Corrigan OI, Healy AM, Tajber L, Drug supersaturation through a water mediated transformation of salts - studies on ciprofloxacin succinate, 10th International Workshop on Crystal Growth of Organic Materials CGOM, Limerick, Ireland, 11-14 June, 2012, 2012 Meeting Abstract, 2012

Paluch KJ, Corrigan OI, Healy AM, Tajber L, Preparation and characterisation of novel solid state forms of ciprofloxacin with dicarboxylic acids, 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Istanbul, Turkey, 19-22 March, 2012, 2012 Meeting Abstract, 2012

Umerska A, Paluch KJ, Inkielewicz-Stępniak I, Santos-Martinez MJ, Corrigan OI, Medina C, Tajber L., Exploring the assembly process and properties of novel crosslinker-free hyaluronate-based polyelectrolyte complex nanocarriers, International Journal of Pharmaceutics, 436, (1-2), 2012, p75 - 87 Journal Article, 2012 TARA - Full Text DOI URL

Curtin V, Hu Y, McArdle P, Erxleben A, Caron V, Tajber L, Corrigan OI, Healy AM, Use of a low glass transition temperature excipient to minimise amorphisation of salbutamol sulphate and sulfadimidine upon co-milling, 10th International Workshop on Crystal Growth of Organic Materials CGOM, Limerick, Ireland, 11-14 June, 2012, 2012 Meeting Abstract, 2012

Amaro MI, Tewes F, Tajber L, Corrigan OI, Healy AM, Physicochemical, physical stability and aerosolisation properties of trehalose/cyclodextrin microparticles, AAPS Annual Meeting and Exposition, Washington, USA, 23-27 October, 2011, 2011 Meeting Abstract, 2011

Caron V, Tajber L, Corrigan OI, Healy AM, Production of sulphonamide/PVP and sulphonamide/Soluplus® amorphous dispersions by ball milling: Construction of physical stability diagrams, AAPS Annual Meeting and Exposition, Washington, USA, 23-27 October, 2011, 2011 Meeting Abstract, 2011

Amaro MI, Tajber L, Corrigan OI, Healy AM, Optimisation of spray drying process conditions for sugar nanoporous microparticles (NPMPs) intended for inhalation, International Journal of Pharmaceutics, 421, (1), 2011, p99 - 109 Journal Article, 2011 DOI TARA - Full Text

Hibbitts A, Sivadas N, Tewes F, Healy AM, Tajber L, Ehrhardt C, Cryan SA, MacLoughlin R, Investigation of fluid physicochemical properties on output in vibrating mesh nebulisers, Journal of Aerosol Medicine and Pulmonary Drug Delivery, 18th Congress of the International Society for Aerosols in Medicine (ISAM), Rotterdam, 18-22 June, 2011, 24, 2011, ppA1 - A66 Conference Paper, 2011 DOI

Tewes F, Gobbo OL, Amaro MI, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Evaluation of HPβCD-PEG microparticles for salmon calcitonin administration via pulmonary delivery, Molecular Pharmaceutics, 8, (5), 2011, p1887 - 1898 Journal Article, 2011 DOI

Amaro MI, Tewes F, Tajber L, Corrigan OI, Healy AM, Formulation and stability of sugar-based salmon calcitonin-loaded nanoporous/nanoparticulate microparticles (NPMPs) for inhalation, Journal of Aerosol Medicine and Pulmonary Drug Delivery, 18th Congress of the International Society for Aerosols in Medicine (ISAM), Rotterdam, 18-22 June, 2011, 24, 2011, ppA1 - A66 Conference Paper, 2011 DOI

Paluch KJ, Tajber L, McCabe T, O'Brien JE, Corrigan O, Healy AM, Preparation and characterisation of novel chlorothiazide potassium solid-state salt forms: intermolecular self assembly suprastructures, European Journal of Pharmaceutical Sciences, 42, (3), 2011, p220 - 229 Journal Article, 2011 DOI TARA - Full Text

Curtin V, Caron V, Tajber L, Corrigan OI, Healy AM, The impact of co-milling sulfadimidine with low glass transition temperature excipients as a strategy for preventing process induced amorphisation, UK and Ireland Controlled Release Society Symposium, Belfast, 13 April, 2011, 2011 Meeting Abstract, 2011

Crean J, Endter S, Tajber L, Inhibition of platelet aggregation by PLGA nanoparticles loaded with non-steroidal anti-inflammatory drugs , UK and Ireland Controlled Release Society Symposium, Belfast, 13 April, 2011, 2011 Meeting Abstract, 2011

Bianco S, Tewes F, Caron V, Tajber L, Corrigan OI, Healy AM, Modification of the solid state of sulfathiazole-sulfathiazole sodium composite systems via spray drying, AAPS Annual Meeting and Exposition, Washington, USA, 23-27 October, 2011, 2011 Meeting Abstract, 2011

Parojcic J, Stojkovic A, Tajber L, Grbic S, Paluch KJ, Djuric Z, Corrigan OI., Biopharmaceutical characterization of ciprofloxacin HCl-ferrous sulfate interaction, Journal of Pharmaceutical Sciences, 100, (12), 2011, p5174 - 5184 Journal Article, 2011 DOI

Ryan SM, Patel H, Kornerup KN, Tajber L, Umerska A, Perretti M, Brayden DJ, Intra-articular delivery of salmon calcitonin nanocomplexes to the K/BxN murine model for treatment of osteoarthritis, European Society for Biomaterials Annual Conference in Dublin, Dublin, 4-9 September, 2011, 2011 Oral Presentation, 2011

Paluch K, Tajber L, Elcoate CJ, Corrigan OI, Lawrence SE, Healy AM, Solid state characterisation of novel active pharmaceutical ingredients: co-crystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt, Journal of Pharmaceutical Sciences, 100, (8), 2011, p3268 - 3283 Journal Article, 2011 DOI TARA - Full Text

Umerska AM, Corrigan OI, Tajber L , Preparation and characterisation of salmon calcitonin loaded hyaluronate-based nanoparticles, UK and Ireland Controlled Release Society Symposium, Belfast, 13 April, 2011, 2011 Meeting Abstract, 2011

Tewes F, Gobbo OL, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, PEG-based microparticles for pulmonary administration of salmon calcitonin, Journal of Aerosol Medicine and Pulmonary Drug Delivery, 18th Congress of the International Society for Aerosols in Medicine (ISAM), Rotterdam, 18-22 June, 2011, 24, 2011, ppA1 - A66 Conference Paper, 2011 DOI

Krzysztof Jan Paluch, Solid-state characteristics of pre and post-spray dried active pharmaceutical ingredients, salts and co-crystalline forms, Trinity College Dublin, 2011 Thesis, 2011 URL

Caron V, Tajber L, Corrigan OI, Healy AM, A comparison of spray drying and milling in the production of amorphous dispersions of sulfathiazole/polyvinylpyrrolidone and sulfadimidine/polyvinylpyrrolidone, Molecular Pharmaceutics, 8, (2), 2011, p532 - 542 Journal Article, 2011 DOI

Ní Ógáin O, Li J, Tajber L, Corrigan OI, Healy AM, Particle engineering of materials for oral inhalation by dry powder inhalers. I - Particles of sugar excipients (trehalose and raffinose) for protein delivery, International Journal of Pharmaceutics, 405, (1-2), 2011, p23 - 35 Journal Article, 2011 DOI TARA - Full Text

Corrigan O, Tajber L, Ryan S, Brayden D, Umerska A, 'A polymeric nanoparticle', University College Dublin, US20140038894, 2011 Patent, 2011 URL

Nolan LM, Li J, Tajber L, Corrigan OI, Healy AM, Particle engineering of materials for oral inhalation by dry powder inhalers. II - Sodium cromoglicate, International Journal of Pharmaceutics, 405, (1-2), 2011, p36 - 46 Journal Article, 2011 DOI TARA - Full Text

Crean J, Endter S, Corrigan OI, Radomski M, Tajber L, Poly-lactide-co-glycolide (PLGA) and hyaluronic acid-chitosan (HACS) nanoparticles (NPs) loaded with ketoprofen: a comparison of their effect on inhibition of platelet aggregation , AAPS Annual Meeting and Exposition, Washington, USA, 23-27 October, 2011, 2011 Meeting Abstract, 2011

Tewes F, Tajber L, Ehrhardt C, Healy AM, Formulation of colistin-ambroxol microparticles for passive targeting of lung infection, AAPS Annual Meeting and Exposition, Washington, USA, 23-27 October, 2011, 2011 Meeting Abstract, 2011

Bianco S, Caron V, Tajber L, Corrigan OI, Healy AM, Alteration of the solid state nature of sulfathiazole and sulfathiazole sodium on spray drying, UK and Ireland Controlled Release Society Symposium, Belfast, 13 April, 2011, 2011 Meeting Abstract, 2011

Caron V, Tajber L, Corrigan OI, Healy AM, Production of amorphous dispersions of sulfonamides/polyvinylpyrrolidone by ball milling, UKPharmSci, APS, the Science of Medicines, Nottingham, UK, 1-3 September, 2010, 2010 Meeting Abstract, 2010

Paluch KJ, Tajber L, McCabe T, O'Brien JE, Corrigan OI, Healy AM, Preparation and solid state characterisation of chlorothiazide sodium intermolecular self assembly suprastructure, European Journal of Pharmaceutical Sciences, 41, (5), 2010, p603 - 611 Journal Article, 2010 TARA - Full Text DOI

Paluch KJ, Tajber L, Elcoate CJ T, Corrigan OI, Lawrence SE, Healy AM, Crystal structure of salbutamol succinate methanolate, Refcode ORUXAB, CCDC Number 801060, CCDC, https://www.ccdc.cam.ac.uk/, 2010 Dataset, 2010 DOI

Amaro MI, Tewes F, Tajber L, Corrigan OI, Healy AM, Characterisation, aerodynamic behaviour and bioactivity of salmon calcitonin-loaded nanoporous/nanoparticulate microparticles (NPMPs), FIP Pharmaceutical Sciences World Congress (PSWC) in association with the AAPS Annual Meeting and Exposition, New Orleans, USA, 14-18, November 2010, 2010 Meeting Abstract, 2010

Tewes F, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Development and characterisation of soluble polymeric particles for pulmonary peptide delivery, European Journal of Pharmaceutical Sciences, 41, (2), 2010, p337 - 352 Journal Article, 2010 DOI TARA - Full Text

Paluch KJ, Tajber L, Corrigan OI, Healy AM, Investigation of physicochemical interactions of spray dried composites comprising polymer and chlorothiazide, chlorothiazide sodium or chlorothiazide potassium, UKPharmSci, APS, the Science of Medicines, Nottingham, UK, 1-3 September, 2010, 2010 Meeting Abstract, 2010

Caron V, Tajber L, Corrigan OI, Healy AM, Production and characterisation of sulfonamide/polyvinylpyrrolidone amorphous dispersions prepared by ball milling, UKPharmSci, APS, the Science of Medicines, Nottingham, UK, 1-3 September, 2010, 2010 Meeting Abstract, 2010

Tewes F, Gobbo OL, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Effect of PEG type and HPβCD on salmon calcitonin biopharmaceutical properties following pulmonary delivery , FIP Pharmaceutical Sciences World Congress (PSWC) in association with the AAPS Annual Meeting and Exposition, New Orleans, USA, 14-18 November, 2010, 2010 Meeting Abstract, 2010

Curtin V, Caron V, Tajber L, Corrigan OI, Healy AM, Transformation of crystalline sulfadimidine and mannitol upon milling and co-milling, 9th International Workshop on Crystal Growth of Organic Materials, Singapore, 4-7 August, 2010, 2010 Oral Presentation, 2010

Grossjohann C, L Tajber L, Corrigan OI, Healy AM, Co-crystal engineering of sulfadimidine by co-grinding in the solid state, 9th International Workshop on Crystal Growth of Organic Materials, Singapore, 4-7 August, 2010, 2010 Meeting Abstract, 2010

Paluch KJ, Tajber L, McCabe T, O'Brien JE, Corrigan OI, Healy AM, Crystal structure of chlorothiazide potassium ethanolate, Refcode APUZOB, CCDC Number 761199, CCDC, https://www.ccdc.cam.ac.uk/, 2010 Dataset, 2010 DOI

Gobbo OL, Tewes F, Swaminathan J, Baginski L, Amaro MI, Umerska AM, Corrigan OI, Tajber L, Healy AM, Ehrhardt C, Comparative in vivo evaluation of different delivery systems for the pulmonary administration of salmon calcitonin , FIP Pharmaceutical Sciences World Congress (PSWC) in association with the AAPS Annual Meeting and Exposition, New Orleans, USA, 14-18 November, 2010, 2010 Meeting Abstract, 2010

Amaro MI, Tajber L, Corrigan OI, Healy AM, Design of experiment to study the effect of spray dryer operating variables on sugar powders intended for inhalation, UKPharmSci, APS, the Science of Medicines, Nottingham, UK, 1-3 September, 2010, 2010 Meeting Abstract, 2010

Paluch KJ, Tajber L, Elcoate CJ T, Corrigan OI, Lawrence SE, Healy AM, Crystal structure of salbutamol adipate, Refcode ORUWUU, CCDC Number 801059, CCDC, https://www.ccdc.cam.ac.uk/, 2010 Dataset, 2010 DOI

Paluch KJ, Tajber L, McCabe T, O'Brien JE, Corrigan OI, Healy AM, Crystal structure of chlorothiazide potassium, Refcode APUZIV, CCDC Number 761198, CCDC, https://www.ccdc.cam.ac.uk/, 2010 Dataset, 2010 DOI

Paluch KJ, Tajber L, McCabe T, O'Brien JE, Corrigan OI, Healy AM, Crystal structure of chlorothiazide sodium, Refcode APUZER, CCDC Number 757605 , CCDC, https://www.ccdc.cam.ac.uk/, 2009 Dataset, 2009 DOI

Tajber L, Corrigan OI, Healy AM, Spray drying of budesonide, formoterol fumarate and their composites-II. Statistical factorial design and in vitro deposition properties, International Journal of Pharmaceutics, 367, (1-2), 2009, p86 - 96 Journal Article, 2009 DOI

Tewes F, Tajber L, Corrigan OI, Healy AM, Development and characterisation of soluble polymeric particles for pulmonary peptide delivery, AAPS Annual Meeting and Exposition, Los Angeles, USA, 8-12 November, 2009, 2009 Meeting Abstract, 2009

Bianco S, Caron V, Tajber L, Corrigan OI, Healy AM, Physico-chemical characterisation of spray dried sulphonamide compounds and their sodium salts, AAPS Annual Meeting and Exposition, Los Angeles, USA, 8-12 November, 2009, 2009 Meeting Abstract, 2009

Umerska AM, Corrigan OI, Tajber L, Preparation and characterisation of hyaluronate-based nanoparticulate carriers suitable for oral peptide delivery, AAPS Annual Meeting and Exposition, Los Angeles, USA, 8-12 November, 2009, 2009 Meeting Abstract, 2009

O'Shea E, Caron V, Tajber L, Corrigan OI, Healy AM, The Effect of Mechanical Activation on the Solid-State Nature of Commercially Available Sulfathiazole, AAPS Annual Meeting and Exposition, Los Angeles, USA, 8-12 November, 2009, 2009 Meeting Abstract, 2009

Paluch KJ, Tajber L, Corrigan OI, Healy AM, An investigation of the effect of spray drying from different solvents on the physicochemical properties of chlorothiazide and chlorothiazide sodium, AAPS Annual Meeting and Exposition, Los Angeles, USA, 8-12 November, 2009, 2009 Meeting Abstract, 2009

Xue L, Radomski A, Corrigan OI, Tajber L, de Souza Menezes F, Endter S, Medina C, Radomski M, Platelet compatibility of PLGA, chitosan and PLGA-chitosan nanoparticles, Nanomedicine, 4, (7), 2009, p735 - 746 Journal Article, 2009 DOI

Paluch K, Tajber L, Zarys metod charakterystyki fizykochemicznej układów amorficznych produkowanych metodą suszenia rozpyłowego (Physicochemical methods of characterisation of amorphous materials produced by spray drying - an outline), Farmacja Polska, 65, (2), 2009, p93 - 99 Review Article, 2009 URL

Tajber L, Corrigan DO, Corrigan OI, Healy AM, Spray drying of budesonide, formoterol fumarate and their composites-I. Physicochemical characterisation, International Journal of Pharmaceutics, 367, (1-2), 2009, p79 - 85 Journal Article, 2009 DOI

Amaro MI, Tajber L, Corrigan OI, Healy AM , Characterisation of sugar nanoporous/nanoparticulate microparticles (NPMPs) and optimisation of the spray drying process for their production, AAPS Annual Meeting and Exposition, Los Angeles, USA, 8-12 November, 2009, 2009 Meeting Abstract, 2009

Caron V, Bianco S, Tajber L, Corrigan OI, Healy AM , Influence of processing on solid state forms of sulphonamide compounds and their mixtures with PVP, AAPS Annual Meeting and Exposition, Los Angeles, USA, 8-12 November, 2009, 2009 Meeting Abstract, 2009

Nolan LM, Tajber L, McDonald BF, Barham AS, Corrigan OI, Healy AM , Excipient-free nanoporous microparticles of budesonide for pulmonary delivery, European Journal of Pharmaceutics and Biopharmaceutics, 37, (5), 2009, p593 - 602 Journal Article, 2009 DOI

Xue Li, Formulation, production and biointeraction of micro and nano-particulates with potential for use in drug delivery, Trinity College Dublin, 2009 Thesis, 2009 URL

Healy AM, McDonald BF, Tajber L, Corrigan OI, Characterisation of excipient-free nanoporous microparticles (NPMPs) of bendroflumethiazide , European Journal of Pharmaceutics and Biopharmaceutics , 69, (3), 2008, p1182 - 1186 Journal Article, 2008 DOI

Katheri AK, Tajber L, Corrigan OI, Healy AM, Spray dried nanoporous microparticles of corticosteroids for dry powder oral inhalation, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, Spain, 1-10, April 2008, 2008 Meeting Abstract, 2008

Tajber L, Crean B, Roberts CJ, Nolan L, Corrigan OI, Healy AM, Budesonide Nanoporous Microparticles (NPMPs) - in vitro Aerosolisation Properties and Atomic Force Microscopy (AFM), 35th Controlled Release Society Annual Meeting & Exposition, New York, USA, 12-16, July 2008, 2008 Meeting Abstract, 2008

Paluch K, Tajber L, Healy AM, Corrigan OI, Comparison of the physico-chemical properties of spray dried chlorothiazide, chlorothiazide sodium and their PVP composite systems, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, Spain, 1-10, April 2008, 2008 Meeting Abstract, 2008

Healy AM, McDonald B, Corrigan OI, Tajber L, 'A method of producing porous microparticles', Trinity College Dublin, US20100092453, 2007 Patent, 2007 URL

McDonald BF, Tajber L, Corrigan OI, Healy AM, Nanoporous microparticles (NPMPs) of budesonide for pulmonary delivery, AAPS Journal, American Association of Pharmaceutical Scientists Annual Meeting, San Antonio, TX, US, 29/10-2/11, 2006, 8, (S2), 2006 Meeting Abstract, 2006

Nolan L, Tajber L, Corrigan OI, Healy AM, The physicochemical characterisation of spray dried nanoporous microparticles (NPMPs) of sulfa compounds, EUFEPS Conference: When Poor Solubility Becomes an Issue: From Early Stage to Proof of Principles, Verona, Italy, 26-27 April, 2006, 2006 Meeting Abstract, 2006

Ni Ogain O, Tajber L, Corrigan OI, Healy AM, Nanoporous microparticles (NPMPs) - a novel drug delivery system for the pulmonary delivery of proteins, AAPS Journal, American Association of Pharmaceutical Scientists Annual Meeting, San Antonio, TX, US, 29/10-2/11, 2006, 8, (S2), 2006 Meeting Abstract, 2006

Lidia Tajber, Investigations of physicochemical properties of spray dried drug-excipient composites directed to inhalable products, Trinity College Dublin, 2005 Thesis, 2005 URL

Tajber L, Corrigan OI, Healy AM, Physicochemical evaluation of PVP-thiazide diuretic interactions in co-spray-dried composites-analysis of glass transition composition relationships, European Journal of Pharmaceutical Sciences, 24, (5), 2005, p553 - 563 Journal Article, 2005 DOI

Tajber L, Healy AM, Corrigan OI, The effect of polyvinylpyrrolidone content on the glass transition temperature of thiazide diuretics, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, Germany, 15-18 March, 2004, 2004, pp711 - 712 Meeting Abstract, 2004

Jastrzebska M, Kocot A, Tajber L, Photoconductivity of synthetic dopa-melanin polymer , Journal of Photochemistry and Photobiology B: Biology, 66, (3), 2002, p201 - 206 Journal Article, 2002 DOI

Tajber L, Kocot A, Vij JK, Merkel K, Zalewska-Rejdak J, Mehl GH, Elsasser R, Goodby JW, Veith M, Orientational order and dynamics of nematic multipodes based on carbosilazane cores using optical and dielectric spectroscopy, Macromolecules, 35, (22), 2002, p8601 - 8608 Journal Article, 2002 DOI

Non-Peer-Reviewed Publications

Umerska A, Tajber L, Polyelectrolyte complexes as nanoparticulate drug delivery systems, European Pharmaceutical Review, 20, (3), 2015, p36-40 Journal Article, 2015

Research Expertise

Description

My research programme concentrates on the fundamental understanding of molecular interactions governing the properties and performance of pharmaceutical substances (actives and additives) at molecular, supramolecular and formulation (drug product) levels. More specifically, the research topics pursued by my group are: . Advancement of the physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs) by conversion into ionic liquids (anti-crystal engineering); development of oral solid formulations containing ionic liquids . Synthesis, phase characterisation and behaviour in formulation of alternative forms of APIs such as salts, cocrystals, amorphous materials, polymorphs and liquid crystals; construction of multi-phase diagrams for stability . Rational preformulation studies leading to quality solid-state formulations . Nanocrystal and polymeric nanoparticle formulation and characterisation methods My research efforts have been supported by Science Foundation Ireland (SFI), Enterprise Ireland, Irish Research Council as well as the European Union. I am involved in the Synthesis and Solid State Pharmaceuticals Centre (https://www.sspc.ie/ ) as a funded investigator. I was awarded a prestigious SFI Career Development Award in 2017 on the development of pharmaceutical ionic liquid forms and also currently serve as Director of Steering Committee in a H2020 RISE network "ORBIS" (Open Research Biopharmaceutical Internships Support (http://orbisproject.eu/ , awarded in 2017). I currently supervise a group of 8 researchers and host visiting ORBIS secondees from the pharmaceutical industry.

Projects

  • Title
    • Synthesis and Solid State Pharmaceutical Centre
  • Funding Agency
    • SFI
  • Date From
    • 2013
  • Date To
    • 2019
  • Title
    • TRANS-INT
  • Funding Agency
    • EU
  • Date From
    • 2012
  • Title
    • Solid State Pharmaceutical Cluster
  • Funding Agency
    • SFI
  • Date From
    • 2007
  • Date To
    • 2013
  • Title
    • Active pharmaceutical ingredients as ionic liquids: significance of protonics and functional profiling for the design of effective medicines
  • Summary
    • A large proportion of pharmaceutical molecules exhibit low aqueous solubility and/or poor membrane transport properties resulting in low oral bioavailability and delivery problems. Thus, many compounds with high pharmacological activity are being dropped from development pipelines. To address the issue of poor solubility and/or permeability of active pharmaceutical ingredients, a new tactic is proposed whereby the active molecule is converted into an ionic liquid (IL), a functional material with superior physicochemical properties to the "parent" molecule. ILs comprise anions and cations and possess low lattice energy and low melting points, often well below 100 °C. Through the systematic investigations of structural properties of ILs, their methods of synthesis, the degree of ionisation and type of proton transport within the ILs as well as extensive pharmaceutical profiling including stability, solubility, permeability and in vitro toxicity, a new generation of ILs with tunable pharmaceutical properties (PILs) will be established. To demonstrate the pharmaceutical developability of PILs and their potential as a platform technology, prototype tablet formulations will be manufactured and tested using novel, bio-relevant dissolution stress test devices. A range of anti-inflammatory and anti-infective molecules will be examined due to their efficacy limitations that are often caused by low solubility and permeability.
  • Funding Agency
    • SFI
  • Date From
    • 2017
  • Date To
    • 2021
  • Title
    • Irish Drug Delivery Network
  • Funding Agency
    • SFI
  • Date From
    • 2007
  • Date To
    • 2013
  • Title
    • ORBIS
  • Funding Agency
    • European Commission

Keywords

Amorphous Materials; Computer modelling of pharmaceutical systems; Crystal engineering; DENDRIMERS; Drug Delivery Systems; Hydrogen bonding; LIQUID CRYSTALS; Nanotechnology; Pharmaceutical co-crystals; Pharmaceutical salts; Physical Chemistry; POLYMER; Polymers; POLYMORPHISM; Porous particles; Respiratory System; Spectroscopy; SPRAY DRYING; Thermal Analysis

Recognition

Awards and Honours

Trinity College Postgraduate Award 2001

Distinction for the Masters thesis in the Master's Degree Dissertations Competition for Faculties of Pharmacy organised by Polish Pharmaceutical Society and Medical Universities 2001

First prize for the Masters thesis in the Interdepartmental Master's Degree Dissertations Competition 2000

Prize from the Czestochowa branch of the Polish Pharmaceutical Chamber for the grades achieved in university degree 2000

M.A. (jure officii) 2015

Memberships

International Association for Pharmaceutical Technology (APV) 2017 – present

American Chemical Society 2013 – present

Controlled Release Society 2008 – present

American Association of Pharmaceutical Scientists 2007 – present