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Helen Sheridan
Associate Professor, Pharmacy

Biography

Helen Sheridan is an Associate Professor in the School of Pharmacy and Pharmaceutical Sciences (SoPPS) at TCD where she holds the position of Director of Research. Her personal research interests lie in the broad area of Natural Product (NP) Chemistry and Traditional Medicine (TM), with an emphasis on Traditional Chinese Medicine(TCM), Ethnopharmacology and Global health. Her work focuses on finding new therapies targeted at diseases with unmet clinical need, in addition to finding natural products suitable for use as nutraceuticals and cosmeceuticals. Helen, with international collaborators, is also involved in establishing global standards for the quality, safety and efficacy of TMs including TCM; activities that are supported through her work as part of a Sino-European Consortium (previously funded by EU-FP7; http://www.gp-tcm.org/), her role on the Board of the International Natural Product Sciences Taskforce (INPST) society (The International Natural Product Sciences Taskforce (INPST) society), in her position as NP expert on the Irish medicines Board (HPRA: Health Products Regulatory Authority) and membership of NPRONET - Natural products discovery and bioengineering network UK.

Helen has supervised 21 research students (PhDs and MScs) to completion, as well as 15 post-doctoral fellows. She currently have 7 researchers in her group. Helen is an NP/ organic chemist and has carried out research on a range of plant and fungal species. During her career she successfully identified a lead molecule from TM which her team brought through a programme of medicinal chemistry, through all preclinical stages of development into human clinical trials. During this period Helen co-founded a TCD Campus company, Trino Therapeutics Ltd and was co-PI on funding of approximately €13 million. The funding for this work began with a grant of €500 from the Royal Irish Academy, progressed to funding from EOLAS (the precursor of SFI) and then this work received significant translational investment from Venture Capital and the Wellcome Trust with €3.5 million as co-PI for a highly competitive Wellcome Strategic Translation Award (STA grant. Helen currently holds an SFI-TIDA award and is collaborator in a second TIDA. During this time she has also been co-applicant on seven published patents in the US, EU and Asia and has acted as patent expert on these projects with patenting agents in Ireland and the US.

In latter years Helen has become more involved in ethnopharmacology on a global level, in particular the link between the established use of traditional medicine and its role in international development. She has supervised 5 research projects in this field in sub-Saharan Africa.

The driving force behind her work is to find new therapeutic treatments for unmet clinical need and to finding meaningful uses for natural molecules. She has learned a lot about the journey from therapeutic drug discovery to human trials, and the challenges and obstacles that line the road. However, experience led decision making about research is invaluable. Through this lens of experience, the molecules Helen's group is working on have real therapeutic potential and have been designed to eliminate some of the insurmountable obstacles to drug development.

Publications and Further Research Outputs

Peer-Reviewed Publications

Grace, C. and Lynch, M.B. and Sheridan, H. and Lott, S. and Fritch, R. and Boland, T.M., Grazing multispecies swards improves ewe and lamb performance, Animal, 13, (8), 2019, p1721-1729 Journal Article, 2019 DOI

Marivane Lemos, Jonas Joaquim Mangabeira da Silva, Cristiane Teixeira Vilhena Bernardes, Mariza Abreu Miranda, Hervé Louis Ghislain Rogez, Rodrigo Cássio Sola Veneziani, Sérgio Ricardo Ambrósio, Sérgio Faloni de Andrade, Astrid Sasse, Helen Sheridan, Jairo Kenupp Bastos, ATIVIDADE ANTIMICROBIANA IN VITRO E IN VIVO FRENTE À HELICOBACTER PYLORI DE EXTRATO DAS FOLHAS DE COPAIFERA OBLONGIFOLIA MART. EX HAYNE, Extensão em Foco, 6, (1), 2019, p1 - 8 Journal Article, 2019

Andy Wai Kan Yeung, Bharat Bhushan Aggarwal, Helen Sheridan, Atanas G. Atanasov et al, Resveratrol, a popular dietary supplement for human and animal health: Quantitative research literature analysis - a review, Animal Science Papers and Reports , 37 , (2), 2019, p103 - 118 Journal Article, 2019

Grace, C. and Boland, T.M. and Sheridan, H. and Brennan, E. and Fritch, R. and Lynch, M.B., The effect of grazing versus cutting on dry matter production of multispecies and perennial ryegrass-only swards, Grass and Forage Science, 2019 Journal Article, 2019 DOI

Traditional-chinese-medicine-from-aqueous-extracts-to-therapeutic-formulae in, editor(s)Aman Dekebo ed. , Plant Extracts, london UK, IntechOpen, 2019, pp1-30 , [JinFan Wang, Astrid Sasse, Helen Sheridan] Book Chapter, 2019 DOI

Frankish, N.H. and McHale, B. and Sheridan, H., The indane diastereoisomers, PH2 and PH5: divergence between their effects in delayed-type hypersensitivity models and a model of colitis, Journal of Pharmacy and Pharmacology, 70, (1), 2018, p101-110 Journal Article, 2018 TARA - Full Text DOI

Hook I, Sheridan, H, Reid C, Trichomes and naphthoquinones protect Streptocarpus dunnii Hook.f. against environmental stresses, South African Journal of Botany , Volume 119, 2018, p193 - 202 Journal Article, 2018

Grace, C. and Boland, T.M. and Sheridan, H. and Lott, S. and Brennan, E. and Fritch, R. and Lynch, M.B., The effect of increasing pasture species on herbage production, chemical composition and utilization under intensive sheep grazing, Grass and Forage Science, 73, (4), 2018, p852-864 Journal Article, 2018 DOI

Cumming, Graham; Zhang, Tao; Scalabrino, Gaia; Frankish, Neil; Sheridan, Helen, Investigation of the Stereoselective Synthesis of the Indane Dimer PH46A, a New Potential Anti-Inflammatory Agent , Organic Process Research & Development, 2018, p1972-1979 Journal Article, 2018 DOI

Andy Wai Kan Yeung, Bharat Bhushan Aggarwal, Helen Sheridan et al., Dietary natural products and their potential to influence health and disease including animal model studies - a review, Animal Science Papers and Reports, 36, (4), 2018, p345-358 Journal Article, 2018

Tao Zhang, Neil Frankish, Gaia Scalabrino and Helen Sheridan, Bioactive Indanes: Comparative in vitro Metabolism Study of PH46A, a New Potential Anti-Inflammatory Agent and Biosynthesis of its Primary Metabolite PH132 , Pharmaceutical Sciences, 9, (2), 2018, p1 - 14 Journal Article, 2018 URL

Zhang, T. and Scalabrino, G. and Frankish, N. and Sheridan, H., Bioactive indanes: Proof of concept study for enantioselective synthetic routes to ph46a, a new potential anti-inflammatory agent, Molecules, 23, (7), 2018, p1503- Journal Article, 2018 DOI TARA - Full Text

Tao Zhang , Gaia Scalabrino , Neil Frankish and Helen Sheridan, "Bioactive Indanes: Proof of Concept Study for Enantioselective Synthetic Routes to PH46A, a New Potential Anti-Inflammatory Agent" , Molecules, 23 , 2018, p1 - 18 Journal Article, 2018 DOI

Composition and quality control of herbal medicines in, editor(s)Heikki Vuorela, Pia Maarit Vuorela, and Olavi Pelkonen , Toxicology of Herbal Products', Springer Science & Business Media. , 2017, [3. Sendker J and Sheridan H] Book Chapter, 2017 URL

Neil Frankish and helen Sheridan, 'Compounds for use in the treatment of inflammatory Bowel Disease', USP, 9,586,885 B2, 2017, Venantius Ltd. Patent, 2017 URL

Fiona Shannon, Astrid Sasse, Helen Sheridan and Michael Heinrich , Are identities oral? Understanding ethnobotanical knowledge after Irish independence (1937-1939), Journal of Ethnobiology and Ethnomedicine, 13, 2017, p65- Journal Article, 2017 DOI URL TARA - Full Text

History and current status of Herbal Medicines' in, editor(s): Heikki Vuorela, Pia Maarit Vuorela, and Olavi Pelkonen. , Toxicology of Herbal Products, Springer Science and Business Media, 2017, [2. Sendker J and Sheridan H: ] Book Chapter, 2017 URL

Erick Motta, Marivane Lemos, Juliana C Costa, PhD. Vilmar C Banderó-Filho.; Astrid Sasse, Helen Sheridan, Jairo K Bastos, , Galloylquinic acid derivatives from Copaifera langsdorffii leaves display gastroprotective activity, Chemico-Biological Interactions, 261, 2017, p145 - 155 Journal Article, 2017 DOI

Imran Nazir, Nisar ur Rahman, Zunaira Alvi, M. Hafizur Rahman, Jandirk Sendker, Tao Zhang, Neil Frankish, Helen Sheridan, Antidiabetic Activities of an LC/MS Fingerprinted Aqueous Extract of Fagonia cretica L. in Preclinical Models*, Planta Medica, 83, 2017, p1-9 Journal Article, 2017 DOI

Frankish N, Sheridan H , 'Compounds for use in the treatment of autoimmune inflammatory disease;.', European patent office, 2864279 B1, 2016, Venantius Ltd. Patent, 2016 URL

Kerstin Rieger, Rochelle H Holm, Helen Sheridan, Access to groundwater and link to the impact on quality of life: A look at the past, present and future public health needs in Mzimba District, Malawi, Groundwater for Sustainable Development, 2016, p117-129 Journal Article, 2016 DOI

Zhang, T., Paluch, K., Scalabrino, G., (...), Healy, A.-M., Sheridan, H. , Molecular structure studies of (1S,2S)-2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol, Journal of Molecular Structure, 1083, 2015, p286-299 Journal Article, 2015 DOI

Helen Sheridan, Brigitte Kopp, Liselotte Krenn, Dean Guo, Jandirk Sendker, Traditional Chinese herbal medicine preparation: invoking the butterfly effect, Science, 350, (6262), 2015, pS64-S66 Journal Article, 2015 URL

Lemos M, Silva JJM, Rogez HLG, Veneziani RCS, Ambrósio SR, Bastos JK, Banderó VC, Sasse A, Sheridan H, , Cytotoxic and apoptogenic properties of C. oblongifolia Mart. ex Hayne and C. duckei Dwyer oleoresin and leaf extract on human gastric carcinoma cells., Brazilian Society of Pharmacology and Experimental Therapeutics (SBFTE), Águas de Lindóia, São Paulo, Brazil, , September 28 to Octo, edited by Conference Committee , 2015 Conference Paper, 2015

N Frankish, H Sheridan -, 'Compounds for use in the Treatment of Autoimmune Inflammatory Disease', USPTO, 20,150,141,523,, 2015, Trino Therapeutics Ltd. Patent, 2015 URL

Bioactive naphthoquinones from higher plants. in, editor(s)Atta-ur-Rahman , Studies in Natural Products Chemistry. Volume 41, Elsevier B.V, 2014, pp119 - 160, [Hook, I., Mills, C and Sheridan H] Book Chapter, 2014 DOI

Fatiha Brahmi, Naïma Guendouze, Helen Sheridan, Caroline Stevigny et al., Metabolic Classification Of Mentha Species By Nmr-Based Metabolomics, Journées internationales AFERP & STOLON , Bruxelles , 22-24 Mai 2013, 2013 Poster, 2013

Helen Sheridan and Neil frankish, Venantius Ltd., Indane dimers for use in the treatment of autoimmune inflammatory disease, 2013, WO 2013/014660 A1 Patent, 2013 URL

Astrid Sasse, Fabio Boylan and Helen Sheridan, Holistic Approaches to Health Maintenance in the B.Sc. Pharmacy. , 14th Biennial CSSI Conference. Mind, Body, Spirit - the holistic approach to the student experience, Dundalk. ireland, June 19-20 2013, 2013 Poster, 2013

Chan K , Banderό V, Frankish N, Sheridan H . , . Inflammation, Cancer And 15- Lipoxygenase-1 - How Hot Is The Link? , London BioNat. , University of East London , March 12th 2013., 2013 Poster, 2013

Tao Zhang, Vilmar Bandero, Tom McCabe, Neil Frankish and Helen Sheridan, 2-(Diphenylmethylidene)-2,3-dihydro-1H-inden-1-one, Acta Cryst. Section E, E69, 2013, po1306 - o1307 Journal Article, 2013 DOI

Sheridan, Helen; (IE). Frankish, Neil; (IE), 'indane Dimers for use in the Treatment of Autoimmune Inflammatory Disease', O'BRIEN, John, A, WO/2013/014660 , 2013, VENANTIUS LIMITED Patent, 2013 URL

Neil Frankish and Helen Sheridan, 'Indane Dimers for Use in The Treatment Of Autoimmune Inflammatory Disease', US, WO2013174916, 2013, Venantius Ltd Patent, 2013 URL

Helen Sheridan, Liselotte Krenn, Renwang Jiang, Ian Sutherland, Svetlana Ignatova, Andreas Marmann, Xinmiao Liang, Jandirk Sendker, The potential of metabolic fingerprinting as a tool for the modernisation of TCM preparations, Journal of Ethnopharmacology, 140, (3), 2012, p482-491 Journal Article, 2012 TARA - Full Text DOI

Frankish N. and Sheridan H, 6-(Methylamino)hexane-1,2,3,4,5-pentanol 4-(((1S,2S)-1-Hydroxy-2,3-dihydro-1H,1'H-[2,2-biinden]-2-yl)methyl)benzoate (PH46A): A Novel Small Molecule With Efficacy In Murine Models Of Colitis, Journal of Medicinal Chemistry, 55, 2012, p5497 - 5505 Journal Article, 2012 DOI

Ta o Zha ng , Tom McCabe , Bartosz Marzec, Neil Frankish and Helen, N -Cyclopentyl- N -(3-oxo-2,3-dihy dro-1 H -inden-1-yl)acetamid, Acta Crystallographica, E68, 2012, p958- Journal Article, 2012 DOI

Frampton C. S., Zhang T., Scalabrino G. A., Frankish N. and Sheridan H., (1S)-1-Phenyl ethanaminium 4-{[(1S,2S)-1-hydroxy-2,3-dihydro-1H,1′H-[2,2′-biinden]-2-yl] methyl} benzoate,, Acta Crystallographica. Section C, 2012, po323 - o326. Journal Article, 2012 DOI

Sheridan H, Nestor C, O'Driscoll L, Hook I., Isolation, structure elucidation, and cytotoxic evaluation of furanonaphthoquinones from in vitro plantlets and cultures of Streptocarpus dunnii., J Nat Prod., 71, (1), 2011, p82 - 85 Journal Article, 2011 DOI URL TARA - Full Text

Sheridan, H. , Nestor, C., O'Driscoll, L., Hook, I., Isolation, structure elucidation, and cytotoxic evaluation of furanonaphthoquinones from in vitro plantlets and cultures of Streptocarpus dunnii, Journal of Natural Products, 74, (1), 2011, p82 - 85 Journal Article, 2011 DOI

Jandirk Sendker, Andreas Marmann, Liselotte Krenn, Helen Sheridan, Ian Sutherland, Svetlana Ignatova, Peter Proksch, Monique Simmonds, Robert Verpoorte, Alberto Dias, Valérian Bunel, You-Ping Zhu, Comprehensive report on the methodology used in the analysis of 'priority list preparations': Deliverable 2.10 of WP2 (FP7 GP-TCM) to European Commission, EU COmmission Brussels, EU, October, 2011, 1-24 Report, 2011

Frankish, N. de Sousa Menezes, F. Mills, C. Sheridan, H., Enhancement of insulin release from the beta-cell line INS-1 by an ethanolic extract of Bauhinia variegata and its major constituent roseoside, Planta Med, 76, (10), 2010, p995-7 Journal Article, 2010 DOI

Sheridan H, Walsh JJ, Cogan C, Jordan M, McCabe T, Passante E, Frankish NH, Diastereoisomers of 2-Benzyl-2, 3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol: Potent anti-inflammatory agents, Bioorganic & Medicinal Chemistry Letters, 19, 2009, p5927 - 5930 Journal Article, 2009 DOI

E Passante, C Ehrhardt, H Sheridan, N Frankish, RBL-2H3 cells are an imprecise model for mast cell mediator release, Inflamm Res, 58, (9), 2009, p611-618 Journal Article, 2009 DOI

Passante, E. Ehrhardt, C. Sheridan, H. Frankish, N., Toll-like receptors and RBL-2H3 mast cells, Inflamm Res, 58 , (Suppl 1), 2009, p11-2 Journal Article, 2009 DOI

H. Sheridan, N. H. Frankish, BRA 101, A Novel Small Molecule with Profound Efficacy In Murine DSS-Colitis, Gut, Gastro 2009, London, 21-25 November 2009, 58, (Suppl II), 2009, ppA454 Meeting Abstract, 2009

Sheridan, H. Walsh, J. J. Jordan, M. Cogan, C. Frankish, N, A series of 1, 2-coupled indane dimers with mast cell stabilisation and smooth muscle relaxation properties, Eur J Med Chem, 44, (12), 2009, p5018-22 Journal Article, 2009

H Sheridan, I Hook, J Coppins, C Nestor, C Ehrhardt, N Frankish, Inhibition of LFA-1 mediated T-cell motility by naphthoquinones, Planta Med, 74, (11), 2008, p1383-1387 Journal Article, 2008 DOI

Minker C, O' Meara J, Visdal-Johnsen L, Hook I, Lobstein A , Sheridan H and Frankish N. , In vivo and in vitro evaluation of the anti-inflammatory activity of seven Plectranthus species. , Planta. Med., 73, 2007, pP074 - P074 Journal Article, 2007

Fábio de Sousa Menezes, Andréa Barreto Mattos Minto, Halliny Siqueira Ruela, Ricardo Machado Kuster, Helen Sheridan, Neil Frankish, Hypoglycemic activity of two Brazilian Bauhinia species: Bauhiniaforfi cata L. and Bauhinia monandra Kurz., Brazilian Journal of Pharmacognosy, 17, ((1)), 2007, p8 - 13 Journal Article, 2007

J.Coppins, I. Hook, C. Nestor, H. Sheridan, N. Frankish, C. Ehrhardt., Inhibition of LFA-1 mediated T-cell motility by naphthoquinones, Royal Academy of Medicine in Ireland, Winter meeting, Dublin City University, 2007, 2007 Conference Paper, 2007

H.Sheridan, N. Frankish and R. Farrell, Investigation into the mast cell stabilizing activity of nature identical and synthetic indanones, J. Pharmacy and Pharmacology, 56, (11), 2004, p1423 Journal Article, 2004

A.L. Simplício, J.F. Gilmer, N. Frankish, H. Sheridan, J.J. Walsh and J.M. Clancy, Ionisation characteristics and elimination rates of some aminoindanones determined by capillary electrophoresis, Journal of Chromatography A, 1045, (1-2), 2004, p233 - 238 Journal Article, 2004

Hook I, Ryan S, Sheridan H. , Biotransformation of aliphatic and aromatic ketones, including several monoterpenoid ketones and their derivatives by five species of marine microalgae, Phytochemistry, 63, (1), 2003, p31 - 36 Journal Article, 2003 DOI

I. Hook, S. Ryan and H. Sheridan, Biotransformation of aliphatic and aromatic ketones, including several monoterpenoid ketones and their derivatives by five species of marine micro-algae, Phytochemistry, 63, 2003, p31 - 36 Journal Article, 2003

H. Sheridan, Indane dimer compounds with smooth muscle relaxing and/or mast cell stabilising and/or anti-inflammatory activity, 2002, US6423752 Patent, 2002

H. Sheridan, Indane dimer compounds with smooth muscle relaxing and/or mast cell stabilizing and/or anti-inflammatory activity, 2002, US-09/092,903, EP-96942551 Patent, 2002

H. Sheridan, Indane compounds and their pharmaceutical use, 2002, US6433021 Patent, 2002

H. Sheridan, Indane dimer compounds and their pharmaceutical use; respiratory and anti-inflammatory, 2002, PCT/IE 96/00080. US-09/093,060, EP-96942550 Patent, 2002

H. Sheridan, Indane compounds with smooth muscle relaxing and/or mast cell stabilizing and/or anti-inflammatory activity, 2002, US-09/092.902, EP-96942552 Patent, 2002

Transgenic Leontopodium (Edelweiss) in, Y.P.S. Bajaj , Biotechnology in Agriculture and Forestry, Berlin, Heidelberg, Springer-Verlag, 2001, pp221-236. , [Hook I, Sheridan H.] Book Chapter, 2001

Essential oil production by transformed roots of Leontopodium alpinum Cass in, editor(s)Y.P.S. Bajaj , Biotechnology in Agriculture and forestry, "Transgenic crops lll" vol 48, Springer Verlag, 2001, pp221 - 236, [I. Hook and H. Sheridan] Book Chapter, 2001

Comer, N., Grey, A.I., Hook, I.L., James, P., Sheridan, H., Erratum: Sesquiterpenes from Leontopodium alpinum (Phytochemistry (1999) 50 (1057-1060) PII: S0031942298006256) , 2000, - 551 Miscellaneous, 2000

HOOK, IL, RYAN, S, SHERIDAN, H, BIOTRANSFORMATION OF AROMATIC ALDEHYDES BY FIVE SPECIES OF MARINE MICROALGAE, PHYTOCHEMISTRY, 51, 1999, p621 - 627 Journal Article, 1999

Farrell, R., Frankish, N.H.., & Sheridan, H., Synthesis and antispasmodic activity of analogues of Natural pterosins, European Journal of Medicinal Chemistry, 34, 1999, p953 - 966 Journal Article, 1999

SHERIDAN, H, FRANKISH, N, FARRELL, R, SYNTHESIS AND ANTISPASMODIC ACTIVITY OF ANALOGUES OF NATURAL PTEROSINS, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 34, 1999, p953 - 966 Journal Article, 1999

Comey N, Grey A, Hook I, James P, Sheridan H. , Sesquiterpenes from Leontopodium alpinum., Phytochemistry, 50, (6), 1999, p1057 - 1060 Journal Article, 1999 DOI

SHERIDAN, H, FRANKISH, N, FARRELL, R, SMOOTH MUSCLE RELAXANT ACTIVITY OF PTEROSIN Z AND RELATED COMPOUNDS, PLANTA MEDICA, 65, 1999, 271 - 272 Miscellaneous, 1999

SHERIDAN, H, CANNING, AM, NOVEL RADICINOL DERIVATIVES FROM LONG-TERM CULTURES OF ALTERNARIA CHRYSANTHEMI, JOURNAL OF NATURAL PRODUCTS, 62, 1999, p1568 - 1569 Journal Article, 1999

Sheridan, H., Frankish, N. H. & Farrell, R, Smooth muscle relaxant activity of pterosin Z and related compounds, Planta Medica, 65, 1999, p271 - 272 Journal Article, 1999

Hook I, Ryan S, Sheridan H. , Biotransformation of aromatic aldehydes by five species of marine microalgae, Phytochemistry, 51, (5), 1999, p621 - 627 Journal Article, 1999 DOI

Comey N, Hook I, Sheridan H, Walsh J. , Isolation of (S)-(-)-2,3-dihydro-2,6-dimethyl - 4H-benzopyran-4-one from roots of Leontopodium alpinum, Journal Of Natural Products (Lloydia) , 60, (2), 1997, p148-149 Journal Article, 1997 DOI

Comey N, Sheridan H, Hook I, Influence of inulin, culture medium and light on the growth and essential oil content of Edelweiss hairy roots., Proceedings of the 27th ISEO Meeting, 27th ISEO Meeting, Vienna, Allured Publishing Corporation, 1997, pp116-119 Conference Paper, 1997

FARRELL, R, KELLEHER, F, SHERIDAN, H, SYNTHESIS OF FERN SESQUITERPENE PTEROSIN Z VIA A NOVEL PALLADIUM-CATALYZED ROUTE, JOURNAL OF NATURAL PRODUCTS, 59, 1996, p446 - 447 Journal Article, 1996

Hook, I., & Comey, N. & Sheridan, H., Essential oil of Edelweiss, Leontopodium alpinum, 25th International Symposium on Essential Oils, Grasse., 1994 Conference Paper, 1994

"Papaver bracteatum", Lindley (Giant Scarlet Poppy) In vitro production of benzophenanthridine alkaloids in, editor(s)Y.P.S. Bajaj , Biotechnology of Medicinal and Aromatic Plants Part VII, Springer Verlag, 1994, pp346 - 365, [I. Hook, R. Lecky and H. Sheridan] Book Chapter, 1994

Lecky R, Hook I, Sheridan H., Enhancement of dihydrosanguinarine production in suspension cultures of Papaver bracteatum, I Medium modifications, Journal Of Natural Products (Lloydia) , 55, (10), 1992, p1513 - 1517 Journal Article, 1992

H. Sheridan, R. Lecky and I. Hook, Enhancement of dihydrosanguinarine production by suspension cultures of Papaver bracteatum 1. Medium modification, J. Nat. Prod., 55, (10), 1992, p1513 Journal Article, 1992

SHERIDAN, H, BHANDARI, P, CATHIN-6-ONE FROM THE ROOT BARK OF PHELLODENDRON-CHINENSE, PLANTA MEDICA, 58, 1992, 299 - 299 Miscellaneous, 1992

Canning A-M, Hook I, Sheridan H. , Bisradicinin: a novel dimmer elicited in cultures of Alternaria chrysanthemi, Journal Of Natural Products (Lloydia) , 55, (4), 1992, p487 - 490. Journal Article, 1992

N. Comey, I. Hook and H. Sheridan, Enhancement of anthocyanin production in cell cultures and hairy roots of L. alpinum, Planta medica, 58, (1), 1992 Journal Article, 1992

H.Sheridan, A. M. Canning, I. Hook, P. James and D. Kelly, Bis-Radicinin: a novel dimer elicited in cultures of Alternaria chrysanthemi, J. Nat. Prod., 55, (4), 1992, p487 Journal Article, 1992

HOOK, I, SHERIDAN, H, WILSON, G, VOLATILE METABOLITES FROM SUSPENSION-CULTURES OF TARAXACUM-OFFICINALE, PHYTOCHEMISTRY, 30, 1992, p3977 - 3979 Journal Article, 1992

H. Sheridan, A. M. Canning and P. James, Stereoselective reduction of radicinin by liquid cultures of Alterneria longipes, J. Nat. Prod., 55, (7), 1992, p986 Journal Article, 1992

Comey, N., Hook, I., Sheridan, H., Enhancement of anthocyanin production in cell cultures and hairy roots of Leontopodium alpinum , Planta Medica , 58, ((7 SUPPL.)), 1992, A605-A606 Journal Article, 1992

Hook I, Sheridan H, Wilson G., Volatile metabolites from suspension cultures of Taraxacum officinale, Phytochemistry , 30, (12), 1991, p3977 - 3979 Journal Article, 1991 DOI

I. Hook, G. Wilson and H.Sheridan, Volatile metabolites from suspension cultures of Taraxacum officinale, Phytochemistry, 30, (12), 1991, p3977 Journal Article, 1991

J. Baldwin, M. Bradley, N.Turner, R. Adlington, A. Pitt and H. Sheridan, α-L-_-Aminoadipoyl-L-cysteinyl-D-allylglycine, and eight deuterated analogues, substrates for the investigation of the mechanism of action of isopenicillin N synthetase, Tetrahedron, 47, (38), 1991, p8203 - 8222 Journal Article, 1991

BHANDARI, P, SHERIDAN, H, PRENYLATED FLAVONOIDS OF PHELLODENDRON-CHINENSE, PROCEEDINGS OF THE ROYAL IRISH ACADEMY SECTION B-BIOLOGICAL GEOLOGICAL AND CHEMICAL SCIENCE, 89, 1990, p91 - 96 Journal Article, 1990

H Sheridan, S Lemon, N Frankish, P Mcardle, T Higgins, JP James, P Bhandari , Synthesis and Antispasmodic Activity of Nature Identical Substituted Indanes and Analogues, European Journal of Medicinal Chemistry, 25, (7), 1990, p603 - 608 Journal Article, 1990

Hook, I., Sheridan, H., Wilson, G., Volatile metabolites with 'apple' odour from suspension cultures of Taraxacum officinale , Planta Medica, 56, (6), 1990, p627-628 Journal Article, 1990 DOI

Hook I, Lecky R, McKenna B, Sheridan H., Biotransformation of linalyl acetate by suspension cultures of Papaver bracteatum, Phytochemistry, 29, (7), 1990, p2143 - 2144 Journal Article, 1990 DOI

HENNESSY, D, HOOK, I, SHERIDAN, H, MCGEE, A, HYDROXYCINNAMIC ACID-ESTERS FROM CELL-SUSPENSION CULTURES AND PLANTS OF LEONTOPODIUM-ALPINUM, PHYTOCHEMISTRY, 28, 1989, p489 - 490 Journal Article, 1989

Neoflavanoids in, editor(s)J.B. Harborne and T.J. Mabry , Flavanoids: Advances in Research. Vol. 2, Chapman and Hall, 1988, pp211 - 232, [D.M.X. Donnelly and H. Sheridan] Book Chapter, 1988

HOOK, I, SHERIDAN, H, WILSON, G, ALKALOIDS OF CELL-CULTURES DERIVED FROM STRAINS OF PAPAVER-BRACTEATUM, PHYTOCHEMISTRY, 27, 1988, p2137 - 2141 Journal Article, 1988

Hook I, Sheridan H, Wilson G., Alkaloids of cell cultures derived from strains of Papaver bracteatum, Phytochemistry, 27, (7), 1988, p2137 - 2141 Journal Article, 1988 DOI

D. Hennessy, I. Hook and H. Sheridan, Hydroxycinnamic esters in tissue cultures of "Leontopodium alpinum", Pharmaceutisch Weekblad Scientific Ed., 21, 9, (4), 1987, p217 Journal Article, 1987

Hook, I., Hennessy, D. & Sheridan, H., Tissue culture of L. alpinum, Gesellschaft fur Arzneipflanzeforschung,, Leiden, 1987 Conference Paper, 1987

Dervilla MX Donnelly, Joseph O'Reilly, Judith Polonsky, M Helen Sheridan, In vitro production and biosynthesis of fomajorin D and S by Fomes annosus (Fr.) Cooke, Journal of the Chemical Society, Perkin Transactions 1, 1987, p1869-1872 Journal Article, 1987

H. Sheridan and D.M.X. Donnelly, Anthraquinones from Trichoderma polysporum, Phytochemistry, 25, (10), 1986, p2302 Journal Article, 1986

H. Sheridan and D.M.X. Donnelly, Biosynthesis of Fomajorin D". Incorporations of [1- 13 C], [2- 13 C] and [1, 2- 13 C 2 ]-acetates", J.C.S. Chem. Commun., 1983, p615 Journal Article, 1983

Non-Peer-Reviewed Publications

Ciara M Fallon, Jessica Smyth, Natalia Lajczak, Helen Sheridan and Stephen J Keely. , Neutraceutical targeting of the bile acid receptor, farnesoid X receptor, for intestinal disease, The FALK Symposium 211 XXV International Bile Acid Meeting: Bile Acids in Health and Disease. , Dublin, Ireland, July 6 - 7, 2018 Conference Paper, 2018

Fiona Shannon, Astrid Sasse, Michael Heinrich and Helen Sheridan, A repository of knowledge - the Schools' Manuscript Collection, offering a unique insight into medicinal practices in 1930s Ireland, 'Interdisciplinary Approaches to the Study of Healing, Charms and Medicine'. , Department of Celtic languages and literature. Harvard University. , April 5-7th 2018., 2018 Conference Paper, 2018

Jinfan Wang, Ingrid Hook, Malte Brummerloh, Jandirk Sendker, Astrid Sasse and Helen Sheridan. , From Monograph to Metabolomics: A Scientific Evaluation of the Traditional Chinese Herbal Medicine Houttuynia cordata Thunb (鱼腥草Yu Xing Cao) Saururaceae - a case study, The 6th Annual Meeting of Good Practice in Traditional Chinese Medicine Research Association (GP-TCM RA). , Jordell Laboratories. Kew Gradens. London UK, July 4-6th. , 2018 Conference Paper, 2018

Fiona Shannon, Astrid Sasse and Helen Sheridan. , Ethnomedicinal practices in 1930s Ireland. History of Medicine Section of the Royal Academy of Medicine, History of Medicine, Dublin, Ireland, 9th May, 2018 Conference Paper, 2018

J. Wang, Ingrid Hook, Malte Brummerloh, Jandirk Sendker, Astrid Sasse and Helen Sheridan. , Best Practice for the Scientific Evaluation of Traditional Herbal Medicines: Houttuynia cordata Thunb (鱼腥草Yu Xing Cao) Saururaceae - A Case Study. , 66th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) jointly with the 11th Shanghai TCM conference, Shanghai, August 26 - 29, 2018 Conference Paper, 2018

Fiona Shannon, Astrid Sasse and Helen Sheridan., A repository of knowledge. The Schools' Manuscript Collection, offering a unique insight into medicinal practices in 1930s Ireland. , London, 2018, The British Society for the History of Pharmacy (BSHP). Invited Talk, 2018

Helen Sheridan, Fiona Shannon, Astrid Sasse and Michael Heinrich, Insight into Healing Herbs used in Post-famine Ireland, 66th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) jointly with the 11th Shanghai TCM conference, Shanghai, China, August 26 - 29, 2018 Conference Paper, 2018

Shanahan, F., Michael heinrich, Sasse, A, Sheridan, H., Traditional Medicinal Knowledge in Ireland in the 1930s - Exploring Botanical Treatments. , 58th Annual Meeting of the Society of Economic Botany. L, Braganca, Portugal, 5th June 2017, edited by Conference Committee , 2017 Conference Paper, 2017

Helen Sheridan , Exploration of the feasibility of setting up the Trinity (or Irish) - Natural Product Foundation (Trinity-NPF of I-NPF) within TCD., CF-2017-0569Y. , Enterprise Ireland, 2017 Report, 2017

Shanahan, F., Sasse, A, Sheridan, H. , An Ethnomedicinal Study of Traditional Plant Remedies of Co. Wexford, Ireland in the 1930s. , 38th All Ireland Schools of Pharmacy Research Conference. , Royal College of Surgeons, Dublin 2. , 21st March 2016, 1, 2016, P1- Conference Paper, 2016

Helen Sheridan and Ciara Smyth, Identification of extracts (and compounds) that could be derived from new plant species, grown in Ireland. An overview of species, market and potential partners who have processing experience, Enterprise ireland 1V-2012-3242., 2014 Report, 2014

Nazir, I., Rahman, N., Chan, K., Frankish, N., Sheridan, H, Ethnobotanical Study of Antidiabetic Plants of Cholistan Desert, District Bahawalpur, Pakistan, London BioNat, University of East London. UK, March 12th 2013., 2013 Poster, 2013

Neil Frankish and Helen Sheridan, Trino Therapeutics Ltd, 2011 Campus Company, 2011 URL

Jandirk Sendker, Andreas Marmann, Liselotte Krenn, Helen Sheridan, Ian Sutherland, Svetlana Ignatova, Peter Proksch, Monique Simmonds, Robert Verpoorte, Alberto Dias, Valérian Bunel, You-Ping Zhu , Deliverable 2.10 of WP2 (FP7 GP-TCM) to European Commission., 2011/10/17, 2011 Dataset, 2011 URL

E Passante, C Ehrhardt, H Sheridan, N Frankish, Effect of novel indanes on the degranulation of rat basophilic leukemia mast cells (RBL-2H3), FASEB J, Experimental Biology Meeting 2007, Washington, DC, 28.04.-02.05.2007, 21, (5), 2007, pp574.9 Meeting Abstract, 2007

Hook, I., Comey, N. & Sheridan, H., Phytochemical evaluation of roots from cultivated L alpinum, Irish Botanists Meeting, University College Dublin, 2001 Conference Paper, 2001

Hook, I., Comey, N. & Sheridan, H., Effect of inulin as carbon source on growth and essential oil content of Edelweiss hairy roots, 27th International Symposium on Essential Oils, Vienna, Austria, 1996 Conference Paper, 1996

Hook, I., Comey, N., James, P. & Sheridan, H., A 2,3- dihydrochromone from the essential oil of edelweiss, Royal Society of Chemistry (TCD Meeting) Drugs from Natural Products. , Trinity College Dublin, 1994 Conference Paper, 1994

Hook, I. Ryan, S. & Sheridan, H., Biotransformation of exogenous organic substrates by marine microalgae, European Marine Biology Symposium, Trinity College Dublin, 1992 Conference Paper, 1992

Hook, I., Comey, N. & Sheridan, H., Essential oil from roots of Edelweiss, Leontopodium alpinum, 23rd International Symposium on Essential Oils, Ayr, Scotland, 1992 Conference Paper, 1992

Hook, I., Sheridan, H. & Waldren, S., Preliminary phytochemical evaluation of Nesocodon mauritianus, Irish Botanists Meeting, University College Dublin, 1991 Conference Paper, 1991

Hook, I. & Sheridan, H., Tissue culture and micropropagation of the fern Onychium japonicum, Plant Biotechnology-Dublin Group meeting , Maynooth, Ireland, 1991 Conference Paper, 1991

Hook, I., Sheridan, H. & Wilson, G., Production of volatile metabolites by tissue cultures of Taraxacum officinale, Gesellschaft fur Arzneipflanzeforschung, Bonn, 1990 Conference Paper, 1990

Hook, I., Lecky, R. & Sheridan, H., Biotransformation of exogenously applied terpenes by cell suspension culture of P bracteatum, Irish Botanists Meeting , Trinity College Dublin, 1989 Conference Paper, 1989

Hook, I., Lecky, R. & Sheridan, H., Biotransformation of substrates by plant cell cultures, Plant Biotechnology - Dublin Group meeting , Trinity College Dublin, 1988 Conference Paper, 1988

Hook, I., Lecky, R. & Sheridan, H., Biotransformation of exogenously applied substrates by cell suspension cultures of P bracteatum, SEB International Symposium, King's College London, Phytochemical Society of Europe, 1988 Conference Paper, 1988

Research Expertise

Description

My research has always been multidisciplinary; built on collaboration with pharmacologists/ molecular-biologists/ bio-technologists/ botanists/anthropologists and sociologists and is recognised at a national and inter-national level. The driving force behind my work is to find new therapeutic treatments for unmet clinical need and to finding meaningful uses for natural molecules, and to improve the position on communities in the developing world who have a cultural and financial reliance on Traditional Medicine. I have learned a lot about the journey from therapeutic drug discovery to human trials, and the challenges and obstacles that line the road. However, experience led decision making about research is invaluable. Through this lens of experience, the molecules my group is working on have real therapeutic potential and have been designed to eliminate some of the insurmountable obstacles to drug development. My drug discovery focus, has been informed by the natural world, ethnomedical practice across the globe; molecular design, based on hybridised natural molecules; and using computer modelling to find natural molecules that target important receptors. In my natural product research I have engaged with International, multidisciplinary Consortia establishing good practice and gold standards for quality, safety and efficacy of complex natural medicines as nutraceuticals, and as food supplements. One of my core research and teaching beliefs is that 'it is at the interface of disciplines and expertise that new ideas and creativity emerge'. My current research falls under four main themes. 1) Multidisciplinary approach Drug discovery for the treatment of inflammatory disease and cancer Finding new therapies targeted at diseases with unmet clinical need. Currently I am PI on an SFI TIDA award and have 50 molecules being tested at level 2 in the Lilly Open Innovation Platform, with six significant nanomolar hits against a key target in Chemotherapy and radiation resistant cancer cells. 2) Drug discovery from the natural world is still ongoing. We use of natural materials (plants, cell cultures, microalgae) for the discovery of novel bio-active materials. 3) Traditional Herbal Medicine. Overview the best practice methodology, recommend applications, and future directions for metabolic profiling, component analysis and purification of secondary metabolites in preparations utilised in Traditional Medicine by large populations (Asia and Africa). Utilising metabolomic techniques to establish best practice for the determination of quality, safety and efficacy of herbal medicines for human and veterinary use. 4) Exploring traditional medicine (TM) in Ireland and in Sub-Saharan-Africa in the context of a changing global healthcare landscape, using a community in West Pokot, Kenya as a case study. I am Co-founder of Trino Therapeutics (Formerly Pharmatrin ltd), a TCD campus company whose activities are centered on drug discovery/development. Through this vehicle my research progressed through a significant Medicinal Chemistry programme of lead optimisation, GMP synthesis of lead, pre-clinical evaluation, regulatory approval and progression through Phase 1 Clinical trials. My ethnomedical research was presented in Harvard (2018), and my overall research work has been presented internationally and most recently on an invited lecture tour in China.

Projects

  • Title
    • Assessment of the therapeutic potential of two lead anti-inflammatory molecules with a novel carbon scaffold in ex-vivo colonic explant tissue.
  • Summary
    • The rigid bicyclic indane (2,3-dihydro-1H-indene) is a 'privileged' sub-structure offering ten potential substitution sites for the design of high-affinity ligands with a 'perfect fit', targeted at a range of receptors. Elaborated indane scaffolds are in clinical use, including: Donepezil (Aricept) a reversible ACE inhibitor and Sulindac (Clinoril) an anti-inflammatory of unknown mechanism. Our ongoing research has led to the discovery of a commercially accessible, novel indane scaffold. 24 analogues (mwt <350) have been synthesised (4-5 steps) from inexpensive starting materials. We have identified two lead molecules which demonstrate anti-inflammatory and anti-angiogenic effects in-vitro. Based on our results, we wish to evaluate their effects on mediators in ex-vivo human ulcerative colitis explants together with their modulating effects on the tumour microenvironment. We anticipate that these lead molecules, alone or as combination with current therapies will reduce the immunosuppressive phenotype of the tumour microenvironment. There is potential for these molecules to treat disease such as IBD, RA, psoriasis; certain forms of cancers e.g. Barrett's oesophagus and also orphan diseases, such as Castleman's disease.
  • Funding Agency
    • SFI
  • Date From
    • July 2018
  • Date To
    • October 2019
  • Title
    • Novel indanes as potential therapies for auto-immune disease
  • Summary
    • Novel indane compounds for the treatment of IBD. From Discovery to Phase 1 Human Trials.
  • Funding Agency
    • Wellcome Trust; Venture capital; Trino Therapeutics Ltd
  • Date From
    • 1999
  • Date To
    • December 2016
  • Title
    • Investigation into Mechanism of action of PH46A
  • Summary
    • Using Molecular biology and High resolution NMR to investigate molecular mechanism of action of the anti inflammatory clinical candidate PH46A
  • Funding Agency
    • Trino Therapeutics Ltd (Industry)
  • Date From
    • December 2015
  • Date To
    • December 2016
  • Title
    • A novel indane scaffold with potential anti-inflammatory agents.
  • Summary
    • Inflammatory bowel disease (IBD) consists of two major forms, Crohn's disease (CD) and ulcerative colitis (UC). Both chronic inflammatory disorders follow a complex interaction of multiple factors in the pathogenesis n IBD. During the last two decades, development of new IBD drugs has expanded the therapeutic options for IBD patients. However, the number of failed therapies especially biologic drugs is noticeably high. There is still a clear gap in addressing this unmet need to improve the treatment of IBD. Development of small molecule drugs (SMDs) have recently resurfaced with new therapeutic agents at various clinical development stages. The discovery of PH46A, a novel first in class, dimeric indane with two chiral centres originated from this research group and has recently completed a Phase I, single ascending dose double-blind, randomized, placebo-controlled study for the treatment of IBD. The scaffold of PH46A incorporates the indane skeleton and is the N-glucamine salt of a single enantiomer PH46 of this novel drug. The current study focusses on two themes: (1) The pharmacological evaluation of PH46 to define a clearer understanding of the mechanism of its molecular action. (2) In addition, we have designed an exciting new indane scaffold. Pharmacological evaluations to characterise the structural activity relationships (SARs) of this group of novel indanes in in vitro and in vivo models have resulted in the discovery of a NOVEL group of molecules with potent IL6 inhibitory properties. These molecules are undergoing further evaluation.
  • Funding Agency
    • Trino Therapeutics Ltd (Industry)
  • Date From
    • 2015
  • Date To
    • 2017
  • Title
    • Traditional Chinese medicine research in the post-genomic era: Good practice,priorities, challenges and opportunities
  • Summary
    • P-TCM is the 1st EU-funded Coordination Action consortium dedicated to tradi-tional Chinese medicine (TCM) research. This paper aims to summarise the objectives, structure andactivities of the consortium andintroduces the position of the consortium regarding good practice,priorities, challenges and opportunities in TCM research. Serving as the introductory paper for the GP-TCM Journal of Ethnopharmacology special issue, this paper describes the roadmap of this special issueand reports how the main outputs of the ten GP-TCM work packages are integrated, and have led toconsortium-wide conclusions
  • Funding Agency
    • EU
  • Date From
    • 2008
  • Date To
    • 2012
  • Title
    • Effect of novel indanes on mast cell function
  • Summary
    • Novel synthetic indanes will be investigated on mast cell function and degrnaulation using harvested peritoneal mast cells, and mast cell lines such as RBL-3H3 and LAD2. Mediators studied will include histamine, cytokines etc.
  • Funding Agency
    • Enterprise Ireland and Trino Therapeutics Ltd
  • Date From
    • 2005
  • Date To
    • 2008
  • Title
    • Novel neuroprotective agents for the treatment of Parkinsons disease and other neurodegenerative disorders
  • Summary
    • Parkinsons disease, with worldwide distribution, is a neurodegenerative disorder with symptoms of tremor, akinesia and rigidity. As part of an ongoing study we have identified a series of compounds with neuroprotective and neuroregenerative properties. We are investigating these molecules as a novel disease-modifying therapy for this important class of diseases
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2008
  • Date To
    • 2009
  • Title
    • Unlocking the Therapeutic Potential of Quinoa as Nutraceutical Modulator of the Farnesoid X Receptor
  • Funding Agency
    • SFI
  • Date From
    • June 2018
  • Date To
    • May 2019

Keywords

ALTERNATIVE MEDICINE; Antiinflammatory drugs; Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis); Biotransformation; Chemical Biology; Development of drugs for malaria, Cancer and inflammatory diseases; Drug discovery; Fungi; Herbal medicine; In Vitro Testing, Trial Methods; Indanes, indanones, muscel, nast cell stabilisation, immunosuppressants; Inflammation; Inflammatory Bowel Disease; Medicinal plants; Multiple Sclerosis; Natural Product Chemistry; Organic chemistry; Over-the-Counter Drugs; Pharmacognosy; Phytochemical and pharmacological evaluations of native and foreign plants; Phytomedicines; Plant and algal cell monocultures; Secondary plant metabolism; The use of cell cultures for the discovery of novel drugs; Traditional and Indigenous health systems in developing countries; Traditional Chinese Medicine

Recognition

Representations

External Examiner to Postgraduate taught Master's Degrees in University College London 2015-2018

Appointed to the Health Products Regulatory Authority (HPRA) Herbal Medicines Sub-Committee 2006 to date

Board Member of the International Natural Product Science taskforce 2017 - To date

External Examiner to Victoria University of Wellington. Wellington, New Zealand 2014

Irish Medicines Board Traditional Herbal Medicinal Products Ad Hoc sub-committee. 2000 - 2006

International Foundation for Science Grant reviewer http://www.ifs.se/ 2009 to date

Grant reviewer for the Medical Research Council UK 2012

Youth Science committee of the Royal Dublin Society 1990-1992

External Examiner Cardiff University PhD Thesis 1991

Awards and Honours

SFI TIDA Award 2017

Appointed to Fellowship of The Royal Society of Chemistry 2017

Wellcome Trust Strategic Translation Award (co-PI) 2013

Irish American Partnership Research Award - with Pfizer 1992

Travel awards: British Council 1991

RIA Travelling award 1990

Department of Education Post Doctoral Fellowship (UCD). 1984-1985

"1851 Overseas Traveling Scholarship". 1983-1984

French Government research Award - CNRS. Gif-Sur-Yvette 1983

NBST Young Researcher award with Dr. Hector Rubelcava (UCD) 1979

Memberships

Fellow of the Royal Society of Chemistry. 1989 – To date

Board member of the Board of Directors of the Natural Product Sciences Task force INPST https://inpst.net/. 2016 – To date

Life member GP-TCM RA (Good Practice in TCM Research Association). 2009 – To date

Member of the SCT (Societe De Chimie Therapeutique The French Society for Medicinal Chemistry) 2014 – To date

Member of the Society for Medicinal Plant and Natural Product Research. Gesellschaft für Arzneipflanzen- und Naturstoff-Forschung e.V. (GA). 2014 – To date