RESEARCH INTERESTS
Anne Marie Healy is Professor of Pharmaceutics and Pharmaceutical Technology in the School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin and is one of the Co-Directors of the Centre for Doctoral Training in Transformative Pharmaceutical Technologies. She is also Co-Principal Investigator of SSPC - the Science Foundation Ireland Research Centre for Pharmaceuticals, and was awarded the SSPC Researcher of the Year in 2019. This award recognises Anne Marie’s many contributions to the Centre with exceptional scientific outputs.
Her research interests include pharmaceutical material science, preformulation and formulation of pharmaceuticals, amorphous solids, co-crystals, formulating poorly soluble drugs, pharmaceutical processing and pulmonary drug delivery.
Anne Marie has a B.Sc. in Pharmacy and a Ph.D. in Pharmaceutics, both from the University of Dublin. She joined the School of Pharmacy, TCD in 1992 as a Lecturer in Pharmaceutics. In 2010 she was elected Fellow of Trinity College.
Professor Healy has published extensively, with over 100 international peer reviewed publications. She has graduated 20 PhD students, mentored 25 postdoctoral researchers, and has been awarded €10 million in competitive grant income.
Professor Healy has received funding from both national and international agencies to progress her research. As well as her involvement as Co-PI with the SSPC, she has held a Science Foundation Ireland Principal Investigator award focused on the development of fixed dose combination products using advanced pharmaceutical processing technologies. She has also received NIH funding to work on a collaborative project with the University of California, San Francisco and University College Dublin aimed at developing novel mucolytic therapies for lung disease. She was awarded a Special Visiting Researcher Fellowship by CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil) in 2014 to further her collaborative research with the Faculty of Pharmacy of the Federal University of Rio de Janeiro.
FINANCIAL SUPPORT
Science Foundation Ireland, Enterprise Ireland, Irish Research Council, CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil), National Institutes of Health (NIH, USA), numerous pharmaceutical companies including: APC, Xeolas, IVAX Pharmaceuticals, Merrion Pharmaceuticals, Velox GmbH, Amebis, Solvotrin Therapeutics, Pfizer, GSK, Merck, Eli Lilly, Janssen, Roche, Bristol-Myers Squibb, Alkermes, UCB Pharma, Abbvie, Clarochem, Innopharma Labs, Glantreo, Dynochem, Eirgen, Novartis, Allergan, Genzyme, Biomarin, FMC, SK Biotek.
Publications and Further Research Outputs
Peer-Reviewed Publications
Autzen Virtanen, A. and MyÅ liÅ"ska, M. and Healy, A.M. and Power, E. and Madi, A. and Sivén, M., The challenge of downstream processing of spray dried amorphous solid dispersions into minitablets designed for the paediatric population â" A sustainable product development approach, European Journal of Pharmaceutical Sciences, 196, (106752), 2024
Andrews, G.P. and Healy, A.M. and Topp, E.M., Introducing the Molecular Pharmaceutics Special Issue on â Advances in Small and Large Molecule Pharmaceutics Research across Irelandâ , Molecular Pharmaceutics, 21, (8), 2024, p3693-3694
Piatek, M. and Grassiri, B. and Oâ Ferrall, L.M. and Piras, A.M. and Batoni, G. and Esin, S. and Oâ Connor, C. and Griffith, D. and Healy, A.M. and Kavanagh, K., Quantitative proteomic analysis reveals Ga(III) polypyridyl catecholate complexes disrupt Aspergillus fumigatus mitochondrial function, Journal of Biological Inorganic Chemistry, 2024
Salomé S. Celi, Raquel Fernández-García, Andreina I. Afonso-Urich, M. Paloma Ballesteros, Anne Marie Healy, Dolores R. Serrano, Co-Delivery of a High Dose of Amphotericin B and Itraconazole by Means of a Dry Powder Inhaler Formulation for the Treatment of Severe Fungal Pulmonary Infections, Pharmaceutics, 15, (11), 2023, p2601
de Pablo E, O'Connell P, Fernández-García R, Marchand S, Chauzy A, Tewes F, Dea-Ayuela MA, Kumar D, Bolás F, Ballesteros MP, Torrado JJ, Healy AM, Serrano DR., Targeting lung macrophages for fungal and parasitic pulmonary infections with innovative amphotericin B dry powder inhalers., International journal of pharmaceutics, 635, 2023, p122788
Addante, A. and Raymond, W. and Gitlin, I. and Charbit, A. and Orain, X. and Scheffler, A.W. and Kuppe, A. and Duerr, J. and Daniltchenko, M. and Drescher, M. and Graeber, S.Y. and Healy, A.-M. and Oscarson, S. and Fahy, J.V. and Mall, M.A., A novel thiol-saccharide mucolytic for the treatment of muco-obstructive lung diseases, European Respiratory Journal, 61, (5), 2023
Fernández-García R, Walsh D, O'Connell P, Slowing K, Raposo R, Paloma Ballesteros M, Jiménez-Cebrián A, Chamorro-Sancho MJ, Bolás-Fernández F, Healy AM, Serrano DR., Can amphotericin B and itraconazole be co-delivered orally? Tailoring oral fixed-dose combination coated granules for systemic mycoses., European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 183, 2023, p74-91
Myslinska M, Stocker MW, Ferguson S, Healy AM., A Comparison of Spray-Drying and Co-Precipitation for the Generation of Amorphous Solid Dispersions (ASDs) of Hydrochlorothiazide and Simvastatin., Journal of pharmaceutical sciences, 2023, pS0022-3549(23)00064-3
Stocker MW, Tsolaki E, Harding MJ, Healy AM, Ferguson S., Combining Isolation-Free and Co-processing Manufacturing Approaches to Access Room Temperature Ionic Liquid Forms of APIs., Journal of pharmaceutical sciences, 2023, pS0022-3549(23)00052-7
Kara, A. and Kumar, D. and Healy, A.M. and Lalatsa, A. and Serrano, D.R., Continuous Manufacturing of Cocrystals Using 3D-Printed Microfluidic Chips Coupled with Spray Coating, Pharmaceuticals, 16, (8), 2023
Shao S., Stocker M.W., Zarrella S., Korter T.M., Singh A., Healy A.M., In Situ Cocrystallization via Spray Drying with Polymer as a Strategy to Prevent Cocrystal Dissociation, Molecular Pharmaceutics, 20, (9), 2023, p4770 - 4785, p4770-4785
Shao S., Bonner D., Twamley B., Singh A., Healy A.M., One Step In Situ Co-Crystallization of Dapsone and Polyethylene Glycols during Fluidized Bed Granulation, Pharmaceutics, 15, (9), 2023
Stocker M.W., Harding M.J., Todaro V., Healy A.M., Ferguson S., Integrated Purification and Formulation of an Active Pharmaceutical Ingredient via Agitated Bed Crystallization and Fluidized Bed Processing, Pharmaceutics, 14, (5), 2022
Fernández-GarcÃa, R. and Muñoz-GarcÃa, J.C. and Wallace, M. and Fabian, L. and González-Burgos, E. and Gómez-Serranillos, M.P. and Raposo, R. and Bolás-Fernández, F. and Ballesteros, M.P. and Healy, A.M. and Khimyak, Y.Z. and Serrano, D.R., Self-assembling, supramolecular chemistry and pharmacology of amphotericin B: Poly-aggregates, oligomers and monomers, Journal of Controlled Release, 341, 2022, p716-732
Khanna, K. and Raymond, W.W. and Jin, J. and Charbit, A.R. and Gitlin, I. and Tang, M. and Werts, A.D. and Barrett, E.G. and Cox, J.M. and Birch, S.M. and Martinelli, R. and Sperber, H.S. and Franz, S. and Duff, T. and Hoffmann, M. and Healy, A.M. and Oscarson, S. and Pöhlmann, S. and Pillai, S.K. and Simmons, G. and Fahy, J.V., Exploring antiviral and anti-inflammatory effects of thiol drugs in COVID-19, American journal of physiology. Lung cellular and molecular physiology, 323, (3), 2022, pL372-L389
Nambiar, A.G. and Singh, M. and Mali, A.R. and Serrano, D.R. and Kumar, R. and Healy, A.M. and Agrawal, A.K. and Kumar, D., Continuous Manufacturing and Molecular Modeling of Pharmaceutical Amorphous Solid Dispersions, AAPS PharmSciTech, 23, (7), 2022
Queiroz, A.L.P. and Kerins, B.M. and Yadav, J. and Farag, F. and Faisal, W. and Crowley, M.E. and Lawrence, S.E. and Moynihan, H.A. and Healy, A.-M. and Vucen, S. and Crean, A.M., Investigating microcrystalline cellulose crystallinity using Raman spectroscopy, Cellulose, 28, (14), 2021, p8971-8985
Todaro V., Healy A.M., Development and characterization of ibuprofen co-crystals granules prepared via fluidized bed granulation in a one-step process"a design of experiment approach, Drug Development and Industrial Pharmacy, 2021
Ayyoubi S, Cerda JR, Fernández-García R, Knief P, Lalatsa A, Marie Healy A, Serrano DR., 3D printed spherical mini-tablets: Geometry versus composition effects in controlling dissolution from personalised solid dosage forms., International journal of pharmaceutics, 2021, p120336
Tsolaki, E. and Stocker, M.W. and Healy, A.M. and Ferguson, S., Formulation of ionic liquid APIs via spray drying processes to enable conversion into single and two-phase solid forms, International Journal of Pharmaceutics, 603, (120669), 2021
Browne, E. and Quinn, S. and Cheyne, S. and Healy, A.M., Design and characterisation of an amorphous formulation of nifedipine for the treatment of autonomic dysreflexia, Journal of Pharmacy and Pharmacology, 73, (7), 2021, p928-936
Kavanagh O., Marie Healy A., Dayton F., Robinson S., O'Reilly N.J., Mahoney B., Arthur A., Walker G., Farragher J.P., Inhaled hydroxychloroquine to improve efficacy and reduce harm in the treatment of COVID-19, Medical Hypotheses, 143, 2020
de Castro R.R., Todaro V., da Silva L.C.R.P., Simon A., do Carmo F.A., de Sousa V.P., Rodrigues C.R., Sarmento B., Healy A.M., Cabral L.M., Development of inhaled formulation of modified clofazimine as an alternative to treatment of tuberculosis: Clofazimine inhaled formulation for tuberculosis, Journal of Drug Delivery Science and Technology, 58, 2020
Tewes F., Brillault J., Gregoire N., Olivier J.-C., Lamarche I., Adier C., Healy A.-M., Marchand S., Comparison between colistin sulfate dry powder and solution for pulmonary delivery, Pharmaceutics, 12, (6), 2020, p1 - 17, p1-17
Jose R. Cerda, Talaya Arifi, Sejad Ayyoubi, Peter Knief, Maria Paloma Ballesteros, William Keeble, Eugen Barbu, Anne Marie Healy, Aikaterini Lalatsa, Dolores R. Serrano, Personalised 3D Printed Medicines: Optimising Material Properties for Successful Passive Diffusion Loading of Filaments for Fused Deposition Modelling of Solid Dosage Forms, Pharmaceutics, 12, (4), 2020, pE345
Suzuki E.Y., Simon A., da Silva A.L., Amaro M.I., de Almeida G.S., Agra L.C., Cabral L.M., Rocco P.R.M., Healy A.M., de Sousa V.P., Effects of a novel roflumilast and formoterol fumarate dry powder inhaler formulation in experimental allergic asthma, International Journal of Pharmaceutics, 588, 2020
Dadou S.M., Senta-Loys Z., Almajaan A., Li S., Jones D.S., Healy A.M., Tian Y., Andrews G.P., The development and validation of a quality by design based process analytical tool for the inline quantification of Ramipril during hot-melt extrusion, International Journal of Pharmaceutics, 584, 2020
David Blanco, Osmo Antikainen, Heikki Räikkönen, Pei Ting Mah, Anne Marie Healy, Anne Mari Juppo, Jouko Yliruusi, Image-based characterization of powder flow to predict the success of pharmaceutical minitablet manufacturing, International Journal of Pharmaceutics, 2020, pE119280
Kelleher J.F., Madi A.M., Gilvary G.C., Tian Y.W., Li S., Almajaan A., Loys Z.S., Jones D.S., Andrews G.P., Healy A.M., Metformin Hydrochloride and Sitagliptin Phosphate Fixed-Dose Combination Product Prepared Using Melt Granulation Continuous Processing Technology, AAPS PharmSciTech, 21, (1), 2020
Focaroli S., Jiang G., O'connell P., Fahy J.V., Healy A.-M., The use of a three-fluid atomising nozzle in the production of spray-dried theophylline/salbutamol sulphate powders intended for pulmonary delivery, Pharmaceutics, 12, (11), 2020, p1 - 18, p1-18
Stocker M.W., Healy A.M., Ferguson S., Spray Encapsulation as a Formulation Strategy for Drug-Based Room Temperature Ionic Liquids: Exploiting Drug-Polymer Immiscibility to Enable Processing for Solid Dosage Forms, Molecular Pharmaceutics, 17, (9), 2020, p3412 - 3424, p3412-3424
Browne E., Worku Z.A., Healy A.M., Physicochemical properties of poly-vinyl polymers and their influence on ketoprofen amorphous solid dispersion performance: A polymer selection case study, Pharmaceutics, 12, (5), 2020, pE433
Andrews, G.P. and Li, S. and Almajaan, A. and Yu, T. and Martini, L. and Healy, A. and Jones, D.S., Fixed Dose Combination Formulations: Multilayered Platforms Designed for the Management of Cardiovascular Disease, Molecular Pharmaceutics, 16, (5), 2019, p1827-1838
Todaro V, Worku ZA, Cabral LM, Healy AM., In Situ Cocrystallization of Dapsone and Caffeine during Fluidized Bed Granulation Processing, AAPS PharmSciTech, 20:28, (1), 2019
Serrano D.R., Fernandez-Garcia R., Mele M., Healy A.M., Lalatsa A., Designing fast-dissolving orodispersible films of amphotericin b for oropharyngeal candidiasis, Pharmaceutics, 11, (8), 2019
Andrews, G.P. and Jones, D.S. and Senta-Loys, Z. and Almajaan, A. and Li, S. and Chevallier, O. and Elliot, C. and Healy, A.M. and Kelleher, J.F. and Madi, A.M. and Gilvary, G.C. and Tian, Y., The development of an inline Raman spectroscopic analysis method as a quality control tool for hot melt extruded ramipril fixed-dose combination products, International Journal of Pharmaceutics, 566, 2019, p476-487
Andrews GP, Jones DS, Senta-Loys Z, Almajaan A, Li S, Chevallier O, Elliot C, Healy AM, Kelleher JF, Madi AM, Gilvary GC, Tian Y., The Development of an Inline Raman Spectroscopic Analysis Method as a Quality Control Tool for Hot Melt Extruded Ramipril Fixed-dose Combination Products., International journal of pharmaceutics, 2019
Mah P.T., O'Connell P., Focaroli S., Lundy R., O'Mahony T.F., Hastedt J.E., Gitlin I., Oscarson S., Fahy J.V., Healy A.M., The use of hydrophobic amino acids in protecting spray dried trehalose formulations against moisture-induced changes, European Journal of Pharmaceutics and Biopharmaceutics, 144, 2019, p139 - 153, p139-153
Antonio Matji, Nicoletta Donato, Adrianna Gagol, Enrique Morales, Luis Carvajal, Dolores R. Serrano, Zelalem A. Worku, Anne Marie Healy, Juan Jose Torrado, Predicting the critical quality attributes of ibuprofen tablets via modelling of process parameters for roller compaction and tabletting, International Journal of Pharmaceutics, 565, 2019, p209--218
Pharmaceutics, Basel, Switzerland, MDPI, [eds.], 2019
Browne E, Charifou R, Worku ZA, Babu RP, Healy AM., Amorphous solid dispersions of ketoprofen and poly-vinyl polymers prepared via electrospraying and spray drying: A comparison of particle characteristics and performance., International journal of pharmaceutics, 566, 2019, p173-184
Nanoparticle Tracking Analysis to Examine the Temperature-Induced Aggregation of Proteins in, editor(s)McManus, J.J. , Protein Self-Assembly: Methods and Protocols , New York, Humana Press, 2019, pp131 - 139, [Sladek S., McComiskey K., Healy A.M., Tajber L.]
Matji A, Donato N, Gagol A, Morales E, Carvajal L, Serrano DR, Worku ZA, Healy AM, Torrado JJ., Predicting the critical quality attributes of ibuprofen tablets via modelling of process parameters for roller compaction and tabletting., International journal of pharmaceutics, 565, 2019, p209-218
Focaroli S, Mah PT, Hastedt JE, Gitlin I, Oscarson S, Fahy JV, Healy AM., A Design of Experiment (DoE) approach to optimise spray drying process conditions for the production of trehalose/leucine formulations with application in pulmonary delivery., International journal of pharmaceutics, 562, 2019, p228-240
Kumar D, Worku ZA, Gao Y, Kamaraju VK, Glennon B, Babu RP, Healy AM, Comparison of wet milling and dry milling routes for ibuprofen pharmaceutical crystals and their impact on pharmaceutical and biopharmaceutical properties, Powder Technology, 330, 2018, p228-238
Walsh D, Serrano DR, Worku ZA, Norris BA, Healy AM, Production of cocrystals in an excipient matrix by spray drying, International Journal of Pharmaceutics, 536, (1), 2018, p467-477
Serrano DR, Walsh D, O'Connell P, Mugheirbi NA, Work, ZA, Bolas-Fernandez F, Galiana C, Dea-Ayuela MA, Healy AM, Optimising the in vitro and in vivo performance of oral cocrystal formulations via spray coating, European Journal of Pharmaceutics and Biopharmaceutics, 124, 2018, p13-27
Kavanagh ON, Albadarin AB, Croker DM, Healy AM, Walker GM., Maximising success in multidrug formulation development: A review., Journal of controlled release : official journal of the Controlled Release Society, 283, 2018, p1-19
Wang J, Radics G, Whelehan M, OÊ"Driscoll A, Healy AM, Gilmer JF, Ledwidge M, Novel Iron-Whey Protein Microspheres Protect Gut Epithelial Cells from Iron-Related Oxidative Stress and Damage and Improve Iron Absorption in Fasting Adults, Acta Haematologica, 2018, p223-232
Lamy B, Tewes F, Serrano DR, Lamarche I, Gobin P, Couet W, Healy AM, Marchand S, New aerosol formulation to control ciprofloxacin pulmonary concentration, Journal of Controlled Release, 271, 2018, p118-126
Walsh D, Serrano DR, Worku ZA, Madi AM, O'Connell P, Twamley B, Healy AM., Engineering of pharmaceutical cocrystals in an excipient matrix: Spray drying versus hot melt extrusion., International journal of pharmaceutics, 551, (1-2), 2018, p241-256
Suzuki ÉY, Amaro MI, de Almeida GS, Cabral LM, Healy AM, de Sousa VP., Development of a new formulation of roflumilast for pulmonary drug delivery to treat inflammatory lung conditions., International journal of pharmaceutics, 550, (1-2), 2018, p89-99
Kelleher JF, Gilvary GC, Madi AM, Jones DS, Li S, Tian Y, Almajaan A, Senta-Loys Z, Andrews GP, Healy AM., A comparative study between hot-melt extrusion and spray-drying for the manufacture of anti-hypertension compatible monolithic fixed-dose combination products., International journal of pharmaceutics, 545, (1-2), 2018, p183-196
do Amaral, L.H., do Carmo, F.A., Amaro, M.I., de Sousa, V.P., da Silva, L.C.R.P., de Almeida, G.S., Rodrigues, C.R., Healy, A.M., Cabral, L.M., Development and characterization of dapsone cocrystal prepared by scalable production methods, AAPS PharmSciTech , 19, (6), 2018, p2687 - 2699
Todaro, V, Persoons, T, Groves, G, Healy, AM, D'Arcy, DM, Characterisation and simulation of hydrodynamics in the paddle, basket and flow-through dissolution testing apparatuses - a review, Dissolution Technologies, 24, (3), 2017, p24 - 36
He, Y. and Glennon, B. and Gao, Y. and Healy, A.-M. and Worku, Z., Tailoring CSD & shape of ibuprofen to improve flow properties in batch & continuous crystallization, 2017-October, 2017, pp576-585
Mugheirbi NA, O'Connell P, Serrano DR, Healy AM, Taylor LS, Tajber L, A Comparative Study on the Performance of Inert and Functionalized Spheres Coated with Solid Dispersions Made of Two Structurally Related Antifungal Drugs, Molecular Pharmaceutics, 14, (11), 2017, p3718-3728
He, Y. and Glennon, B. and Gao, Y. and Healy, A.-M. and Worku, Z., Tailoring CSD & shape of ibuprofen to improve flow properties in batch & continuous crystallization, 2, 2017, pp1106-1115
He, Y. and Glennon, B. and Gao, Y. and Healy, A.-M. and Worku, Z., Tailoring csd & shape of ibuprofen to improve flow properties in batch & continuous crystallization, 2017-October, 2017, pp413-422
Rolón M, Serrano DR, Lalatsa A, de Pablo E, Torrado JJ, Ballesteros MP, Healy AM, Vega, C, Corone C, Bolás-Fernández F, Dea-Ayuela MA, Engineering oral and parenteral amorphous amphotericin B formulations against experimental Trypanosoma cruzi infections, Molecular Pharmaceutics, 14, (4), 2017, p1095-1106
Worku ZA, Kumar D, Gomes JV, He Y, Glennon B, Ramisetty KA, Rasmuson ÅC, O'Connell P, Gallagher KH, Woods T, Shastri NR, Healy AM , Modelling and understanding powder flow properties and compactability of selected active pharmaceutical ingredients, excipients and physical mixtures from critical material properties, International Journal of Pharmaceutics, 531, (1), 2017, p191-204
Healy, AM, Worku, ZA, Kumar, D, Madi, AM, Pharmaceutical solvates, hydrates and amorphous forms: a special emphasis on cocrystals, Advanced Drug Delivery Reviews, 117, 2017, p25-46
Simon A, Amaro MI, Healy AM, Cabral LM, de Sousa VP, Development of a discriminative in vitro release test for rivastigmine transdermal patches using pharmacopeial apparatuses: USP 5 and USP 6, AAPS PharmSciTech, 18 , (7), 2017, 2561-2569
Dul M, Paluch KJ, Healy AM, Sasse A, Tajber L, Optimisation of the self-assembly process: production of stable, alginate-based polyelectrolyte nanocomplexes with protamine, Journal of Nanoparticle Research, 19, (6), 2017, p221 - 231
Amharar Y, Curtin V, Gallagher KH, O'Siochru E, O'Connell P, Healy AM, Mitigating unwanted amorphisation: A screening method for the selection of suitable excipients, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 81, 2016, p181-8
Zelikin AN, Ehrhardt C, Healy AM, Materials and methods for delivery of biological drugs, Nature Chemistry, 8, (11), 2016, p997-1007
Simon A, Amaro MI, Cabral LM, Healy AM, de Sousa VP, Development of a novel dry powder inhalation formulation for the delivery of rivastigmine hydrogen tartrate, International journal of pharmaceutics, 501, (1-2), 2016, p124-38
Tewes F, Brillault J, Lamy B, O'Connell P, Olivier JC, Couet W, Healy AM, Ciprofloxacin-loaded inorganic-organic composite microparticles to treat bacterial lung infection, Molecular pharmaceutics, 13, (1), 2016, p100-12
Simon A, Amaro MI, Healy AM, Cabral LM, de Sousa VP, Comparative evaluation of rivastigmine permeation from a transdermal system in the Franz cell using synthetic membranes and pig ear skin with in vivo-in vitro correlation, International Journal of Pharmaceutics, 512, (1), 2016, p234 - 241
Serrano DR, O'Connell P, Paluch KJ, Walsh D, Healy AM, Cocrystal habit engineering to improve drug dissolution and alter derived powder properties, The Journal of pharmacy and pharmacology, 68, (5), 2016, p665-7
Tewes, F, Gobbo, OL, Ehrhardt, C, Healy, AM, Amorphous calcium carbonate based-microparticles for peptide pulmonary delivery, ACS Applied materials and interfaces, 8, (2), 2016, p1164-1175
Serrano DR, Persoons T, D'Arcy DM, Galiana C, Dea-Ayuela MA, Healy AM, Modelling and shadowgraph imaging of cocrystal dissolution and assessment of in vitro antimicrobial activity for sulfadimidine/4-aminosalicylic acid cocrystals, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 89, 2016, p125-36
Serrano DR, Mugheirbi NA, O'Connell P, Leddy N, Healy AM, Tajber L, Impact of substrate properties on the formation of spherulitic films: a case study of salbutamol sulfate, Crystal Growth and Design, 16, (7), 2016, p3853 - 3858
Tao Z, Paluch K, Scalabrino G, Frankish N, Healy AM, Sheridan H, Molecular structure studies of (1S,2S)-2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol, Journal of Molecular Structure, 2015, p286 - 299
Amaro MI, Tajber L, Corrigan OI, Healy AM, Co-spray dried carbohydrate microparticles: crystallisation delay/inhibition and improved aerosolization characteristics through the incorporation of hydroxypropyl-ß-cyclodextrin with amorphous raffinose or trehalose, Pharmaceutical Research, 32, (1), 2015, p180 - 195
Knopp MM, Tajber L, Tian Y, Olesen NE, Jones DS, Kozyra A, Löbmann K, Paluch K, Brennan CM, Holm R, Healy AM, Andrews GP, Rades T, Comparative study of different methods for the prediction of drug-polymer solubility, Molecular Pharmaceutics, 12, (9), 2015, p3408 - 3419
Dul M, Paluch KJ, Kelly H, Healy AM, Sasse A, Tajber L, Self-assembled carrageenan/protamine polyelectrolyte nanoplexes-investigation of critical parameters governing their formation and characteristics, Carbohydrate Polymers, 123, 2015, p339 - 349
Amaro MI, Tewes F, Gobbo O, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Formulation, stability and pharmacokinetics of sugar-based salmon calcitonin-loaded nanoporous/nanoparticulate microparticles (NPMPs) for inhalation, International Journal of Pharmaceutics, 483, (1-2), 2015, p6-18
Serrano DR, Gallagher KH, Healy AM, Emerging nanonisation technologies: tailoring crystalline versus amorphous nanomaterials, Current topics in medicinal chemistry, 15, (22), 2015, p2327-40
D. R. Serrano, T. Persoons, D. M. D'Arcy, C. Galiana, M. A. Dea-Ayuela, A. M. Healy, Shadowgraph Imaging of Cocrystal Dissolution and In Vitro Activity Determination , AAPS Annual Meeting and Exposition, Orlando, Florida, USA, Oct 25-29, 2015, ppW5128-
Amaro MI, Simon A, Cabral LM, de Sousa VP, Healy AM, Rivastigmine hydrogen tartrate polymorphs: solid-state characterisation of transition and polymorphic conversion via milling, Solid State Sciences, 49, 2015, p29 - 36
Barham AS, Tewes F, Healy AM, Moisture diffusion and permeability characteristics of hydroxypropylmethylcellulose and hard gelatin capsules., International journal of pharmaceutics, 478, (2), 2015, p796-803
Grossjohann C, Serrano DR, Paluch KJ, O'Connell P, Vella-Zarb L, Manesiotis P, McCabe T, Tajber L, Corrigan OI, Healy AM, Polymorphism in sulfadimidine/4-aminosalicylic acid cocrystals: solid state characterization and physicochemical properties, Journal of Pharmaceutical Sciences, 104, (4), 2015, p1385-13
Holmes MS, Seheult JN, O'Connell P, D'Arcy S, Ehrhardt C, Healy AM, Costello RW, Reilly RB, An acoustic-based method to detect and quantify the effect of exhalation into a dry powder inhaler., Journal of aerosol medicine and pulmonary drug delivery, 28, (4), 2015, p247 - 253
Tian Y, Caron V, Jones DS, Healy AM, Andrews GP, Using Flory-Huggins phase diagrams as a pre-formulation tool for the production of amorphous solid dispersions: a comparison between hot-melt extrusion and spray drying, The Journal of pharmacy and pharmacology, 66, (2), 2014, p256-74
Amharar Y, Curtin V, Gallagher KH, Healy AM, Solubility of crystalline organic compounds in high and low molecular weight amorphous matrices above and below the glass transition by zero enthalpy extrapolation, International journal of pharmaceutics, 472, (1-2), 2014, p241-7
Seheult JN, O'Connell P, Tee KC, Bholah T, Al Bannai H, Sulaiman I, MacHale E, D'Arcy S, Holmes MS, Bergin D, Reeves E, Reilly RB, Crispino-O'Connell G, Ehrhardt C, Healy AM, Costello RW, The acoustic features of inhalation can be used to quantify aerosol delivery from a Diskus" dry powder inhaler, Pharmaceutical research, 31, (10), 2014, p2735-47
Tewes F, Ehrhardt C, Healy AM, Superparamagnetic iron oxide nanoparticles (SPIONs)-loaded Trojan microparticles for targeted aerosol delivery to the lung, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V, 86, (1), 2014, p98-104
Swaminathan J, Gobbo OL, Tewes F, Healy AM, Ehrhardt C, Encapsulation into PEG-liposomes does not improve the bioavailability of pulmonary delivered salmon calcitonin, Journal of Aerosol Medicine and Pulmonary Drug Delivery, 27, (1), 2014, p1-11
Healy AM, Amaro MI, Paluch KJ, Tajber L, Dry powders for oral inhalation free of lactose carrier particles, Advanced Drug Delivery Reviews, 75, 2014, p32 - 52
Caron V, Hu Y, Tajber L, Erxleben A, Corrigan OI, McArdle P, Healy AM, Amorphous solid dispersions of sulfonamide/Soluplus® and sulfonamide/PVP prepared by ball milling, AAPS PharmSciTech, 14, (1), 2013, p464-474
Holmes MS, Seheult JN, O'Connell P, D'Arcy S, Ehrhardt C, Healy AM, Costello RW, Reilly RB, Exhaling into a Diskus (TM) inhaler before inhalation has a detrimental effect on subsequent drug delivery, Irish Journal of Medical Science, , 182, (Suppl 10), 2013, ppS452 - S453
Paluch KJ, Tajber L, Corrigan OI, Healy AM, Impact of alternative solid state forms and specific surface area of high-dose, hydrophilic active pharmaceutical ingredients on tabletability, Molecular Pharmaceutics, 10, (10), 2013, p3628 - 3639
Molecular Pharmaceutics, ACS Publications, [eds.], 2013-2020
Bianco S, Tewes F, Tajber L, Caron V, Corrigan OI, Healy AM, Bulk, surface properties and water uptake mechanisms of salt/acid amorphous composite systems, International Journal of Pharmaceutics, 456, (1), 2013, p143 - 152
Tewes F, Paluch KJ, Tajber L, Gulati K, Kalantri D, Ehrhardt C, Healy AM, Steroid/mucokinetic hybrid nanoporous microparticles for pulmonary drug delivery, European Journal of Pharmaceutics and Biopharmaceutics, 85, (3), 2013, p604 - 613
Curtin V, Amharar Y, Gallagher KH, Corcoran S, Tajber L, Corrigan OI, Healy AM, Reducing mechanical activation-induced amorphisation of salbutamol sulphate by co-processing with selected carboxylic acids, International Journal of Pharmaceutics, 456, (2), 2013, p508 - 516
Paluch KJ, McCabe T, Müller-Bunz H, Corrigan OI, Healy AM, Tajber L, Formation and physicochemical properties of crystalline and amorphous salts with different stoichiometries formed between ciprofloxacin and succinic acid, Molecular Pharmaceutics, 10, (10), 2013, p3640 - 3654
Surfactants in pharmaceutical products and systems. in, editor(s)Swarbrick J and Boylan JC , Encyclopedia of Pharmaceutical Science and Technology 4th Edition, New York, Taylor and Francis, 2013, pp3464 - 3476, [Tewes F, Corrigan OI, Healy AM]
Hu Y, MacFhionnghaile P, Caron V, Tajber L, Healy AM, Erxleben A, Formation, physical stability and quantification of process induced disorder in cryo-milled samples of a model polymorphic drug, Journal of Pharmaceutical Sciences, 102, (1), 2013, p93 - 103
Curtin V, Amharar Y, Hu Y, Erxleben A, McArdle P, Caron V, Tajber L, Corrigan OI, Healy AM, Investigation of the capacity of low glass transition temperature excipients to minimize amorphization of sulfadimidine on comilling, Molecular Pharmaceutics , 10, (1), 2013, p386-396
Paluch KJ, Amaro MI, Tajber L, Corrigan OI, Healy AM, Impact of process variables on the micromeritic and physicochemical properties of spray dried microparticles - Part II. Physicochemical characterisation of spray dried materials, Journal of Pharmacy and Pharmacology, 64, (11), 2012, p1583 - 1591
Baginski L, Tewes F, Buckley ST, Healy AM, Bakowsky U, Ehrhardt C, Investigations on the fate of inhaled salmon calcitonin at the respiratory epithelial barrier, Pharmaceutical Research, 29, (1), 2012, p332-341
Paluch KJ, Tajber L, Corrigan OI, Healy AM, Impact of process variables on the micromeritic and physicochemical properties of spray dried porous microparticles - Part I. Introduction of a new Morphology Classification System, Journal of Pharmacy and Pharmacology, 64, (11), 2012, p1570 - 1582
Bianco S, Caron V, Tajber L, Corrigan OI, Nolan LM, Hu Y, Healy AM, Modification of the solid state nature of sulfathiazole and sulfathiazole sodium by spray drying, AAPS PharmSciTech, 13, (2), 2012, p647 - 660
Baginski L, Gobbo OL, Tewes F, Salomon JJ, Healy AM, Bakowsky U, Ehrhardt C, In vitro and in vivo characterisation of PEG-lipid based micellar complexes of salmon calcitonin for pulmonary delivery, Pharm Res, 29, (6), 2012, p1425-1434
Grossjohann C, Eccles KS, Maguire AR, Lawrence SE, Tajber L, Corrigan OI, Healy AM, Characterisation, solubility and intrinsic dissolution behaviour of benzamide:dibenzyl sulfoxide cocrystal, International Journal of Pharmaceutics, 422, (1-2), 2012, p24-32
Ní Ógáin O, Tajber L, Corrigan OI, Healy AM, Spray drying from organic solvents to prepare nanoporous/nanoparticulate microparticles (NPMPs) of protein:excipient composites designed for oral inhalation, Journal of Pharmacy and Pharmacology, 64, (9), 2012, p1275 - 1290
Paluch KJ, Tajber L, Adamczyk B, Corrigan OI, Healy AM, A novel approach to crystallisation of nanodispersible microparticles by spray drying for improved tabletability, International Journal of Pharmaceutics, 436, (1-2), 2012, p873 - 876
Gad S, Tajber L, Corrigan OI Healy AM, Preparation and characterisation of novel spray dried nano-structured para-aminosalicylic acid particulates for pulmonary delivery: impact of ammonium carbonate on morphology, chemical composition and solid state, Journal of Pharmacy and Pharmacology, 64, (9), 2012, p1264 - 1274
Paluch KJ, Tajber L, McCabe T, O'Brien JE, Corrigan O, Healy AM, Preparation and characterisation of novel chlorothiazide potassium solid-state salt forms: intermolecular self assembly suprastructures, European Journal of Pharmaceutical Sciences, 42, (3), 2011, p220 - 229
Nolan LM, Li J, Tajber L, Corrigan OI, Healy AM, Particle engineering of materials for oral inhalation by dry powder inhalers. II - Sodium cromoglicate, International Journal of Pharmaceutics, 405, (1-2), 2011, p36 - 46
Caron V, Tajber L, Corrigan OI, Healy AM, A comparison of spray drying and milling in the production of amorphous dispersions of sulfathiazole/polyvinylpyrrolidone and sulfadimidine/polyvinylpyrrolidone, Molecular Pharmaceutics, 8, (2), 2011, p532 - 542
Tewes F, Gobbo OL, Amaro MI, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Evaluation of HPβCD-PEG microparticles for salmon calcitonin administration via pulmonary delivery, Molecular Pharmaceutics, 8, (5), 2011, p1887 - 1898
Ní Ógáin O, Li J, Tajber L, Corrigan OI, Healy AM, Particle engineering of materials for oral inhalation by dry powder inhalers. I - Particles of sugar excipients (trehalose and raffinose) for protein delivery, International Journal of Pharmaceutics, 405, (1-2), 2011, p23 - 35
Amaro MI, Tajber L, Corrigan OI, Healy AM, Optimisation of spray drying process conditions for sugar nanoporous microparticles (NPMPs) intended for inhalation, International Journal of Pharmaceutics, 421, (1), 2011, p99 - 109
Paluch K, Tajber L, Elcoate CJ, Corrigan OI, Lawrence SE, Healy AM, Solid state characterisation of novel active pharmaceutical ingredients: co-crystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt, Journal of Pharmaceutical Sciences, 100, (8), 2011, p3268 - 3283
Hao HX, Su WY, Barrett M, Caron V, Healy AM, Glennon B, A calibration-free application of Raman spectroscopy to the monitoring of mannitol crystallization and its polymorphic transformation, Organic Process Research & Development, 14, 2010, p1209 - 1214
Caron V, Tajber L, Corrigan OI, Healy AM, Production of amorphous dispersions of sulfonamides/polyvinylpyrrolidone by ball milling, Journal of Pharmacy and Pharmacology, UK-PharmSci 2010, Nottingham, UK, 2010, 62, (10), 2010, pp1347 - 1348
Paluch KJ, Tajber L, McCabe T, O'Brien JE, Corrigan OI, Healy AM, Preparation and solid state characterisation of chlorothiazide sodium intermolecular self assembly suprastructure, European Journal of Pharmaceutical Sciences, 41, (5), 2010, p603 - 611
Tewes F, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Development and characterisation of soluble polymeric particles for pulmonary peptide delivery, European Journal of Pharmaceutical Sciences, 41, (2), 2010, p337 - 352
Paluch, K.J., Tajber, L., Corrigan, O.I., Healy, A.M., Investigation of physicochemical interactions of spray dried composites comprising polymer and chlorothiazide, chlorothiazide sodium or chlorothiazide potassium, APS Amorphous III proceedings, Nottingham, 2010, 2010
Amaro MI, Tajber, L, Corrigan OI, Healy AM, Design of experiment to study the effect of spray dryer operating variables on sugar powders intended for inhalation, Journal of Pharmacy and Pharmacology, UK-PharmSci 2010, Nottingham, UK, 62, (10 Sp. Iss.), 2010, pp1413 - 1414
D'Arcy DM, Liu B, Bradley G, Healy AM, Corrigan OI, Hydrodynamic and species transfer simulations in the USP 4 dissolution apparatus: considerations for dissolution in a low velocity pulsing flow, Pharmaceutical Research, 27, (2), 2010, p246-58
Paluch, K.J., Tajber, L., McCabe, T., O'Brien, J.E., Corrigan, O.I., Healy, A.M., Salt or intermolecular self-assembly - physicochemical analysis of crystalline chlorothiazide and chlorothiazide sodium, All Ireland Schools of Pharmacy 32nd Research Seminar, Belfast, 2010, 2010
D'Arcy DM, Healy AM, Corrigan OI, Towards determining appropriate hydrodynamic conditions for in vitro in vivo correlations using computational fluid dynamics, European Journal of Pharmaceutical Sciences, 37, (3-4), 2009, p291 - 299
McMahon NM, Crane LJ, Ruskin HJ, Crane M, D'Arcy DM, Healy AM, Corrigan OI, A numerical model of a drug particle dissolving in a dissolution test apparatus, Proceedings in Applied Mathematics and Mechanics (PAMM), 80th Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM), Gdansk, 9 - 13 February 2009, 9, (1), 2009, pp655 - 656
Paluch KJ, Tajber L, Corrigan OI, Healy AM, An investigation of the effect of spray drying from different solvents on the physicochemical properties of chlorothiazide and chlorothiazide sodium, AAPS Annual Meeting and Exposition, Los Angeles, USA, 8-12 November, 2009, 2009
Tajber L, Corrigan DO, Corrigan OI, Healy AM, Spray drying of budesonide, formoterol fumarate and their composites-I. Physicochemical characterisation, International Journal of Pharmaceutics, 367, (1-2), 2009, p79 - 85
Healy AM, McDonald B, Corrigan OI, Tajber L, 'A method of producing porous microparticles', Trinity College Dublin, US20100092453, 2009
Tajber L, Corrigan OI, Healy AM, Spray drying of budesonide, formoterol fumarate and their composites-II. Statistical factorial design and in vitro deposition properties, International Journal of Pharmaceutics, 367, (1-2), 2009, p86 - 96
McDonnell D, Redmond B, D'Arcy DM, Healy AM, Corrigan OI, An analysis of drug dissolution rates in the USP 24 type 2 apparatus, Proceedings in Applied Mathematics and Mechanics (PAMM), 80th Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM), Gdansk, 9 - 13 February 2009, 9, (1), 2009, pp691 - 692
Nolan LM, Tajber L, McDonald BF, Barham AS, Corrigan OI, Healy AM, Excipient-free nanoporous microparticles of budesonide for pulmonary delivery, European Journal of Pharmaceutical Sciences, 37, 2009, p593 - 602
Tajber L, Crean B, Roberts CJ, Nolan L, Corrigan OI, Healy AM, Budesonide Nanoporous Microparticles (NPMPs) - in vitro Aerosolisation Properties and Atomic Force Microscopy (AFM), 35th Controlled Release Society Annual Meeting & Exposition, New York, USA, 12-16, July 2008, 2008
Healy AM, McDonald BF, Tajber L, Corrigan OI, Characterisation of excipient-free nanoporous microparticles (NPMPs) of bendroflumethiazide , European Journal of Pharmaceutics and Biopharmaceutics , 69, (3), 2008, p1182 - 1186
Paluch K, Tajber L, Healy AM, Corrigan OI, Comparison of the physico-chemical properties of spray dried chlorothiazide, chlorothiazide sodium and their PVP composite systems, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, Spain, 1-10, April 2008, 2008
Katheri AK, Tajber L, Corrigan OI, Healy AM, Spray dried nanoporous microparticles of corticosteroids for dry powder oral inhalation, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, Spain, 1-10, April 2008, 2008
Healy AM, McDonald BF, Tajber L, Corrigan OI, Characterisation of excipient-free nanoporous microparticles (NPMPs) of bendroflumethiazide, European Journal of Pharmaceutics and Biopharmaceutics, 69, (3), 2008, p1182 - 1186
D'Arcy D.M., Corrigan, O.I., Healy, A.M., Investigating the hydrodynamics involved in early in vito in vivo correlations - computational fluid dynamics (CFD) simulations of hydrodynamics in the Levy beaker apparatus., PSWC 3rd World congress of the Board of Pharmaceutical Sciences of the FIP., Amsterdam, The Netherlands, April, 2007
ffrg(ed.), The physicochemical characterisation of porous sodium cromoglicate particles for inhalation, Journal of Aerosol Science, 20, (2), 2007, 168 p
D'Arcy, D.M., Corrigan, O.I., Healy, A.M., Use of Computational Fluid Dynamics (CFD) to investigate hydrodynamics involved in in vitro in vivo correlations (IVIVC) , EUFEPS/COST B 25 conference on Bioavailability (BA) and Bioequivalence (BE): Focus on physiological factors and variability., Athens, Greece, October, 2007
Surfactants in pharmaceutical products and systems in, editor(s)Swarbrick J , Encyclopedia of Pharmaceutical Technology 3rd Edition, New York, Taylor and Francis, 2006, pp3583 - 3596, [Corrigan OI, Healy AM]
Tajber, L., Healy, A.M., Corrigan,O.I., Characterisation of the thermal behaviour of PVP-sulfa compound composites, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva, Switzerland, 27-30 March, 2006
D'Arcy DM, Corrigan OI, Healy AM, Evaluation of hydrodynamics in the basket dissolution apparatus using computational fluid dynamics-Dissolution rate implications., European Journal of Pharmaceutical Sciences, 27, (2-3), 2006, p259 - 267
Corrigan DO, Corrigan OI, Healy AM, Physicochemical and in vitro deposition properties of salbutamol sulphate/ipratropium bromide and salbutamol sulphate/excipient spray dried mixtures for use in dry powder inhalers, International Journal of Pharmaceutics, 322, (1-2), 2006, p22 - 30
Ni Ogain, O., Tajber, L., Corrigan, O.I. and Healy, A.M., Nanoporous microparticles (NPMPs) - a novel drug delivery system for the pulmonary delivery of proteins, AAPS Journal, American Association of Pharmaceutical Scientists Annual Meeting, San Antonio, USA, November 2006, 8, (S2), American Association of Pharmaceutical Scientists, 2006, ppW5076
Corrigan DO, Healy AM, Corrigan OI, Preparation and release of salbutamol from chitosan and chitosan co-spray dried compacts and multiparticulates, European Journal of Pharmaceutics and Biopharmaceutics, 62, (3), 2006, p295 - 305
McDonald, B.F., Tajber, L., Corrigan, O.I. and Healy, A.M., Nanoporous microparticles (NPMPs) of budesonide for pulmonary delivery, AAPS Journal, American Association of Pharmaceutical Scientists Annual Meeting, San Antonio, USA, November 2006, 8, (S2), American Association of Pharmaceutical Scientists, 2006, ppM1241
Nolan, L., Tajber, L., Corrigan, O.I. and Healy, A.M., The physicochemical characterisation of spray dried nanoporous microparticles (NPMPs) of sulfa compounds, EUFEPS Conference: When Poor Solubility Becomes an Issue: From Early Stage to Proof of Principles, Verona, Italy, 26-27 April, 2006
D'Arcy, D., Fagan, F., O'Neill, E., Corrigan, O.I. and Healy, A.M., Dissolution under conditions of natural convection - investigating the effect of orientation and solubility, EUFEPS Conference: When Poor Solubility Becomes an Issue: From Early Stage to Proof of Principles, Verona, Italy, 26-27 April, 2006, pp59
D'Arcy DM, Corrigan OI, Healy AM, Hydrodynamic simulation (computational fluid dynamics) of asymmetrically positioned tablets in the paddle dissolution apparatus: impact on dissolution rate and variability, Journal of Pharmacy and Pharmacology, 57, 2005, p1243 - 1250
D'Arcy, D.M., Corrigan, O.I. and Healy, A.M., Use of computational fluid dynamics to model fluid flow and interpret dissolution rate data for the basket dissolution apparatus, 1st PharmSciFair, Pharmaceutical sciences Fair and Exhibition, Nice, France, 2005, ppP0292
Pharmaceutical Technology Europe, UBM plc/Americas, [eds.], 2005-2020
Tajber L, Healy AM, Corrigan OI, Physicochemical evaluation of PVP-thiazide diuretic interactions in co-spray dried composites - analysis of glass transition composition relationships, European Journal of Pharmaceutical Sciences, 24, (5), 2005, p553 - 563
Mackie CA, Healy AM, Roberts K, Ryder S, A comparison of community pharmacy methadone services between Dublin and Glasgow: (1) Extent of service provision in 1997/1998 and views of pharmacists on existing provision and future service developments, Journal of Substance Use, 9, (5), 2004, p235 - 251
Tajber, L., Healy, A.M. and Corrigan, O.I., The effect of polyvinylpyrrolidone content on the glass transition temperature of thiazide diuretics, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, Germany, 2004, 2004, pp711 - 712
Corrigan DO, Corrigan OI, Healy AM, Predicting the physical state of spray dried composites: salbutamol sulphate/lactose and salbutamol sulphate/polyethylene glycol co-spray dried systems, International Journal of Pharmaceutics, 273, (1-2), 2004, p171 - 182
McCarthy LG, Bradley G, Sexton JC, Corrigan OI, Healy AM, Computational fluid dynamics (CFD) modeling of the paddle dissolution apparatus: agitation rate, mixing patterns and fluid velocities, AAPS PharmSciTech (http://www.aapspharmscitech.org), 5, (2), 2004, pE31
Crane M, Hurley N, Crane L, Healy AM, Corrigan OI, Gallagher KM, McCarthy LG, Simulation of the USP drug delivery problem using CFD: experimental, numerical and mathematical aspects, Simulation Modelling Practice and Theory, 12, (2), 2004, p147 - 158
Crane M, Crane L, Healy AM, Corrigan OI, Gallagher KM, McCarthy LG, Pohlhausen solution for the mass flux from a multi-layered compact in the USP drug dissolution apparatus, Simulation Modelling Practice and Theory, 12, (6), 2004, p397 - 411
D'Arcy, D.M., Corrigan, O.I. and Healy, A.M., Analysis of variation in dissolution rate with position in the USP paddle apparatus using computational fluid dynamics, European Conference on Drug Delivery and Pharmaceutical Technology, Seville, Spain, May, 2004, pp64 (abstract)
Tajber, L., Healy, A.M. and Corrigan, O.I., The effect of polyvinylpyrrolidone content on the glass transition temperature of thiazide diuretics, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, Germany, 15-18 March, 2004, pp711 - 712
McCarthy, L.G., Corrigan, O.I. and Healy, A.M., Modelling drug release from multi-layered compacts with potential for zero-order release kinetics, European Conference on Drug Delivery and Pharmaceutical Technology, Seville, Spain, May, 2004, pp152 (abstract)
Corrigan DO, Healy AM, Corrigan OI, The effect of spray drying solutions of bendroflumethiazide/polyethylene glycol on the physicochemical properties of the resultant materials, International Journal of Pharmaceutics, 262, (1-2), 2003, p125 - 137
McCarthy LG, Kosiol C, Healy AM, Bradley G, Sexton JC, Corrigan OI, Simulating the hydrodynamic conditions in the United States Pharmacopeia paddle dissolution apparatus, AAPS PharmSciTech (http://www.aapspharmscitech.org), 4, (2), 2003, pE22
Corrigan DO, Healy AM, Corrigan OI, The effect of spray drying solutions of polyethylene glycol (PEG) and lactose/PEG on their physicochemical properties, International Journal of Pharmaceutics, 235, (1-2), 2002, p193 - 205
Healy AM, McCarthy LG, Gallagher KM, Corrigan OI, Sensitivity of dissolution rate to location in the paddle dissolution apparatus, Jourrnal of Pharmacy and Pharmacology, 54, (3), 2002, p441 - 444
Surfactants in pharmaceutical products and systems in, editor(s)Swarbrick J and Boylan JC , Encyclopedia of Pharmaceutical Technology 2nd Edition, New York, Marcel Dekker, 2002, pp2639 - 2653, [Corrigan OI, Healy AM]
Healy AM, Corrigan OI, Dissolution testing of enteric coated aspirin tablets, Irish Pharmacy Journal, 75, (6), 1997, p189 - 190
Surfactants in pharmaceutical products and systems in, editor(s)Swarbrick J and Boylan JC , Encyclopedia of Pharmaceutical Technology Volume 14, New York, Marcel Dekker, 1996, pp295 - 331, [Corrigan OI, Healy AM]
Healy AM, Corrigan OI, The influence of excipient particle size, solubility and acid strength on the dissolution of an acidic drug from two-component compacts, International Journal of Pharmaceutics, 143, 1996, p211 - 221
Healy AM, Corrigan OI, Allan JEM, The effect of dissolution on the surface texture of model pharmaceutical systems as assessed by non-contact laser profilometry, Pharmaceutical Technology Europe, 7, (8), 1995, p14 - 22
Healy AM, Corrigan OI, Dissolution testing of five brands of tamoxifen citrate tablets available in the Republic of Ireland, Irish Pharmacy Journal, 72, (10), 1994, p306 - 311
Healy AM, Corrigan OI, Predicting the dissolution rate of ibuprofen-excipient compressed mixtures in reactive media, International Journal of Pharmaceutics, 84, (2), 1992, p167 - 173
Non-Peer-Reviewed Publications
Test, Test, 2021
Healy, A.M., Parojčić, J., Srcic, S., Juppo, A., Andrews, G., McSweeney, N, Glennon, B., Lu trik, M, Jones, I. Milne, J. Corrigan, B. Kinahan, M., Tully, R. , Linking industry and academia in teaching pharmaceutical development and manufacture (LIAT-Ph), European Industrial Pharmacy, 21, 2014, p9 - 10
Healy, A.M., Linking Industry and Academe. A case study, FORUM, Spring , 2014, p38-
F Tewes, L Tajber, C Ehrhardt, AM Healy, Formulation of colistin-ambroxol microparticles for passive targeting of lung infections, AAPS J, 25th Annual Meeting of the AAPS, Washington, DC, 23-27/11/2011, 13, (S2), 2011, ppM1046
Crean, A.M., Healy, A.M., Changing concepts for 21st Century Drug Product Manufacturing, UK and Ireland Controlled Release Society (UKICRS) Newsletter , 2011, - 4-5
Paluch, K.J., Tajber, L., Corrigan, O.I., Healy, A.M., Solid state characterisation of novel active pharmaceutical ingredients: co-crystal of (R,S) salbutamol mono-adipate and (R,S) salbutamol hemisuccinate, Solid State Pharmaceutical Cluster Meeting, Limerick, 2010, 2010
Paluch K, Tajber L, Corrigan OI, Healy AM, An investigation of the effect of spray drying from different solvents on the physicochemical properties of chlorothiazide and chlorothiazide sodium, IRCSET Symposium Innovation fuelling the Smart Society, Dublin, 2009, 2009
Paluch K., Tajber L., Healy A.M., Corrigan O. , Impact of solvent variable on chlorothiazide and chlorothiazide sodium physico-chemical properties, processed by spray drying, All Ireland Schools of Pharmacy 31st Research Seminar, Dublin, 2009, 2009
Paluch, K., Tajber, L., Healy, A.M. and Corrigan, O.I., Solid-state characteristics of spray dried chlorothiazide, chlorothiazide-PVP composites, sodium chlorothiazide and sodium chlorothiazide-PVP composites, All Ireland Schools of Pharmacy 30th Research Seminar, Cork, 2008, 2008
D'Arcy, D.M., Corrigan, O.I. and Healy, A.M., Dissolution modelling of off-centre compacts in the paddle dissolution apparatus, Schools of Pharmacy Research Seminar, Trinity College Dublin, 21st to 22nd March, 2005, pp33 (abstract)
Healy, A.M., Particle formation processes for pharmaceuticals, Irish Chemical News, 16, (2), 2002, p6 - 11
Research Expertise
Projects
- Title
- Approaches to Drying Hydrated Active Pharmaceutical Ingredients (APIs)
- Summary
- In this project we will study the impact of drying conditions on the crystal form of the API and develop possible strategies to ensure the form is correctly managed during small scale and then large-scale drying operations.
- Funding Agency
- Irish Research Council/APC Ltd.
- Date From
- 01/10/2018
- Date To
- 30/09/2022
- Title
- The Development of Novel, Age-appropriate Oral Liquid Formulations to Meet Unmet Needs of Paediatric Patients
- Summary
- The goal of this project is to develop age-appropriate liquid formulations of two active pharmaceutical ingredients, which will address unmet patient needs.
- Funding Agency
- Irish Research Council/Xeolas Ltd.
- Date From
- 01/01/2017
- Date To
- 31/12/2020
- Title
- Mechanism of Mucus Pathology in Asthma Exacerbations
- Summary
- This project aims to advance understanding of mucus pathology in acute severe asthma and to hasten a new drug development program for thiol-saccharides as a novel mucolytic treatment for mucus pathology in acute asthma.
- Funding Agency
- National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI)
- Date From
- 01/04/2016
- Date To
- 31/03/2021
- Title
- Carbohydrate-based Therapy for Lung Disease
- Summary
- The goal of this project is to translate our discovery of an unsuspected mechanism of mucus pathology into a mucolytic drug strategy that could benefit millions of patients with mucus-associated lung disease.
- Funding Agency
- National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI)
- Date From
- 01/07/2016
- Date To
- 30/06/2021
- Title
- Development of Fixed Dose Combination Products using Advanced Pharmaceutical Processing Technologies
- Summary
- The goal of this project is to develop novel fixed dose combination products using continuous pharmaceutical processes, thus addressing the issue of poor patient compliance, which is frequently associated with the long term and multiple dosage regimes, typical of CVD or diabetes.
- Funding Agency
- Science Foundation Ireland / Department for the Economy (Northern Ireland)
- Date From
- 01/09/2015
- Date To
- 31/08/2019
- Title
- Synthesis and Solid State Pharmaceutical Centre - Drug Product Formulation and Manufacture Strand projects
- Summary
- The goal of the SSPC research programme is to gain a better understanding of mechanisms, control processes and predicting outcomes for the efficient and environmentally sustainable production of safe medicines. Specific projects being managed by AMH: Identification and control of critical API characteristics for robust drug product performance; Tailoring crystal size distributions for improved formulation performance; Advancing conventional solid dosage formulation and processing for crystalline API; Amorphous solids and composites.
- Funding Agency
- Science Foundation Ireland
- Date From
- 01/06/2013
- Date To
- 31/05/2019
- Title
- Advanced Materials & Bioengineering Research Centre (AMBER) - The development of microparticle-based solid dosage forms for the prevention and treatment of iron deficiency
- Summary
- The goal of this project is to design and develop a tabletted formulation based on iron-loaded microparticles for prevention and treatment of iron deficiency.
- Funding Agency
- Science Foundation Ireland / Solvotrin Therapeutics
- Date From
- 11/08/2014
- Date To
- 31/05/2019
- Title
- EPSRC-SFI Centre for Doctoral Training in Transformative Pharmaceutical Technologies
- Funding Agency
- Science Foundation Ireland
- Date From
- 01/09/2019
- Date To
- 31/08/2027
- Title
- Synthesis & Solid State Pharmaceutical Centre (SSPC)-PharM5
- Funding Agency
- Science Foundation Ireland
- Date From
- 01/06/2019
- Date To
- 31/05/2025
Recognition
Representations
Grant reviewer for the Biotechnology and Biological Sciences Research Council (BBSRC), UK
Grant Reviewer for The Netherlands Organisation for Scientific Research (NWO)
Treasurer of the Irish Platform for Patient Organisations, Science & Industry (IPPOSI)
Member of the Board of the Irish Platform for Patient Organisations, Science & Industry (IPPOSI)
Committee member and Mentor for WiSSPC (Women in the Synthesis and Solid State Pharmaceutical Centre)
Hospital Professional Awards judging panel member
Adjunct Experiential Instructor, St Louis College of Pharmacy
External Examiner to Griffith College Dublin: MSc in Pharmaceutical Business and Technology
Grant reviewer for the Austrian Science Fund (FWF)
Expert consultant/witness for US based pharmaceutical company in patent related litigation case
Expert consultant/witness for Irish based pharmaceutical company in patent related litigation case
Irish Pharmacy Awards judging panel member
External Examiner to University of Bradford: MSc in Pharmaceutical Technology
Grant reviewer for the Engineering and Physical Sciences Research Council (EPSRC), UK
Judge for the national secondary school competition: Debating Science Issues (DSI)
Member of the Implementation Steering Group for the Five-Year Integrated Pharmacy Programme
Invited Medical and Scientific Advisory Board Member, Solvotrin Therapeutics Ltd.
Co-ordinator of the EU-funded Erasmus Lifelong Learning Programme Project: Linking Industry and Academia in Pharmaceutical Development and Manufacture (LIAT-Ph)
Member of the National Pharmacy Forum
Member of the Editorial Advisory Board of Molecular Pharmaceutics
Invited Scientific Advisory Board Member, Alkermes Ltd.
Co-PI, Strand Leader and Member of Management Committee of the Synthesis and Solid State Pharmaceutical Centre
Member of the Accreditation Panel for the PSI Statutory Visit to the level 8 BPharm Degree Course at University College Cork
Member of interview panel for General Manager of Synthesis and Solid State Pharmaceutical Centre, UL
Member of interview panel for Chief Pharmacist position, Department of Health
Grant reviewer for Fundação para a Ciência e a Tecnologia, I.P. (FCT) - Portuguese public funding agency for R&D
External Examiner to Hibernia College: MSc in Pharmaceutical Medicine
External Examiner to Dublin Institute of Technology, School of Food Science and Environmental Health: Higher Certificate in Pharmacy Technician Studies
Member of the Curriculum Development Sub-forum of the National Pharmacy Forum
External Examiner for the Pharmaceutical Society of Ireland to the Professional Registration Examination
External Examiner to Dublin Institute of Technology, School of Chemical and Pharmaceutical Sciences: MSc in Pharmaceutical Quality Assurance & Regulation; MSc in Pharmaceutical Quality Assurance & Biotechnology
Member of assessment/interview panel to fill lecturing post in the Department of Chemical and Bioprocess Engineering in UCD
External Examiner to Carlow Institute of Technology, Department of Science and Health: Higher Certificate in Science - Pharmacy Technician Studies
Member of the Pharmaceutical Society of Ireland's Steering Group for the Pharmacy Education and Accreditation Reviews (PEARs) project
Co-PI, Strand Leader and Member of Management Committee of the Solid State Pharmaceutical Cluster
Member of the Validation Panel for the BSc (Ordinary) Validation of Medicinal Products at Dublin Institute of Technology, School of Chemical and Pharmaceutical Sciences
Member of the Editorial Advisory Board of Pharmaceutical Technology Europe
Enterprise Ireland Grant Reviewer
External examiner for PhD candidates in: University College London (x1), University of Helsonki (x1), Queen's University Belfast School of Pharmacy (x5), University of Nottingham School of Pharmacy (x1), University of Bradford School of Pharmacy (x1), the Royal College of Surgeons in Ireland School of Pharmacy (x1), University College Dublin School of Chemical and Bioprocess Engineering (x2), The Islamia University of Bahawalpur-Pakistan school of Pharmacy (x2)
Member of assessment/interview panel to fill lecturing post in the Department of Chemical and Bioprocess Engineering in UCD
Honorary Treasurer and Chairperson (elected) of the Finance Committee of the Pharmaceutical Society of Ireland
Member of the Accreditation Committee of the Pharmaceutical Society of Ireland established to review new School of Pharmacy courses in RCSI and UCC
Consultant to a number of pharmaceutical companies
Member of the Strategy Group of the Pharmaceutical Society of Ireland
Member of the Board of Directors/Board of Management of Kenlis Publications Ltd., publisher of the Irish Pharmacy Journal
Member of the Schools Committee of the Pharmaceutical Society of Ireland
Member (elected) of the Council of the Pharmaceutical Society of Ireland
Regular reviewer for scientific journals (16) in the areas of Pharmaceutical Sciences
Awards and Honours
Special Visiting Researcher Fellowship - awarded by CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil)
Fellowship of Trinity College Dublin
Mendell Award for Scientific Excellence (at the 13th International Conference on Pharmaceutical Technology, Strasbourg, France)
Pharmaceutical Society of Ireland Gold Medal
Jim Hegarty Memorial Prize in Pharmaceutical Chemistry
University of Dublin, Trinity College Non-Foundation Scholarship
Pharma Industry Awards, Pharma Research Centre of the Year - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader]
Pharma Industry Awards, Pharma Research Centre of the Year - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader]
Pharma Industry Awards, Research & Development Achievement Award - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader]
Pharma Industry Awards, Partnership Alliance of the Year - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader]
Memberships
Member of Pharmacists in Industry, Education and Regulatory (PIER)
Member of the Academy of Pharmaceutical Scientists (UK)
Member of AAPS (American Association of Pharmaceutical Scientists)
Member of the Pharmaceutical Society of Ireland