Biography
Helen Sheridan is an Associate Professor in the School of Pharmacy and Pharmaceutical Sciences (SoPPS) at TCD where she holds the position of Director of Research. Her personal research interests lie in the broad area of Natural Product (NP) Chemistry and Traditional Medicine (TM), with an emphasis on Traditional Chinese Medicine(TCM), Ethnopharmacology and Global health. Her work focuses on finding new therapies targeted at diseases with unmet clinical need, in addition to finding natural products suitable for use as nutraceuticals and cosmeceuticals. Helen, with international collaborators, is also involved in establishing global standards for the quality, safety and efficacy of TMs including TCM; activities that are supported through her work as part of a Sino-European Consortium (previously funded by EU-FP7; http://www.gp-tcm.org/), her role on the Board of the International Natural Product Sciences Taskforce (INPST) society (The International Natural Product Sciences Taskforce (INPST) society), in her position as NP expert on the Irish medicines Board (HPRA: Health Products Regulatory Authority) and membership of NPRONET - Natural products discovery and bioengineering network UK.
Helen has supervised 21 research students (PhDs and MScs) to completion, as well as 15 post-doctoral fellows. She currently have 7 researchers in her group. Helen is an NP/ organic chemist and has carried out research on a range of plant and fungal species. During her career she successfully identified a lead molecule from TM which her team brought through a programme of medicinal chemistry, through all preclinical stages of development into human clinical trials. During this period Helen co-founded a TCD Campus company, Trino Therapeutics Ltd and was co-PI on funding of approximately 13 million. The funding for this work began with a grant of 500 from the Royal Irish Academy, progressed to funding from EOLAS (the precursor of SFI) and then this work received significant translational investment from Venture Capital and the Wellcome Trust with 3.5 million as co-PI for a highly competitive Wellcome Strategic Translation Award (STA grant. Helen currently holds an SFI-TIDA award and is collaborator in a second TIDA. During this time she has also been co-applicant on seven published patents in the US, EU and Asia and has acted as patent expert on these projects with patenting agents in Ireland and the US.
In latter years Helen has become more involved in ethnopharmacology on a global level, in particular the link between the established use of traditional medicine and its role in international development. She has supervised 5 research projects in this field in sub-Saharan Africa.
The driving force behind her work is to find new therapeutic treatments for unmet clinical need and to finding meaningful uses for natural molecules. She has learned a lot about the journey from therapeutic drug discovery to human trials, and the challenges and obstacles that line the road. However, experience led decision making about research is invaluable. Through this lens of experience, the molecules Helen's group is working on have real therapeutic potential and have been designed to eliminate some of the insurmountable obstacles to drug development.
Publications and Further Research Outputs
Peer-Reviewed Publications
Frankish, N.H. and McHale, B. and Sheridan, H., The indane diastereoisomers, PH2 and PH5: divergence between their effects in delayed-type hypersensitivity models and a model of colitis, Journal of Pharmacy and Pharmacology, 70, (1), 2018, p101-110
Andy Wai Kan Yeung, Bharat Bhushan Aggarwal, Helen Sheridan et al., Dietary natural products and their potential to influence health and disease including animal model studies - a review, Animal Science Papers and Reports, 36, (4), 2018, p345-358
Hook I, Sheridan, H, Reid C, Trichomes and naphthoquinones protect Streptocarpus dunnii Hook.f. against environmental stresses, South African Journal of Botany , Volume 119, 2018, p193 - 202
Cumming, Graham; Zhang, Tao; Scalabrino, Gaia; Frankish, Neil; Sheridan, Helen, Investigation of the Stereoselective Synthesis of the Indane Dimer PH46A, a New Potential Anti-Inflammatory Agent , Organic Process Research & Development, 2018, p1972-1979
Tao Zhang, Neil Frankish, Gaia Scalabrino and Helen Sheridan, Bioactive Indanes: Comparative in vitro Metabolism Study of PH46A, a New Potential Anti-Inflammatory Agent and Biosynthesis of its Primary Metabolite PH132 , Pharmaceutical Sciences, 9, (2), 2018, p1 - 14
Tao Zhang , Gaia Scalabrino , Neil Frankish and Helen Sheridan, "Bioactive Indanes: Proof of Concept Study for Enantioselective Synthetic Routes to PH46A, a New Potential Anti-Inflammatory Agent" , Molecules, 23 , 2018, p1 - 18
Zhang, T. and Scalabrino, G. and Frankish, N. and Sheridan, H., Bioactive indanes: Proof of concept study for enantioselective synthetic routes to ph46a, a new potential anti-inflammatory agent, Molecules, 23, (7), 2018, p1503-
History and current status of Herbal Medicines' in, editor(s): Heikki Vuorela, Pia Maarit Vuorela, and Olavi Pelkonen. , Toxicology of Herbal Products, Springer Science and Business Media, 2017, [2. Sendker J and Sheridan H: ]
Erick Motta, Marivane Lemos, Juliana C Costa, PhD. Vilmar C Banderó-Filho.; Astrid Sasse, Helen Sheridan, Jairo K Bastos, , Galloylquinic acid derivatives from Copaifera langsdorffii leaves display gastroprotective activity, Chemico-Biological Interactions, 261, 2017, p145 - 155
Imran Nazir, Nisar ur Rahman, Zunaira Alvi, M. Hafizur Rahman, Jandirk Sendker, Tao Zhang, Neil Frankish, Helen Sheridan, Antidiabetic Activities of an LC/MS Fingerprinted Aqueous Extract of Fagonia cretica L. in Preclinical Models*, Planta Medica, 83, 2017, p1-9
Neil Frankish and helen Sheridan, 'Compounds for use in the treatment of inflammatory Bowel Disease', USP, 9,586,885 B2, 2017, Venantius Ltd.
Fiona Shannon, Astrid Sasse, Helen Sheridan and Michael Heinrich , Are identities oral? Understanding ethnobotanical knowledge after Irish independence (1937-1939), Journal of Ethnobiology and Ethnomedicine, 13, 2017, p65-
Composition and quality control of herbal medicines in, editor(s)Heikki Vuorela, Pia Maarit Vuorela, and Olavi Pelkonen , Toxicology of Herbal Products', Springer Science & Business Media. , 2017, [3. Sendker J and Sheridan H]
Kerstin Rieger, Rochelle H Holm, Helen Sheridan, Access to groundwater and link to the impact on quality of life: A look at the past, present and future public health needs in Mzimba District, Malawi, Groundwater for Sustainable Development, 2016, p117-129
Frankish N, Sheridan H , 'Compounds for use in the treatment of autoimmune inflammatory disease;.', European patent office, 2864279 B1, 2016, Venantius Ltd.
Lemos M, Silva JJM, Rogez HLG, Veneziani RCS, Ambrósio SR, Bastos JK, Banderó VC, Sasse A, Sheridan H, , Cytotoxic and apoptogenic properties of C. oblongifolia Mart. ex Hayne and C. duckei Dwyer oleoresin and leaf extract on human gastric carcinoma cells., Brazilian Society of Pharmacology and Experimental Therapeutics (SBFTE), Águas de Lindóia, São Paulo, Brazil, , September 28 to Octo, edited by Conference Committee , 2015
Helen Sheridan, Brigitte Kopp, Liselotte Krenn, Dean Guo, Jandirk Sendker, Traditional Chinese herbal medicine preparation: invoking the butterfly effect, Science, 350, (6262), 2015, pS64-S66
Zhang, T., Paluch, K., Scalabrino, G., (...), Healy, A.-M., Sheridan, H. , Molecular structure studies of (1S,2S)-2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol, Journal of Molecular Structure, 1083, 2015, p286-299
N Frankish, H Sheridan -, 'Compounds for use in the Treatment of Autoimmune Inflammatory Disease', USPTO, 20,150,141,523,, 2015, Trino Therapeutics Ltd.
Bioactive naphthoquinones from higher plants. in, editor(s)Atta-ur-Rahman , Studies in Natural Products Chemistry. Volume 41, Elsevier B.V, 2014, pp119 - 160, [Hook, I., Mills, C and Sheridan H]
Tao Zhang, Vilmar Bandero, Tom McCabe, Neil Frankish and Helen Sheridan, 2-(Diphenylmethylidene)-2,3-dihydro-1H-inden-1-one, Acta Cryst. Section E, E69, 2013, po1306 - o1307
Neil Frankish and Helen Sheridan, 'Indane Dimers for Use in The Treatment Of Autoimmune Inflammatory Disease', US, WO2013174916, 2013, Venantius Ltd
Helen Sheridan and Neil frankish, Venantius Ltd., Indane dimers for use in the treatment of autoimmune inflammatory disease, 2013, WO 2013/014660 A1
Chan K , Banderό V, Frankish N, Sheridan H . , . Inflammation, Cancer And 15- Lipoxygenase-1 - How Hot Is The Link? , London BioNat. , University of East London , March 12th 2013., 2013
Astrid Sasse, Fabio Boylan and Helen Sheridan, Holistic Approaches to Health Maintenance in the B.Sc. Pharmacy. , 14th Biennial CSSI Conference. Mind, Body, Spirit - the holistic approach to the student experience, Dundalk. ireland, June 19-20 2013, 2013
Fatiha Brahmi, Naïma Guendouze, Helen Sheridan, Caroline Stevigny et al., Metabolic Classification Of Mentha Species By Nmr-Based Metabolomics, Journées internationales AFERP & STOLON , Bruxelles , 22-24 Mai 2013, 2013
Sheridan, Helen; (IE). Frankish, Neil; (IE), 'indane Dimers for use in the Treatment of Autoimmune Inflammatory Disease', O'BRIEN, John, A, WO/2013/014660 , 2013, VENANTIUS LIMITED
Frankish N. and Sheridan H, 6-(Methylamino)hexane-1,2,3,4,5-pentanol 4-(((1S,2S)-1-Hydroxy-2,3-dihydro-1H,1'H-[2,2-biinden]-2-yl)methyl)benzoate (PH46A): A Novel Small Molecule With Efficacy In Murine Models Of Colitis, Journal of Medicinal Chemistry, 55, 2012, p5497 - 5505
Ta o Zha ng , Tom McCabe , Bartosz Marzec, Neil Frankish and Helen, N -Cyclopentyl- N -(3-oxo-2,3-dihy dro-1 H -inden-1-yl)acetamid, Acta Crystallographica, E68, 2012, p958-
Frampton C. S., Zhang T., Scalabrino G. A., Frankish N. and Sheridan H., (1S)-1-Phenyl ethanaminium 4-{[(1S,2S)-1-hydroxy-2,3-dihydro-1H,1′H-[2,2′-biinden]-2-yl] methyl} benzoate,, Acta Crystallographica. Section C, 2012, po323 - o326.
Helen Sheridan, Liselotte Krenn, Renwang Jiang, Ian Sutherland, Svetlana Ignatova, Andreas Marmann, Xinmiao Liang, Jandirk Sendker, The potential of metabolic fingerprinting as a tool for the modernisation of TCM preparations, Journal of Ethnopharmacology, 140, (3), 2012, p482-491
Sheridan H, Nestor C, O'Driscoll L, Hook I., Isolation, structure elucidation, and cytotoxic evaluation of furanonaphthoquinones from in vitro plantlets and cultures of Streptocarpus dunnii., J Nat Prod., 71, (1), 2011, p82 - 85
Jandirk Sendker, Andreas Marmann, Liselotte Krenn, Helen Sheridan, Ian Sutherland, Svetlana Ignatova, Peter Proksch, Monique Simmonds, Robert Verpoorte, Alberto Dias, Valérian Bunel, You-Ping Zhu, Comprehensive report on the methodology used in the analysis of 'priority list preparations': Deliverable 2.10 of WP2 (FP7 GP-TCM) to European Commission, EU COmmission Brussels, EU, October, 2011, 1-24
Sheridan, H. , Nestor, C., O'Driscoll, L., Hook, I., Isolation, structure elucidation, and cytotoxic evaluation of furanonaphthoquinones from in vitro plantlets and cultures of Streptocarpus dunnii, Journal of Natural Products, 74, (1), 2011, p82 - 85
Frankish, N. de Sousa Menezes, F. Mills, C. Sheridan, H., Enhancement of insulin release from the beta-cell line INS-1 by an ethanolic extract of Bauhinia variegata and its major constituent roseoside, Planta Med, 76, (10), 2010, p995-7
E Passante, C Ehrhardt, H Sheridan, N Frankish, RBL-2H3 cells are an imprecise model for mast cell mediator release, Inflamm Res, 58, (9), 2009, p611-618
Sheridan H, Walsh JJ, Cogan C, Jordan M, McCabe T, Passante E, Frankish NH, Diastereoisomers of 2-Benzyl-2, 3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol: Potent anti-inflammatory agents, Bioorganic & Medicinal Chemistry Letters, 19, 2009, p5927 - 5930
Sheridan, H. Walsh, J. J. Jordan, M. Cogan, C. Frankish, N, A series of 1, 2-coupled indane dimers with mast cell stabilisation and smooth muscle relaxation properties, Eur J Med Chem, 44, (12), 2009, p5018-22
H. Sheridan, N. H. Frankish, BRA 101, A Novel Small Molecule with Profound Efficacy In Murine DSS-Colitis, Gut, Gastro 2009, London, 21-25 November 2009, 58, (Suppl II), 2009, ppA454
Passante, E. Ehrhardt, C. Sheridan, H. Frankish, N., Toll-like receptors and RBL-2H3 mast cells, Inflamm Res, 58 , (Suppl 1), 2009, p11-2
H Sheridan, I Hook, J Coppins, C Nestor, C Ehrhardt, N Frankish, Inhibition of LFA-1 mediated T-cell motility by naphthoquinones, Planta Med, 74, (11), 2008, p1383-1387
Minker C, O' Meara J, Visdal-Johnsen L, Hook I, Lobstein A , Sheridan H and Frankish N. , In vivo and in vitro evaluation of the anti-inflammatory activity of seven Plectranthus species. , Planta. Med., 73, 2007, pP074 - P074
Fábio de Sousa Menezes, Andréa Barreto Mattos Minto, Halliny Siqueira Ruela, Ricardo Machado Kuster, Helen Sheridan, Neil Frankish, Hypoglycemic activity of two Brazilian Bauhinia species: Bauhiniaforfi cata L. and Bauhinia monandra Kurz., Brazilian Journal of Pharmacognosy, 17, ((1)), 2007, p8 - 13
J.Coppins, I. Hook, C. Nestor, H. Sheridan, N. Frankish, C. Ehrhardt., Inhibition of LFA-1 mediated T-cell motility by naphthoquinones, Royal Academy of Medicine in Ireland, Winter meeting, Dublin City University, 2007, 2007
H.Sheridan, N. Frankish and R. Farrell, Investigation into the mast cell stabilizing activity of nature identical and synthetic indanones, J. Pharmacy and Pharmacology, 56, (11), 2004, p1423
A.L. Simplício, J.F. Gilmer, N. Frankish, H. Sheridan, J.J. Walsh and J.M. Clancy, Ionisation characteristics and elimination rates of some aminoindanones determined by capillary electrophoresis, Journal of Chromatography A, 1045, (1-2), 2004, p233 - 238
Hook I, Ryan S, Sheridan H. , Biotransformation of aliphatic and aromatic ketones, including several monoterpenoid ketones and their derivatives by five species of marine microalgae, Phytochemistry, 63, (1), 2003, p31 - 36
I. Hook, S. Ryan and H. Sheridan, Biotransformation of aliphatic and aromatic ketones, including several monoterpenoid ketones and their derivatives by five species of marine micro-algae, Phytochemistry, 63, 2003, p31 - 36
H. Sheridan, Indane compounds with smooth muscle relaxing and/or mast cell stabilizing and/or anti-inflammatory activity, 2002, US-09/092.902, EP-96942552
H. Sheridan, Indane compounds and their pharmaceutical use, 2002, US6433021
H. Sheridan, Indane dimer compounds and their pharmaceutical use; respiratory and anti-inflammatory, 2002, PCT/IE 96/00080. US-09/093,060, EP-96942550
H. Sheridan, Indane dimer compounds with smooth muscle relaxing and/or mast cell stabilizing and/or anti-inflammatory activity, 2002, US-09/092,903, EP-96942551
H. Sheridan, Indane dimer compounds with smooth muscle relaxing and/or mast cell stabilising and/or anti-inflammatory activity, 2002, US6423752
Transgenic Leontopodium (Edelweiss) in, Y.P.S. Bajaj , Biotechnology in Agriculture and Forestry, Berlin, Heidelberg, Springer-Verlag, 2001, pp221-236. , [Hook I, Sheridan H.]
Essential oil production by transformed roots of Leontopodium alpinum Cass in, editor(s)Y.P.S. Bajaj , Biotechnology in Agriculture and forestry, "Transgenic crops lll" vol 48, Springer Verlag, 2001, pp221 - 236, [I. Hook and H. Sheridan]
Comer, N., Grey, A.I., Hook, I.L., James, P., Sheridan, H., Erratum: Sesquiterpenes from Leontopodium alpinum (Phytochemistry (1999) 50 (1057-1060) PII: S0031942298006256) , 2000, - 551
Farrell, R., Frankish, N.H.., & Sheridan, H., Synthesis and antispasmodic activity of analogues of Natural pterosins, European Journal of Medicinal Chemistry, 34, 1999, p953 - 966
Comey N, Grey A, Hook I, James P, Sheridan H. , Sesquiterpenes from Leontopodium alpinum., Phytochemistry, 50, (6), 1999, p1057 - 1060
SHERIDAN, H, FRANKISH, N, FARRELL, R, SYNTHESIS AND ANTISPASMODIC ACTIVITY OF ANALOGUES OF NATURAL PTEROSINS, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 34, 1999, p953 - 966
SHERIDAN, H, FRANKISH, N, FARRELL, R, SMOOTH MUSCLE RELAXANT ACTIVITY OF PTEROSIN Z AND RELATED COMPOUNDS, PLANTA MEDICA, 65, 1999, 271 - 272
Sheridan, H., Frankish, N. H. & Farrell, R, Smooth muscle relaxant activity of pterosin Z and related compounds, Planta Medica, 65, 1999, p271 - 272
SHERIDAN, H, CANNING, AM, NOVEL RADICINOL DERIVATIVES FROM LONG-TERM CULTURES OF ALTERNARIA CHRYSANTHEMI, JOURNAL OF NATURAL PRODUCTS, 62, 1999, p1568 - 1569
Hook I, Ryan S, Sheridan H. , Biotransformation of aromatic aldehydes by five species of marine microalgae, Phytochemistry, 51, (5), 1999, p621 - 627
HOOK, IL, RYAN, S, SHERIDAN, H, BIOTRANSFORMATION OF AROMATIC ALDEHYDES BY FIVE SPECIES OF MARINE MICROALGAE, PHYTOCHEMISTRY, 51, 1999, p621 - 627
Comey N, Sheridan H, Hook I, Influence of inulin, culture medium and light on the growth and essential oil content of Edelweiss hairy roots., Proceedings of the 27th ISEO Meeting, 27th ISEO Meeting, Vienna, Allured Publishing Corporation, 1997, pp116-119
Comey N, Hook I, Sheridan H, Walsh J. , Isolation of (S)-(-)-2,3-dihydro-2,6-dimethyl - 4H-benzopyran-4-one from roots of Leontopodium alpinum, Journal Of Natural Products (Lloydia) , 60, (2), 1997, p148-149
FARRELL, R, KELLEHER, F, SHERIDAN, H, SYNTHESIS OF FERN SESQUITERPENE PTEROSIN Z VIA A NOVEL PALLADIUM-CATALYZED ROUTE, JOURNAL OF NATURAL PRODUCTS, 59, 1996, p446 - 447
Hook, I., & Comey, N. & Sheridan, H., Essential oil of Edelweiss, Leontopodium alpinum, 25th International Symposium on Essential Oils, Grasse., 1994
"Papaver bracteatum", Lindley (Giant Scarlet Poppy) In vitro production of benzophenanthridine alkaloids in, editor(s)Y.P.S. Bajaj , Biotechnology of Medicinal and Aromatic Plants Part VII, Springer Verlag, 1994, pp346 - 365, [I. Hook, R. Lecky and H. Sheridan]
H. Sheridan, A. M. Canning and P. James, Stereoselective reduction of radicinin by liquid cultures of Alterneria longipes, J. Nat. Prod., 55, (7), 1992, p986
N. Comey, I. Hook and H. Sheridan, Enhancement of anthocyanin production in cell cultures and hairy roots of L. alpinum, Planta medica, 58, (1), 1992
Comey, N., Hook, I., Sheridan, H., Enhancement of anthocyanin production in cell cultures and hairy roots of Leontopodium alpinum , Planta Medica , 58, ((7 SUPPL.)), 1992, A605-A606
Canning A-M, Hook I, Sheridan H. , Bisradicinin: a novel dimmer elicited in cultures of Alternaria chrysanthemi, Journal Of Natural Products (Lloydia) , 55, (4), 1992, p487 - 490.
Lecky R, Hook I, Sheridan H., Enhancement of dihydrosanguinarine production in suspension cultures of Papaver bracteatum, I Medium modifications, Journal Of Natural Products (Lloydia) , 55, (10), 1992, p1513 - 1517
H.Sheridan, A. M. Canning, I. Hook, P. James and D. Kelly, Bis-Radicinin: a novel dimer elicited in cultures of Alternaria chrysanthemi, J. Nat. Prod., 55, (4), 1992, p487
SHERIDAN, H, BHANDARI, P, CATHIN-6-ONE FROM THE ROOT BARK OF PHELLODENDRON-CHINENSE, PLANTA MEDICA, 58, 1992, 299 - 299
HOOK, I, SHERIDAN, H, WILSON, G, VOLATILE METABOLITES FROM SUSPENSION-CULTURES OF TARAXACUM-OFFICINALE, PHYTOCHEMISTRY, 30, 1992, p3977 - 3979
H. Sheridan, R. Lecky and I. Hook, Enhancement of dihydrosanguinarine production by suspension cultures of Papaver bracteatum 1. Medium modification, J. Nat. Prod., 55, (10), 1992, p1513
I. Hook, G. Wilson and H.Sheridan, Volatile metabolites from suspension cultures of Taraxacum officinale, Phytochemistry, 30, (12), 1991, p3977
Hook I, Sheridan H, Wilson G., Volatile metabolites from suspension cultures of Taraxacum officinale, Phytochemistry , 30, (12), 1991, p3977 - 3979
J. Baldwin, M. Bradley, N.Turner, R. Adlington, A. Pitt and H. Sheridan, α-L-_-Aminoadipoyl-L-cysteinyl-D-allylglycine, and eight deuterated analogues, substrates for the investigation of the mechanism of action of isopenicillin N synthetase, Tetrahedron, 47, (38), 1991, p8203 - 8222
H Sheridan, S Lemon, N Frankish, P Mcardle, T Higgins, JP James, P Bhandari , Synthesis and Antispasmodic Activity of Nature Identical Substituted Indanes and Analogues, European Journal of Medicinal Chemistry, 25, (7), 1990, p603 - 608
Hook, I., Sheridan, H., Wilson, G., Volatile metabolites with 'apple' odour from suspension cultures of Taraxacum officinale , Planta Medica, 56, (6), 1990, p627-628
BHANDARI, P, SHERIDAN, H, PRENYLATED FLAVONOIDS OF PHELLODENDRON-CHINENSE, PROCEEDINGS OF THE ROYAL IRISH ACADEMY SECTION B-BIOLOGICAL GEOLOGICAL AND CHEMICAL SCIENCE, 89, 1990, p91 - 96
Hook I, Lecky R, McKenna B, Sheridan H., Biotransformation of linalyl acetate by suspension cultures of Papaver bracteatum, Phytochemistry, 29, (7), 1990, p2143 - 2144
HENNESSY, D, HOOK, I, SHERIDAN, H, MCGEE, A, HYDROXYCINNAMIC ACID-ESTERS FROM CELL-SUSPENSION CULTURES AND PLANTS OF LEONTOPODIUM-ALPINUM, PHYTOCHEMISTRY, 28, 1989, p489 - 490
Hook I, Sheridan H, Wilson G., Alkaloids of cell cultures derived from strains of Papaver bracteatum, Phytochemistry, 27, (7), 1988, p2137 - 2141
HOOK, I, SHERIDAN, H, WILSON, G, ALKALOIDS OF CELL-CULTURES DERIVED FROM STRAINS OF PAPAVER-BRACTEATUM, PHYTOCHEMISTRY, 27, 1988, p2137 - 2141
Neoflavanoids in, editor(s)J.B. Harborne and T.J. Mabry , Flavanoids: Advances in Research. Vol. 2, Chapman and Hall, 1988, pp211 - 232, [D.M.X. Donnelly and H. Sheridan]
Hook, I., Hennessy, D. & Sheridan, H., Tissue culture of L. alpinum, Gesellschaft fur Arzneipflanzeforschung,, Leiden, 1987
D. Hennessy, I. Hook and H. Sheridan, Hydroxycinnamic esters in tissue cultures of "Leontopodium alpinum", Pharmaceutisch Weekblad Scientific Ed., 21, 9, (4), 1987, p217
Dervilla MX Donnelly, Joseph O'Reilly, Judith Polonsky, M Helen Sheridan, In vitro production and biosynthesis of fomajorin D and S by Fomes annosus (Fr.) Cooke, Journal of the Chemical Society, Perkin Transactions 1, 1987, p1869-1872
H. Sheridan and D.M.X. Donnelly, Anthraquinones from Trichoderma polysporum, Phytochemistry, 25, (10), 1986, p2302
H. Sheridan and D.M.X. Donnelly, Biosynthesis of Fomajorin D". Incorporations of [1- 13 C], [2- 13 C] and [1, 2- 13 C 2 ]-acetates", J.C.S. Chem. Commun., 1983, p615
Non-Peer-Reviewed Publications
Fiona Shannon, Astrid Sasse, Michael Heinrich and Helen Sheridan, A repository of knowledge - the Schools' Manuscript Collection, offering a unique insight into medicinal practices in 1930s Ireland, 'Interdisciplinary Approaches to the Study of Healing, Charms and Medicine'. , Department of Celtic languages and literature. Harvard University. , April 5-7th 2018., 2018
Fiona Shannon, Astrid Sasse and Helen Sheridan. , Ethnomedicinal practices in 1930s Ireland. History of Medicine Section of the Royal Academy of Medicine, History of Medicine, Dublin, Ireland, 9th May, 2018
J. Wang, Ingrid Hook, Malte Brummerloh, Jandirk Sendker, Astrid Sasse and Helen Sheridan. , Best Practice for the Scientific Evaluation of Traditional Herbal Medicines: Houttuynia cordata Thunb (鱼腥草Yu Xing Cao) Saururaceae - A Case Study. , 66th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) jointly with the 11th Shanghai TCM conference, Shanghai, August 26 - 29, 2018
Jinfan Wang, Ingrid Hook, Malte Brummerloh, Jandirk Sendker, Astrid Sasse and Helen Sheridan. , From Monograph to Metabolomics: A Scientific Evaluation of the Traditional Chinese Herbal Medicine Houttuynia cordata Thunb (鱼腥草Yu Xing Cao) Saururaceae - a case study, The 6th Annual Meeting of Good Practice in Traditional Chinese Medicine Research Association (GP-TCM RA). , Jordell Laboratories. Kew Gradens. London UK, July 4-6th. , 2018
Ciara M Fallon, Jessica Smyth, Natalia Lajczak, Helen Sheridan and Stephen J Keely. , Neutraceutical targeting of the bile acid receptor, farnesoid X receptor, for intestinal disease, The FALK Symposium 211 XXV International Bile Acid Meeting: Bile Acids in Health and Disease. , Dublin, Ireland, July 6 - 7, 2018
Helen Sheridan, Fiona Shannon, Astrid Sasse and Michael Heinrich, Insight into Healing Herbs used in Post-famine Ireland, 66th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) jointly with the 11th Shanghai TCM conference, Shanghai, China, August 26 - 29, 2018
Fiona Shannon, Astrid Sasse and Helen Sheridan., A repository of knowledge. The Schools' Manuscript Collection, offering a unique insight into medicinal practices in 1930s Ireland. , London, 2018, The British Society for the History of Pharmacy (BSHP).
Helen Sheridan , Exploration of the feasibility of setting up the Trinity (or Irish) - Natural Product Foundation (Trinity-NPF of I-NPF) within TCD., CF-2017-0569Y. , Enterprise Ireland, 2017
Shanahan, F., Michael heinrich, Sasse, A, Sheridan, H., Traditional Medicinal Knowledge in Ireland in the 1930s - Exploring Botanical Treatments. , 58th Annual Meeting of the Society of Economic Botany. L, Braganca, Portugal, 5th June 2017, edited by Conference Committee , 2017
Shanahan, F., Sasse, A, Sheridan, H. , An Ethnomedicinal Study of Traditional Plant Remedies of Co. Wexford, Ireland in the 1930s. , 38th All Ireland Schools of Pharmacy Research Conference. , Royal College of Surgeons, Dublin 2. , 21st March 2016, 1, 2016, P1-
Helen Sheridan and Ciara Smyth, Identification of extracts (and compounds) that could be derived from new plant species, grown in Ireland. An overview of species, market and potential partners who have processing experience, Enterprise ireland 1V-2012-3242., 2014
Nazir, I., Rahman, N., Chan, K., Frankish, N., Sheridan, H, Ethnobotanical Study of Antidiabetic Plants of Cholistan Desert, District Bahawalpur, Pakistan, London BioNat, University of East London. UK, March 12th 2013., 2013
Neil Frankish and Helen Sheridan, Trino Therapeutics Ltd, 2011
Jandirk Sendker, Andreas Marmann, Liselotte Krenn, Helen Sheridan, Ian Sutherland, Svetlana Ignatova, Peter Proksch, Monique Simmonds, Robert Verpoorte, Alberto Dias, Valérian Bunel, You-Ping Zhu , Deliverable 2.10 of WP2 (FP7 GP-TCM) to European Commission., 2011/10/17, 2011
E Passante, C Ehrhardt, H Sheridan, N Frankish, Effect of novel indanes on the degranulation of rat basophilic leukemia mast cells (RBL-2H3), FASEB J, Experimental Biology Meeting 2007, Washington, DC, 28.04.-02.05.2007, 21, (5), 2007, pp574.9
Hook, I., Comey, N. & Sheridan, H., Phytochemical evaluation of roots from cultivated L alpinum, Irish Botanists Meeting, University College Dublin, 2001
Hook, I., Comey, N. & Sheridan, H., Effect of inulin as carbon source on growth and essential oil content of Edelweiss hairy roots, 27th International Symposium on Essential Oils, Vienna, Austria, 1996
Hook, I., Comey, N., James, P. & Sheridan, H., A 2,3- dihydrochromone from the essential oil of edelweiss, Royal Society of Chemistry (TCD Meeting) Drugs from Natural Products. , Trinity College Dublin, 1994
Hook, I. Ryan, S. & Sheridan, H., Biotransformation of exogenous organic substrates by marine microalgae, European Marine Biology Symposium, Trinity College Dublin, 1992
Hook, I., Comey, N. & Sheridan, H., Essential oil from roots of Edelweiss, Leontopodium alpinum, 23rd International Symposium on Essential Oils, Ayr, Scotland, 1992
Hook, I., Sheridan, H. & Waldren, S., Preliminary phytochemical evaluation of Nesocodon mauritianus, Irish Botanists Meeting, University College Dublin, 1991
Hook, I. & Sheridan, H., Tissue culture and micropropagation of the fern Onychium japonicum, Plant Biotechnology-Dublin Group meeting , Maynooth, Ireland, 1991
Hook, I., Sheridan, H. & Wilson, G., Production of volatile metabolites by tissue cultures of Taraxacum officinale, Gesellschaft fur Arzneipflanzeforschung, Bonn, 1990
Hook, I., Lecky, R. & Sheridan, H., Biotransformation of exogenously applied terpenes by cell suspension culture of P bracteatum, Irish Botanists Meeting , Trinity College Dublin, 1989
Hook, I., Lecky, R. & Sheridan, H., Biotransformation of exogenously applied substrates by cell suspension cultures of P bracteatum, SEB International Symposium, King's College London, Phytochemical Society of Europe, 1988
Hook, I., Lecky, R. & Sheridan, H., Biotransformation of substrates by plant cell cultures, Plant Biotechnology - Dublin Group meeting , Trinity College Dublin, 1988
Research Expertise
Description
My research has always been multidisciplinary; built on collaboration with pharmacologists/ molecular-biologists/ bio-technologists/ botanists/anthropologists and sociologists and is recognised at a national and inter-national level. The driving force behind my work is to find new therapeutic treatments for unmet clinical need and to finding meaningful uses for natural molecules, and to improve the position on communities in the developing world who have a cultural and financial reliance on Traditional Medicine. I have learned a lot about the journey from therapeutic drug discovery to human trials, and the challenges and obstacles that line the road. However, experience led decision making about research is invaluable. Through this lens of experience, the molecules my group is working on have real therapeutic potential and have been designed to eliminate some of the insurmountable obstacles to drug development. My drug discovery focus, has been informed by the natural world, ethnomedical practice across the globe; molecular design, based on hybridised natural molecules; and using computer modelling to find natural molecules that target important receptors. In my natural product research I have engaged with International, multidisciplinary Consortia establishing good practice and gold standards for quality, safety and efficacy of complex natural medicines as nutraceuticals, and as food supplements. One of my core research and teaching beliefs is that 'it is at the interface of disciplines and expertise that new ideas and creativity emerge'. My current research falls under four main themes. 1) Multidisciplinary approach Drug discovery for the treatment of inflammatory disease and cancer Finding new therapies targeted at diseases with unmet clinical need. Currently I am PI on an SFI TIDA award and have 50 molecules being tested at level 2 in the Lilly Open Innovation Platform, with six significant nanomolar hits against a key target in Chemotherapy and radiation resistant cancer cells. 2) Drug discovery from the natural world is still ongoing. We use of natural materials (plants, cell cultures, microalgae) for the discovery of novel bio-active materials. 3) Traditional Herbal Medicine. Overview the best practice methodology, recommend applications, and future directions for metabolic profiling, component analysis and purification of secondary metabolites in preparations utilised in Traditional Medicine by large populations (Asia and Africa). Utilising metabolomic techniques to establish best practice for the determination of quality, safety and efficacy of herbal medicines for human and veterinary use. 4) Exploring traditional medicine (TM) in Ireland and in Sub-Saharan-Africa in the context of a changing global healthcare landscape, using a community in West Pokot, Kenya as a case study. I am Co-founder of Trino Therapeutics (Formerly Pharmatrin ltd), a TCD campus company whose activities are centered on drug discovery/development. Through this vehicle my research progressed through a significant Medicinal Chemistry programme of lead optimisation, GMP synthesis of lead, pre-clinical evaluation, regulatory approval and progression through Phase 1 Clinical trials. My ethnomedical research was presented in Harvard (2018), and my overall research work has been presented internationally and most recently on an invited lecture tour in China.Projects
- Title
- Novel indanes as potential therapies for auto-immune disease
- Summary
- Novel indane compounds for the treatment of IBD. From Discovery to Phase 1 Human Trials.
- Funding Agency
- Wellcome Trust; Venture capital; Trino Therapeutics Ltd
- Date From
- 1999
- Date To
- December 2016
- Title
- Investigation into Mechanism of action of PH46A
- Summary
- Using Molecular biology and High resolution NMR to investigate molecular mechanism of action of the anti inflammatory clinical candidate PH46A
- Funding Agency
- Trino Therapeutics Ltd (Industry)
- Date From
- December 2015
- Date To
- December 2016
- Title
- A novel indane scaffold with potential anti-inflammatory agents.
- Summary
- Inflammatory bowel disease (IBD) consists of two major forms, Crohn's disease (CD) and ulcerative colitis (UC). Both chronic inflammatory disorders follow a complex interaction of multiple factors in the pathogenesis n IBD. During the last two decades, development of new IBD drugs has expanded the therapeutic options for IBD patients. However, the number of failed therapies especially biologic drugs is noticeably high. There is still a clear gap in addressing this unmet need to improve the treatment of IBD. Development of small molecule drugs (SMDs) have recently resurfaced with new therapeutic agents at various clinical development stages. The discovery of PH46A, a novel first in class, dimeric indane with two chiral centres originated from this research group and has recently completed a Phase I, single ascending dose double-blind, randomized, placebo-controlled study for the treatment of IBD. The scaffold of PH46A incorporates the indane skeleton and is the N-glucamine salt of a single enantiomer PH46 of this novel drug. The current study focusses on two themes: (1) The pharmacological evaluation of PH46 to define a clearer understanding of the mechanism of its molecular action. (2) In addition, we have designed an exciting new indane scaffold. Pharmacological evaluations to characterise the structural activity relationships (SARs) of this group of novel indanes in in vitro and in vivo models have resulted in the discovery of a NOVEL group of molecules with potent IL6 inhibitory properties. These molecules are undergoing further evaluation.
- Funding Agency
- Trino Therapeutics Ltd (Industry)
- Date From
- 2015
- Date To
- 2017
- Title
- Traditional Chinese medicine research in the post-genomic era: Good practice,priorities, challenges and opportunities
- Summary
- P-TCM is the 1st EU-funded Coordination Action consortium dedicated to tradi-tional Chinese medicine (TCM) research. This paper aims to summarise the objectives, structure andactivities of the consortium andintroduces the position of the consortium regarding good practice,priorities, challenges and opportunities in TCM research. Serving as the introductory paper for the GP-TCM Journal of Ethnopharmacology special issue, this paper describes the roadmap of this special issueand reports how the main outputs of the ten GP-TCM work packages are integrated, and have led toconsortium-wide conclusions
- Funding Agency
- EU
- Date From
- 2008
- Date To
- 2012
- Title
- Effect of novel indanes on mast cell function
- Summary
- Novel synthetic indanes will be investigated on mast cell function and degrnaulation using harvested peritoneal mast cells, and mast cell lines such as RBL-3H3 and LAD2. Mediators studied will include histamine, cytokines etc.
- Funding Agency
- Enterprise Ireland and Trino Therapeutics Ltd
- Date From
- 2005
- Date To
- 2008
- Title
- Novel neuroprotective agents for the treatment of Parkinsons disease and other neurodegenerative disorders
- Summary
- Parkinsons disease, with worldwide distribution, is a neurodegenerative disorder with symptoms of tremor, akinesia and rigidity. As part of an ongoing study we have identified a series of compounds with neuroprotective and neuroregenerative properties. We are investigating these molecules as a novel disease-modifying therapy for this important class of diseases
- Funding Agency
- Enterprise Ireland
- Date From
- 2008
- Date To
- 2009
Recognition
Representations
External Examiner to Postgraduate taught Master's Degrees in University College London
Appointed to the Health Products Regulatory Authority (HPRA) Herbal Medicines Sub-Committee
Board Member of the International Natural Product Science taskforce
External Examiner to Victoria University of Wellington. Wellington, New Zealand
Irish Medicines Board Traditional Herbal Medicinal Products Ad Hoc sub-committee.
International Foundation for Science Grant reviewer http://www.ifs.se/
Grant reviewer for the Medical Research Council UK
Youth Science committee of the Royal Dublin Society
External Examiner Cardiff University PhD Thesis
Awards and Honours
SFI TIDA Award
Appointed to Fellowship of The Royal Society of Chemistry
Wellcome Trust Strategic Translation Award (co-PI)
Irish American Partnership Research Award - with Pfizer
Travel awards: British Council
RIA Travelling award
Department of Education Post Doctoral Fellowship (UCD).
"1851 Overseas Traveling Scholarship".
French Government research Award - CNRS. Gif-Sur-Yvette
NBST Young Researcher award with Dr. Hector Rubelcava (UCD)
Memberships
Fellow of the Royal Society of Chemistry.
Board member of the Board of Directors of the Natural Product Sciences Task force INPST https://inpst.net/.
Life member GP-TCM RA (Good Practice in TCM Research Association).
Member of the SCT (Societe De Chimie Therapeutique The French Society for Medicinal Chemistry)
Member of the Society for Medicinal Plant and Natural Product Research. Gesellschaft für Arzneipflanzen- und Naturstoff-Forschung e.V. (GA).