Publications and Further Research Outputs
Peer-Reviewed Publications
Mugheirbi N, O'Connell P, Serrano D, Healy AM, Taylor L, Tajber L, A comparative study on the performance of inert and functionalized spheres coated with solid dispersions made of two structurally related antifungal drugs, Molecular Pharmaceutics, 2017
Dul M, Paluch KJ, Healy AM, Sasse A, Tajber L, Optimisation of the self-assembly process: production of stable, alginate-based polyelectrolyte nanocomplexes with protamine, Journal of Nanoparticle Research, 19, (6), 2017, p221 - 231
Mesallati H, Tajber L, Polymer/amorphous salt solid dispersions of ciprofloxacin, Pharmaceutical Research, 34, (11), 2017, p2425 - 2439
Borges VRA, Tavares M, Silva JH, Tajber L, Boylan F, Ribeiro A, Nasciuti LE, Cabral L, Sousa VP, Development and characterization of poly(lactic-co-glycolic) acid nanoparticles loaded with copaiba oleoresin, Pharmaceutical Development and Technology , 1, (1), 2017, p1 - 22
Umerska A, Corrigan OI, Tajber L, Design of chondroitin sulfate-based polyelectrolyte nanoplexes: Formation of nanocarriers with chitosan and a case study of salmon calcitonin, Carbohydrate Polymers, 156, 2017, p276 - 284
Mesallati H, Umerska A, Paluch KJ, Tajber L, Amorphous polymeric drug salts as ionic solid dispersion forms of ciprofloxacin, Molecular Pharmaceutics, 14, 2017, p2209 - 2223
Mesallati H, Conroy D, Hudson S, Tajber L, Preparation and characterization of amorphous ciprofloxacin-amino acid salts, European Journal of Pharmaceutics and Biopharmaceutics, 121, 2017, p73 - 89
Mugheirbi N, Fleischer K, Tajber L, A rare case of mesomorphic behavior-molecular reorientation of itraconazole liquid crystal induced by a hygrothermal treatment, Crystal Growth and Design, 16, (3), 2016, p1329 - 1336
Mesallati H, Mugheirbi NA, Tajber L, Two faces of ciprofloxacin: investigation of proton transfer in solid state transformations, Crystal Growth and Design, 16, (11), 2016, p6574 - 6585
Serrano DR, Mugheirbi NA, O'Connell P, Leddy N, Healy AM, Tajber L, Impact of substrate properties on the formation of spherulitic films: a case study of salbutamol sulfate, Crystal Growth and Design, 16, (7), 2016, p3853 - 3858
Knapik J, Wojnarowska Z, Grzybowska K, Tajber L, Mesallati H, Paluch K, Paluch M, Molecular dynamics and physical stability of amorphous nimesulide drug and its binary drug-polymer systems, Molecular Pharmaceutics, 13, (6), 2016, p1937 - 1946
Wlodarski K, Tajber L, Sawicki W., Physicochemical properties of direct compression tablets with spray dried and ball milled solid dispersions of tadalafil in PVP-VA, European Journal of Pharmaceutics and Biopharmaceutics, 109, 2016, p14 - 23
Knopp MM, Tajber L, Tian Y, Olesen NE, Jones DS, Kozyra A, Löbmann K, Paluch K, Brennan CM, Holm R, Healy AM, Andrews GP, Rades T, Comparative study of different methods for the prediction of drug-polymer solubility, Molecular Pharmaceutics, 12, (9), 2015, p3408 - 3419
Amaro MI, Tewes F, Gobbo O, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Formulation, stability and pharmacokinetics of sugar-based salmon calcitonin-loaded nanoporous/nanoparticulate microparticles (NPMPs) for inhalation., International Journal of Pharmaceutics, 483, (1-2), 2015, p6 - 18
Wojnarowska Z, Paluch KJ, Shoifet E, Schick C, Tajber L, Knapik J, Wlodarczyk P, Grzybowska K, Hensel-Bielowka S, Verevkin SP, Paluch M, Molecular origin of enhanced proton conductivity in anhydrous ionic systems., Journal of the American Chemical Society, 137, (3), 2015, p1157 - 1164
Mugheirbi NA, Tajber L, Mesophase and size manipulation of itraconazole liquid crystalline nanoparticles produced via quasi nanoemulsion precipitation., European Journal of Pharmaceutics and Biopharmaceutics, 96, 2015, p226 - 236
Knapik J, Wojnarowska Z, Grzybowska K, Jurkiewicz K, Tajber L, Paluch M, Molecular dynamics and physical stability of coamorphous ezetimib and indapamide mixtures, Molecular Pharmaceutics, 12, (10), 2015, p3610 - 3619
Amaro MI, Tajber L, Corrigan OI, Healy AM, Co-spray dried carbohydrate microparticles: crystallisation delay/inhibition and improved aerosolization characteristics through the incorporation of hydroxypropyl-ß-cyclodextrin with amorphous raffinose or trehalose, Pharmaceutical Research, 32, (1), 2015, p180 - 195
Grossjohann C, Serrano DR, Paluch KJ, O'Connell P, Vella-Zarb L, Manesiotis P, Mccabe T, Tajber L, Corrigan OI, Healy AM, Polymorphism in sulfadimidine/4-aminosalicylic acid cocrystals: solid-state characterization and physicochemical properties., Journal of Pharmaceutical Sciences, 104, (4), 2015, p1385 - 1398
Umerska A, Paluch KJ, Santos-Martinez MJ, Medina C, Corrigan OI, Tajber L, Chondroitin-based nanoplexes as peptide delivery systems--Investigations into the self-assembly process, solid-state and extended release characteristics., European Journal of Pharmaceutics and Biopharmaceutics, 93, 2015, p242 - 253
Wlodarski K, Sawicki W, Kozyra A, Tajber L, Physical stability of solid dispersions with respect to thermodynamic solubility of tadalafil in PVP-VA., European Journal of Pharmaceutics and Biopharmaceutics, 96, 2015, p237 - 246
Dul M, Paluch KJ, Kelly H, Healy AM, Sasse A, Tajber L, Self-assembled carrageenan/protamine polyelectrolyte nanoplexes-Investigation of critical parameters governing their formation and characteristics., Carbohydrate Polymers, 123, 2015, p339 - 349
Wlodarski K, Sawicki W, Haber K, Knapik J, Wojnarowska Z, Paluch M, Lepek P, Hawelek L, Tajber L, Physicochemical properties of tadalafil solid dispersions - Impact of polymer on the apparent solubility and dissolution rate of tadalafil., European Journal of Pharmaceutics and Biopharmaceutics, 94, 2015, p106 - 115
Mugheirbi NA, Tajber L, Crystal habits of itraconazole microcrystals: unusual isomorphic intergrowths induced via tuning recrystallization conditions, Molecular Pharmaceutics, 12, (9), 2015, p3468 - 3478
Umerska A, Paluch KJ, Santos-Martinez MJ, Corrigan OI, Medina C, Tajber L, Self-assembled hyaluronate/protamine polyelectrolyte nanoplexes: synthesis, stability, biocompatibility and potential use as peptide carriers, Journal of Biomedical Nanotechnology, 10, (12), 2014, p3658 - 3673
Wlodarski K, Sawicki W, Paluch KJ, Tajber L, Grembecka M, Hawelek L, Wojnarowska Z, Grzybowska K, Talik E, Paluch M, The influence of amorphization methods on the apparent solubility and dissolution rate of tadalafil., European Journal of Pharmaceutical Sciences, 62, 2014, p132 - 140
Santos-Martinez MJ, Rahme K, Corbalan JJ, Faulkner C, Holmes JD, Tajber L, Medina C, Radomski MW, Pegylation increases platelet biocompatibility of gold nanoparticles., Journal of Biomedical Nanotechnology, 10, (6), 2014, p1004 - 1015
Umerska A, Corrigan OI, Tajber L, Intermolecular interactions between salmon calcitonin, hyaluronate, and chitosan and their impact on the process of formation and properties of peptide-loaded nanoparticles., International Journal of Pharmaceutics, 477, (1-2), 2014, p102 - 112
Healy AM, Amaro MI, Paluch KJ, Tajber L, Dry powders for oral inhalation free of lactose carrier particles, Advanced Drug Delivery Reviews, 75, 2014, p32 - 52
Mugheirbi NA, Paluch KJ, Tajber L, Heat induced evaporative antisolvent nanoprecipitation (HIEAN) of itraconazole., International Journal of Pharmaceutics, 471, (1-2), 2014, p400 - 411
Stojkovic A, Tajber L, Paluch KJ, Djuric Z, Parojcic J, Corrigan OI, Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution., Acta Pharmaceutica, 64, (1), 2014, p77 - 88
Wojnarowska Z, Kolodziejczyk K, Paluch KJ, Tajber L, Grzybowska K, Ngai KL, Paluch M, Decoupling of conductivity relaxation from structural relaxation in protic ionic liquids and general properties., Physical Chemistry Chemical Physics, 15, (23), 2013, p9205 - 9211
Paluch KJ, McCabe T, Müller-Bunz H, Corrigan OI, Healy AM, Tajber L, Formation and physicochemical properties of crystalline and amorphous salts with different stoichiometries formed between ciprofloxacin and succinic acid, Molecular Pharmaceutics, 10, (10), 2013, p3640 - 3654
de Sousa VP, Crean J, de Almeida Borges VR, Rodrigues CR, Tajber L, Boylan F, Cabral LM, Nanostructured systems containing babassu (Orbignya speciosa) oil as a potential alternative therapy for benign prostatic hyperplasia., International Journal of Nanomedicine, 8, 2013, p3129 - 3139
Caron V, Hu Y, Tajber L, Erxleben A, Corrigan OI, McArdle P, Healy AM, Amorphous solid dispersions of sulfonamide/Soluplus® and sulfonamide/PVP prepared by ball milling., AAPS PharmSciTech, 14, (1), 2013, p464 - 474
Salt Forms: Pharmaceutical Aspects in, editor(s)James Swarbrick , Encyclopedia of Pharmaceutical Technology, CRC Press, 2013, pp3041 - 3051, [Corrigan OI, Tajber L]
Ryan SM, McMorrow J, Umerska A, Patel HB, Kornerup KN, Tajber L, Murphy EP, Perretti M, Corrigan OI, Brayden DJ, An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis., Journal of Controlled Release, 167, (2), 2013, p120 - 129
Wojnarowska Z, Grzybowska K, Hawelek L, Dulski M, Wrzalik R, Gruszka I, Paluch M, Pienkowska K, Sawicki W, Bujak P, Paluch KJ, Tajber L, Markowski J, Molecular dynamics, physical stability and solubility advantage from amorphous indapamide drug., Molecular Pharmaceutics, 10, (10), 2013, p3612 - 3627
Wojnarowska Z, Paluch KJ, Shoifet E, Schick C, Tajber L, Knapik J, Wlodarczyk P, Grzybowska K, Hensel-Bielowka S, Verevkin SP, Paluch M, Crystal structure of lidocaine succinate, Refcode ROYWIN, CCDC Number 935179, CCDC, https://www.ccdc.cam.ac.uk/, 2013
Curtin V, Amharar Y, Hu Y, Erxleben A, McArdle P, Caron V, Tajber L, Corrigan OI, Healy AM, Investigation of the capacity of low glass transition temperature excipients to minimize amorphization of sulfadimidine on comilling., Molecular Pharmaceutics, 10, (1), 2013, p386 - 396
Tewes F, Paluch KJ, Tajber L, Gulati K, Kalantri D, Ehrhardt C, Healy AM, Steroid/mucokinetic hybrid nanoporous microparticles for pulmonary drug delivery, European Journal of Pharmaceutics and Biopharmaceutics, 85, (3), 2013, p604 - 613
Wojnarowska Z, Paluch KJ, Shoifet E, Schick C, Tajber L, Knapik J, Wlodarczyk P, Grzybowska K, Hensel-Bielowka S, Verevkin SP, Paluch M, Crystal structure of lidocaine phosphate, Refcode ROYWOT, CCDC Number 935178, CCDC, https://www.ccdc.cam.ac.uk/, 2013
Curtin V, Amharar Y, Gallagher KH, Corcoran S, Tajber L, Corrigan OI, Healy AM, Reducing mechanical activation-induced amorphisation of salbutamol sulphate by co-processing with selected carboxylic acids, International Journal of Pharmaceutics, 456, (2), 2013, p508 - 516
Paluch KJ, Tajber L, Corrigan OI, Healy AM, Impact of alternative solid state forms and specific surface area of high-dose, hydrophilic active pharmaceutical ingredients on tabletability, Molecular Pharmaceutics, 10, (10), 2013, p3628 - 3639
Bianco S, Tewes F, Tajber L, Caron V, Corrigan OI, Healy AM, Bulk, surface properties and water uptake mechanisms of salt/acid amorphous composite systems, International Journal of Pharmaceutics, 456, (1), 2013, p143 - 152
Hu Y, MacFhionnghaile P, Caron V, Tajber L, Healy AM, Erxleben A, Formation, physical stability and quantification of process induced disorder in cryo-milled samples of a model polymorphic drug, Journal of Pharmaceutical Sciences, 102, (1), 2013, p93 - 103
Paluch KJ, Tajber L, Corrigan OI, Healy AM, Impact of process variables on the micromeritic and physicochemical properties of spray dried porous microparticles - Part I. Introduction of a new Morphology Classification System, Journal of Pharmacy and Pharmacology, 64, (11), 2012, p1570 - 1582
Gad S, Tajber L, Corrigan OI Healy AM, Preparation and characterisation of novel spray dried nano-structured para-aminosalicylic acid particulates for pulmonary delivery: impact of ammonium carbonate on morphology, chemical composition and solid state, Journal of Pharmacy and Pharmacology, 64, (9), 2012, p1264 - 1274
Paluch KJ, Tajber L, Adamczyk B, Corrigan OI, Healy AM, A novel approach to crystallisation of nanodispersible microparticles by spray drying for improved tabletability, International Journal of Pharmaceutics, 436, (1-2), 2012, p873 - 876
Paluch KJ, McCabe T, Müller-Bunz H, Corrigan OI, Healy AM, Tajber L, Crystal structure of ciprofloxacin succinate, Refcode QABTUL, CCDC Number 870866, CCDC, https://www.ccdc.cam.ac.uk/, 2012
Mori A, Oleszycka E, Sharp FA, Coleman M, Ozasa Y, Singh M, O'Hagan DT, Tajber L, Corrigan OI, McNeela EA, Lavelle EC, The vaccine adjuvant alum inhibits IL-12 by promoting PI3 kinase signaling while chitosan does not inhibit IL-12 and enhances Th1 and Th17 responses., European Journal of Immunology, 42, (10), 2012, p2709 - 2719
Paluch KJ, McCabe T, Müller-Bunz H, Corrigan OI, Healy AM, Tajber L, Crystal structure of ciprofloxacin succinate, Refcode QABTOF, CCDC Number 870867, CCDC, https://www.ccdc.cam.ac.uk/, 2012
Paluch KJ, Amaro MI, Tajber L, Corrigan OI, Healy AM, Impact of process variables on the micromeritic and physicochemical properties of spray dried microparticles - Part II. Physicochemical characterisation of spray dried materials, Journal of Pharmacy and Pharmacology, 64, (11), 2012, p1583 - 1591
Bianco S, Caron V, Tajber L, Corrigan OI, Nolan LM, Hu Y, Healy AM, Modification of the solid state nature of sulfathiazole and sulfathiazole sodium by spray drying, AAPS PharmSciTech, 13, (2), 2012, p647 - 660
Umerska A, Paluch KJ, Inkielewicz-Stępniak I, Santos-Martinez MJ, Corrigan OI, Medina C, Tajber L., Exploring the assembly process and properties of novel crosslinker-free hyaluronate-based polyelectrolyte complex nanocarriers, International Journal of Pharmaceutics, 436, (1-2), 2012, p75 - 87
Ní Ógáin O, Tajber L, Corrigan OI, Healy AM, Spray drying from organic solvents to prepare nanoporous/nanoparticulate microparticles (NPMPs) of protein:excipient composites designed for oral inhalation, Journal of Pharmacy and Pharmacology, 64, (9), 2012, p1275 - 1290
Grossjohann C, Eccles KS, Maguire AR, Lawrence SE, Tajber L, Corrigan OI, Healy AM, Characterisation, solubility and intrinsic dissolution behaviour of benzamide:dibenzyl sulfoxide cocrystal, International Journal of Pharmaceutics, 422, (1-2), 2012, p24-32
Amaro MI, Tajber L, Corrigan OI, Healy AM, Optimisation of spray drying process conditions for sugar nanoporous microparticles (NPMPs) intended for inhalation, International Journal of Pharmaceutics, 421, (1), 2011, p99 - 109
Caron V, Tajber L, Corrigan OI, Healy AM, A comparison of spray drying and milling in the production of amorphous dispersions of sulfathiazole/polyvinylpyrrolidone and sulfadimidine/polyvinylpyrrolidone, Molecular Pharmaceutics, 8, (2), 2011, p532 - 542
Paluch K, Tajber L, Elcoate CJ, Corrigan OI, Lawrence SE, Healy AM, Solid state characterisation of novel active pharmaceutical ingredients: co-crystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt, Journal of Pharmaceutical Sciences, 100, (8), 2011, p3268 - 3283
Tewes F, Gobbo OL, Amaro MI, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Evaluation of HPβCD-PEG microparticles for salmon calcitonin administration via pulmonary delivery, Molecular Pharmaceutics, 8, (5), 2011, p1887 - 1898
Ní Ógáin O, Li J, Tajber L, Corrigan OI, Healy AM, Particle engineering of materials for oral inhalation by dry powder inhalers. I - Particles of sugar excipients (trehalose and raffinose) for protein delivery, International Journal of Pharmaceutics, 405, (1-2), 2011, p23 - 35
Parojcic J, Stojkovic A, Tajber L, Grbic S, Paluch KJ, Djuric Z, Corrigan OI., Biopharmaceutical characterization of ciprofloxacin HCl-ferrous sulfate interaction, Journal of Pharmaceutical Sciences, 100, (12), 2011, p5174 - 5184
Nolan LM, Li J, Tajber L, Corrigan OI, Healy AM, Particle engineering of materials for oral inhalation by dry powder inhalers. II - Sodium cromoglicate, International Journal of Pharmaceutics, 405, (1-2), 2011, p36 - 46
Paluch KJ, Tajber L, McCabe T, O'Brien JE, Corrigan O, Healy AM, Preparation and characterisation of novel chlorothiazide potassium solid-state salt forms: intermolecular self assembly suprastructures, European Journal of Pharmaceutical Sciences, 42, (3), 2011, p220 - 229
Paluch KJ, Tajber L, Elcoate CJ T, Corrigan OI, Lawrence SE, Healy AM, Crystal structure of salbutamol succinate methanolate, Refcode ORUXAB, CCDC Number 801060, CCDC, https://www.ccdc.cam.ac.uk/, 2010
Paluch KJ, Tajber L, McCabe T, O'Brien JE, Corrigan OI, Healy AM, Crystal structure of chlorothiazide potassium ethanolate, Refcode APUZOB, CCDC Number 761199, CCDC, https://www.ccdc.cam.ac.uk/, 2010
Paluch, K.J., Tajber, L., Corrigan, O.I., Healy, A.M., Investigation of physicochemical interactions of spray dried composites comprising polymer and chlorothiazide, chlorothiazide sodium or chlorothiazide potassium, APS Amorphous III proceedings, Nottingham, 2010, 2010
Tewes F, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Development and characterisation of soluble polymeric particles for pulmonary peptide delivery, European Journal of Pharmaceutical Sciences, 41, (2), 2010, p337 - 352
Paluch KJ, Tajber L, McCabe T, O'Brien JE, Corrigan OI, Healy AM, Crystal structure of chlorothiazide potassium, Refcode APUZIV, CCDC Number 761198, CCDC, https://www.ccdc.cam.ac.uk/, 2010
Paluch KJ, Tajber L, Elcoate CJ T, Corrigan OI, Lawrence SE, Healy AM, Crystal structure of salbutamol adipate, Refcode ORUWUU, CCDC Number 801059, CCDC, https://www.ccdc.cam.ac.uk/, 2010
Paluch KJ, Tajber L, McCabe T, O'Brien JE, Corrigan OI, Healy AM, Preparation and solid state characterisation of chlorothiazide sodium intermolecular self assembly suprastructure, European Journal of Pharmaceutical Sciences, 41, (5), 2010, p603 - 611
Paluch, K.J., Tajber, L., McCabe, T., O'Brien, J.E., Corrigan, O.I., Healy, A.M., Salt or intermolecular self-assembly - physicochemical analysis of crystalline chlorothiazide and chlorothiazide sodium, All Ireland Schools of Pharmacy 32nd Research Seminar, Belfast, 2010, 2010
Paluch, K.J., Tajber, L., McCabe, T., O'Brien, J.E., Corrigan, O.I., Healy, A.M., Intermolecular self-assemblies of chlorothiazide potassium solvates- physicochemical characterisation, 9th International Workshop on Crystal Growth of Organic Materials, Singapore, 2010, 2010
Paluch KJ, Tajber L, McCabe T, O'Brien JE, Corrigan OI, Healy AM, Crystal structure of chlorothiazide sodium, Refcode APUZER, CCDC Number 757605 , CCDC, https://www.ccdc.cam.ac.uk/, 2009
Caron, V., Bianco, S., Tajber, L., Corrigan, O.I., Healy, A.M., Influence of processing on solid state forms of sulphonamide compounds and their mixtures with PVP, AAPS Annual Meeting and Exposition, 8-12 November, Los Angeles, 2009, 2009, ppM1304
Amaro, M.I., Tajber, L., Corrigan, O.I., Healy, A.M., Characterisation of sugar nanoporous/nanoparticulate microparticles (NPMPs) and optimisation of the spray drying process for their production, AAPS Annual Meeting and Exposition, 8-12 November, Los Angeles, 2009, 2009, ppW4064
Xue L, Radomski A, Corrigan OI, Tajber L, de Souza Menezes F, Endter S, Medina C, Radomski M, Platelet compatibility of PLGA, chitosan and PLGA-chitosan nanoparticles, Nanomedicine, 4, (7), 2009, p735 - 746
O'Shea, E., Caron, V., Tajber, L., Corrigan, O.I., Healy, A.M., The Effect of Mechanical Activation on the Solid-State Nature of Commercially Available Sulfathiazole, AAPS Annual Meeting and Exposition, 8-12 November, Los Angeles, 2009, 2009, ppW4378
Bianco, S., Caron, V., Tajber, L., Corrigan, O.I., Healy, A.M., Physico-chemical characterisation of spray dried sulphonamide compounds and their sodium salts, AAPS Annual Meeting and Exposition, 8-12 November, Los Angeles, 2009, 2009, ppM1302
Paluch, K., Tajber, L., Corrigan, O.I., Healy, A.M., An investigation of the effect of spray drying from different solvents on the physicochemical properties of chlorothiazide and chlorothiazide sodium, AAPS Annual Meeting and Exposition, 8-12 November, Los Angeles, 2009, 2009, ppM1333
Umerska, A., Corrigan, O.I., Tajber, L., Preparation and characterisation of hyaluronate-based nanoparticulate carriers suitable for oral peptide delivery, AAPS Annual Meeting and Exposition, 8-12 November, Los Angeles, 2009, 2009
Tajber L, Corrigan OI, Healy AM, Spray drying of budesonide, formoterol fumarate and their composites-II. Statistical factorial design and in vitro deposition properties, International Journal of Pharmaceutics, 367, (1-2), 2009, p86 - 96
Tajber L, Corrigan DO, Corrigan OI, Healy AM, Spray drying of budesonide, formoterol fumarate and their composites-I. Physicochemical characterisation, International Journal of Pharmaceutics, 367, (1-2), 2009, p79 - 85
Nolan LM, Tajber L, McDonald BF, Barham AS, Corrigan OI, Healy AM , Excipient-free nanoporous microparticles of budesonide for pulmonary delivery, European Journal of Pharmaceutics and Biopharmaceutics, 37, (5), 2009, p593 - 602
Paluch K, Tajber L, Zarys metod charakterystyki fizykochemicznej układów amorficznych produkowanych metodą suszenia rozpyłowego (Physicochemical methods of characterisation of amorphous materials produced by spray drying - an outline), Farmacja Polska, 65, (2), 2009, p93 - 99
Paluch K., Tajber L., Healy A.M., Corrigan O. , Impact of solvent variable on chlorothiazide and chlorothiazide sodium physico-chemical properties, processed by spray drying, All Ireland Schools of Pharmacy 31st Research Seminar, Dublin, 2009, 2009
Tewes, F., Tajber, L., Corrigan, O.I., Healy, A.M., Development and characterisation of soluble polymeric particles for pulmonary peptide delivery, AAPS Annual Meeting and Exposition, 8-12 November, Los Angeles, 2009, 2009, ppW4070
Paluch, K., Tajber, L., Healy, A.M. and Corrigan, O.I., Solid-state characteristics of spray dried chlorothiazide, chlorothiazide-PVP composites, sodium chlorothiazide and sodium chlorothiazide-PVP composites, All Ireland Schools of Pharmacy 30th Research Seminar, Cork, 2008, 2008
Katheri, A.K., Tajber, L. Corrigan, O.I. and Healy, A.M., Spray dried nanoporous microparticles of corticosteroids for dry powder oral inhalation, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, Spain, 1-10, April, 2008, 2008
Healy AM, McDonald BF, Tajber L, Corrigan OI, Characterisation of excipient-free nanoporous microparticles (NPMPs) of bendroflumethiazide , European Journal of Pharmaceutics and Biopharmaceutics , 69, (3), 2008, p1182 - 1186
Tajber, L. Crean, B., Roberts, C.J., Nolan, L., Corrigan, O.I. and Healy, A.M., Budesonide Nanoporous Microparticles (NPMPs) - in vitro Aerosolisation Properties and Atomic Force Microscopy (AFM), 35th Controlled Release Society Annual Meeting & Exposition, New York, USA, 12-16, July 2008, 2008
Paluch, K., Tajber, L., Healy, A.M. and Corrigan, O.I., Comparison of the physico-chemical properties of spray dried chlorothiazide, chlorothiazide sodium and their PVP composite systems, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, Spain, 1-10, April, 2008, 2008
Healy, A.M., McDonald, B., Corrigan, O.I. and Tajber, L., A method of producing porous microparticles, 2007, WO/2007/086039
Nolan, L., Tajber, L., Corrigan, O.I. and Healy, A.M., The physicochemical characterisation of spray dried nanoporous microparticles (NPMPs) of sulfa compounds, EUFEPS Conference: When Poor Solubility Becomes an Issue: From Early Stage to Proof of Principles, Verona, Italy, 26-27 April, 2006, 2006
Ni Ogain, O., Tajber, L., Corrigan, O.I. and Healy, A.M., Nanoporous microparticles (NPMPs) - a novel drug delivery system for the pulmonary delivery of proteins, AAPS Journal, American Association of Pharmaceutical Scientists Annual Meeting, 2006, 8, (S2), American Association of Pharmaceutical Scientists, 2006, ppW5076
McDonald, B.F., Tajber, L., Corrigan, O.I. and Healy, A.M., Nanoporous microparticles (NPMPs) of budesonide for pulmonary delivery, AAPS Journal, American Association of Pharmaceutical Scientists Annual Meeting, 2006, 8, (S2), American Association of Pharmaceutical Scientists, 2006, ppM1241
Tajber L, Corrigan OI, Healy AM, Physicochemical evaluation of PVP-thiazide diuretic interactions in co-spray-dried composites-analysis of glass transition composition relationships, European Journal of Pharmaceutical Sciences, 24, (5), 2005, p553 - 563
Tajber, L., Healy, A.M. and Corrigan, O.I, The effect of polyvinylpyrrolidone content on the glass transition temperature of thiazide diuretics, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, Germany, 15-18 March, 2004, 2004, pp711 - 712
Tajber L, Kocot A, Vij JK, Merkel K, Zalewska-Rejdak J, Mehl GH, Elsasser R, Goodby JW, Veith M, Orientational order and dynamics of nematic multipodes based on carbosilazane cores using optical and dielectric spectroscopy, Macromolecules, 35, (22), 2002, p8601 - 8608
Jastrzebska M, Kocot A, Tajber L, Photoconductivity of synthetic dopa-melanin polymer , Journal of Photochemistry and Photobiology B: Biology, 66, (3), 2002, p201 - 206
Non-Peer-Reviewed Publications
Umerska A., Tajber L., Polyelectrolyte complexes as nanoparticulate drug delivery systems, European Pharmaceutical Review, 20, (3), 2015, p36-40
F Tewes, L Tajber, C Ehrhardt, AM Healy, Formulation of colistin-ambroxol microparticles for passive targeting of lung infections, AAPS J, 25th Annual Meeting of the AAPS, Washington, DC, 23-27/11/2011, 13, (S2), 2011, ppM1046
Paluch, K.J., Tajber, L., Corrigan, O.I., Healy, A.M., Solid state characterisation of novel active pharmaceutical ingredients: co-crystal of (R,S) salbutamol mono-adipate and (R,S) salbutamol hemisuccinate, Solid State Pharmaceutical Cluster Meeting, Limerick, 2010, 2010
Paluch K, Tajber L, Corrigan OI, Healy AM, An investigation of the effect of spray drying from different solvents on the physicochemical properties of chlorothiazide and chlorothiazide sodium, IRCSET Symposium Innovation fuelling the Smart Society, Dublin, 2009, 2009
Research Expertise
Projects
- Title
- TRANS-INT
- Funding Agency
- EU
- Date From
- 2012
- Title
- Synthesis and Solid State Pharmaceutical Centre
- Funding Agency
- SFI
- Date From
- 2013
- Date To
- 2019
- Title
- Solid State Pharmaceutical Cluster
- Funding Agency
- SFI
- Date From
- 2007
- Date To
- 2013
- Title
- Active pharmaceutical ingredients as ionic liquids: significance of protonics and functional profiling for the design of effective medicines
- Summary
- A large proportion of pharmaceutical molecules exhibit low aqueous solubility and/or poor membrane transport properties resulting in low oral bioavailability and delivery problems. Thus, many compounds with high pharmacological activity are being dropped from development pipelines. To address the issue of poor solubility and/or permeability of active pharmaceutical ingredients, a new tactic is proposed whereby the active molecule is converted into an ionic liquid (IL), a functional material with superior physicochemical properties to the "parent" molecule. ILs comprise anions and cations and possess low lattice energy and low melting points, often well below 100 °C. Through the systematic investigations of structural properties of ILs, their methods of synthesis, the degree of ionisation and type of proton transport within the ILs as well as extensive pharmaceutical profiling including stability, solubility, permeability and in vitro toxicity, a new generation of ILs with tunable pharmaceutical properties (PILs) will be established. To demonstrate the pharmaceutical developability of PILs and their potential as a platform technology, prototype tablet formulations will be manufactured and tested using novel, bio-relevant dissolution stress test devices. A range of anti-inflammatory and anti-infective molecules will be examined due to their efficacy limitations that are often caused by low solubility and permeability.
- Funding Agency
- Science Foundation Ireland
- Date From
- 2017
- Date To
- 2021
Recognition
Awards and Honours
Trinity College Postgraduate Award
Distinction for the M. Sc. thesis in the Master's Degree Dissertations Competition for Faculties of Pharmacy organised by Polish Pharmaceutical Society and Medical Universities
First prize for the M.Sc. thesis in the Interdepartmental Master's Degree Dissertations Competition
Prize from the Czestochowa branch of the Polish Pharmaceutical Chamber for the grades achieved in university degree
Memberships
American Chemical Society
American Association of Pharmaceutical Scientists
Controlled Release Society