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Competencies & Equipment

  • Drug design, synthesis, purification & characterisation
  • Conventional and microwave synthetic technologies
  • Combinatorial /Library design
  • Drug discovery from Natural Products
  • Structure-activity relationships
  • Drug stability studies
  • Mass spectrometry
  • Molecular biology, including cloning
  • Site-directed mutagenesis
  • Reporter gene expression studies
  • Genotyping, SNPs and VNTRs identification
  • Mammalian cell culture (class 10,000 clean rooms)
  • Protein-based assays
  • Cellular-based assays including:
  • Morphology
  • Anti-proliferative /cytotoxic
  • Cell cycle, migration
  • Invasion
  • Apoptosis /anoikis
  • Tubule formation & angiogenesis
  • Ex vivo: aortic ring assay of angiogenesis/vasculature
  • In vivo xenograft models for efficacy, necrosis and tumour vasculature shutdown
  • Quartz Crystal Microbalance with Dissipation (QCM-D)
  • Nano-toxicology evaluation
  • Tumour cell-induced platelet aggregation (TCIPA) analysis
  • Exosomes isolation & characterisation
  • Pre-formulation studies
  • Solid state characterisation
  • In vitro aerosol deposition characterisation
  • Pharmaceutical processing methods:
  • Milling
  • Spray drying
  • Freeze drying
  • Compaction
  • Thermal analysis infrared spectroscopy
  • Powder X-ray diffraction
  • Micromeritic properties analysis
  • Nanoparticle characterisation
  • Pharmacokinetic & pharmacodynamic studies
  • Physicochemical characterisation salts, cocrystals, amorphous, polymeric APIs forms
  • Spray drying
  • Translational clinical trials (with ICORG and first-in-man through spinouts companies)
  • Pharmacoeconomics
  • IP disclosure & patent filing

Access to Core Facilities:

Class 10,000 cleanrooms for mammalian cell culture
Microarrays, qPCR
advanced microscopy (confocal microscopy, transmission & scanning electron microscopy)
Fluorescence-activated cell sorting (FACS)
NMR, X-Ray, MS
In vivo core

The School of Pharmacy and Pharmaceutical Sciences welcomes new partners and collaborators.

Please contact us at:

The School of Pharmacy & Pharmaceutical Sciences,
Panoz Institute,
Trinity College,
Dublin 2,

Head of School and Directors: