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Drug Development

  • Design, chemical synthesis and evaluation of novel molecular structures as potential clinical drugs: for breast cancerand Burkitt’s Lymphoma
  • Azetidinone analogues of Combretastatin A-4 as tubulin targeting agents
  • Selective Estrogen receptor modulators and tubulin-targeting drugs
  • Pro-drug optimisation of our current candidates
  • Synthesis and biochemistry of ER and tubulin antagonists

  • Dual ER/aromatase and tubulin/aromatase targeting products
  • Dual acting HSP 90 / tubulin targeting products
  • Design of Multidrug resistance/P-glycoprotein modulators
  • Natural Product Drug Discovery
  • Anti-cancer lead discovery from Ethno-medicine (Sub-Saharan Africa, India and Pakistan) and evidence-based traditional Chinese medicine
  • Anti-cancer lead discovery from natural sources (Marine, Terrestrial plants, fungi and microorganisms)
    Cross-hybridisation of naturally occurring molecules to form novel anti-cancer scaffolds

Pharmacy Professors Associated with Disease, Drug Mechanisms & Safety

Boylan, Fabio
Frankish, Neil
Gilmer, John
Meegan, Mary
Quigley, John
Sheridan, Helen
Walsh, John