David Finlay
Asst Prof. Cancer Biology &Therapeutics, Biochemistry
Asst Prof. Cancer Biology &Therapeutics, Pharmacy
Publications and Further Research Outputs
Peer-Reviewed Publications
Simon J. Lawless, Nidhi Kedia-Mehta, Jessica F. Walls, Ryan McGarrigle, Orla Convery, Linda V. Sinclair, Maria N. Navarro, James Murray, David K. Finlay, Glucose represses dendritic cell-induced T cell responses, Nature Communications, (8), 2017, p15620-
Clair M. Gardiner and David K. Finlay, What Fuels Natural Killers? Metabolism and NK Cell Responses, Frontiers in Immunolobgy, 8, 2017
Roisin Loftus, Amino acid-dependent mTORC1 and cMyc signaling is essential for Natural Killer cell metabolic and functional responses, Trinity College Dublin, 2017
Nadine Assmann, Katie L. O'Brien, Raymond P. Donnelly, Lydia Dyck, Vanessa Zaiatz-Bittencourt, Róisín M. Loftus, Paul Heinrich, Peter J. Oefner, Lydia Lynch, Clair M. Gardiner, Katja Dettmer & David K. Finlay, Srebp-controlled glucose metabolism is essential for NK cell functional responses, Nature Immunology, 2017
Viel S, Marçais A, Guimaraes FS, Loftus R, Rabilloud J, Grau M, Degouve S, Djebali S, Sanlaville A, Charrier E, Bienvenu J, Marie JC, Caux C, Marvel J, Town L, Huntington ND, Bartholin L, Finlay D, Smyth MJ, Walzer T, TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway., Science Signalling, 9, 2016, pra19-
Walls J, Sinclair L, Finlay D, Nutrient sensing, signal transduction and immune responses., Seminars in Immunology, 28, (5), 2016, p396-407
Loftus RM, Finlay DK, Immunometabolism; cellular metabolism turns immune regulator., Journal of Biological Chemistry, 291, (1), 2016, p1 - 10
Assmann N, Finlay DK., Metabolic regulation of immune responses: therapeutic opportunities., Journal of Clinical Investigation, 126, (6), 2016, p2031 - 2039
Keating SE, Zaiatz-Bittencourt V, Loftus RM, Keane C, Brennan K, Finlay DK, Gardiner CM., Metabolic Reprogramming Supports IFN-γ Production by CD56bright NK Cells., Journal of Immunology, 196, (6), 2016, p2552 - 2560
Simon Lawless, Nutrient availability regulates Dendritic cell metabolism and function to modulate T cell responses, Trinity College Dublin, 2015
David Finlay, Starved human T lymphocytes keep fighting., European Journal of Immunology, 2015
David Finlay, Glucose, glycolysis and lymphocyte responses., Molecular Immunology, 2015
David Finlay, Metabolic regulation of natural killer cells, Biochemical Society Transactions, 43, (4), 2015, p758 - 762.
Rayond Donelly, Sterol Response Element Binding Protein is a crucial regulator of Natural Killer cell metabolism and function, Trinity College Dublin, 2015
Zarrouk M, Finlay DK, Foretz M, Viollet B, Cantrell DA, Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells., PloS one, 9, (9), 2014, pe106710
David Finlay, IRF4 links antigen affinity to CD8(+) T-cell metabolism., Journal of Immunology and Cell Biology , 92, 2014, p6 - 7
Donnelly, R.P., Loftus, R.M., Keating, S.E., (...), Gardiner, C.M., Finlay, D.K., MTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function, Journal of Immunology, 193, (9), 2014, p4477-4484
Finlay DK, mTORC1 regulates CD8+ T-cell glucose metabolism and function independently of PI3K and PKB., Biochemical Society transactions, 41, (2), 2013, p681-6
Rolf J, Zarrouk M, Finlay DK, Foretz M, Viollet B, Cantrell DA., AMPKα1: A glucose sensor that controls CD8 T-cell memory., European Journal of Immunology, 43, (4), 2013, p889-96
David K. Finlay, Ella Rosenzweig, Linda V. Sinclair, Carmen Feijoo-Carnero, Jens L. Hukelmann, Julia Rolf, Andrey A. Panteleyev, Klaus Okkenhaug, Doreen A. Cantrell, PDK1 regulation of mTOR and Hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells, Journal of Experimental Medicine, 209, (13), 2012, p2441 - 2453
David K Finlay, Regulation of glucose metabolism in T cells: new insight into the role of phosphoinositide 3-kinases, Frontiers in Immunology, 3, 2012, p247-
Finlay DK, Cantrell DA, Metabolism, migration and memory in cytotoxic T cells, Nature Reviews Immunology, 11, (2), 2011, p109 - 117
Finlay DK, Cantrell DA, The co-ordination of T cell function by Serine/threonine kinases, Cold Spring Harbour Perspectives in Biology, 3, (1), 2011
Finlay D, Cantrell D, The coordination of T-cell function by serine/threonine kinases., Cold Spring Harbor perspectives in biology, 3, (1), 2011, pa002261
Macintyre A, Finlay DK, Preston G, Sinclair LV, Waugh CM, Tamas P, Feijoo C, Okkenhaug K, Cantrell DA, Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism, Immunity, 34, (2), 2011, p224 - 236
Finlay DK, Kelly AP, Clarke R, Sinclair LV, Deak M, Alessi DR, Cantrell DA, Temporal differences in the dependency on Phosphoinositide dependent kinase 1 distinguish the development of Vα14 iNKT cells, regulatory T cells and conventional T cells, Journal of Immunology, 185, (10), 2010, p5973 - 5982
Finlay DK, Cantrell DA, Phosphoinositide 3-kinase and mammalian target of rapamycin pathways control T-cell migration, Annals - New York Academy of Sciences, 1183, 2010, p149 - 157
Tamás P, Macintyre A, Finlay D, Clarke R, Feijoo-Carnero C, Ashworth A, Cantrell D, LKB1 is essential for the proliferation of T cell progenitors and mature peripheral T cells, European Journal of Immunology, 40, (1), 2010, p242 - 253
Finlay D, Cantrell D, Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration., Annals of the New York Academy of Sciences, 1183, 2010, p149-57
Finlay DK., Sinclair LV., Fejoo C., Waugh C., Hagenbeek TJ., Spits H., Cantrell DA. , Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes, Journal of Experimental Medcine, 206, (11), 2009, p2441 - 2454
Waugh C., Sinclair LV., Finlay DK., Bayascas J., Cantrell DA., Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation, Molecular Cellular Biology, 29, (21), 2009, p5952 - 5962
Sauer S, Bruno L, Hertweck A, Finlay D, Leleu M, Spivakov M, Knight ZA, Cobb BS, Cantrell D, O'Connor E, Shokat KM, Fisher AG, Merkenschlager M., T cell receptor signaing controls Foxp3 expression via PI3K, Akt and mTOR., PNAS, 105, (22), 2008, p7797 - 7802
Sinclair LV., Finlay D., Fejoo C., Cornish GH., Gray A., Ager A., Okkenhaug K., Hagenbeek TJ., Spits H., Cantrell DA, Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking, Nature Immunology, 9, (5), 2008, p513 - 521
Kelly AP., Finlay DK., Hinton HJ., Clarke RG., Fiorini E, Radtke F., Cantrell DA, Notch-induced T cell development requires phosphoinositide-dependent kinase 1, EMBO Journal, 26, (14), 2007, p3441 - 3450
Finlay D., Ruiz-Alcaraz AJ., Lipina C., Perrier S., Sutherland C, A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression, Journal of Molecular Endocrinology, 37, (2), 2006, p227 - 237
Liu HK, Perrier S, Lipina C, Finlay D, McLauchlan H, Hastie CJ, Hundal HS, Sutherland C, Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226, BMC Molecular Biology, 7, (14), 2006
Lipina C., Huang X., Finlay D., McManus EJ., Alessi DR., Sutherland C, Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3, Biochemical Journal, 392, (3), 2005, p633 - 639
Finlay D., Patel S., Dickson L.M., Shapiro N., Marquez R., Rhodes C.J., Sutherland C., Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element, BMC Molecular Biology, 5, (15), 2004
Non-Peer-Reviewed Publications
David Finlay, What fuels Natural Killers? Metabolic regulation of NK cells , Institute Seminar, Heinrich Pette Institute, Hamburg, Germany, April, 2017, Marcus Altfeld
David Finlay, Glucose represses Dendritic Cell-induced T cell responses, Institute Seminar, Medical University of Vienna, Institute of Medical GeneticsUniversity of , 6th December, 2016, homas Weichhart, PhD
David Finlay, Nutrients control immune responses , Irish Society of Immunology, Trinity College Dublin, September , 2015
David Finlay, Glucose and glycolysis are anti-inflammatory in Dendritic cells , 111th International Titisee Conference, Titisee, Germany, April, 2015
David Finlay, Metabolic regulation of Natural Killer Cells , American Association of Immunology (AAI), New Orleans, 9 May, 2015
Finlay DK, Cantrell DA, The role of PKB in CD8 T cells - Dogma versus Reality, . Keystone Symposia on PI-3-Kinase Signalling Pathways, Keystone, Colorado, USA, Feb, 2011