Trinity College Dublin

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David Finlay
Asst Prof. Cancer Biology &Therapeutics, Biochemistry
Asst Prof. Cancer Biology &Therapeutics, Pharmacy

Publications and Further Research Outputs

Peer-Reviewed Publications

Assmann, A., O'Brien, K, Donnelly, R, Loftus, R, Heinrich, P., Oefner, P.J., Gardiner, C.M., Dettmer, K., Finlay, D.K, Sterol regulatory element binding proteins (Srebp) are essential for metabolic and functional responses in activated Natural Killer cells, Nature Immunology, 2017 Journal Article, 2017

Clair M. Gardiner and David K. Finlay, What Fuels Natural Killers? Metabolism and NK Cell Responses, Frontiers in Immunolobgy, 8, 2017 Review Article, 2017 DOI TARA - Full Text

Roisin Loftus, Amino acid-dependent mTORC1 and cMyc signaling is essential for Natural Killer cell metabolic and functional responses, Trinity College Dublin, 2017 Thesis, 2017

Simon J. Lawless, Nidhi Kedia-Mehta, Jessica F. Walls, Ryan McGarrigle, Orla Convery, Linda V. Sinclair, Maria N. Navarro, James Murray, David K. Finlay, Glucose represses dendritic cell-induced T cell responses, Nature Communications, (8), 2017, p15620- Journal Article, 2017 URL DOI TARA - Full Text

Assmann N, Finlay DK., Metabolic regulation of immune responses: therapeutic opportunities., Journal of Clinical Investigation, 126, (6), 2016, p2031 - 2039 Review Article, 2016 URL

Keating SE, Zaiatz-Bittencourt V, Loftus RM, Keane C, Brennan K, Finlay DK, Gardiner CM., Metabolic Reprogramming Supports IFN-γ Production by CD56bright NK Cells., Journal of Immunology, 196, (6), 2016, p2552 - 2560 Journal Article, 2016 URL DOI

Walls J, Sinclair L, Finlay D, Nutrient sensing, signal transduction and immune responses., Seminars in Immunology, 28, (5), 2016, p396-407 Journal Article, 2016 DOI

Loftus RM, Finlay DK, Immunometabolism; cellular metabolism turns immune regulator., Journal of Biological Chemistry, 291, (1), 2016, p1 - 10 Review Article, 2016 Other URL DOI

Viel S, Marçais A, Guimaraes FS, Loftus R, Rabilloud J, Grau M, Degouve S, Djebali S, Sanlaville A, Charrier E, Bienvenu J, Marie JC, Caux C, Marvel J, Town L, Huntington ND, Bartholin L, Finlay D, Smyth MJ, Walzer T, TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway., Science Signalling, 9, 2016, pra19- Journal Article, 2016 DOI

David Finlay, Starved human T lymphocytes keep fighting., European Journal of Immunology, 2015 Review Article, 2015 URL DOI

David Finlay, Metabolic regulation of natural killer cells, Biochemical Society Transactions, 43, (4), 2015, p758 - 762. Review Article, 2015 DOI URL

Simon Lawless, Nutrient availability regulates Dendritic cell metabolism and function to modulate T cell responses, Trinity College Dublin, 2015 Thesis, 2015

David Finlay, Glucose, glycolysis and lymphocyte responses., Molecular Immunology, 2015 Review Article, 2015 DOI URL

Rayond Donelly, Sterol Response Element Binding Protein is a crucial regulator of Natural Killer cell metabolism and function, Trinity College Dublin, 2015 Thesis, 2015

Donnelly, R.P., Loftus, R.M., Keating, S.E., (...), Gardiner, C.M., Finlay, D.K., MTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function, Journal of Immunology, 193, (9), 2014, p4477-4484 Journal Article, 2014 DOI TARA - Full Text

David Finlay, IRF4 links antigen affinity to CD8(+) T-cell metabolism., Journal of Immunology and Cell Biology , 92, 2014, p6 - 7 Review Article, 2014 URL DOI

Zarrouk M, Finlay DK, Foretz M, Viollet B, Cantrell DA, Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells., PloS one, 9, (9), 2014, pe106710 Journal Article, 2014 TARA - Full Text DOI

Finlay DK, mTORC1 regulates CD8+ T-cell glucose metabolism and function independently of PI3K and PKB., Biochemical Society transactions, 41, (2), 2013, p681-6 Journal Article, 2013 DOI

Rolf J, Zarrouk M, Finlay DK, Foretz M, Viollet B, Cantrell DA., AMPKα1: A glucose sensor that controls CD8 T-cell memory., European Journal of Immunology, 43, (4), 2013, p889-96 Journal Article, 2013 TARA - Full Text DOI URL

David K Finlay, Regulation of glucose metabolism in T cells: new insight into the role of phosphoinositide 3-kinases, Frontiers in Immunology, 3, 2012, p247- Journal Article, 2012 TARA - Full Text DOI URL

David K. Finlay, Ella Rosenzweig, Linda V. Sinclair, Carmen Feijoo-Carnero, Jens L. Hukelmann, Julia Rolf, Andrey A. Panteleyev, Klaus Okkenhaug, Doreen A. Cantrell, PDK1 regulation of mTOR and Hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells, Journal of Experimental Medicine, 209, (13), 2012, p2441 - 2453 Journal Article, 2012 URL

Finlay D, Cantrell D, The coordination of T-cell function by serine/threonine kinases., Cold Spring Harbor perspectives in biology, 3, (1), 2011, pa002261 Journal Article, 2011 DOI

Macintyre A, Finlay DK, Preston G, Sinclair LV, Waugh CM, Tamas P, Feijoo C, Okkenhaug K, Cantrell DA, Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism, Immunity, 34, (2), 2011, p224 - 236 Journal Article, 2011 TARA - Full Text

Finlay DK, Cantrell DA, Metabolism, migration and memory in cytotoxic T cells, Nature Reviews Immunology, 11, (2), 2011, p109 - 117 Review Article, 2011 DOI TARA - Full Text

Finlay DK, Cantrell DA, The co-ordination of T cell function by Serine/threonine kinases, Cold Spring Harbour Perspectives in Biology, 3, (1), 2011 Review Article, 2011 TARA - Full Text

Finlay DK, Cantrell DA, Phosphoinositide 3-kinase and mammalian target of rapamycin pathways control T-cell migration, Annals - New York Academy of Sciences, 1183, 2010, p149 - 157 Review Article, 2010 URL DOI

Finlay D, Cantrell D, Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration., Annals of the New York Academy of Sciences, 1183, 2010, p149-57 Journal Article, 2010 DOI TARA - Full Text

Finlay DK, Kelly AP, Clarke R, Sinclair LV, Deak M, Alessi DR, Cantrell DA, Temporal differences in the dependency on Phosphoinositide dependent kinase 1 distinguish the development of Vα14 iNKT cells, regulatory T cells and conventional T cells, Journal of Immunology, 185, (10), 2010, p5973 - 5982 Journal Article, 2010 TARA - Full Text

Tamás P, Macintyre A, Finlay D, Clarke R, Feijoo-Carnero C, Ashworth A, Cantrell D, LKB1 is essential for the proliferation of T cell progenitors and mature peripheral T cells, European Journal of Immunology, 40, (1), 2010, p242 - 253 Journal Article, 2010 TARA - Full Text

Waugh C., Sinclair LV., Finlay DK., Bayascas J., Cantrell DA., Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation, Molecular Cellular Biology, 29, (21), 2009, p5952 - 5962 Journal Article, 2009 TARA - Full Text

Finlay DK., Sinclair LV., Fejoo C., Waugh C., Hagenbeek TJ., Spits H., Cantrell DA. , Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes, Journal of Experimental Medcine, 206, (11), 2009, p2441 - 2454 Journal Article, 2009 TARA - Full Text

Sauer S, Bruno L, Hertweck A, Finlay D, Leleu M, Spivakov M, Knight ZA, Cobb BS, Cantrell D, O'Connor E, Shokat KM, Fisher AG, Merkenschlager M., T cell receptor signaing controls Foxp3 expression via PI3K, Akt and mTOR., PNAS, 105, (22), 2008, p7797 - 7802 Journal Article, 2008 TARA - Full Text

Sinclair LV., Finlay D., Fejoo C., Cornish GH., Gray A., Ager A., Okkenhaug K., Hagenbeek TJ., Spits H., Cantrell DA, Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking, Nature Immunology, 9, (5), 2008, p513 - 521 Journal Article, 2008 TARA - Full Text

Kelly AP., Finlay DK., Hinton HJ., Clarke RG., Fiorini E, Radtke F., Cantrell DA, Notch-induced T cell development requires phosphoinositide-dependent kinase 1, EMBO Journal, 26, (14), 2007, p3441 - 3450 Journal Article, 2007 TARA - Full Text

Finlay D., Ruiz-Alcaraz AJ., Lipina C., Perrier S., Sutherland C, A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression, Journal of Molecular Endocrinology, 37, (2), 2006, p227 - 237 Journal Article, 2006 TARA - Full Text

Liu HK, Perrier S, Lipina C, Finlay D, McLauchlan H, Hastie CJ, Hundal HS, Sutherland C, Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226, BMC Molecular Biology, 7, (14), 2006 Journal Article, 2006 URL DOI TARA - Full Text

Lipina C., Huang X., Finlay D., McManus EJ., Alessi DR., Sutherland C, Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3, Biochemical Journal, 392, (3), 2005, p633 - 639 Journal Article, 2005 DOI URL TARA - Full Text

Finlay D., Patel S., Dickson L.M., Shapiro N., Marquez R., Rhodes C.J., Sutherland C., Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element, BMC Molecular Biology, 5, (15), 2004 Journal Article, 2004 URL DOI TARA - Full Text

Non-Peer-Reviewed Publications

David Finlay, Glucose represses Dendritic Cell-induced T cell responses, Institute Seminar, Medical University of Vienna, Institute of Medical GeneticsUniversity of , 6th December, 2016, homas Weichhart, PhD Invited Talk, 2016

David Finlay, Metabolic regulation of Natural Killer Cells , American Association of Immunology (AAI), New Orleans, 9 May, 2015 Invited Talk, 2015

David Finlay, Nutrients control immune responses , Irish Society of Immunology, Trinity College Dublin, September , 2015 Invited Talk, 2015

David Finlay, Glucose and glycolysis are anti-inflammatory in Dendritic cells , 111th International Titisee Conference, Titisee, Germany, April, 2015 Invited Talk, 2015

Finlay DK, Cantrell DA, The role of PKB in CD8 T cells - Dogma versus Reality, . Keystone Symposia on PI-3-Kinase Signalling Pathways, Keystone, Colorado, USA, Feb, 2011 Invited Talk, 2011

Research Expertise

Description

Manipulating immune responses has the potential to provide therapy for a wide range of diseases from autoimmunity to cancer. The serine/threonine kinase mTORC1 (mammalian Target of Rapamycin complex 1) is a key regulator of immune cell function: inhibition of mTORC1 in T cells promotes regulatory T cell responses while inhibition of mTORC1 in dendritic cells (DC) promotes a more proinflammatory DC phenotype. Therefore, mTORC1 signalling has diverse roles in immune cell subsets and is potentially a crucial therapeutic target for manipulating immune responses. Work performed in non-immune cell systems has established that mTORC1 is a key regulator of various aspects of cellular metabolism: energy metabolism, lipid synthesis and autophagy. My recent research in CD8 T cells links mTORC1-regulated glycolysis to the control of fundamental effector functions and thus promotes the idea that mTORC1 signaling integrates the control of cellular metabolism and immune cell function. Our research is further characterising the links between mTORC1 controlled metabolism and T cell and DC function. This research aims to establish novel strategies to manipulate the function of (1) T cells - to promote immune tolerance for the treatment of autoimmune disease and (2) DC - to drive potent anti-tumour immune responses. Ongoing projects are investigating: . Deciphering the mTORC1 dependent mechanisms controlling dendritic cell metabolism and function . Characterising the role of mTORC1/Srebp signaling in directing the differentiation and function of T lymphocytes.

Keywords

Biochemistry, metabolism; Cell signalling, proliferation & differentiation; GLUCOSE METABOLISM; Immunity; LEUKEMIA; LIPID METABOLISM; MOUSE MODEL; PROTEIN KINASES; Regulation of Metabolism; T CELLS; Transcriptional regulation


Last updated 9 September 2016 by School of Pharmacy & Pharmaceutical Sciences (Email).