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Assistant Professor Maria Jose Santos-Martinez

Nanopharmaceutical Drug Discovery

Peer Reviewed

Pharmacological characterization of nanoparticle-induced platelet microaggregation using Quartz Crystal Microbalance with Dissipation: comparison with light aggregometry. Santos-Martinez MJ; Tomaszewski KA; Medina C; Bazoud D; Gilmer JF, Radomski MW. International Journal of Nanomedicine. 2015 Aug 13;10:5107-19.

Chondroitin-based nanoplexes as peptide delivery systems - investigations into the self-assembly process, solid-state and extended release characteristics. Umerska A, Paluch KJ, Santos-Martinez MJ, Medina C, Corrigan OI, Tajber L.. Eur J Pharm Biopharm. 2015 Jun;93:242-53.

CuO nanoparticles induce apoptosis by impairing the antioxidant defense and detoxification systems in the mouse hippocampal HT22 cell line: protective effect of crocetin. Niska K, Santos-Martinez MJ, Radomski MW, Inkielewicz-Stepniak I. Toxicology in Vitro. 2015 Jun; 29(4): 663-71.

Nanodiagnostics, Nanopharmacology and Nanotoxicology of Platelet - Vessel Wall Interactions. Tomaszewski KA, Radomski MW, Santos-Martinez MJ. Nanomedicine (Lond). 2015 May; 10(9): 1451-75.

CdTe quantum dots induce activation of human platelets: implications for nanoparticle hemocompatibility. Samuel SP, Santos-Martinez MJ, Medina C, Jain N, Gerard VA, Radomski MW, Gun’ko Y, Prina-Mello A, Volkov Y. International Journal of Nanomedicine. Int J Nanomedicine. 2015 Apr 29;10:2723-34.

Blood biocompatibility of surface-bound multi-walled carbon nanotubes. Gaffney AM, Santos-Martinez MJ, Satti A, Major TC, Wynne KJ, Gun'ko YK, Annich GM, Elia G, Radomski MW. Nanomedicine. 2015 Jan;11(1):39-46

Self-assembled hyaluronate/protamine polyelectrolyte nanoplexes: synthesis, stability, biocompatibility and potential use as peptide carriers. Umerska A; Paluch KJ; Santos-Martinez MJ; Corrigan OI; Medina C; Tajber L. Journal of Biomedical Nanotechnology, 2014 Dec;10(12): 3658-73.

Clinically relevant dissolution testing: exploring albumin concentrations in testing of parenteral formulations. D’Arcy DM; Connell Y; Santos-Martinez MJ. Central European Symposium on Pharmaceutical Technology (CESPT) Conference, 2014 Sep.

Pegylation increases platelet biocompatibility of gold nanoparticles. Santos-Martinez MJ; Rahme K; Medina C; Corbalan JJ; Faulkner C; Holmes J; Medina C; Radomski MW. Journal of Biomedical Nanotechnology ; 2014 Jun;10(6):1004-15.

Inhibition of thromboxane pathways in monocytes impedes cell invasiveness. Glezeva N; Santos-Martinez MJ; Watson C; McDonald K; Medina C; Gilmer J; Ledwidge M. European Journal of Heart failure; 2014 May;16:208-209.

Pharmacological and toxicological effects of co-exposure of human gingival fibroblasts to silver nanoparticles and sodium fluoride. Inkielewicz-Stepniak I, Santos-Martinez MJ, Medina C, Radomski MW. Int J Nanomedicine. 2014 Apr 2; 9:1677-87.

Mechanisms of Platelet-Stimulated Colon Cancer Invasion: Role of Clusterin and Thrombospondin-1 in Regulation of the P38MAPK-MMP-9 Pathway. Radziwon-Balicka; Santos-Martinez MJ; Corbalan JJ; O’Sullivan S; Treumann A; Radomski MW, Medina C. Carcinogenesis; 2014 Feb;35(2):324-32.

Nanoparticle adhesion to the cell membrane and its effect on nanoparticle uptake efficiency. Lesniak A; Salvati A; Santos-Martinez MJ; Radomski MW; Dawson KA; Aberg C. Journal of the American Chemical Society; 2013 Jan 30;135(4):1438-44.

Exploring the assembly process and properties of novel crosslinker-free hyaluronate-based polyelectrolyte complex nanocarriers. Umerska A; Paluch, K; Inkielewicz-Stepniak, I; Santos-Martinez, MJ ; Corrigan, OI ; Medina, C ; Tajber, L. International Journal of Pharmaceutics; 2012 Oct 15;436(1-2):75-87.

The use of quartz crystal microbalance with dissipation (QCM-D) for studying nanoparticle-induced platelet aggregation. Santos-Martinez MJ; Inkielewicz-Stepniak I; Medina C; Rahme K; D'Arcy DM; Fox D; Holmes JD; Zhang H; Radomski MW. International Journal of Nanomedicine. 2012;7:243-55.

Differential inhibition of tumour cell-induced platelet aggregation by the nicotinate aspirin prodrug (ST0702) and aspirin. Medina C; Harmon S; Inkielewicz I; Santos-Martinez MJ; Jones M; Cantwell P ; Bazou D ; Ledwidge M ; Radomski MW; Gilmer JF. British Journal of Pharmacology. 2012 Jun;166(3):938-49.

Mechanisms of aggregation inhibition by aspirin and nitrate-aspirin prodrugs in human platelets. Harmon S; Inkielewicz-Stepniak I; Jones M; ; Ledwidge M ; Santos-Martinez MJ; Medina C; Radomski M; Gilmer JF. British Journal of Pharmacology. 2012 Jan;64(1):77-89.

Analysis of platelet function: role of microfluidics and nanodevices. Santos-Martinez MJ; Prina-Mello A; Medina C; Radomski M. Analyst. 2011 Dec 21;136(24):5120-5126.

Transforming growth factor-beta type 1 receptor (ALK5) and Smad proteins mediate TIMP-1 and collagen synthesis in experimental intestinal fibrosis. Medina C; Santos-Martinez MJ; Santana A; Paz-Cabrera MC; Johnston MJ; Mourelle M; Salas A; Guarner F. Journal of Pathology. 2011 Aug;224(4):461-72.

Elucidation of flow-mediated tumour cell-induced platelet aggregation using an ultrasound standing wave trap. Bazou D; Santos-Martinez MJ; Medina C; Radomski MW. British Journal of Pharmacology. 2011 Apr;162(7):1577-89.

A nanoscale resolution assay of flow-induced platelet microaggregation. Santos-Martinez MJ; Medina C; Prina-Mello A; Conroy J; Samuels SP; Volkov Y; Radomski MW. Kardiochirurgia I Torakochirurgia Polska. 2010 Dec;7(4):365-375.

Matrix metalloproteinases in platelet function: coming of age. Santos-Martinez MJ; Medina C; Gilmer JF; Radomski MW. Journal of Thrombosis and Haemostasis. 2008 Mar; 6(3):514-6.

Role of Matrix Metalloproteinases in platelet function. Santos-Martinez MJ; Medina C; Jurasz P; Radomski MW. Thrombosis Research 2008;121(4):535-42.

Development and pharmacological characterization of a novel plasma-based in vitro angiogenesis assay. Jurasz P; Santos-Martinez MJ; Radomska A; Radomski MW. Kardiochirugia I Torakochirugia Polska. 2007 Jun; 4(2):126-130.

Nanopharmacology: Clinical and Toxicological significance. Medina C; Santos-Martinez MJ; Radomski A; Corrigan O; Radomski MW. British Journal of Pharmacology 2007 Mar;150(5):552-8.

PKCδ Mediates Platelet-Induced Breast Cancer Cell Invasion.Alonso-Escolano D; Medina C; Cieslik K; Radomski A; Jurasz P; Santos-Martinez MJ; Jiffar T; Ruvolo P; Radomski M. Journal of Pharmacology and Experimental Therapeutics. 2006;318(1):373-80.

Generation of platelet angiostatin mediated by urokinase plasminogen activator: effects on angiogenesis. Jurasz P; Santos-Martinez MJ; Radomska A; Radomski MW. Journal of Thrombosis and Haemostasis. 2006 May;4(5):1095-106.

Platelet aggregation-induced by Caco-2 cells: regulation by matrix metalloproteinase-2 and adenosine diphosphate. Medina C; Jurasz P; Santos-Martinez MJ; Jeong SS; Mitsky T; Chen R; Radomski MW. Journal of Pharmacology and Experimental Therapeutics. 2006 May;317(2):739-45.

Lung cancer at a University Hospital: Epidemiological and Histological Characteristics of a Recent and a Historical Series. Santos-Martinez MJ; Curull V; Blanco ML; Macia F; Mojal S; Vila J; Broquetas JM. Archivos de Bronconeumologia 2005;41(6):307-12.

Legionella pneumophila pneumonia community epidemic outbreak in Barcelona: "The Barceloneta outbreak". Effect on the early diagnosis and treatment. Jerico Alba C; Nogues Solan X; Santos-Martinez MJ; Felez Flor M; Garces Jarque JM; Marinosa Marre M; Sanz Salvador X. Revista Clinica Espaṅola 2004;204(2):70-74.

Outcomes and clinical characteristics of patients with pulmonary fibrosis and respiratory failure admitted to an intensive care unit. A study of 20 cases.