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Anne-Marie Healy
Professor, Pharmacy
Co-ordinator MSc course Pharm.Technology, School Office - Pharmacy & Pharmceut Sci

Publications and Further Research Outputs

Peer-Reviewed Publications

Todaro, V, Persoons, T, Groves, G, Healy, AM, D'Arcy, DM, Characterisation and simulation of hydrodynamics in the paddle, basket and flow-through dissolution testing apparatuses - a review, Dissolution Technologies, 24, (3), 2017, p24 - 36 Review Article, 2017 DOI

Dul M, Paluch KJ, Healy AM, Sasse A, Tajber L, Optimisation of the self-assembly process: production of stable, alginate-based polyelectrolyte nanocomplexes with protamine, Journal of Nanoparticle Research, 19, (6), 2017, p221 - 231 Journal Article, 2017 DOI

Worku, Z.A. and Kumar, D. and Gomes, J.V. and He, Y. and Glennon, B. and Ramisetty, K.A. and Rasmuson, Ã .C. and O'Connell, P. and Gallagher, K.H. and Woods, T. and Shastri, N.R. and Healy, A.-M., Modelling and understanding powder flow properties and compactability of selected active pharmaceutical ingredients, excipients and physical mixtures from critical material properties, International Journal of Pharmaceutics, 531, (1), 2017, p191-204 Journal Article, 2017 DOI

Healy, AM, Worku, ZA, Kumar, D, Madi, AM, Pharmaceutical solvates, hydrates and amorphous forms: a special emphasis on cocrystals, Advanced Drug Delivery Reviews, 117, 2017, p25-46 Review Article, 2017 DOI TARA - Full Text

Simon A, Amaro MI, Healy AM, Cabral LM, de Sousa VP, Development of a discriminative in vitro release test for rivastigmine transdermal patches using pharmacopeial apparatuses: USP 5 and USP 6, AAPS PharmSciTech, 18 , (7), 2017, 2561-2569 Journal Article, 2017 DOI

Rolón M, Serrano DR, Lalatsa A, de Pablo E, Torrado JJ, Ballesteros MP, Healy AM, Vega, C, Corone C, Bolás-Fernández F, Dea-Ayuela MA, Engineering oral and parenteral amorphous amphotericin B formulations against experimental Trypanosoma cruzi infections, Molecular Pharmaceutics, 14, (4), 2017, p1095-1106 Journal Article, 2017 DOI

Zelikin AN, Ehrhardt C, Healy AM, Materials and methods for delivery of biological drugs, Nature Chemistry, 8, (11), 2016, p997-1007 Review Article, 2016 DOI

Serrano DR, Mugheirbi NA, O'Connell P, Leddy N, Healy AM, Tajber L, Impact of substrate properties on the formation of spherulitic films: a case study of salbutamol sulfate, Crystal Growth and Design, 16, (7), 2016, p3853 - 3858 Journal Article, 2016 TARA - Full Text URL DOI

Tewes F, Brillault J, Lamy B, O'Connell P, Olivier JC, Couet W, Healy AM, Ciprofloxacin-loaded inorganic-organic composite microparticles to treat bacterial lung infection, Molecular pharmaceutics, 13, (1), 2016, p100-12 Journal Article, 2016 DOI

Amharar Y, Curtin V, Gallagher KH, O'Siochru E, O'Connell P, Healy AM, Mitigating unwanted amorphisation: A screening method for the selection of suitable excipients, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 81, 2016, p181-8 Journal Article, 2016 DOI TARA - Full Text

Tewes F, Gobbo OL, Ehrhardt C, Healy AM, Amorphous calcium carbonate based-microparticles for peptide pulmonary delivery, ACS applied materials & interfaces, 8, (2), 2016, p1164-75 Journal Article, 2016 DOI

Simon A, Amaro MI, Healy AM, Cabral LM, de Sousa VP, Comparative evaluation of rivastigmine permeation from a transdermal system in the Franz cell using synthetic membranes and pig ear skin with in vivo-in vitro correlation, International Journal of Pharmaceutics, 512, (1), 2016, p234 - 241 Journal Article, 2016 DOI URL TARA - Full Text

Tewes, F, Gobbo, OL, Ehrhardt, C, Healy, AM, Amorphous calcium carbonate based-microparticles for peptide pulmonary delivery, ACS Applied materials and interfaces, 8, (2), 2016, p1164-1175 Journal Article, 2016 DOI TARA - Full Text

Serrano DR, Persoons T, D'Arcy DM, Galiana C, Dea-Ayuela MA, Healy AM, Modelling and shadowgraph imaging of cocrystal dissolution and assessment of in vitro antimicrobial activity for sulfadimidine/4-aminosalicylic acid cocrystals, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 89, 2016, p125-36 Journal Article, 2016 TARA - Full Text DOI

Serrano DR, O'Connell P, Paluch KJ, Walsh D, Healy AM, Cocrystal habit engineering to improve drug dissolution and alter derived powder properties, The Journal of pharmacy and pharmacology, 68, (5), 2016, p665-7 Journal Article, 2016 TARA - Full Text DOI

Simon A, Amaro MI, Cabral LM, Healy AM, de Sousa VP, Development of a novel dry powder inhalation formulation for the delivery of rivastigmine hydrogen tartrate, International journal of pharmaceutics, 501, (1-2), 2016, p124-38 Journal Article, 2016 TARA - Full Text DOI

Dul M, Paluch KJ, Kelly H, Healy AM, Sasse A, Tajber L, Self-assembled carrageenan/protamine polyelectrolyte nanoplexes-investigation of critical parameters governing their formation and characteristics, Carbohydrate Polymers, 123, 2015, p339 - 349 Journal Article, 2015 DOI URL

Amaro MI, Simon A, Cabral LM, de Sousa VP, Healy AM, Rivastigmine hydrogen tartrate polymorphs: solid-state characterisation of transition and polymorphic conversion via milling, Solid State Sciences, 49, 2015, p29 - 36 Journal Article, 2015 DOI TARA - Full Text

D. R. Serrano, T. Persoons, D. M. D'Arcy, C. Galiana, M. A. Dea-Ayuela, A. M. Healy, Shadowgraph Imaging of Cocrystal Dissolution and In Vitro Activity Determination , AAPS Annual Meeting and Exposition, Orlando, Florida, USA, Oct 25-29, 2015, ppW5128- Meeting Abstract, 2015 URL

Knopp MM, Tajber L, Tian Y, Olesen NE, Jones DS, Kozyra A, Löbmann K, Paluch K, Brennan CM, Holm R, Healy AM, Andrews GP, Rades T, Comparative study of different methods for the prediction of drug-polymer solubility, Molecular Pharmaceutics, 12, (9), 2015, p3408 - 3419 Journal Article, 2015 DOI

Amaro MI, Tewes F, Gobbo O, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Formulation, stability and pharmacokinetics of sugar-based salmon calcitonin-loaded nanoporous/nanoparticulate microparticles (NPMPs) for inhalation, International Journal of Pharmaceutics, 483, (1-2), 2015, p6-18 Journal Article, 2015 TARA - Full Text DOI

Amaro MI, Tajber L, Corrigan OI, Healy AM, Co-spray dried carbohydrate microparticles: crystallisation delay/inhibition and improved aerosolization characteristics through the incorporation of hydroxypropyl-ß-cyclodextrin with amorphous raffinose or trehalose, Pharmaceutical Research, 32, (1), 2015, p180 - 195 Journal Article, 2015 TARA - Full Text DOI

Holmes MS, Seheult JN, O'Connell P, D'Arcy S, Ehrhardt C, Healy AM, Costello RW, Reilly RB, An acoustic-based method to detect and quantify the effect of exhalation into a dry powder inhaler., Journal of aerosol medicine and pulmonary drug delivery, 28, (4), 2015, p247 - 253 Journal Article, 2015 DOI

Grossjohann C, Serrano DR, Paluch KJ, O'Connell P, Vella-Zarb L, Manesiotis P, McCabe T, Tajber L, Corrigan OI, Healy AM, Polymorphism in sulfadimidine/4-aminosalicylic acid cocrystals: solid state characterization and physicochemical properties, Journal of Pharmaceutical Sciences, 104, (4), 2015, p1385-13 Journal Article, 2015 TARA - Full Text DOI

Tao Z, Paluch K, Scalabrino G, Frankish N, Healy AM, Sheridan H, Molecular structure studies of (1S,2S)-2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol, Journal of Molecular Structure, 2015, p286 - 299 Journal Article, 2015 URL TARA - Full Text

Barham AS, Tewes F, Healy AM, Moisture diffusion and permeability characteristics of hydroxypropylmethylcellulose and hard gelatin capsules., International journal of pharmaceutics, 478, (2), 2015, p796-803 Journal Article, 2015 DOI TARA - Full Text

Serrano DR, Gallagher KH, Healy AM, Emerging nanonisation technologies: tailoring crystalline versus amorphous nanomaterials, Current topics in medicinal chemistry, 15, (22), 2015, p2327-40 Review Article, 2015 TARA - Full Text DOI

Swaminathan J, Gobbo OL, Tewes F, Healy AM, Ehrhardt C, Encapsulation into PEG-liposomes does not improve the bioavailability of pulmonary delivered salmon calcitonin, Journal of Aerosol Medicine and Pulmonary Drug Delivery, 27, (1), 2014, p1-11 Journal Article, 2014 DOI

Seheult JN, O'Connell P, Tee KC, Bholah T, Al Bannai H, Sulaiman I, MacHale E, D'Arcy S, Holmes MS, Bergin D, Reeves E, Reilly RB, Crispino-O'Connell G, Ehrhardt C, Healy AM, Costello RW, The acoustic features of inhalation can be used to quantify aerosol delivery from a Diskus" dry powder inhaler, Pharmaceutical research, 31, (10), 2014, p2735-47 Journal Article, 2014 TARA - Full Text DOI

Amharar Y, Curtin V, Gallagher KH, Healy AM, Solubility of crystalline organic compounds in high and low molecular weight amorphous matrices above and below the glass transition by zero enthalpy extrapolation, International journal of pharmaceutics, 472, (1-2), 2014, p241-7 Journal Article, 2014 DOI TARA - Full Text

Healy AM, Amaro MI, Paluch KJ, Tajber L, Dry powders for oral inhalation free of lactose carrier particles, Advanced Drug Delivery Reviews, 75, 2014, p32 - 52 Review Article, 2014 TARA - Full Text DOI

Tian Y, Caron V, Jones DS, Healy AM, Andrews GP, Using Flory-Huggins phase diagrams as a pre-formulation tool for the production of amorphous solid dispersions: a comparison between hot-melt extrusion and spray drying, The Journal of pharmacy and pharmacology, 66, (2), 2014, p256-74 Journal Article, 2014 DOI

Tewes F, Ehrhardt C, Healy AM, Superparamagnetic iron oxide nanoparticles (SPIONs)-loaded Trojan microparticles for targeted aerosol delivery to the lung, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V, 86, (1), 2014, p98-104 Journal Article, 2014 DOI TARA - Full Text

Paluch KJ, McCabe T, Müller-Bunz H, Corrigan OI, Healy AM, Tajber L, Formation and physicochemical properties of crystalline and amorphous salts with different stoichiometries formed between ciprofloxacin and succinic acid, Molecular Pharmaceutics, 10, (10), 2013, p3640 - 3654 Journal Article, 2013 TARA - Full Text DOI

Tewes F, Paluch KJ, Tajber L, Gulati K, Kalantri D, Ehrhardt C, Healy AM, Steroid/mucokinetic hybrid nanoporous microparticles for pulmonary drug delivery, European Journal of Pharmaceutics and Biopharmaceutics, 85, (3), 2013, p604 - 613 Journal Article, 2013 DOI TARA - Full Text

Curtin V, Amharar Y, Gallagher KH, Corcoran S, Tajber L, Corrigan OI, Healy AM, Reducing mechanical activation-induced amorphisation of salbutamol sulphate by co-processing with selected carboxylic acids, International Journal of Pharmaceutics, 456, (2), 2013, p508 - 516 Journal Article, 2013 DOI TARA - Full Text

Surfactants in pharmaceutical products and systems. in, editor(s)Swarbrick J and Boylan JC , Encyclopedia of Pharmaceutical Science and Technology 4th Edition, New York, Taylor and Francis, 2013, pp3464 - 3476, [Tewes F, Corrigan OI, Healy AM] Book Chapter, 2013

Paluch KJ, Tajber L, Corrigan OI, Healy AM, Impact of alternative solid state forms and specific surface area of high-dose, hydrophilic active pharmaceutical ingredients on tabletability, Molecular Pharmaceutics, 10, (10), 2013, p3628 - 3639 Journal Article, 2013 URL

Curtin V, Amharar Y, Hu Y, Erxleben A, McArdle P, Caron V, Tajber L, Corrigan OI, Healy AM, Investigation of the capacity of low glass transition temperature excipients to minimize amorphization of sulfadimidine on comilling, Molecular Pharmaceutics , 10, (1), 2013, p386-396 Journal Article, 2013 DOI

Hu Y, MacFhionnghaile P, Caron V, Tajber L, Healy AM, Erxleben A, Formation, physical stability and quantification of process induced disorder in cryo-milled samples of a model polymorphic drug, Journal of Pharmaceutical Sciences, 102, (1), 2013, p93 - 103 Journal Article, 2013 DOI

Caron V, Hu Y, Tajber L, Erxleben A, Corrigan OI, McArdle P, Healy AM, Amorphous solid dispersions of sulfonamide/Soluplus® and sulfonamide/PVP prepared by ball milling, AAPS PharmSciTech, 14, (1), 2013, p464-474 Journal Article, 2013 DOI TARA - Full Text

Holmes MS, Seheult JN, O'Connell P, D'Arcy S, Ehrhardt C, Healy AM, Costello RW, Reilly RB, Exhaling into a Diskus (TM) inhaler before inhalation has a detrimental effect on subsequent drug delivery, Irish Journal of Medical Science, , 182, (Suppl 10), 2013, ppS452 - S453 Conference Paper, 2013

Bianco S, Tewes F, Tajber L, Caron V, Corrigan OI, Healy AM, Bulk, surface properties and water uptake mechanisms of salt/acid amorphous composite systems, International Journal of Pharmaceutics, 456, (1), 2013, p143 - 152 Journal Article, 2013 DOI TARA - Full Text

Paluch KJ, Amaro MI, Tajber L, Corrigan OI, Healy AM, Impact of process variables on the micromeritic and physicochemical properties of spray dried microparticles - Part II. Physicochemical characterisation of spray dried materials, Journal of Pharmacy and Pharmacology, 64, (11), 2012, p1583 - 1591 Journal Article, 2012 TARA - Full Text DOI

Baginski L, Gobbo OL, Tewes F, Salomon JJ, Healy AM, Bakowsky U, Ehrhardt C, In vitro and in vivo characterisation of PEG-lipid based micellar complexes of salmon calcitonin for pulmonary delivery, Pharm Res, 29, (6), 2012, p1425-1434 Journal Article, 2012 DOI

Gad S, Tajber L, Corrigan OI Healy AM, Preparation and characterisation of novel spray dried nano-structured para-aminosalicylic acid particulates for pulmonary delivery: impact of ammonium carbonate on morphology, chemical composition and solid state, Journal of Pharmacy and Pharmacology, 64, (9), 2012, p1264 - 1274 Journal Article, 2012 DOI TARA - Full Text

Ní Ógáin O, Tajber L, Corrigan OI, Healy AM, Spray drying from organic solvents to prepare nanoporous/nanoparticulate microparticles (NPMPs) of protein:excipient composites designed for oral inhalation, Journal of Pharmacy and Pharmacology, 64, (9), 2012, p1275 - 1290 Journal Article, 2012 TARA - Full Text DOI

Baginski L, Tewes F, Buckley ST, Healy AM, Bakowsky U, Ehrhardt C, Investigations on the fate of inhaled salmon calcitonin at the respiratory epithelial barrier, Pharmaceutical Research, 29, (1), 2012, p332-341 Journal Article, 2012 DOI

Bianco S, Caron V, Tajber L, Corrigan OI, Nolan LM, Hu Y, Healy AM, Modification of the solid state nature of sulfathiazole and sulfathiazole sodium by spray drying, AAPS PharmSciTech, 13, (2), 2012, p647 - 660 Journal Article, 2012 DOI

Paluch KJ, Tajber L, Corrigan OI, Healy AM, Impact of process variables on the micromeritic and physicochemical properties of spray dried porous microparticles - Part I. Introduction of a new Morphology Classification System, Journal of Pharmacy and Pharmacology, 64, (11), 2012, p1570 - 1582 Journal Article, 2012 TARA - Full Text DOI

Grossjohann C, Eccles KS, Maguire AR, Lawrence SE, Tajber L, Corrigan OI, Healy AM, Characterisation, solubility and intrinsic dissolution behaviour of benzamide:dibenzyl sulfoxide cocrystal, International Journal of Pharmaceutics, 422, (1-2), 2012, p24-32 Journal Article, 2012 TARA - Full Text DOI

Paluch KJ, Tajber L, Adamczyk B, Corrigan OI, Healy AM, A novel approach to crystallisation of nanodispersible microparticles by spray drying for improved tabletability, International Journal of Pharmaceutics, 436, (1-2), 2012, p873 - 876 Journal Article, 2012 URL DOI

Tewes F, Gobbo OL, Amaro MI, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Evaluation of HPβCD-PEG microparticles for salmon calcitonin administration via pulmonary delivery, Molecular Pharmaceutics, 8, (5), 2011, p1887 - 1898 Journal Article, 2011 DOI

Paluch KJ, Tajber L, McCabe T, O'Brien JE, Corrigan O, Healy AM, Preparation and characterisation of novel chlorothiazide potassium solid-state salt forms: intermolecular self assembly suprastructures, European Journal of Pharmaceutical Sciences, 42, (3), 2011, p220 - 229 Journal Article, 2011 DOI TARA - Full Text

Paluch K, Tajber L, Elcoate CJ, Corrigan OI, Lawrence SE, Healy AM, Solid state characterisation of novel active pharmaceutical ingredients: co-crystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt, Journal of Pharmaceutical Sciences, 100, (8), 2011, p3268 - 3283 Journal Article, 2011 TARA - Full Text DOI

Caron V, Tajber L, Corrigan OI, Healy AM, A comparison of spray drying and milling in the production of amorphous dispersions of sulfathiazole/polyvinylpyrrolidone and sulfadimidine/polyvinylpyrrolidone, Molecular Pharmaceutics, 8, (2), 2011, p532 - 542 Journal Article, 2011 DOI

Nolan LM, Li J, Tajber L, Corrigan OI, Healy AM, Particle engineering of materials for oral inhalation by dry powder inhalers. II - Sodium cromoglicate, International Journal of Pharmaceutics, 405, (1-2), 2011, p36 - 46 Journal Article, 2011 DOI TARA - Full Text

Amaro MI, Tajber L, Corrigan OI, Healy AM, Optimisation of spray drying process conditions for sugar nanoporous microparticles (NPMPs) intended for inhalation, International Journal of Pharmaceutics, 421, (1), 2011, p99 - 109 Journal Article, 2011 TARA - Full Text DOI

Ní Ógáin O, Li J, Tajber L, Corrigan OI, Healy AM, Particle engineering of materials for oral inhalation by dry powder inhalers. I - Particles of sugar excipients (trehalose and raffinose) for protein delivery, International Journal of Pharmaceutics, 405, (1-2), 2011, p23 - 35 Journal Article, 2011 TARA - Full Text DOI

Tewes F, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Development and characterisation of soluble polymeric particles for pulmonary peptide delivery, European Journal of Pharmaceutical Sciences, 41, (2), 2010, p337 - 352 Journal Article, 2010 TARA - Full Text DOI

Paluch, K.J., Tajber, L., McCabe, T., O'Brien, J.E., Corrigan, O.I., Healy, A.M., Salt or intermolecular self-assembly - physicochemical analysis of crystalline chlorothiazide and chlorothiazide sodium, All Ireland Schools of Pharmacy 32nd Research Seminar, Belfast, 2010, 2010 Poster, 2010

Paluch, K.J., Tajber, L., McCabe, T., O'Brien, J.E., Corrigan, O.I., Healy, A.M., Intermolecular self-assemblies of chlorothiazide potassium solvates- physicochemical characterisation, 9th International Workshop on Crystal Growth of Organic Materials, Singapore, 2010, 2010 Oral Presentation, 2010

Hao HX, Su WY, Barrett M, Caron V, Healy AM, Glennon B, A calibration-free application of Raman spectroscopy to the monitoring of mannitol crystallization and its polymorphic transformation, Organic Process Research & Development, 14, 2010, p1209 - 1214 Journal Article, 2010

Caron V, Tajber L, Corrigan OI, Healy AM, Production of amorphous dispersions of sulfonamides/polyvinylpyrrolidone by ball milling, Journal of Pharmacy and Pharmacology, UK-PharmSci 2010, Nottingham, UK, 2010, 62, (10), 2010, pp1347 - 1348 Conference Paper, 2010

Paluch, K.J., Tajber, L., Corrigan, O.I., Healy, A.M., Investigation of physicochemical interactions of spray dried composites comprising polymer and chlorothiazide, chlorothiazide sodium or chlorothiazide potassium, APS Amorphous III proceedings, Nottingham, 2010, 2010 Poster, 2010

Amaro MI, Tajber, L, Corrigan OI, Healy AM, Design of experiment to study the effect of spray dryer operating variables on sugar powders intended for inhalation, Journal of Pharmacy and Pharmacology, UK-PharmSci 2010, Nottingham, UK, 62, (10 Sp. Iss.), 2010, pp1413 - 1414 Conference Paper, 2010

Paluch KJ, Tajber L, McCabe T, O'Brien JE, Corrigan OI, Healy AM, Preparation and solid state characterisation of chlorothiazide sodium intermolecular self assembly suprastructure, European Journal of Pharmaceutical Sciences, 41, (5), 2010, p603 - 611 Journal Article, 2010 TARA - Full Text DOI

D'Arcy DM, Liu B, Bradley G, Healy AM, Corrigan OI, Hydrodynamic and species transfer simulations in the USP 4 dissolution apparatus: considerations for dissolution in a low velocity pulsing flow, Pharmaceutical Research, 27, (2), 2010, p246-58 Journal Article, 2010 DOI

McMahon NM, Crane LJ, Ruskin HJ, Crane M, D'Arcy DM, Healy AM, Corrigan OI, A numerical model of a drug particle dissolving in a dissolution test apparatus, Proceedings in Applied Mathematics and Mechanics (PAMM), 80th Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM), Gdansk, 9 - 13 February 2009, 9, (1), 2009, pp655 - 656 Conference Paper, 2009

McDonnell D, Redmond B, D'Arcy DM, Healy AM, Corrigan OI, An analysis of drug dissolution rates in the USP 24 type 2 apparatus, Proceedings in Applied Mathematics and Mechanics (PAMM), 80th Annual Meeting of the International Association of Applied Mathematics and Mechanics (GAMM), Gdansk, 9 - 13 February 2009, 9, (1), 2009, pp691 - 692 Conference Paper, 2009

D'Arcy DM, Healy AM, Corrigan OI, Towards determining appropriate hydrodynamic conditions for in vitro in vivo correlations using computational fluid dynamics, European Journal of Pharmaceutical Sciences, 37, (3-4), 2009, p291 - 299 Journal Article, 2009

Paluch, K., Tajber, L., Corrigan, O.I., Healy, A.M., An investigation of the effect of spray drying from different solvents on the physicochemical properties of chlorothiazide and chlorothiazide sodium, AAPS Annual Meeting and Exposition, 8-12 November, Los Angeles, 2009, 2009, ppM1333 Poster, 2009

Nolan LM, Tajber L, McDonald BF, Barham AS, Corrigan OI, Healy AM, Excipient-free nanoporous microparticles of budesonide for pulmonary delivery, European Journal of Pharmaceutical Sciences, 37, 2009, p593 - 602 Journal Article, 2009 DOI

Tajber L, Corrigan DO, Corrigan OI, Healy AM, Spray drying of budesonide, formoterol fumarate and their composites-I. Physicochemical characterisation, International Journal of Pharmaceutics, 367, (1-2), 2009, p79 - 85 Journal Article, 2009 DOI

Tajber L, Corrigan OI, Healy AM, Spray drying of budesonide, formoterol fumarate and their composites-II. Statistical factorial design and in vitro deposition properties, International Journal of Pharmaceutics, 367, (1-2), 2009, p86 - 96 Journal Article, 2009 DOI

Paluch K., Tajber L., Healy A.M., Corrigan O. , Impact of solvent variable on chlorothiazide and chlorothiazide sodium physico-chemical properties, processed by spray drying, All Ireland Schools of Pharmacy 31st Research Seminar, Dublin, 2009, 2009 Meeting Abstract, 2009

Healy AM, McDonald BF, Tajber L, Corrigan OI, Characterisation of excipient-free nanoporous microparticles (NPMPs) of bendroflumethiazide , European Journal of Pharmaceutics and Biopharmaceutics , 69, (3), 2008, p1182 - 1186 Journal Article, 2008 DOI

Paluch, K., Tajber, L., Healy, A.M. and Corrigan, O.I., Comparison of the physico-chemical properties of spray dried chlorothiazide, chlorothiazide sodium and their PVP composite systems, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, Spain, 1-10, April, 2008, 2008 Meeting Abstract, 2008

Paluch, K., Tajber, L., Healy, A.M. and Corrigan, O.I., Solid-state characteristics of spray dried chlorothiazide, chlorothiazide-PVP composites, sodium chlorothiazide and sodium chlorothiazide-PVP composites, All Ireland Schools of Pharmacy 30th Research Seminar, Cork, 2008, 2008 Meeting Abstract, 2008

Katheri, A.K., Tajber, L. Corrigan, O.I. and Healy, A.M., Spray dried nanoporous microparticles of corticosteroids for dry powder oral inhalation, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, Spain, 1-10, April, 2008, 2008 Meeting Abstract, 2008

Tajber, L. Crean, B., Roberts, C.J., Nolan, L., Corrigan, O.I. and Healy, A.M., Budesonide Nanoporous Microparticles (NPMPs) - in vitro Aerosolisation Properties and Atomic Force Microscopy (AFM), 35th Controlled Release Society Annual Meeting & Exposition, New York, USA, 12-16, July 2008, 2008 Meeting Abstract, 2008

Healy AM, McDonald BF, Tajber L, Corrigan OI, Characterisation of excipient-free nanoporous microparticles (NPMPs) of bendroflumethiazide, European Journal of Pharmaceutics and Biopharmaceutics, 69, (3), 2008, p1182 - 1186 Journal Article, 2008

Healy, A.M., McDonald, B., Corrigan, O.I. and Tajber, L., A method of producing porous microparticles, 2007, WO/2007/086039 Patent, 2007 URL

D'Arcy, D.M., Corrigan, O.I., Healy, A.M., Use of Computational Fluid Dynamics (CFD) to investigate hydrodynamics involved in in vitro in vivo correlations (IVIVC) , EUFEPS/COST B 25 conference on Bioavailability (BA) and Bioequivalence (BE): Focus on physiological factors and variability., Athens, Greece, October, 2007 Poster, 2007

D'Arcy D.M., Corrigan, O.I., Healy, A.M., Investigating the hydrodynamics involved in early in vito in vivo correlations - computational fluid dynamics (CFD) simulations of hydrodynamics in the Levy beaker apparatus., PSWC 3rd World congress of the Board of Pharmaceutical Sciences of the FIP., Amsterdam, The Netherlands, April, 2007 Poster, 2007

ffrg(ed.), The physicochemical characterisation of porous sodium cromoglicate particles for inhalation, Journal of Aerosol Science, 20, (2), 2007, 168 p Proceedings of a Conference, 2007

D'Arcy DM, Corrigan OI, Healy AM, Evaluation of hydrodynamics in the basket dissolution apparatus using computational fluid dynamics-Dissolution rate implications., European Journal of Pharmaceutical Sciences, 27, (2-3), 2006, p259 - 267 Journal Article, 2006 DOI

Corrigan DO, Healy AM, Corrigan OI, Preparation and release of salbutamol from chitosan and chitosan co-spray dried compacts and multiparticulates, European Journal of Pharmaceutics and Biopharmaceutics, 62, (3), 2006, p295 - 305 Journal Article, 2006

Ni Ogain, O., Tajber, L., Corrigan, O.I. and Healy, A.M., Nanoporous microparticles (NPMPs) - a novel drug delivery system for the pulmonary delivery of proteins, AAPS Journal, American Association of Pharmaceutical Scientists Annual Meeting, San Antonio, USA, November 2006, 8, (S2), American Association of Pharmaceutical Scientists, 2006, ppW5076 Meeting Abstract, 2006 URL

Nolan, L., Tajber, L., Corrigan, O.I. and Healy, A.M., The physicochemical characterisation of spray dried nanoporous microparticles (NPMPs) of sulfa compounds, EUFEPS Conference: When Poor Solubility Becomes an Issue: From Early Stage to Proof of Principles, Verona, Italy, 26-27 April, 2006 Meeting Abstract, 2006

D'Arcy, D., Fagan, F., O'Neill, E., Corrigan, O.I. and Healy, A.M., Dissolution under conditions of natural convection - investigating the effect of orientation and solubility, EUFEPS Conference: When Poor Solubility Becomes an Issue: From Early Stage to Proof of Principles, Verona, Italy, 26-27 April, 2006, pp59 Meeting Abstract, 2006

Corrigan DO, Corrigan OI, Healy AM, Physicochemical and in vitro deposition properties of salbutamol sulphate/ipratropium bromide and salbutamol sulphate/excipient spray dried mixtures for use in dry powder inhalers, International Journal of Pharmaceutics, 322, (1-2), 2006, p22 - 30 Journal Article, 2006 DOI

Tajber, L., Healy, A.M., Corrigan,O.I., Characterisation of the thermal behaviour of PVP-sulfa compound composites, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Geneva, Switzerland, 27-30 March, 2006 Meeting Abstract, 2006

McDonald, B.F., Tajber, L., Corrigan, O.I. and Healy, A.M., Nanoporous microparticles (NPMPs) of budesonide for pulmonary delivery, AAPS Journal, American Association of Pharmaceutical Scientists Annual Meeting, San Antonio, USA, November 2006, 8, (S2), American Association of Pharmaceutical Scientists, 2006, ppM1241 Meeting Abstract, 2006 URL

Surfactants in pharmaceutical products and systems in, editor(s)Swarbrick J , Encyclopedia of Pharmaceutical Technology 3rd Edition, New York, Taylor and Francis, 2006, pp3583 - 3596, [Corrigan OI, Healy AM] Book Chapter, 2006

Tajber L, Healy AM, Corrigan OI, Physicochemical evaluation of PVP-thiazide diuretic interactions in co-spray dried composites - analysis of glass transition composition relationships, European Journal of Pharmaceutical Sciences, 24, (5), 2005, p553 - 563 Journal Article, 2005

D'Arcy, D.M., Corrigan, O.I. and Healy, A.M., Use of computational fluid dynamics to model fluid flow and interpret dissolution rate data for the basket dissolution apparatus, 1st PharmSciFair, Pharmaceutical sciences Fair and Exhibition, Nice, France, 2005, ppP0292 Meeting Abstract, 2005

D'Arcy DM, Corrigan OI, Healy AM, Hydrodynamic simulation (computational fluid dynamics) of asymmetrically positioned tablets in the paddle dissolution apparatus: impact on dissolution rate and variability, Journal of Pharmacy and Pharmacology, 57, 2005, p1243 - 1250 Journal Article, 2005

McCarthy, L.G., Corrigan, O.I. and Healy, A.M., Modelling drug release from multi-layered compacts with potential for zero-order release kinetics, European Conference on Drug Delivery and Pharmaceutical Technology, Seville, Spain, May, 2004, pp152 (abstract) Meeting Abstract, 2004

D'Arcy, D.M., Corrigan, O.I. and Healy, A.M., Analysis of variation in dissolution rate with position in the USP paddle apparatus using computational fluid dynamics, European Conference on Drug Delivery and Pharmaceutical Technology, Seville, Spain, May, 2004, pp64 (abstract) Meeting Abstract, 2004

Crane M, Hurley N, Crane L, Healy AM, Corrigan OI, Gallagher KM, McCarthy LG, Simulation of the USP drug delivery problem using CFD: experimental, numerical and mathematical aspects, Simulation Modelling Practice and Theory, 12, (2), 2004, p147 - 158 Journal Article, 2004

McCarthy LG, Bradley G, Sexton JC, Corrigan OI, Healy AM, Computational fluid dynamics (CFD) modeling of the paddle dissolution apparatus: agitation rate, mixing patterns and fluid velocities, AAPS PharmSciTech (http://www.aapspharmscitech.org), 5, (2), 2004, pE31 Journal Article, 2004 URL

Tajber, L., Healy, A.M. and Corrigan, O.I., The effect of polyvinylpyrrolidone content on the glass transition temperature of thiazide diuretics, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, Germany, 2004, 2004, pp711 - 712 Meeting Abstract, 2004

Mackie CA, Healy AM, Roberts K, Ryder S, A comparison of community pharmacy methadone services between Dublin and Glasgow: (1) Extent of service provision in 1997/1998 and views of pharmacists on existing provision and future service developments, Journal of Substance Use, 9, (5), 2004, p235 - 251 Journal Article, 2004

Corrigan DO, Corrigan OI, Healy AM, Predicting the physical state of spray dried composites: salbutamol sulphate/lactose and salbutamol sulphate/polyethylene glycol co-spray dried systems, International Journal of Pharmaceutics, 273, (1-2), 2004, p171 - 182 Journal Article, 2004 DOI

Crane M, Crane L, Healy AM, Corrigan OI, Gallagher KM, McCarthy LG, Pohlhausen solution for the mass flux from a multi-layered compact in the USP drug dissolution apparatus, Simulation Modelling Practice and Theory, 12, (6), 2004, p397 - 411 Journal Article, 2004

Tajber, L., Healy, A.M. and Corrigan, O.I., The effect of polyvinylpyrrolidone content on the glass transition temperature of thiazide diuretics, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, Germany, 15-18 March, 2004, pp711 - 712 Meeting Abstract, 2004

Corrigan DO, Healy AM, Corrigan OI, The effect of spray drying solutions of bendroflumethiazide/polyethylene glycol on the physicochemical properties of the resultant materials, International Journal of Pharmaceutics, 262, (1-2), 2003, p125 - 137 Journal Article, 2003

McCarthy LG, Kosiol C, Healy AM, Bradley G, Sexton JC, Corrigan OI, Simulating the hydrodynamic conditions in the United States Pharmacopeia paddle dissolution apparatus, AAPS PharmSciTech (http://www.aapspharmscitech.org), 4, (2), 2003, pE22 Journal Article, 2003 URL

Surfactants in pharmaceutical products and systems in, editor(s)Swarbrick J and Boylan JC , Encyclopedia of Pharmaceutical Technology 2nd Edition, New York, Marcel Dekker, 2002, pp2639 - 2653, [Corrigan OI, Healy AM] Book Chapter, 2002

Corrigan DO, Healy AM, Corrigan OI, The effect of spray drying solutions of polyethylene glycol (PEG) and lactose/PEG on their physicochemical properties, International Journal of Pharmaceutics, 235, (1-2), 2002, p193 - 205 Journal Article, 2002 DOI

Healy AM, McCarthy LG, Gallagher KM, Corrigan OI, Sensitivity of dissolution rate to location in the paddle dissolution apparatus, Jourrnal of Pharmacy and Pharmacology, 54, (3), 2002, p441 - 444 Journal Article, 2002 DOI

Healy AM, Corrigan OI, Dissolution testing of enteric coated aspirin tablets, Irish Pharmacy Journal, 75, (6), 1997, p189 - 190 Journal Article, 1997

Surfactants in pharmaceutical products and systems in, editor(s)Swarbrick J and Boylan JC , Encyclopedia of Pharmaceutical Technology Volume 14, New York, Marcel Dekker, 1996, pp295 - 331, [Corrigan OI, Healy AM] Book Chapter, 1996

Healy AM, Corrigan OI, The influence of excipient particle size, solubility and acid strength on the dissolution of an acidic drug from two-component compacts, International Journal of Pharmaceutics, 143, 1996, p211 - 221 Journal Article, 1996

Healy AM, Corrigan OI, Allan JEM, The effect of dissolution on the surface texture of model pharmaceutical systems as assessed by non-contact laser profilometry, Pharmaceutical Technology Europe, 7, (8), 1995, p14 - 22 Journal Article, 1995

Healy AM, Corrigan OI, Dissolution testing of five brands of tamoxifen citrate tablets available in the Republic of Ireland, Irish Pharmacy Journal, 72, (10), 1994, p306 - 311 Journal Article, 1994

Healy AM, Corrigan OI, Predicting the dissolution rate of ibuprofen-excipient compressed mixtures in reactive media, International Journal of Pharmaceutics, 84, (2), 1992, p167 - 173 Journal Article, 1992

Pharmaceutical Technology Europe, UBM plc/Americas, [eds.], 2005-date Editorial Board,

Molecular Pharmaceutics, ACS Publications, [eds.], 2013-date Editorial Board,

Non-Peer-Reviewed Publications

F Tewes, L Tajber, C Ehrhardt, AM Healy, Formulation of colistin-ambroxol microparticles for passive targeting of lung infections, AAPS J, 25th Annual Meeting of the AAPS, Washington, DC, 23-27/11/2011, 13, (S2), 2011, ppM1046 Meeting Abstract, 2011

Paluch, K.J., Tajber, L., Corrigan, O.I., Healy, A.M., Solid state characterisation of novel active pharmaceutical ingredients: co-crystal of (R,S) salbutamol mono-adipate and (R,S) salbutamol hemisuccinate, Solid State Pharmaceutical Cluster Meeting, Limerick, 2010, 2010 Poster, 2010

Paluch K, Tajber L, Corrigan OI, Healy AM, An investigation of the effect of spray drying from different solvents on the physicochemical properties of chlorothiazide and chlorothiazide sodium, IRCSET Symposium Innovation fuelling the Smart Society, Dublin, 2009, 2009 Poster, 2009

D'Arcy, D.M., Corrigan, O.I. and Healy, A.M., Dissolution modelling of off-centre compacts in the paddle dissolution apparatus, Schools of Pharmacy Research Seminar, Trinity College Dublin, 21st to 22nd March, 2005, pp33 (abstract) Conference Paper, 2005

Research Expertise

Description

My research programme is focused on obtaining an increased understanding of the physicochemical properties of active and excipient materials used in a variety of different dosage forms, and on using that knowledge to improve product design in terms of in vitro and subsequently in vivo performance. This research objective is achieved through collaborative efforts and interdisciplinary research with both academic and industry partners, nationally and abroad. My research field is aligned with "Therapeutics: Synthesis, Formulation, Processing and Drug Delivery" which is one of 14 priority areas for research identified under the National Research Prioritisation Exercise (NRPE). My current research spans three principal strands: (i) Pharmaceutical material science (ii) Particle engineering for pulmonary drug delivery, and (iii) Enabling formulations for poorly soluble and poorly bioavailable therapeutic agents (i) Pharmaceutical material science Research under this theme is aimed at understanding how solid state and micromeritic characteristics of drug and excipient materials are impacted by pharmaceutical processing, and how formulation and/or processing may be optimized so as to control physicochemical characteristics and drug product performance for oral solid dosage forms. My expertise in this area has led to me taking on the role of Co-PI and Strand Leader in the Synthesis and Solid State Pharmaceutical Centre (SSPC), an SFI-industry co-funded research centre. (ii) Particle engineering for pulmonary drug delivery Sophisticated particle engineering processes enable improved delivery of powders via oral inhalation. In my group, we have developed an internationally recognised expertise in formulation and particle engineering by spray drying for dry powder inhalation. This expertise led to me being invited to join an international collaborative translational NIH-funded €8 million project, led by the University of California San Francisco, aimed at developing a novel mucolytic therapy for the treatment of lung disease, including cystic fibrosis and asthma. The project commenced in 2016. (iii) Enabling formulations for poorly soluble and poorly bioavailable therapeutic agents It is estimated that more than 60% of new drug molecules display poor aqueous solubility, due to an increased size and lipophilicity. There is a need for enabling formulations for such therapeutic agents which have suboptimal bioavailability. Alterations of the solid state form by means of salification, cocrystallization or amorphisation are options which we have explored, as is microencapsulation for controlled release. My group's expertise in this area forms the basis for a number of projects in the SSPC and in AMBER (Advanced Materials and BioEngineering Research centre), another SFI-industry funded research centre, where I am a funded investigator.

Keywords

Amorphous Materials; Computer modelling of pharmaceutical systems; Materials Sciences; Mechanisms of dissolution; Mechanisms of drug release from solid dosage forms; SPRAY DRYING

Recognition

Representations

Member of the Board of the Irish Platform for Patient Organisations, Science & Industry (IPPOSI) 2017-date

Hospital Professional Awards judging panel member 2017

External Examiner to Griffith College Dublin: MSc in Pharmaceutical Business and Technology 2016-date

Grant reviewer for the Austrian Science Fund (FWF) 2016

Expert consultant/witness for US based pharmaceutical company in patent related litigation case 2016

Expert consultant/witness for Irish based pharmaceutical company in patent related litigation case 2016

Irish Pharmacy Awards judging panel member 2016

External Examiner to University of Bradford: MSc in Pharmaceutical Technology 2015-date

Grant reviewer for the Engineering and Physical Sciences Research Council (EPSRC), UK 2015

Judge for the national secondary school competition: Debating Science Issues (DSI) 2015

Member of the Implementation Steering Group for the Five-Year Integrated Pharmacy Programme 2014-date

Invited Medical and Scientific Advisory Board Member, Solvotrin Therapeutics Ltd. 2014-date

Co-ordinator of the EU-funded Erasmus Lifelong Learning Programme Project: Linking Industry and Academia in Pharmaceutical Development and Manufacture (LIAT-Ph) 2013-2015

Member of the National Pharmacy Forum 2013-2014

Member of the Editorial Advisory Board of Molecular Pharmaceutics 2013-date

Invited Scientific Advisory Board Member, Alkermes Ltd. 2013-2016

Co-PI, Strand Leader and Member of Management Committee of the Synthesis and Solid State Pharmaceutical Centre 2013-date

Member of the Accreditation Panel for the PSI Statutory Visit to the level 8 BPharm Degree Course at University College Cork 2013

Member of interview panel for General Manager of Synthesis and Solid State Pharmaceutical Centre, UL 2013

Member of interview panel for Chief Pharmacist position, Department of Health 2013

Grant reviewer for Fundação para a Ciência e a Tecnologia, I.P. (FCT) - Portuguese public funding agency for R&D 2012-2016

External Examiner to Hibernia College: MSc in Pharmaceutical Medicine 2012-date

External Examiner to Dublin Institute of Technology, School of Food Science and Environmental Health: Higher Certificate in Pharmacy Technician Studies 2012-2015

Member of the Curriculum Development Sub-forum of the National Pharmacy Forum 2011-2013

External Examiner for the Pharmaceutical Society of Ireland to the Professional Registration Examination 2011-2013

External Examiner to Dublin Institute of Technology, School of Chemical and Pharmaceutical Sciences: MSc in Pharmaceutical Quality Assurance & Regulation; MSc in Pharmaceutical Quality Assurance & Biotechnology 2009-2012

Member of assessment/interview panel to fill lecturing post in the Department of Chemical and Bioprocess Engineering in UCD 2010

External Examiner to Carlow Institute of Technology, Department of Science and Health: Higher Certificate in Science - Pharmacy Technician Studies 2009-2012

Member of the Pharmaceutical Society of Ireland's Steering Group for the Pharmacy Education and Accreditation Reviews (PEARs) project 2008-2010

Co-PI, Strand Leader and Member of Management Committee of the Solid State Pharmaceutical Cluster 2007-2013

Member of the Validation Panel for the BSc (Ordinary) Validation of Medicinal Products at Dublin Institute of Technology, School of Chemical and Pharmaceutical Sciences 2006

Member of the Editorial Advisory Board of Pharmaceutical Technology Europe 2005-date

Enterprise Ireland Grant Reviewer 2005-2007

External examiner for PhD candidates in: Queen's University Belfast School of Pharmacy (x4), University of Nottingham School of Pharmacy (x1), University of Bradford School of Pharmacy (x1), the Royal College of Surgeons in Ireland School of Pharmacy (x1), University College Dublin School of Chemical and Bioprocess Engineering (x2), The Islamia University of Bahawalpur-Pakistan school of Pharmacy (x1) 2005-date

Member of assessment/interview panel to fill lecturing post in the Department of Chemical and Bioprocess Engineering in UCD 2004

Honorary Treasurer and Chairperson (elected) of the Finance Committee of the Pharmaceutical Society of Ireland 2003-2006

Member of the Accreditation Committee of the Pharmaceutical Society of Ireland established to review new School of Pharmacy courses in RCSI and UCC 2000-2004

Consultant to a number of pharmaceutical companies 2000-date

Member of the Strategy Group of the Pharmaceutical Society of Ireland 2000

Member of the Board of Directors/Board of Management of Kenlis Publications Ltd., publisher of the Irish Pharmacy Journal 1999-2007

Member of the Schools Committee of the Pharmaceutical Society of Ireland 1997-2006

Member (elected) of the Council of the Pharmaceutical Society of Ireland 1997-2006

Regular reviewer for scientific journals (16) in the areas of Pharmaceutical Sciences 1995-date

Awards and Honours

Special Visiting Researcher Fellowship - awarded by CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil) 2014

Fellowship of Trinity College Dublin 2010

Mendell Award for Scientific Excellence (at the 13th International Conference on Pharmaceutical Technology, Strasbourg, France) 1994

Pharmaceutical Society of Ireland Gold Medal 1989

Jim Hegarty Memorial Prize in Pharmaceutical Chemistry 1989

University of Dublin, Trinity College Non-Foundation Scholarship 1987

Pharma Industry Awards, Pharma Research Centre of the Year - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader] 2016

Pharma Industry Awards, Pharma Research Centre of the Year - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader] 2015

Pharma Industry Awards, Research & Development Achievement Award - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader] 2015

Pharma Industry Awards, Partnership Alliance of the Year - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader] 2014

Memberships

Member of Pharmacists in Industry, Education and Regulatory (PIER) 2013 – date

Member of the Academy of Pharmaceutical Scientists (UK) 2005 – date

Member of AAPS (American Association of Pharmaceutical Scientists) 2000 – date

Member of the Pharmaceutical Society of Ireland 1990 – date


Last updated 9 September 2016 by School of Pharmacy & Pharmaceutical Sciences (Email).