Biography
Publications and Further Research Outputs
Peer-Reviewed Publications
Abautret-Daly Á, Dempsey E, Riestra S, de Francisco-García R, Parra-Blanco A, Rodrigo L, Medina C, Connor TJ, Harkin A., Gut-brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease, Acta Neuropsychiatr, March 8, 2017, p1 - 22
Antithrombotic agents in, editor(s)Ignacio Lizasoain, MA Moro , Velazquez. Farmacologica clinica y basica, 2017, [MJ Santos-Martinez, MW Radomski, C Medina]
Abautret-Daly Á, Dempsey E, Riestra S, de Francisco-García R, Parra-Blanco A, Rodrigo L, Medina C, Connor TJ, Harkin A., Association between psychological measures with inflammatory and disease-related markers of inflammatory bowel disease, International Journal of Psychiatry & Clinical Practise, Mar 29, 2017, p1 - 10
O'Sullivan S, Wang J, Pigott MT, Docherty N, Boyle N, Lis SK, Gilmer JF, Medina C, Inhibition of matrix metalloproteinase-9 by a barbiturate-nitrate hybrid ameliorates dextran sulphate sodium-induced colitis: effect on inflammation-related genes, British Journal of Pharmacology, 174, (7), 2017, p512 - 524
E Dempsey, A Abautret-Daly, A Harkin, C Medina, N Docherty, Central neuroinflammation in inflammatory bowel disease: evidence for a central increase in iNOS enzyme in an animal model of colitis, European Neuropsychopharmacology, 25, 2015, ppS47-S47
Samuel S., Santos-Martinez M., Medina C., Jain N., Radomski MW., Prina-Mello A., Volkov Y., CdTe quantum dots induce activation of human platelets: Implications for nanoparticle hemocompatibility, International Journal of Nanomedicine, 10, 2015, p2723-2734
E Dempsey, A Abautret-Daly, J Downing, A Harkin, C Medina, Evidence for central molecular changes and changes to neuronal activity in an animal model of inflammatory bowel disease, European Neuropsychopharmacology, 2015, 25, 2015, ppS233-S234
Santos-Martinez, M.J., Tomaszewski, K., Medina, C., Bazou, D., Gilmer, J.F., Radomski, M.W. , Pharmacological characterization of nanoparticle-induced platelet microaggregation using quartz crystal microbalance with dissipation: comparison with light aggregometry, International Journal of Nanomedicine, 10, 2015, p5107 - 5119
Umerska A, Paluch KJ, Santos-Martinez MJ, Medina C, Corrigan OI, Tajber L, Chondroitin-based nanoplexes as peptide delivery systems--Investigations into the self-assembly process, solid-state and extended release characteristics., European Journal of Pharmaceutics and Biopharmaceutics, 93, 2015, p242 - 253
O'Sullivan S, Gilmer JF, Medina C, Matrix metalloproteinases in inflammatory bowel disease: an update, Mediators of Inflammation, 2015, p964131-
Santos-Martinez, M.J., Rahme, K., Corbalan, J.J., Faulkner, C., Holmes, J., Tajber, L., Medina, C., Radomski, M.W. , Pegylation increases platelet biocompatibility of gold nanoparticles. , Journal of Biomedical Nanotechnology, 10, 2014, p1004 - 1015
N Glezeva, M Santos-Martinez, C Watson, K Mcdonald, C Medina, J Gilmer, M Ledwidge, Inhibition of thromboxane pathways in monocytes impedes cell invasiveness, European Journal of Heart Failure, 16, 2014, pp208-209
Inkielewicz-Stepniak, I., Santos-Martinez, M.J., Medina, C., Radomski, M.W. , Pharmacological and toxicological effects of co-exposure of human gingival fibroblasts to silver nanoparticles and sodium fluoride, International Journal of Nanomedicine, 9, 2014, p1677 - 1678
B Hall, G Holleran, S O'Sullivan, S Smith, B Ryan, C Medina, D McNamara, Crohn's disease in an irish population-A genotype-phenotype analysis , Journal of Crohn's and Colitis, 9th ECCO Conference, Denmark, 8, (S1), 2014, ppS345-
Radziwon-Balicka A, Santos-Martinez MJ, Corbalan JJ, O'Sullivan S, Treumann A, Gilmer JF, Radomski MW, Medina C, Mechanisms of platelet-stimulated colon cancer invasion: role of clusterin and thrombospondin 1 in regulation of the P38MAPK-MMP-9 pathway., Carcinogenesis, 35, (2), 2014, p324 - 332
Umerska A, Paluch KJ, Santos-Martinez MJ, Corrigan OI, Medina C, Tajber L, Self-assembled hyaluronate/protamine polyelectrolyte nanoplexes: synthesis, stability, biocompatibility and potential use as peptide carriers, Journal of Biomedical Nanotechnology, 10, (12), 2014, p3658 - 3673
O'Sullivan, S., Medina, C., Ledwige, M., Radomski, M.W., Gilmer, J.F, Nitric oxide-matrix metaloproteinase-9 interactions: Biological and pharmacological significance: NO and MMP-9 interactions, Biochimica et biophysica acta, 1843, (3), 2014, p603-617
S. Paul-Samuels, MJ Santos-Martinez, C Medina, N Jain, MW Radomski, A Prina-Mello, Y Volkov, . CdTe qunatum dots induce activation of human platelets. , American Journal of Medicine, Amerian Physician Scientists Association, Chicago, USA, , April 2013, 2013
Wang, J., Radomski, M.W., Medina, C., Gilmer, J.F, MMP inhibition by barbiturate homodimers, Bioorganic and Medicinal Chemistry Letters, 23, 2013, p444 - 447
A. Abautret-Daly, N Murphy, N Docherty, C. Medina, T.J. Connor, A. Harkin, Behavioural changes in the DSS model of colitis are associated with long-term systematic anc central induction of iNOS in rats, Proceedings of Neuroscience Ireland, 7th Annual Meeting Neuroscience Ireland, 2012
A. Abautret-Daly, C. Medina, T.J. Connor, A. Harkin, Altered peripheral, circulating and central tryptophan concentrations in the DSS model of colitis., Proceedings of Neuroscience Ireland , 7th Annual Meeting of Neuroscience Ireland, Dublin, September, 2012., 2012
JJ Corbalan, C Medina, A Jacoby, T Malinski, MW Radomski, Amorphus Silica Nanopartilces Aggregate Human Platelets: Potential Implications for Vascular Haemostasis., International Journal of Nanomedicine, 7, 2012, p631 - 639
Medina C, Harmon S, Inkielewicz I, Santos-Martinez MJ, Jones M, Cantwell P, Bazou D, Ledwidge M, Radomski MW, Gilmer JF., Differential Inhibition of Tumor Cell-Induced Platelet Aggregation by Nicotinate Aspirin Prodrug (ST0702) and Aspirin., British Journal of Pharmacology, 166, (3 ), 2012, p938 - 949
S Harmon, I Inkielewicz, M Jones, M Ledwidge, C Medina, MW Radomski, JF Gilmer, In Vitro Pharmacology of Aspirin Prodrugs in Human Platelets , J Pharm Pharmacol , 64, 2012, p77 - 89
Radziwon-Balicka A, Medina C, O'Driscoll L, Treumann A, Bazou D, Inkielewicz-Stepniak I, Radomski A, Jow H, Sawicki G, Radomski MW., Platelets increase survival of adenocarcinoma cells challenged with anticancer drugs: mechanisms and implications for chemoresistance. , Brit. J. Pharmacol., 167, (4), 2012, p787 - 804
J Wang, S O'Sullivan, S Harmon, R Keaveney, MW Radomski, C Medina, JF Gilmer, DESIGN OF BARBITURATE-NITRATE HYBRIDS THAT INHIBIT MMP-9 ACTIVITY AND SECRETION, Journal Medicinal Chemistry, 55, (5), 2012, p2154 - 2162
Umerska A, Paluch KJ, Inkielewicz-Stępniak I, Santos-Martinez MJ, Corrigan OI, Medina C, Tajber L., Exploring the assembly process and properties of novel crosslinker-free hyaluronate-based polyelectrolyte complex nanocarriers, International Journal of Pharmaceutics, 436, (1-2), 2012, p75 - 87
Wang, J., O'Sullivan, S., Harmon, S., Keaveney, R., Radomski, M., Medina, C., Gilmer, J. , Design of barbiturate-nitrate hybrids that inhibit MMP-9 and secretion, Journal of Medicinal Chemistry, 55, 2012, p2154 - 2162
ST Buckley, C Medina, AM Davies, C Ehrhardt, Cytoskeletal re-arrangement in TGF-beta1-induced alveolar epithelial-mesenchymal transition studied by atomic force microscopy and high-content analysis, Nanomed - Nanotechnol Biol Med, 8, (3), 2012, p355-364
MJ Santos-Martinez, I Inkielewicz-Stepniaka, C Medina, K Rahme, DM D'Arcy, D Fox, JD Holmes, H Zhang, MW Radomski, The Use of Quartz Crystal Microbalance with Dissipation (QCM-D) for Studying Nanopaticle-Induced Platelet Aggregation., International Journal of Nanomedicine, 7, 2012, p243 - 255
C Ehrhardt, C Medina, ST Buckley, Interaction of RAGE with focal adhesion molecules during alveolar epithelial-mesenchymal transition, FASEB J, Experimental Biology Meeting 2011, Washington, DC, 09-13/04/2011, 25, 2011, pp865.1
C Medina, MJ Santos-Martinez, A Santana, MC Paz-Cabrera, MJ Johnston, M Mourelle, A Salas, F Guarner, TGF-Beta Type 1 Receptor (ALK5) and SMAD Proteins Mediate TIMP-1 and Collagen Synthesis in Experimental Intestinal Fibrosis, Journal of Pathology, 224, 2011, p461 - 472
C Ehrhardt, C Medina, AM Davies, ST Buckley, The receptor for advanced glycation end-products (RAGE) interacts with focal adhesion molecules in epithelial-mesenchymal transition (EMT) of alveolar epithelial cells, Am J Respir Crit Care Med , eeting of the American Thoracic Society 2011, Denver, CO, 13-18/05/2011, 183, 2011, ppA3502
ST Buckley, C Medina, M Kasper, C Ehrhardt, Interplay between the receptor for advanced glycation end-products (RAGE), CD44 and focal adhesion molecules in epithelial-mesenchymal transition of alveolar epithelial cells, Am J Physiol Lung Cell Mol Physiol, 300, (4), 2011, pL548-L559
D Bazou, MJ Santos-Martinez, C Medina, MW Radomski, Elucidation of Flow Mediated TCIPA Using an Ultrasound Standing Wave Trap, British Journal of Pharmacology, 162, (7), 2011, p1577 - 1589
C Ehrhardt, C Medina, AM Davies, ST Buckley, Using atomic force microscopy and high-content analysis for investigations into cytoskeletal re-arrangement during TGF-β1-induced alveolar epithelial-mesenchymal transition, Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society 2011, Denver, CO, 13-18/05/2011, 183, 2011, ppA3501
Santos-Martinez, M.J., Prina-Mello, A., Medina, C., Radomski, M.W. , Analysis of platelet function: role of microfluidics and nanodevices, Analyst, 136, 2011, p5120 - 5126
Corbalan, J.J., Medina, C., Jacoby, A., Malinski, T., Radomski, M.W. , Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells - inflammatory and cytotoxicity effects. , International Journal of Nanomedicine, 6, 2011, p1 - 15
J Wang, C Medina, MW Radomski, JF Gilmer, N-subsituted homopiperazine barbiturates as gelatinase inhibitors, Bioorganic & Medicinal Chemistry, 19, (16), 2011, p4985-4999
C Ehrhardt, C Medina, AM Davies, ST Buckley, Novel tools for investigations of cytoskeletal re-arrangement during alveolar epithelial-mesenchymal transition, FASEB J, Experimental Biology Meeting 2011, Washington, DC, 09-13/04/2011, 25, 2011, pp856.2
ST Buckley, C Medina, C Ehrhardt, A role for RAGE and ERM proteins in EMT of human alveolar epithelial cells, Am J Respir Crit Care Med , Annual Meeting of the American Thoracic Society 2010, New Orleans, LA, 14-19/05/2010, 181, (1), 2010, ppA1234
A Abautret-Daly, C Medina, TJ Connor, A Harkin, Anxiety related behaviour in an animal model of experimental colitis is associated with a long-term systemic and central inflammatory response, Brain, Behaviour and Immunity, 17th Annual Meeting of The PsychoNeuroImmunology Research Society, Dublin, 24, 2010, ppS55
ST Buckley, C Medina, C Ehrhardt, RAGE and ERM proteins in EMT of human alveolar epithelial cells, FASEB J, Experimental Biology Meeting 2010, Anaheim, CA, 24-28/04/2010, 24, 2010, pp612.21
A Abautret-Daly, C Medina, TJ Connor, A Harkin, Behavioural disturbances observed in experimental colitis are associated with activation of the kyneurine pathway and expression of hepatic tryptophan 2,3 dioxygenase, Brain, Behaviour and Immunity, 17th Annual Meeting of The PsychoNeuroImmunology Research Society, Dublin, June 2010, 2010, ppS50
A Abautret-Daly, C Medina, TJ Connor, A Harkin, Evidence of depression and anxiety related behavioural disturbances associated with activation of the kyneurine pathway and expression of hepatic tryptophan 2,3 dioxygenase in animal models of IBD., Brain, Behaviour and Immunity, FENS Forum, Amsterdam, July 2010, 2010
ST Buckley, C Medina, C Ehrhardt, Differential susceptibility to epithelial-mesenchymal transition (EMT) of alveolar, bronchial and intestinal epithelial cells in vitro and the effect of angiotensin II receptor inhibition, Cell Tissue Res, 342, (1), 2010, p39-51
Pharmacological significance of nanoparticles in, editor(s)Klaus D Sattler , Handbook of Nanophysics, CRC Press, 2010, [C Medina, MW Radomski]
A Abautret-Daly, C Medina, TJ Connor, A Harkin, Evidence of depression and anxiety related behavioural disturbances associated with the activation of the kyneurine pathway and expression of hepatic tryptophan 2,3 dioxygenase in an animal model of IBD, Brain, Behaviour and Immunity, Drugs & the brain workshops, Braga, 2010, 2010
I Inkielewicz-Stepniak, J Gilmer, M Radomski, W Czarnowski, C Medina, The effect of new aspirin prodrugs on blood platelet and tumor cells in an 'in vitro'study, Toxicology Letters, XII International Congress of Toxicology, Barcelona, 196, 2010, ppS258-S259
Santos-Martinez, MJ, Medina, C, Prina-Mello, A, Conroy, J, Samuels, SP, Volkov, Y, Radomski, MW, A nanoscale resolution assay of flow-induced platelet microaggregation, Kardiochirurgia i Torakochirurgia Polska, 7, (4), 2010, p365-375
ST Buckley, C Medina, C Ehrhardt, Investigations into the role of RAGE and ERM proteins in EMT of human alveolar epithelial cells, Acta Physiologica, Joint Meeting of the Scandinavian and German Physiological Societies, København, Denmark, 27-30/3/2010, 198, (S677), 2010, pp146 - 147
ST Buckley, C Medina, C Ehrhardt, Characterisation of the role of inflammatory cytokines in EMT and cell migration in alveolar epithelial cells, Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society 2009, San Diego, CA, 15-20/05/2009, 179, (1), 2009, ppA5298
A Radziwon, C Medina, L O'Driscoll, MW Radomski, Platelets inhibit drug chemotherapy-induced cancer cell apoptosis, 7th International Cancer Conference, Dublin, 2009
ST Buckley, C Medina, C Ehrhardt, Characterisation of the role of inflammatory cytokines in EMT and cell migration in alveolar epithelial cells, FASEB J, Experimental Biology Meeting 2009, New Orleans, LA, 18-22/04/2009, 23, 2009, pp997.2
RM Claramunt, L. Bouissane, MP Cabildo, MP Cornago, J Elguero, A Radziwon, C Medina, Synthesis and biological evaluation of curcuminoid pyrazoles as new therapeutic agents in inflammatory bowel disease: effect on matrix metalloproteinases., Bioorganic & Medicinal Chemistry, 17, (3), 2009, p1290-1296
ST Buckley, C Medina, C Ehrhardt, Effect of TGF-β1 and inflammatory cytokines on EMT and cell migration in alveolar epithelial cells, Acta Physiol , 88th Annual Meeting of the German Physiological Society, Giessen, Germany, 22-25/03/2009, 195, (S669), 2009, pp14
ST Buckley, C Medina, C Ehrhardt, Assessment of the role of inflammatory cytokines in EMT and cell migration in alveolar epithelial cells, Eur Respir J, European Respiratory Society Annual Congress 2009, Wien, Austria, 12-16/09/2009, 22, (S53), 2009, pp582
ST Buckley, C Medina, C Ehrhardt, The role of the receptor for advanced glycation end products (RAGE) in epithelial-mesenchymal transition in the lung: a potential therapeutic target, AAPS J, 23rd Annual Meeting of the AAPS, Los Angeles, CA, 08-12/11/2009, 11, (S2), 2009, ppW5006
Li, X., Radomski, A., Corrigan, O.I., Tajber, L., De Sousa Menezes, F., Endter, S., Medina, C., Radomski, M.W. , The Platelet Compatibility of Poly(lactide-co-glycolide) (PLGA), Chitosan and PLGA- Chitosan Nanoparticles, Nanomedicine, 4, 2009, p735 - 746
Jones, M., Inkielewicz, I., Medina, C., Santos-Martinzez, M.J., Radomski, M.W., Radomski, A., Lally, M.N., Moriarty, L.M., Gaynor, J., Carolan, C.G., Coyne, D., O'Byrne, P., Clancy, J.M., Gilmer, J.F. , Isosorbide-based aspirin prodrugs: integration of nitric oxide releasing groups. , Journal of Medicinal Chemistry, 52, (21), 2009, p6588-6598
Santos-Martinez MJ, Medina C, Gilmer JF, Radomski MW., Matrix metalloproteinases in platelet function: coming of age, Journal of Thrombosis and Haemostasis, 6, (3), 2008, p514 - 516
Santos-Martínez MJ, Medina C, Jurasz P, Radomski MW., Role of metalloproteinases in platelet function, Thrombosis Research, 121, 2008, p535 - 542
Radziwon A, O'Dwyer R, Medina C, Radomski MW., Inhibition of platelet-stimulated matrix metalloproteinase-9 generation in Caco-2 cells by selective MAP kinase inhibitors., 6TH International Cancer Conference, St. James's Hospital in Dublin., 2008
Gilmer JF, Inkielewicz I, Jones M, Radomski A, Medina C, Santos Martinez MW, Radomski MW, Clancy JM, In vitro activation and platelet inhibition effects of the first true aspirin and nitro-aspirin prodrugs, Bioorganic Medicinal Chemistry, IBC's 13th Annual World Congress " Drug Discovery and Development of Innovative Therapeutics" August 4-7th 2008. , 2008
L Bouissane, MP Cabildo, MP Cornago, RM Claramunt, J Elguero, C. Medina, Synthesis and biological evaluation of curcuminum pyrazoles as nex therapeutic agents in IBD, Bioorganic Medicinal Chemistry, Tetrahedron Symposium, Challenges in Organic & Bioorganic Chemistry., San Diego, USA, 2008
Medina, C., Gilmer, J. and Radomski, M.W., Matrix metalloproteinase-9 (MMP-9) as a therapeutic target for treatment of inflammatory bowel disease, Norgine, Harefield, U.K, 14 April 2008, 2008, Dr. M. Farrell
S Videla, J Vilaseca, C Medina, M Mourelle, F Guarner, A Salas, J-R Malagelada, Modulatory Effect of NO on Mast Cells in DSS-Induced Colitis, Digestive Diseases and Sciences, 52, 2007, p45 - 51
S Videla, A Lugea, J Vilaseca, F Guarner, F Treserra, A Salas, E Crespo, C Medina, JR Malagelada, PEG Enhances Colonic Barrier Function and Ameliorates Experimental Colitis in Rats, International Journal of Colorectal Disease, 22, 2007, p571 - 580
Medina, C., Santos-Martinez, M.J., Radomski, A., Corrigan, O.I., Radomski, M.W., Nanoparticles: pharmacological and toxicological significance, British Journal of Pharmacology, 150, 2007
Medina, C., Jurasz, P., Santos-Martinez, M.J., Jeong, S.S., Mitzky, R., Chen, R., Radomski, M.W. , Platelet aggregation induced by Caco-2 cells: regulation by matrix metalloproteinase-2 and adenosine diphosphate, Journal of Pharmacology and Experimental Therapeutics, 317, (2), 2006, p739 - 745
S Videla, J Vilaseca, C Medina, M Mourelle, F Guarner, A Salas, J-R Malagelada, Phosphodiesterase-IV Inhibition Prevents Chronic Colitis and Intestinal Fibrosis, Journal of Pharmacology Experimental Therapeutics , 316, 2006, p940 - 945
C Medina, A Santana, MC Paz-Cabrera, A Parra-Blanco, D Nicolas-Perez, Z Gimeno-Garcia, E Quintero, Increased Activity and Expression of Gelatinases in Ischemic Colitis, Digestive Diseases and Sciences, 51, 2006, p2393 - 2399
AZ Gimeno-García, C Paz-Cabrera, E Salido, C Medina, A Jiménez, A Santana, A Parra-Blanco, D Nicolás, E Quintero, UP-regulation of MMP-9 in familiar adenomatous polyposis, Gastroenterologia Hepatologia, IX Spanish Gastroenterology Association, Madrid, 2006
A Parra-Blanco, AZ Gimeno-García, D Nicolás- Pérez, C García, C Medina, L Díaz-Flores, B Grosso, A Jiménez, E Quintero, Risk for High-Grade Dysplasia or Invasive Carcinoma in Colorectal Flat Adenomas, Gastroenterol Hepatol, 29, 2006, p602 - 609
AZ Gimeno-García, A Santana, A Jiménez, A Parra-Blanco, D Nicolás-Pérez, C Paz-Cabrera, F Díaz-González, C Medina, L Díaz-Flores, E Quintero, UP-Regulation of Gelatinases in the Colorectal Adenoma-Carcinoma Sequence, European Journal of Cancer, Sept 12, 2006, pEpub ahead-
M Menacho, Y Barrios, MC Paz-Cabrera, C Medina, A Pardo, E Salido, E Quintero, Inflammatory bowel disease and homocystinuria., Gastroenterologia Hepatologia, IX Spanish Gastroenterology Association, Madrid, 2006
D Alonso-Escolano, C Medina, K Cieslik, A Radomski, P Jurasz, MJ Santos-Martinez, P Ruvolo, MW Radomski, PKCä Mediates Platelet-Induced Breast Cancer Cell Invasion, Journal of Pharmacology Experimental therapeutics, 318, 2006, p373 - 380
A Santana, C Medina, MC Paz, F Díaz, E Farre, A Salas, MW Radomski, E Quintero, Attenuation of DSS-Induced Colitis in MMP-9 Deficient Mice, World Journal of Gastroenterology, 12, 2006, p6464 - 6472
Medina, C., Radomski, M.W, Role of Matrix Metalloproteinases in Intestinal Inflammation, Journal of Pharmacology and Experimental Therapeutics, 318, (3), 2006, p933-938
Medina, C., Santana, A., Paz, M.C., Diaz, F., Farre, E., Salas, A., Radomski, M.W., Quintero, E., Matrix metalloproteinase-9 modulates intestinal injury in rats with transmural colitis. , Journal of Leukocyte Biology, 79, 2006, p954 - 962
F Casellas, JI Arenas, S Baudet, S Fábregas, N García, J Gelabert, C Medina, I Ochotorena, M Papo, L Rodrigo, J-R Malagelada, Impairement of Health Related Quality of Life in Patients with Inflammatory Bowel Disease. A Spanish Multicenter Study., Inflammatory Bowel Disease , 11, 2005, p488 - 496
A Santana, C Medina, MC Paz Cabrera, F Diaz-Gonzalez, E Ferre, A Salas, MW Radomski, E Quintero. , Deletion of MMP-9 attenuates intestinal injury in DSS-induced colitis, Gastroenterologia Hepatologia, VIII Spanish Gastroenterology Association, Madrid, 2005
A Santana, C Medina, MC Paz-Cabrera, F Diaz-Gonzalez, E Ferre, A Salas, MW Radomski, E Quintero, Deletion of MMP-9 attenuates intestinal injury in DSS-induced colitis, Gastroenterology, American Gastroentorolgy Asociation, Chicago, USA,, 2005
C Medina, A Santana, M LLopis, MC Paz-Cabrera, M Antolin, F Guarner, J Vilaseca, M Mourelle, C Gonzalez, A Salas, E Quintero, JR Malagelada, Transmural Colonic Inflammation Induced by Bacteroides Fragilis: Implication of Matrix Metalloproteinases, Inflammatory Bowel Disease, 11 , 2005, p99 - 105
AZ Gimeno, A Parra-Blanco, J Ortega, D Nicolás, C Medina, E Quintero, Colonic Dieulafoy Lesions Treated Endoscopically with Hemoclips, Diseases of Colon and Rectum, 47 , 2004, p1539 - 1943
C Medina, J Vilaseca, S Videla, R Fabra, JR Armengol-Miró, JR Malagelada, Outcome of Patients with Ischemic Colitis: Review of Fifty Three Cases, Diseases of Colon and Rectum, 47 , 2004, p180 - 184
AZ Gimeno-García, A Santana, A Parra-Blanco, C Medina, D Nicolás-Pérez, MC Paz-Cabrera, F Díaz-Gonzalez, A Jiménez, L Díaz-Flores, E Quintero, UP-regulation of MMP-9 in adenomatous polyposis., Gastroenterology, American Gastroentorolgy Asociation, New Orleans, 2004
AZ Gimeno-García, A Santana, A Parra-Blanco, C Medina, D Nicolás-Pérez, MC Paz-Cabrera, F Díaz-Gonzalez, A Jiménez, L Díaz-Flores, E Quintero, UP-regulation of MMP-9 in adenomatous polyposis., Gastroenterologia Hepatologia, VII Spanish Gastroenterology Association, Madrid, 2004
C Medina, A Santana, E Quintero, MW Radomski, F Guarner, Matrix Metalloproteinases in Gastrointestinal Disorders, Gastroenterol Hepatol , 27, 2004, p491 - 497
F Casellas, JI Arenas, S Baudet, S Fabregas, N Garcia, J Galabert, C Medina, I Otxotorena, M Papo, L Rodrigo, JR Malagelada, Quality of life in inflammatory bowel disease: Spanish study, Gastroenterologia Hepatologia, LVIII Spanish Congress of Digestive Diseases, Valencia, 2004
C Medina, A Santana, MC Paz-Cabrera, F Diaz-Gonzalez, E Quintero, UP-regulation of MMP-9 in a rat model of experimental colitis, Gastroenterologia Hepatologia, VII Spanish Gastroenterology Association, Madrid, 2004
C Medina, A Santana, MC Paz-Cabrera, F Diaz-Gonzalez, E Quintero. , UP-regulation of MMP-9 in a rat model of experimental colitis, Gastroenterology, American Gastroentorolgy Asociation, New Orleans, 2004
. Medina, Y. Barrios, M-C. Paz-Cabrera, M. Menacho, J-A Ortega-Sanchez, A. Jiménez, E. Salido, E. Quintero, Implication of MMP-9 genetic polymorphism on Crohn's disease behaviour, Gastroenterologia Hepatologia, XII Catalan Gastroenterology Association., Lleida, Spain, 2003
Medina, C., Videla, S., Radomski, A., Radomski M.W., Antolin, M., Guarner, F., Vilaseca, J., Salas, A., Malagelada, J.R. , Increased activity and expression of matrix metaloproteinase-9 in a rat model of distal colitis. , American Journal of Physiology, 284, (1), 2003, pG116 - G122
C. Medina, M. Llopis, M. Antolín, S. Videla, F. Guarner, J. Vilaseca, R. Freire, C. I. Gonzalez, A. Salas, E. Quintero, J-R Malagelada, Implication of MMPs in transmural inflammation induced by bacteroides fragilis, Gastroenterology, American Gastroenterolgy Association, Orlando, USA, 2003
C. Medina, Y. Barrios, M-C. Paz-Cabrera, M. Menacho, J-A Ortega-Sanchez, A. Jiménez, E. Salido, E. Quintero, Implication of MMP-9 genetic polymorphism on Crohn's disease behaviour, Gastroenterologia Hepatologia, VI Spanish Gastroenterology Association., Madrid, 2003
C. Medina, M. Llopis, M. Antolín, S. Videla, F. Guarner, J. Vilaseca, R. Freire, A. Salas, E. Quintero, JR Malagelada, Implication of MMPs in transmural inflammation induced by bacteroides fragilis, Gastroenterologia Hepatologia, XII Catalan Gastroenterology Association., Lleida, Spain, 2003
Gimeno, A. Parra, C. García, D. Nicolás, C. Medina, L. Diaz-Flores, E. Quintero, Prevalence of high grade dysplasia in flat adenomas., European Journal of Gastroenterology, Association of National European and Mediterranean Societies of Gastroenterology, Madrid, 2003
Gimeno, A. Parra, C. García, D. Nicolás, C. Medina, L. Diaz-Flores, E. Quintero, Prevalence of high grade dysplasia in flat adenomas., Gastroenterologia Hepatologia, VI Spanish Gastroenterology Association., Madrid, 2003
C. Medina, M. Llopis, M. Antolín, S. Videla, F. Guarner, J. Vilaseca, R. Freire, A. Salas, E. Quintero, JR Malagelada, Implication of MMPs in transmural inflammation induced by bacteroides fragilis, Gastroenterologia Hepatologia, VI Spanish Gastroenterology Association., Madrid, 2003
M Antolín, C Medina, A García-Lafuente, S Videla, F Guarner, J Vilaseca, A Salas, JR Malagelada, Anti-inflammatory effect of lactobacillus in DSS-induced colitis, Gastroenterologia Hepatologia, V Spanish Gastroenterology Association, Madrid, 2002
M Antolín, C Medina, A García-Lafuente, S Videla, F Guarner, J Vilaseca, A Salas, JR Malagelada, Anti-inflammatory effect of lactobacillus in DSS-induced colitis, Gastroenterologia Hepatologia, XI Catalan Gastroenterology Association, Reus, Spain, 2002
S Baudet, C Medina, J Andreu, J Vilaseca, JR Malagelada, Effect of Short-Term Octreotide Therapy and Total Parenteral Nutrition on Development of Biliary Sludge or Lithiasis, Hepatogastroenterology, 62 , 2002, p609 - 612
Medina, C., Videla, S., Radomski, A., Radomski, M., Antolin, F., Guarner, F., Vilaseca, J., Salas, A., Malagelada, J.R, Therapeutic effect of phenanthroline in two rat models of inflammatory bowel disease. , Scandinavian Journal of Gastroenterology, 36, 2001, p1314 - 1319
C Medina, S Videla, A Radomski, MW Radomski, M Antolín, F Guarner, J Vilaseca, A Salas, JR Malagelada, UP-regulation of MMP-9 in an experimental model of ulcerative colitis, Gastroenterologia Hepatologia, IV Spanish Gastroenterology Association, Madrid, 2001
C Medina, S Videla, A Radomski, MW Radomski, M Antolín, F Guarner, J Vilaseca, A Salas, JR Malagelada, UP-regulation of MMP-9 in an experimental model of ulcerative colitis, Gastroenterologia Hepatologia, X Catalan Gastroenterology Association., Lloret de Mar, Spain, 2001
C Medina, R Fabra, J Vilaseca, JR Armengol, JR Malagelada, Clinical characteristics of patients with ischaemic colitis, Gastroenterologia Hepatologia, X Catalan Gastroenterology Association., Lloret de Mar, Spain, 2001
E Arcos, C Medina, F Mearin, J Larish, L Guarner, JR Malagelada, Achalasia Presenting as Acute Airway Obstruction, Digestive Diseases and Sciences, 10, 2000, p2079 - 2083
C Medina, M Vergara, F Casellas, J Naval, F Lara, JR Malagelada, Patient Assessment of the Long-Term Benefits of Surgery in Inflammatory Bowel Disease, Rev Clin Esp , 200, 2000, p470 - 474
C Medina, S Videla, MW Radomski, M Antolín, F Guarner, J Vilaseca, A Salas, JR Malagelada, Inhibition of MMPs prevents tissue injury and fibrotic complications in two rat models of IBD, Gastroenterologia Hepatologia, IX Catalan Gastroenterology Association, Tortosa, Spain, 2000
S Videla, C Medina, M Antolín, F Guarner, J Vilaseca, A Salas, JR Malagelada, Butiric acid enema prevents inflammation in DSS-induced colitis, Gastroenterologia Hepatologia, IX Catalan Gastroenterology Association, Tortosa, Spain, 2000
C Medina, T Molins, L Guarner, JR Malagelada, Cerebrovascular Accident as the Form of Presentation of a Pancreatic Cystadenocarcinoma: an Unusual Form of Presentation in a Rare Tumor, Gastroenterol Hepatol, 23, 2000, p132 - 134
C Medina, S Videla, MW Radomski, M Antolín, F Guarner, J Vilaseca, A Salas, JR Malagelada, Inhibition of MMPs prevents tissue injury and fibrotic complications in two rat models of IBD, Gastroenterology, American Gastroentorolgy Asociation, San Diego, USA, 2000
C Medina, R Fabra, J Vilaseca, JR Armengol, JR Malagelada, Clinical characteristics of pateients with ischaemic colitis, Gastroenterologia Hepatologia, XXVII Spanish Congress of Digestive Diseases, La Corunya, Spain, 2000
C Medina, M Vergara, F Casellas, J Naval, F Lara, JR Malagelada, Patient assessment of the long-term benefits of surgery in IBD, Gastroenterologia Hepatologia, XXV Spanish Society for Digestive Diseases, Oviedo, Spain, 1998
C Medina, M Vergara, F Casellas, J Naval, F Lara, JR Malagelada, Influence of the Smoking Habit in the Surgery of Inflammatory Bowel Disease, Rev Esp Enf Dig , 90, 1998, p771 - 774
X Fraga, M Vergara, C Medina, F Casellas, Bermejo, JR Malagelada, Effects of smoking on the presentation and clinical course of IBD, Gastroenterologia Hepatologia, V Catalan Gastroenterology Association, Gerona, Spain, 1997
C Medina, M Vergara, F Casellas, J Naval, F Lara, JR Malagelada, Effects of smoking habit in the surgery of IBD, Gastroenterologia Hepatologia, VI Catalan Gastroenterology Association, Andorra, 1997
JS Baudet, JR Armengol, C Medina, A Accarino, J Vilaseca, JR Malagelada, Percutaneous endoscopic gastrostomy as a treatment for chronic gastric, Endoscopy , 29, (2), 1997, p147 - 148
F Casellas, X Fraga, M Vergara, C Medina, Bermejo, JR Malagelada, Effects of smoking on the presentation and clinical course of IBD, Gastroenterologia Hepatologia, XXIV Spanish Society for Digestive Diseases, Sevilla, Spain, 1997
X Fernández, M Vergara, C Medina, F Casellas, L Bermejo, J-R Malagelada, Effects of smoking on the presentation and clinical course of inflammatory bowel disease , European Journal of Gastroenterology and Hepatology , 9, (7), 1997, p683 - 687
Non-Peer-Reviewed Publications
Santos-Martinez, M.J., Medina, C., Prina-Mello, A., Conroy, J., Samuels, S.P., Volkov, Y., Radomski, M.W., Nanobalance: a novel method for the measurement of flow-induced platelet aggregation, Nanomedicine: Seminar and Workshop, Centre for Research on Nanostructures and Nanodevices Trinity College Dublin, 29 June 2009, 2009
Corbalan, J.J., Medina, C., Radomski, M.W., Differential stimulation of inflammatory reactions by silica and poystyrene nanoparticles, Nanomedicine Seminar and Workshop, Centre for Research on Adaptive Nanostructures and Nanodevices Trinity College Dublin,, 29 June 2009, 2009
Radziwon, A., Medina, C., O'Driscoll, L., Radomski, M.W., Platelets inhibit drug chemotherapy-induced cancer apoptosis, Joint Schools of Pharmacy Research Seminar, Trinity College Dublin, 26-27 March 2009, 2009
Radziwon A, O'Dwyer R, Medina C, Radomski MW., Inhibition of platelet-stimulated matrix metalloproteinase-9 generation in Caco-2 cells by selective MAP kinase inhibitors., Conference All-Ireland Schools of Pharmacy, 2008
Santos-Martinez, M.J., Medina, C., Booth, J., Radomski, M.W., A novel method for the measurement of platelet aggregation under flow conditions using nanobalance., All-Ireland Schools of Pharmacy Research Seminar 2007, Dublin, Ireland, 2-3 April 2007, 2007
Hopkins, H., O'Brien, L., Radomska, A., Medina, C., Gilmer, J.F., Radomski, M.W., Inhibition of human platelet aggregation by a novel isosorbide-based aspirin analogue ISAS, All-Ireland Schools of Pharmacy Research Seminar 2007, Dublin, Ireland, 2-3 April 2007, 2007, pp23 - 23
Santos-Martinez, M.J., Medina, C., Radomska, A., Radomski, M.W., Clinician-scientist: a hobby for few, career prosepects for some and training for all practicioners? , Kardiochirurgia i Torakochirurgia Polska, 2, 2005, p17-19
J Gilmer, M Ledwige, P O'Flynn, S Harmon, MW Radomski, C Medina, 'Compounds with super-aspirin effects', European Patent Office, 20 January 2012
Research Expertise
Recognition
Representations
Member of organizing committee of All Ireland Schools of Pharmacy meeting which is held annually throughout the country.
REVIEWER FOR THE FOLLOWING FUNDING AGENCIES: Philip Morris External Research Program Award, USA; Inflammatory Bowel Disease Grants, The Broad Foundation, USA; ComGRAD grants, Canada.
REFEREE FOR THE FOLLOWING JOURNALS: Nanomaterials, Int J Nanomedicine, The Journal of Pathology, Journal of Leukocyte Biology, BBA-Molecular Cell Research, Journal of Experimental Pharmacology and Therapeutics, British Journal of Pharmacology, Neurogastrointestinal Motility, European Journal of Gastroenterology and Hepatology, Thrombosis Research, The Journal of Obstetrics and Gynaecology Research, European Journal of Obstetrics & Gynecology and Reproductive Biology.
Member of the Irish Platelet Working Group
Member of the Canary Gastroenterologist Association.
Memner of the Spanish Gastroenterologist Association
Member of Spanish Research Society in Ireland
Member of the Irish Association of Pharmacologists
Awards and Honours
SFI Stokes lectureship
Fellowship of Secretaria de Estado de Educacion y Universidades, Ministry of Education (MECD/Fulbright), Spain (EX2004-0396) to gain experience overseas
CRANN Innovation Award, TCD
Memberships
Irish Association of Pharmacologists
Spanish Research Society in Ireland
Irish Platelet Working Group
Spanish Gastroenterologist Association
Canary Gastroetnerologist Association