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Carlos Medina Martin
Assistant Professor, Pharmacy

Biography

Dr. Carlos Medina was born in Tenerife, Spain. After studying Medicine at University of La Laguna, he specialized in Gastroenterology at Vall d'Hebron Hospital, Barcelona and was consultant gastroneterologist at Hospital Universitario de Canarias, Tenerife. He obtained his PhD in Medicine from the Universitat Autonoma de Barcelona in 2004 studying new molecular targets in different experimental models of colitis. He conducted post-doctoral studies funded by the Spanish Ministry of Science and Education (MECD/Fulbright)at the Institute of Molecular Medicine, Texas Medical Center, Houston, focused on platelet-tumour cell interactions under the supervision of Prof Radomski. In 2007 he was appointed as Science Foundation Ireland Stokes lecturer in Pharmacology, School of Pharmacy, TCD. Presently he leads a pharmacology research group which has been mainly supported by SFI and Enterprise Ireland. His research is primarily focused on: 1) pharmacological treatments for gastrointestinal diseases including liver; 2) platelet-tumour cell interactions and 3) nanomedicine. Dr Medina has published more than 60 scientific articles and contributed to more than 55 posters and presentations at national and international conferences.

Publications and Further Research Outputs

Peer-Reviewed Publications

Abautret-Daly Á, Dempsey E, Riestra S, de Francisco-García R, Parra-Blanco A, Rodrigo L, Medina C, Connor TJ, Harkin A., Gut-brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease, Acta Neuropsychiatr, March 8, 2017, p1 - 22 Review Article, 2017 DOI

O'Sullivan S, Wang J, Pigott MT, Docherty N, Boyle N, Lis SK, Gilmer JF, Medina C, Inhibition of matrix metalloproteinase-9 by a barbiturate-nitrate hybrid ameliorates dextran sulphate sodium-induced colitis: effect on inflammation-related genes, British Journal of Pharmacology, 174, (7), 2017, p512 - 524 Journal Article, 2017 DOI

Abautret-Daly Á, Dempsey E, Riestra S, de Francisco-García R, Parra-Blanco A, Rodrigo L, Medina C, Connor TJ, Harkin A., Association between psychological measures with inflammatory and disease-related markers of inflammatory bowel disease, International Journal of Psychiatry & Clinical Practise, Mar 29, 2017, p1 - 10 Journal Article, 2017 DOI

Antithrombotic agents in, editor(s)Ignacio Lizasoain, MA Moro , Velazquez. Farmacologica clinica y basica, 2017, [MJ Santos-Martinez, MW Radomski, C Medina] Book Chapter, 2017

Umerska A, Paluch KJ, Santos-Martinez MJ, Medina C, Corrigan OI, Tajber L, Chondroitin-based nanoplexes as peptide delivery systems--Investigations into the self-assembly process, solid-state and extended release characteristics., European Journal of Pharmaceutics and Biopharmaceutics, 93, 2015, p242 - 253 Journal Article, 2015 TARA - Full Text DOI

E Dempsey, A Abautret-Daly, J Downing, A Harkin, C Medina, Evidence for central molecular changes and changes to neuronal activity in an animal model of inflammatory bowel disease, European Neuropsychopharmacology, 2015, 25, 2015, ppS233-S234 Conference Paper, 2015

E Dempsey, A Abautret-Daly, A Harkin, C Medina, N Docherty, Central neuroinflammation in inflammatory bowel disease: evidence for a central increase in iNOS enzyme in an animal model of colitis, European Neuropsychopharmacology, 25, 2015, ppS47-S47 Conference Paper, 2015

Santos-Martinez, M.J., Tomaszewski, K., Medina, C., Bazou, D., Gilmer, J.F., Radomski, M.W. , Pharmacological characterization of nanoparticle-induced platelet microaggregation using quartz crystal microbalance with dissipation: comparison with light aggregometry, International Journal of Nanomedicine, 10, 2015, p5107 - 5119 Journal Article, 2015 TARA - Full Text DOI

O'Sullivan S, Gilmer JF, Medina C, Matrix metalloproteinases in inflammatory bowel disease: an update, Mediators of Inflammation, 2015, p964131- Review Article, 2015 TARA - Full Text DOI

Samuel S., Santos-Martinez M., Medina C., Jain N., Radomski MW., Prina-Mello A., Volkov Y., CdTe quantum dots induce activation of human platelets: Implications for nanoparticle hemocompatibility, International Journal of Nanomedicine, 10, 2015, p2723-2734 Journal Article, 2015 DOI TARA - Full Text

Umerska A, Paluch KJ, Santos-Martinez MJ, Corrigan OI, Medina C, Tajber L, Self-assembled hyaluronate/protamine polyelectrolyte nanoplexes: synthesis, stability, biocompatibility and potential use as peptide carriers, Journal of Biomedical Nanotechnology, 10, (12), 2014, p3658 - 3673 Journal Article, 2014 TARA - Full Text DOI

Radziwon-Balicka A, Santos-Martinez MJ, Corbalan JJ, O'Sullivan S, Treumann A, Gilmer JF, Radomski MW, Medina C, Mechanisms of platelet-stimulated colon cancer invasion: role of clusterin and thrombospondin 1 in regulation of the P38MAPK-MMP-9 pathway., Carcinogenesis, 35, (2), 2014, p324 - 332 Journal Article, 2014 TARA - Full Text

Inkielewicz-Stepniak, I., Santos-Martinez, M.J., Medina, C., Radomski, M.W. , Pharmacological and toxicological effects of co-exposure of human gingival fibroblasts to silver nanoparticles and sodium fluoride, International Journal of Nanomedicine, 9, 2014, p1677 - 1678 Journal Article, 2014 DOI TARA - Full Text

O'Sullivan, S., Medina, C., Ledwige, M., Radomski, M.W., Gilmer, J.F, Nitric oxide-matrix metaloproteinase-9 interactions: Biological and pharmacological significance: NO and MMP-9 interactions, Biochimica et biophysica acta, 1843, (3), 2014, p603-617 Review Article, 2014 TARA - Full Text DOI

N Glezeva, M Santos-Martinez, C Watson, K Mcdonald, C Medina, J Gilmer, M Ledwidge, Inhibition of thromboxane pathways in monocytes impedes cell invasiveness, European Journal of Heart Failure, 16, 2014, pp208-209 Conference Paper, 2014

Santos-Martinez, M.J., Rahme, K., Corbalan, J.J., Faulkner, C., Holmes, J., Tajber, L., Medina, C., Radomski, M.W. , Pegylation increases platelet biocompatibility of gold nanoparticles. , Journal of Biomedical Nanotechnology, 10, 2014, p1004 - 1015 Journal Article, 2014

B Hall, G Holleran, S O'Sullivan, S Smith, B Ryan, C Medina, D McNamara, Crohn's disease in an irish population-A genotype-phenotype analysis , Journal of Crohn's and Colitis, 9th ECCO Conference, Denmark, 8, (S1), 2014, ppS345- Meeting Abstract, 2014 DOI

Wang, J., Radomski, M.W., Medina, C., Gilmer, J.F, MMP inhibition by barbiturate homodimers, Bioorganic and Medicinal Chemistry Letters, 23, 2013, p444 - 447 Journal Article, 2013 TARA - Full Text

S. Paul-Samuels, MJ Santos-Martinez, C Medina, N Jain, MW Radomski, A Prina-Mello, Y Volkov, . CdTe qunatum dots induce activation of human platelets. , American Journal of Medicine, Amerian Physician Scientists Association, Chicago, USA, , April 2013, 2013 Conference Paper, 2013

MJ Santos-Martinez, I Inkielewicz-Stepniaka, C Medina, K Rahme, DM D'Arcy, D Fox, JD Holmes, H Zhang, MW Radomski, The Use of Quartz Crystal Microbalance with Dissipation (QCM-D) for Studying Nanopaticle-Induced Platelet Aggregation., International Journal of Nanomedicine, 7, 2012, p243 - 255 Journal Article, 2012 TARA - Full Text

A. Abautret-Daly, N Murphy, N Docherty, C. Medina, T.J. Connor, A. Harkin, Behavioural changes in the DSS model of colitis are associated with long-term systematic anc central induction of iNOS in rats, Proceedings of Neuroscience Ireland, 7th Annual Meeting Neuroscience Ireland, 2012 Conference Paper, 2012

Radziwon-Balicka A, Medina C, O'Driscoll L, Treumann A, Bazou D, Inkielewicz-Stepniak I, Radomski A, Jow H, Sawicki G, Radomski MW., Platelets increase survival of adenocarcinoma cells challenged with anticancer drugs: mechanisms and implications for chemoresistance. , Brit. J. Pharmacol., 167, (4), 2012, p787 - 804 Journal Article, 2012 DOI TARA - Full Text URL

J Wang, S O'Sullivan, S Harmon, R Keaveney, MW Radomski, C Medina, JF Gilmer, DESIGN OF BARBITURATE-NITRATE HYBRIDS THAT INHIBIT MMP-9 ACTIVITY AND SECRETION, Journal Medicinal Chemistry, 55, (5), 2012, p2154 - 2162 Journal Article, 2012

ST Buckley, C Medina, AM Davies, C Ehrhardt, Cytoskeletal re-arrangement in TGF-beta1-induced alveolar epithelial-mesenchymal transition studied by atomic force microscopy and high-content analysis, Nanomed - Nanotechnol Biol Med, 8, (3), 2012, p355-364 Journal Article, 2012 TARA - Full Text DOI

Umerska A, Paluch KJ, Inkielewicz-Stępniak I, Santos-Martinez MJ, Corrigan OI, Medina C, Tajber L., Exploring the assembly process and properties of novel crosslinker-free hyaluronate-based polyelectrolyte complex nanocarriers, International Journal of Pharmaceutics, 436, (1-2), 2012, p75 - 87 Journal Article, 2012 TARA - Full Text URL DOI

Wang, J., O'Sullivan, S., Harmon, S., Keaveney, R., Radomski, M., Medina, C., Gilmer, J. , Design of barbiturate-nitrate hybrids that inhibit MMP-9 and secretion, Journal of Medicinal Chemistry, 55, 2012, p2154 - 2162 Journal Article, 2012 DOI

A. Abautret-Daly, C. Medina, T.J. Connor, A. Harkin, Altered peripheral, circulating and central tryptophan concentrations in the DSS model of colitis., Proceedings of Neuroscience Ireland , 7th Annual Meeting of Neuroscience Ireland, Dublin, September, 2012., 2012 Conference Paper, 2012

S Harmon, I Inkielewicz, M Jones, M Ledwidge, C Medina, MW Radomski, JF Gilmer, In Vitro Pharmacology of Aspirin Prodrugs in Human Platelets , J Pharm Pharmacol , 64, 2012, p77 - 89 Journal Article, 2012 TARA - Full Text

Medina C, Harmon S, Inkielewicz I, Santos-Martinez MJ, Jones M, Cantwell P, Bazou D, Ledwidge M, Radomski MW, Gilmer JF., Differential Inhibition of Tumor Cell-Induced Platelet Aggregation by Nicotinate Aspirin Prodrug (ST0702) and Aspirin., British Journal of Pharmacology, 166, (3 ), 2012, p938 - 949 Journal Article, 2012 DOI TARA - Full Text

JJ Corbalan, C Medina, A Jacoby, T Malinski, MW Radomski, Amorphus Silica Nanopartilces Aggregate Human Platelets: Potential Implications for Vascular Haemostasis., International Journal of Nanomedicine, 7, 2012, p631 - 639 Journal Article, 2012 TARA - Full Text

ST Buckley, C Medina, M Kasper, C Ehrhardt, Interplay between the receptor for advanced glycation end-products (RAGE), CD44 and focal adhesion molecules in epithelial-mesenchymal transition of alveolar epithelial cells, Am J Physiol Lung Cell Mol Physiol, 300, (4), 2011, pL548-L559 Journal Article, 2011 TARA - Full Text DOI

Santos-Martinez, M.J., Prina-Mello, A., Medina, C., Radomski, M.W. , Analysis of platelet function: role of microfluidics and nanodevices, Analyst, 136, 2011, p5120 - 5126 Review Article, 2011 DOI TARA - Full Text

C Ehrhardt, C Medina, AM Davies, ST Buckley, Novel tools for investigations of cytoskeletal re-arrangement during alveolar epithelial-mesenchymal transition, FASEB J, Experimental Biology Meeting 2011, Washington, DC, 09-13/04/2011, 25, 2011, pp856.2 Conference Paper, 2011

C Ehrhardt, C Medina, AM Davies, ST Buckley, Using atomic force microscopy and high-content analysis for investigations into cytoskeletal re-arrangement during TGF-β1-induced alveolar epithelial-mesenchymal transition, Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society 2011, Denver, CO, 13-18/05/2011, 183, 2011, ppA3501 Conference Paper, 2011

C Ehrhardt, C Medina, AM Davies, ST Buckley, The receptor for advanced glycation end-products (RAGE) interacts with focal adhesion molecules in epithelial-mesenchymal transition (EMT) of alveolar epithelial cells, Am J Respir Crit Care Med , eeting of the American Thoracic Society 2011, Denver, CO, 13-18/05/2011, 183, 2011, ppA3502 Conference Paper, 2011

Corbalan, J.J., Medina, C., Jacoby, A., Malinski, T., Radomski, M.W. , Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells - inflammatory and cytotoxicity effects. , International Journal of Nanomedicine, 6, 2011, p1 - 15 Journal Article, 2011 TARA - Full Text

C Ehrhardt, C Medina, ST Buckley, Interaction of RAGE with focal adhesion molecules during alveolar epithelial-mesenchymal transition, FASEB J, Experimental Biology Meeting 2011, Washington, DC, 09-13/04/2011, 25, 2011, pp865.1 Conference Paper, 2011

C Medina, MJ Santos-Martinez, A Santana, MC Paz-Cabrera, MJ Johnston, M Mourelle, A Salas, F Guarner, TGF-Beta Type 1 Receptor (ALK5) and SMAD Proteins Mediate TIMP-1 and Collagen Synthesis in Experimental Intestinal Fibrosis, Journal of Pathology, 224, 2011, p461 - 472 Journal Article, 2011

J Wang, C Medina, MW Radomski, JF Gilmer, N-subsituted homopiperazine barbiturates as gelatinase inhibitors, Bioorganic & Medicinal Chemistry, 19, (16), 2011, p4985-4999 Journal Article, 2011 TARA - Full Text

D Bazou, MJ Santos-Martinez, C Medina, MW Radomski, Elucidation of Flow Mediated TCIPA Using an Ultrasound Standing Wave Trap, British Journal of Pharmacology, 162, (7), 2011, p1577 - 1589 Journal Article, 2011 TARA - Full Text

Pharmacological significance of nanoparticles in, editor(s)Klaus D Sattler , Handbook of Nanophysics, CRC Press, 2010, [C Medina, MW Radomski] Book Chapter, 2010

A Abautret-Daly, C Medina, TJ Connor, A Harkin, Evidence of depression and anxiety related behavioural disturbances associated with activation of the kyneurine pathway and expression of hepatic tryptophan 2,3 dioxygenase in animal models of IBD., Brain, Behaviour and Immunity, FENS Forum, Amsterdam, July 2010, 2010 Conference Paper, 2010

ST Buckley, C Medina, C Ehrhardt, RAGE and ERM proteins in EMT of human alveolar epithelial cells, FASEB J, Experimental Biology Meeting 2010, Anaheim, CA, 24-28/04/2010, 24, 2010, pp612.21 Conference Paper, 2010

ST Buckley, C Medina, C Ehrhardt, Differential susceptibility to epithelial-mesenchymal transition (EMT) of alveolar, bronchial and intestinal epithelial cells in vitro and the effect of angiotensin II receptor inhibition, Cell Tissue Res, 342, (1), 2010, p39-51 Journal Article, 2010 DOI

A Abautret-Daly, C Medina, TJ Connor, A Harkin, Evidence of depression and anxiety related behavioural disturbances associated with the activation of the kyneurine pathway and expression of hepatic tryptophan 2,3 dioxygenase in an animal model of IBD, Brain, Behaviour and Immunity, Drugs & the brain workshops, Braga, 2010, 2010 Conference Paper, 2010

I Inkielewicz-Stepniak, J Gilmer, M Radomski, W Czarnowski, C Medina, The effect of new aspirin prodrugs on blood platelet and tumor cells in an 'in vitro'study, Toxicology Letters, XII International Congress of Toxicology, Barcelona, 196, 2010, ppS258-S259 Conference Paper, 2010

A Abautret-Daly, C Medina, TJ Connor, A Harkin, Behavioural disturbances observed in experimental colitis are associated with activation of the kyneurine pathway and expression of hepatic tryptophan 2,3 dioxygenase, Brain, Behaviour and Immunity, 17th Annual Meeting of The PsychoNeuroImmunology Research Society, Dublin, June 2010, 2010, ppS50 Conference Paper, 2010

A Abautret-Daly, C Medina, TJ Connor, A Harkin, Anxiety related behaviour in an animal model of experimental colitis is associated with a long-term systemic and central inflammatory response, Brain, Behaviour and Immunity, 17th Annual Meeting of The PsychoNeuroImmunology Research Society, Dublin, 24, 2010, ppS55 Conference Paper, 2010

ST Buckley, C Medina, C Ehrhardt, Investigations into the role of RAGE and ERM proteins in EMT of human alveolar epithelial cells, Acta Physiologica, Joint Meeting of the Scandinavian and German Physiological Societies, København, Denmark, 27-30/3/2010, 198, (S677), 2010, pp146 - 147 Conference Paper, 2010

ST Buckley, C Medina, C Ehrhardt, A role for RAGE and ERM proteins in EMT of human alveolar epithelial cells, Am J Respir Crit Care Med , Annual Meeting of the American Thoracic Society 2010, New Orleans, LA, 14-19/05/2010, 181, (1), 2010, ppA1234 Conference Paper, 2010

Santos-Martinez, MJ, Medina, C, Prina-Mello, A, Conroy, J, Samuels, SP, Volkov, Y, Radomski, MW, A nanoscale resolution assay of flow-induced platelet microaggregation, Kardiochirurgia i Torakochirurgia Polska, 7, (4), 2010, p365-375 Journal Article, 2010

RM Claramunt, L. Bouissane, MP Cabildo, MP Cornago, J Elguero, A Radziwon, C Medina, Synthesis and biological evaluation of curcuminoid pyrazoles as new therapeutic agents in inflammatory bowel disease: effect on matrix metalloproteinases., Bioorganic & Medicinal Chemistry, 17, (3), 2009, p1290-1296 Journal Article, 2009 DOI

ST Buckley, C Medina, C Ehrhardt, Characterisation of the role of inflammatory cytokines in EMT and cell migration in alveolar epithelial cells, Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society 2009, San Diego, CA, 15-20/05/2009, 179, (1), 2009, ppA5298 Conference Paper, 2009

A Radziwon, C Medina, L O'Driscoll, MW Radomski, Platelets inhibit drug chemotherapy-induced cancer cell apoptosis, 7th International Cancer Conference, Dublin, 2009 Conference Paper, 2009

ST Buckley, C Medina, C Ehrhardt, Effect of TGF-β1 and inflammatory cytokines on EMT and cell migration in alveolar epithelial cells, Acta Physiol , 88th Annual Meeting of the German Physiological Society, Giessen, Germany, 22-25/03/2009, 195, (S669), 2009, pp14 Conference Paper, 2009

ST Buckley, C Medina, C Ehrhardt, Assessment of the role of inflammatory cytokines in EMT and cell migration in alveolar epithelial cells, Eur Respir J, European Respiratory Society Annual Congress 2009, Wien, Austria, 12-16/09/2009, 22, (S53), 2009, pp582 Conference Paper, 2009

ST Buckley, C Medina, C Ehrhardt, The role of the receptor for advanced glycation end products (RAGE) in epithelial-mesenchymal transition in the lung: a potential therapeutic target, AAPS J, 23rd Annual Meeting of the AAPS, Los Angeles, CA, 08-12/11/2009, 11, (S2), 2009, ppW5006 Conference Paper, 2009

Jones, M., Inkielewicz, I., Medina, C., Santos-Martinzez, M.J., Radomski, M.W., Radomski, A., Lally, M.N., Moriarty, L.M., Gaynor, J., Carolan, C.G., Coyne, D., O'Byrne, P., Clancy, J.M., Gilmer, J.F. , Isosorbide-based aspirin prodrugs: integration of nitric oxide releasing groups. , Journal of Medicinal Chemistry, 52, (21), 2009, p6588-6598 Journal Article, 2009 DOI

Li, X., Radomski, A., Corrigan, O.I., Tajber, L., De Sousa Menezes, F., Endter, S., Medina, C., Radomski, M.W. , The Platelet Compatibility of Poly(lactide-co-glycolide) (PLGA), Chitosan and PLGA- Chitosan Nanoparticles, Nanomedicine, 4, 2009, p735 - 746 Journal Article, 2009 URL

ST Buckley, C Medina, C Ehrhardt, Characterisation of the role of inflammatory cytokines in EMT and cell migration in alveolar epithelial cells, FASEB J, Experimental Biology Meeting 2009, New Orleans, LA, 18-22/04/2009, 23, 2009, pp997.2 Conference Paper, 2009

Santos-Martinez MJ, Medina C, Gilmer JF, Radomski MW., Matrix metalloproteinases in platelet function: coming of age, Journal of Thrombosis and Haemostasis, 6, (3), 2008, p514 - 516 Review Article, 2008 DOI

Gilmer JF, Inkielewicz I, Jones M, Radomski A, Medina C, Santos Martinez MW, Radomski MW, Clancy JM, In vitro activation and platelet inhibition effects of the first true aspirin and nitro-aspirin prodrugs, Bioorganic Medicinal Chemistry, IBC's 13th Annual World Congress " Drug Discovery and Development of Innovative Therapeutics" August 4-7th 2008. , 2008 Conference Paper, 2008

Santos-Martínez MJ, Medina C, Jurasz P, Radomski MW., Role of metalloproteinases in platelet function, Thrombosis Research, 121, 2008, p535 - 542 Review Article, 2008

Medina, C., Gilmer, J. and Radomski, M.W., Matrix metalloproteinase-9 (MMP-9) as a therapeutic target for treatment of inflammatory bowel disease, Norgine, Harefield, U.K, 14 April 2008, 2008, Dr. M. Farrell Invited Talk, 2008

Radziwon A, O'Dwyer R, Medina C, Radomski MW., Inhibition of platelet-stimulated matrix metalloproteinase-9 generation in Caco-2 cells by selective MAP kinase inhibitors., 6TH International Cancer Conference, St. James's Hospital in Dublin., 2008 Conference Paper, 2008

L Bouissane, MP Cabildo, MP Cornago, RM Claramunt, J Elguero, C. Medina, Synthesis and biological evaluation of curcuminum pyrazoles as nex therapeutic agents in IBD, Bioorganic Medicinal Chemistry, Tetrahedron Symposium, Challenges in Organic & Bioorganic Chemistry., San Diego, USA, 2008 Conference Paper, 2008

Medina, C., Santos-Martinez, M.J., Radomski, A., Corrigan, O.I., Radomski, M.W., Nanoparticles: pharmacological and toxicological significance, British Journal of Pharmacology, 150, 2007 Review Article, 2007 TARA - Full Text DOI URL

S Videla, J Vilaseca, C Medina, M Mourelle, F Guarner, A Salas, J-R Malagelada, Modulatory Effect of NO on Mast Cells in DSS-Induced Colitis, Digestive Diseases and Sciences, 52, 2007, p45 - 51 Journal Article, 2007

S Videla, A Lugea, J Vilaseca, F Guarner, F Treserra, A Salas, E Crespo, C Medina, JR Malagelada, PEG Enhances Colonic Barrier Function and Ameliorates Experimental Colitis in Rats, International Journal of Colorectal Disease, 22, 2007, p571 - 580 Journal Article, 2007

A Santana, C Medina, MC Paz, F Díaz, E Farre, A Salas, MW Radomski, E Quintero, Attenuation of DSS-Induced Colitis in MMP-9 Deficient Mice, World Journal of Gastroenterology, 12, 2006, p6464 - 6472 Journal Article, 2006

M Menacho, Y Barrios, MC Paz-Cabrera, C Medina, A Pardo, E Salido, E Quintero, Inflammatory bowel disease and homocystinuria., Gastroenterologia Hepatologia, IX Spanish Gastroenterology Association, Madrid, 2006 Conference Paper, 2006

AZ Gimeno-García, A Santana, A Jiménez, A Parra-Blanco, D Nicolás-Pérez, C Paz-Cabrera, F Díaz-González, C Medina, L Díaz-Flores, E Quintero, UP-Regulation of Gelatinases in the Colorectal Adenoma-Carcinoma Sequence, European Journal of Cancer, Sept 12, 2006, pEpub ahead- Journal Article, 2006

D Alonso-Escolano, C Medina, K Cieslik, A Radomski, P Jurasz, MJ Santos-Martinez, P Ruvolo, MW Radomski, PKCä Mediates Platelet-Induced Breast Cancer Cell Invasion, Journal of Pharmacology Experimental therapeutics, 318, 2006, p373 - 380 Journal Article, 2006 TARA - Full Text

C Medina, A Santana, MC Paz-Cabrera, A Parra-Blanco, D Nicolas-Perez, Z Gimeno-Garcia, E Quintero, Increased Activity and Expression of Gelatinases in Ischemic Colitis, Digestive Diseases and Sciences, 51, 2006, p2393 - 2399 Journal Article, 2006

A Parra-Blanco, AZ Gimeno-García, D Nicolás- Pérez, C García, C Medina, L Díaz-Flores, B Grosso, A Jiménez, E Quintero, Risk for High-Grade Dysplasia or Invasive Carcinoma in Colorectal Flat Adenomas, Gastroenterol Hepatol, 29, 2006, p602 - 609 Journal Article, 2006

Medina, C., Santana, A., Paz, M.C., Diaz, F., Farre, E., Salas, A., Radomski, M.W., Quintero, E., Matrix metalloproteinase-9 modulates intestinal injury in rats with transmural colitis. , Journal of Leukocyte Biology, 79, 2006, p954 - 962 Journal Article, 2006 TARA - Full Text DOI URL

Medina, C., Jurasz, P., Santos-Martinez, M.J., Jeong, S.S., Mitzky, R., Chen, R., Radomski, M.W. , Platelet aggregation induced by Caco-2 cells: regulation by matrix metalloproteinase-2 and adenosine diphosphate, Journal of Pharmacology and Experimental Therapeutics, 317, (2), 2006, p739 - 745 Journal Article, 2006 URL DOI TARA - Full Text

Medina, C., Radomski, M.W, Role of Matrix Metalloproteinases in Intestinal Inflammation, Journal of Pharmacology and Experimental Therapeutics, 318, (3), 2006, p933-938 Review Article, 2006 DOI URL TARA - Full Text

AZ Gimeno-García, C Paz-Cabrera, E Salido, C Medina, A Jiménez, A Santana, A Parra-Blanco, D Nicolás, E Quintero, UP-regulation of MMP-9 in familiar adenomatous polyposis, Gastroenterologia Hepatologia, IX Spanish Gastroenterology Association, Madrid, 2006 Conference Paper, 2006

S Videla, J Vilaseca, C Medina, M Mourelle, F Guarner, A Salas, J-R Malagelada, Phosphodiesterase-IV Inhibition Prevents Chronic Colitis and Intestinal Fibrosis, Journal of Pharmacology Experimental Therapeutics , 316, 2006, p940 - 945 Journal Article, 2006

F Casellas, JI Arenas, S Baudet, S Fábregas, N García, J Gelabert, C Medina, I Ochotorena, M Papo, L Rodrigo, J-R Malagelada, Impairement of Health Related Quality of Life in Patients with Inflammatory Bowel Disease. A Spanish Multicenter Study., Inflammatory Bowel Disease , 11, 2005, p488 - 496 Journal Article, 2005

A Santana, C Medina, MC Paz Cabrera, F Diaz-Gonzalez, E Ferre, A Salas, MW Radomski, E Quintero. , Deletion of MMP-9 attenuates intestinal injury in DSS-induced colitis, Gastroenterologia Hepatologia, VIII Spanish Gastroenterology Association, Madrid, 2005 Conference Paper, 2005

A Santana, C Medina, MC Paz-Cabrera, F Diaz-Gonzalez, E Ferre, A Salas, MW Radomski, E Quintero, Deletion of MMP-9 attenuates intestinal injury in DSS-induced colitis, Gastroenterology, American Gastroentorolgy Asociation, Chicago, USA,, 2005 Conference Paper, 2005

C Medina, A Santana, M LLopis, MC Paz-Cabrera, M Antolin, F Guarner, J Vilaseca, M Mourelle, C Gonzalez, A Salas, E Quintero, JR Malagelada, Transmural Colonic Inflammation Induced by Bacteroides Fragilis: Implication of Matrix Metalloproteinases, Inflammatory Bowel Disease, 11 , 2005, p99 - 105 Journal Article, 2005

C Medina, A Santana, MC Paz-Cabrera, F Diaz-Gonzalez, E Quintero, UP-regulation of MMP-9 in a rat model of experimental colitis, Gastroenterologia Hepatologia, VII Spanish Gastroenterology Association, Madrid, 2004 Conference Paper, 2004

C Medina, J Vilaseca, S Videla, R Fabra, JR Armengol-Miró, JR Malagelada, Outcome of Patients with Ischemic Colitis: Review of Fifty Three Cases, Diseases of Colon and Rectum, 47 , 2004, p180 - 184 Journal Article, 2004

AZ Gimeno-García, A Santana, A Parra-Blanco, C Medina, D Nicolás-Pérez, MC Paz-Cabrera, F Díaz-Gonzalez, A Jiménez, L Díaz-Flores, E Quintero, UP-regulation of MMP-9 in adenomatous polyposis., Gastroenterology, American Gastroentorolgy Asociation, New Orleans, 2004 Conference Paper, 2004

AZ Gimeno, A Parra-Blanco, J Ortega, D Nicolás, C Medina, E Quintero, Colonic Dieulafoy Lesions Treated Endoscopically with Hemoclips, Diseases of Colon and Rectum, 47 , 2004, p1539 - 1943 Journal Article, 2004

F Casellas, JI Arenas, S Baudet, S Fabregas, N Garcia, J Galabert, C Medina, I Otxotorena, M Papo, L Rodrigo, JR Malagelada, Quality of life in inflammatory bowel disease: Spanish study, Gastroenterologia Hepatologia, LVIII Spanish Congress of Digestive Diseases, Valencia, 2004 Conference Paper, 2004

C Medina, A Santana, E Quintero, MW Radomski, F Guarner, Matrix Metalloproteinases in Gastrointestinal Disorders, Gastroenterol Hepatol , 27, 2004, p491 - 497 Review Article, 2004

C Medina, A Santana, MC Paz-Cabrera, F Diaz-Gonzalez, E Quintero. , UP-regulation of MMP-9 in a rat model of experimental colitis, Gastroenterology, American Gastroentorolgy Asociation, New Orleans, 2004 Conference Paper, 2004

AZ Gimeno-García, A Santana, A Parra-Blanco, C Medina, D Nicolás-Pérez, MC Paz-Cabrera, F Díaz-Gonzalez, A Jiménez, L Díaz-Flores, E Quintero, UP-regulation of MMP-9 in adenomatous polyposis., Gastroenterologia Hepatologia, VII Spanish Gastroenterology Association, Madrid, 2004 Conference Paper, 2004

C. Medina, M. Llopis, M. Antolín, S. Videla, F. Guarner, J. Vilaseca, R. Freire, C. I. Gonzalez, A. Salas, E. Quintero, J-R Malagelada, Implication of MMPs in transmural inflammation induced by bacteroides fragilis, Gastroenterology, American Gastroenterolgy Association, Orlando, USA, 2003 Conference Paper, 2003

C. Medina, M. Llopis, M. Antolín, S. Videla, F. Guarner, J. Vilaseca, R. Freire, A. Salas, E. Quintero, JR Malagelada, Implication of MMPs in transmural inflammation induced by bacteroides fragilis, Gastroenterologia Hepatologia, VI Spanish Gastroenterology Association., Madrid, 2003 Conference Paper, 2003

Medina, C., Videla, S., Radomski, A., Radomski M.W., Antolin, M., Guarner, F., Vilaseca, J., Salas, A., Malagelada, J.R. , Increased activity and expression of matrix metaloproteinase-9 in a rat model of distal colitis. , American Journal of Physiology, 284, (1), 2003, pG116 - G122 Journal Article, 2003 URL DOI

Gimeno, A. Parra, C. García, D. Nicolás, C. Medina, L. Diaz-Flores, E. Quintero, Prevalence of high grade dysplasia in flat adenomas., Gastroenterologia Hepatologia, VI Spanish Gastroenterology Association., Madrid, 2003 Conference Paper, 2003

C. Medina, M. Llopis, M. Antolín, S. Videla, F. Guarner, J. Vilaseca, R. Freire, A. Salas, E. Quintero, JR Malagelada, Implication of MMPs in transmural inflammation induced by bacteroides fragilis, Gastroenterologia Hepatologia, XII Catalan Gastroenterology Association., Lleida, Spain, 2003 Conference Paper, 2003

. Medina, Y. Barrios, M-C. Paz-Cabrera, M. Menacho, J-A Ortega-Sanchez, A. Jiménez, E. Salido, E. Quintero, Implication of MMP-9 genetic polymorphism on Crohn's disease behaviour, Gastroenterologia Hepatologia, XII Catalan Gastroenterology Association., Lleida, Spain, 2003 Conference Paper, 2003

Gimeno, A. Parra, C. García, D. Nicolás, C. Medina, L. Diaz-Flores, E. Quintero, Prevalence of high grade dysplasia in flat adenomas., European Journal of Gastroenterology, Association of National European and Mediterranean Societies of Gastroenterology, Madrid, 2003 Conference Paper, 2003

C. Medina, Y. Barrios, M-C. Paz-Cabrera, M. Menacho, J-A Ortega-Sanchez, A. Jiménez, E. Salido, E. Quintero, Implication of MMP-9 genetic polymorphism on Crohn's disease behaviour, Gastroenterologia Hepatologia, VI Spanish Gastroenterology Association., Madrid, 2003 Conference Paper, 2003

S Baudet, C Medina, J Andreu, J Vilaseca, JR Malagelada, Effect of Short-Term Octreotide Therapy and Total Parenteral Nutrition on Development of Biliary Sludge or Lithiasis, Hepatogastroenterology, 62 , 2002, p609 - 612 Journal Article, 2002

M Antolín, C Medina, A García-Lafuente, S Videla, F Guarner, J Vilaseca, A Salas, JR Malagelada, Anti-inflammatory effect of lactobacillus in DSS-induced colitis, Gastroenterologia Hepatologia, XI Catalan Gastroenterology Association, Reus, Spain, 2002 Conference Paper, 2002

M Antolín, C Medina, A García-Lafuente, S Videla, F Guarner, J Vilaseca, A Salas, JR Malagelada, Anti-inflammatory effect of lactobacillus in DSS-induced colitis, Gastroenterologia Hepatologia, V Spanish Gastroenterology Association, Madrid, 2002 Conference Paper, 2002

Medina, C., Videla, S., Radomski, A., Radomski, M., Antolin, F., Guarner, F., Vilaseca, J., Salas, A., Malagelada, J.R, Therapeutic effect of phenanthroline in two rat models of inflammatory bowel disease. , Scandinavian Journal of Gastroenterology, 36, 2001, p1314 - 1319 Journal Article, 2001

C Medina, S Videla, A Radomski, MW Radomski, M Antolín, F Guarner, J Vilaseca, A Salas, JR Malagelada, UP-regulation of MMP-9 in an experimental model of ulcerative colitis, Gastroenterologia Hepatologia, IV Spanish Gastroenterology Association, Madrid, 2001 Conference Paper, 2001

C Medina, S Videla, A Radomski, MW Radomski, M Antolín, F Guarner, J Vilaseca, A Salas, JR Malagelada, UP-regulation of MMP-9 in an experimental model of ulcerative colitis, Gastroenterologia Hepatologia, X Catalan Gastroenterology Association., Lloret de Mar, Spain, 2001 Conference Paper, 2001

C Medina, R Fabra, J Vilaseca, JR Armengol, JR Malagelada, Clinical characteristics of patients with ischaemic colitis, Gastroenterologia Hepatologia, X Catalan Gastroenterology Association., Lloret de Mar, Spain, 2001 Conference Paper, 2001

S Videla, C Medina, M Antolín, F Guarner, J Vilaseca, A Salas, JR Malagelada, Butiric acid enema prevents inflammation in DSS-induced colitis, Gastroenterologia Hepatologia, IX Catalan Gastroenterology Association, Tortosa, Spain, 2000 Conference Paper, 2000

C Medina, S Videla, MW Radomski, M Antolín, F Guarner, J Vilaseca, A Salas, JR Malagelada, Inhibition of MMPs prevents tissue injury and fibrotic complications in two rat models of IBD, Gastroenterology, American Gastroentorolgy Asociation, San Diego, USA, 2000 Conference Paper, 2000

C Medina, M Vergara, F Casellas, J Naval, F Lara, JR Malagelada, Patient Assessment of the Long-Term Benefits of Surgery in Inflammatory Bowel Disease, Rev Clin Esp , 200, 2000, p470 - 474 Journal Article, 2000

E Arcos, C Medina, F Mearin, J Larish, L Guarner, JR Malagelada, Achalasia Presenting as Acute Airway Obstruction, Digestive Diseases and Sciences, 10, 2000, p2079 - 2083 Journal Article, 2000

C Medina, T Molins, L Guarner, JR Malagelada, Cerebrovascular Accident as the Form of Presentation of a Pancreatic Cystadenocarcinoma: an Unusual Form of Presentation in a Rare Tumor, Gastroenterol Hepatol, 23, 2000, p132 - 134 Journal Article, 2000

C Medina, S Videla, MW Radomski, M Antolín, F Guarner, J Vilaseca, A Salas, JR Malagelada, Inhibition of MMPs prevents tissue injury and fibrotic complications in two rat models of IBD, Gastroenterologia Hepatologia, IX Catalan Gastroenterology Association, Tortosa, Spain, 2000 Conference Paper, 2000

C Medina, R Fabra, J Vilaseca, JR Armengol, JR Malagelada, Clinical characteristics of pateients with ischaemic colitis, Gastroenterologia Hepatologia, XXVII Spanish Congress of Digestive Diseases, La Corunya, Spain, 2000 Conference Paper, 2000

C Medina, M Vergara, F Casellas, J Naval, F Lara, JR Malagelada, Patient assessment of the long-term benefits of surgery in IBD, Gastroenterologia Hepatologia, XXV Spanish Society for Digestive Diseases, Oviedo, Spain, 1998 Conference Paper, 1998

C Medina, M Vergara, F Casellas, J Naval, F Lara, JR Malagelada, Influence of the Smoking Habit in the Surgery of Inflammatory Bowel Disease, Rev Esp Enf Dig , 90, 1998, p771 - 774 Journal Article, 1998

JS Baudet, JR Armengol, C Medina, A Accarino, J Vilaseca, JR Malagelada, Percutaneous endoscopic gastrostomy as a treatment for chronic gastric, Endoscopy , 29, (2), 1997, p147 - 148 Journal Article, 1997 DOI

C Medina, M Vergara, F Casellas, J Naval, F Lara, JR Malagelada, Effects of smoking habit in the surgery of IBD, Gastroenterologia Hepatologia, VI Catalan Gastroenterology Association, Andorra, 1997 Conference Paper, 1997

F Casellas, X Fraga, M Vergara, C Medina, Bermejo, JR Malagelada, Effects of smoking on the presentation and clinical course of IBD, Gastroenterologia Hepatologia, XXIV Spanish Society for Digestive Diseases, Sevilla, Spain, 1997 Conference Paper, 1997

X Fernández, M Vergara, C Medina, F Casellas, L Bermejo, J-R Malagelada, Effects of smoking on the presentation and clinical course of inflammatory bowel disease , European Journal of Gastroenterology and Hepatology , 9, (7), 1997, p683 - 687 Journal Article, 1997

X Fraga, M Vergara, C Medina, F Casellas, Bermejo, JR Malagelada, Effects of smoking on the presentation and clinical course of IBD, Gastroenterologia Hepatologia, V Catalan Gastroenterology Association, Gerona, Spain, 1997 Conference Paper, 1997

Non-Peer-Reviewed Publications

Santos-Martinez, M.J., Medina, C., Prina-Mello, A., Conroy, J., Samuels, S.P., Volkov, Y., Radomski, M.W., Nanobalance: a novel method for the measurement of flow-induced platelet aggregation, Nanomedicine: Seminar and Workshop, Centre for Research on Nanostructures and Nanodevices Trinity College Dublin, 29 June 2009, 2009 Poster, 2009

Radziwon, A., Medina, C., O'Driscoll, L., Radomski, M.W., Platelets inhibit drug chemotherapy-induced cancer apoptosis, Joint Schools of Pharmacy Research Seminar, Trinity College Dublin, 26-27 March 2009, 2009 Oral Presentation, 2009

Corbalan, J.J., Medina, C., Radomski, M.W., Differential stimulation of inflammatory reactions by silica and poystyrene nanoparticles, Nanomedicine Seminar and Workshop, Centre for Research on Adaptive Nanostructures and Nanodevices Trinity College Dublin,, 29 June 2009, 2009 Poster, 2009

Radziwon A, O'Dwyer R, Medina C, Radomski MW., Inhibition of platelet-stimulated matrix metalloproteinase-9 generation in Caco-2 cells by selective MAP kinase inhibitors., Conference All-Ireland Schools of Pharmacy, 2008 Meeting Abstract, 2008

Hopkins, H., O'Brien, L., Radomska, A., Medina, C., Gilmer, J.F., Radomski, M.W., Inhibition of human platelet aggregation by a novel isosorbide-based aspirin analogue ISAS, All-Ireland Schools of Pharmacy Research Seminar 2007, Dublin, Ireland, 2-3 April 2007, 2007, pp23 - 23 Oral Presentation, 2007

Santos-Martinez, M.J., Medina, C., Booth, J., Radomski, M.W., A novel method for the measurement of platelet aggregation under flow conditions using nanobalance., All-Ireland Schools of Pharmacy Research Seminar 2007, Dublin, Ireland, 2-3 April 2007, 2007 Oral Presentation, 2007

Santos-Martinez, M.J., Medina, C., Radomska, A., Radomski, M.W., Clinician-scientist: a hobby for few, career prosepects for some and training for all practicioners? , Kardiochirurgia i Torakochirurgia Polska, 2, 2005, p17-19 Review Article, 2005

J Gilmer, M Ledwige, P O'Flynn, S Harmon, MW Radomski, C Medina, 'Compounds with super-aspirin effects', European Patent Office, 20 January 2012 Patent, URL

Research Expertise

Keywords

CANCER; CROHN'S DISEASE; Genetics of inflammatory disease; GI Physiology; Inflammation; Inflammatory Bowel Disease; MATRIX METALLOPROTEINASES; Molecular basis to inflammation and innate immunity; ULCERATIVE COLITIS

Recognition

Representations

Member of organizing committee of All Ireland Schools of Pharmacy meeting which is held annually throughout the country.

REVIEWER FOR THE FOLLOWING FUNDING AGENCIES: Philip Morris External Research Program Award, USA; Inflammatory Bowel Disease Grants, The Broad Foundation, USA; ComGRAD grants, Canada.

REFEREE FOR THE FOLLOWING JOURNALS: Nanomaterials, Int J Nanomedicine, The Journal of Pathology, Journal of Leukocyte Biology, BBA-Molecular Cell Research, Journal of Experimental Pharmacology and Therapeutics, British Journal of Pharmacology, Neurogastrointestinal Motility, European Journal of Gastroenterology and Hepatology, Thrombosis Research, The Journal of Obstetrics and Gynaecology Research, European Journal of Obstetrics & Gynecology and Reproductive Biology.

Member of the Irish Platelet Working Group 2011

Member of the Canary Gastroenterologist Association. 2001

Memner of the Spanish Gastroenterologist Association 2001

Member of Spanish Research Society in Ireland 2017

Member of the Irish Association of Pharmacologists 2017

Awards and Honours

SFI Stokes lectureship 2008-2013

Fellowship of Secretaria de Estado de Educacion y Universidades, Ministry of Education (MECD/Fulbright), Spain (EX2004-0396) to gain experience overseas 2004-2006

CRANN Innovation Award, TCD 2010

Memberships

Irish Association of Pharmacologists 2017 – present

Spanish Research Society in Ireland 2017 – present

Irish Platelet Working Group 2011 – present

Spanish Gastroenterologist Association 2001 – present

Canary Gastroetnerologist Association 2001 – present


Last updated 9 September 2016 by School of Pharmacy & Pharmaceutical Sciences (Email).