Trinity College Dublin

Skip to main content.

Top Level TCD Links

Helen Sheridan
Associate Professor, Pharmacy

Biography

Dr Helen Sheridan; was educated in St. Paul's Secondary School in Greenhills Dublin - where her passion for science was fuelled by her inspirational teachers Sr. Elizabeth Walsh and Mr. Edward Mc. Donald. She completed her Ph. D in University College Dublin under another inspirational figure Professor DMX Donnelly. Helen was awarded a 'Royal Commission for the Exhibition of 1851' Overseas Fellowship for Postdoctoral research which was carried out at the Dyson Perrins laboratories at Oxford University under the direction of Professor Sir Jack Baldwin. Following further research periods at University College Dublin and the CNRS at Gif-sur-Yvette she was appointed as a lecturer in Natural Products Chemistry to the Department of Pharmacognosy, School of Pharmacy in Trinity College Dublin in 1985. She was appointed advisor to the 'National Drugs Advisory Board', now the 'The Irish Medicines Board' in 2000 and currently serves on the Traditional Herbal Medicinal sub-committee. She has undertaken original research in traditional medicine and development of new medicines using plants and cell cultures (plant, fungal and animal) for which she has received state funding. She has received funding (€12M) to support the development of novel anti-inflammatory and immunomodulatory compounds which are the subject of a number of patents. She is part of an international Sino-European consortium working to promote and support networking and coordination of research activities applying functional genomics in the context of Traditional Chinese Medicine (TCM). The consortium was awarded funding through EU-FP7 (co-ordination grant). Dr. Sheridan is Director of research at the School of Pharmacy and Pharmaceutical Sciences. She is Co-founder of Trino Therapeutics Ltd (formerly Pharmatrin Ltd.) a TCD campus company. Principal investors the Wellcome Trust, VC's and Enterprise Ireland.

Publications and Further Research Outputs

Peer-Reviewed Publications

Frankish, Neil; McHale, Brendan; Sheridan, Helen,, The indane diastereoisomers, PH2 and PH5: divergence between their effects in DTH models and a model of colitis" by F, Journal of Pharmacy and Pharmacology, 2017 Journal Article, 2017

Imran Nazir, Nisar ur Rahman, Zunaira Alvi, M. Hafizur Rahman, Jandirk Sendker, Tao Zhang, Neil Frankish, Helen Sheridan, Antidiabetic Activities of an LC/MS Fingerprinted Aqueous Extract of Fagonia cretica L. in Preclinical Models*, Planta Medica, 83, 2017, p1-9 Journal Article, 2017 DOI

History and current status of Herbal Medicines' in, editor(s): Heikki Vuorela, Pierre Duez, Pia Maarit Vuorela, and Olavi Pelkonen. , Toxicology of Herbal Products, Springer Science and Business Media, 2017, [2. Sendker J and Sheridan H: ] Book Chapter, 2017

Erick Motta, Marivane Lemos, Juliana C Costa, PhD. Vilmar C Banderó-Filho.; Astrid Sasse, Helen Sheridan, Jairo K Bastos, , Galloylquinic acid derivatives from Copaifera langsdorffii leaves display gastroprotective activity, Chemico-Biological Interactions, 261, 2017, p145-155 Journal Article, 2017

Composition and quality control of herbal medicines in, editor(s)Heikki Vuorela, Pierre Duez, Pia Maarit Vuorela, and Olavi Pelkonen , Toxicology of Herbal Products', Springer Science & Business Media. , 2017, [3. Sendker J and Sheridan H] Book Chapter, 2017

Kerstin Rieger, Rochelle H Holm, Helen Sheridan, Access to groundwater and link to the impact on quality of life: A look at the past, present and future public health needs in Mzimba District, Malawi, Groundwater for Sustainable Development, 2016, p117-129 Journal Article, 2016

Helen Sheridan, Brigitte Kopp, Liselotte Krenn, Dean Guo, Jandirk Sendker, Traditional Chinese herbal medicine preparation: invoking the butterfly effect, Science, 350, (6262), 2015, pS64-S66 Journal Article, 2015

Zhang, T., Paluch, K., Scalabrino, G., (...), Healy, A.-M., Sheridan, H. , Molecular structure studies of (1S,2S)-2-benzyl-2,3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol, Journal of Molecular Structure, 1083, 2015, p286-299 Journal Article, 2015 DOI

emos M, Silva JJM, Rogez HLG, Veneziani RCS, Ambrósio SR, Bastos JK, Banderó VC, Sasse A, Sheridan H, , Cytotoxic and apoptogenic properties of C. oblongifolia Mart. ex Hayne and C. duckei Dwyer oleoresin and leaf extract on human gastric carcinoma cells., Brazilian Society of Pharmacology and Experimental Therapeutics (SBFTE), Águas de Lindóia, São Paulo, Brazil, , September 28 to Octo, edited by Conference Committee , 2015 Conference Paper, 2015

N Frankish, H Sheridan -, 'COMPOUNDS FOR USE IN THE TREATMENT OF AUTOIMMUNE INFLAMMATORY DISEASE ', USPTO, 20,150,141,523,, 2015, Trino Therapeutics Ltd. Patent, 2015 URL

Bioactive naphthoquinones from higher plants. in, editor(s)Atta-ur-Rahman , STUDIES IN NATURAL PRODUCTS CHEMISTRY Volume 41, Elsevier B.V, 2014, pp119 - 160, [Hook, I., Mills, C and Sheridan H] Book Chapter, 2014 DOI

Helen Sheridan and Neil frankish, Venantius Ltd., Indane dimers for use in the treatment of autoimmune inflammatory disease, 2013, WO 2013/014660 A1 Patent, 2013 URL

Fatiha Brahmi, Naïma Guendouze, Helen Sheridan, Caroline Stevigny, Pierre Duez, Anh Tho Nguyen, Metabolic Classification Of Mentha Species By Nmr-Based Metabolomics, Journées internationales AFERP & STOLON , Bruxelles , 22-24 Mai 2013, 2013 Poster, 2013

SHERIDAN, Helen; (IE). FRANKISH, Neil; (IE), VENANTIUS LIMITED, INDANE DIMERS FOR USE IN THE TREATMENT OF AUTOIMMUNE INFLAMMATORY DISEASE, 2013, WO/2013/014660 Patent, 2013 URL

Astrid Sasse, Fabio Boylan and Helen Sheridan, Holistic Approaches to Health Maintenance in the B.Sc. Pharmacy. , 14th Biennial CSSI Conference. Mind, Body, Spirit - the holistic approach to the student experience, Dundalk. ireland, June 19-20 2013, 2013 Poster, 2013

Neil Frankish and Helen Sheridan, Venantius Ltd, INDANE DIMERS FOR USE IN THE TREATMENT OF AUTOIMMUNE INFLAMMATORY DISEASE, 2013, WO2013174916 Patent, 2013 URL

Tao Zhang, Vilmar Bandero, Tom McCabe, Neil Frankish and Helen Sheridan, 2-(Diphenylmethylidene)-2,3-dihydro-1H-inden-1-one, Acta Cryst. Section E, E69, 2013, po1306 - o1307 Journal Article, 2013 DOI

Chan K , Banderό V, Frankish N, Sheridan H . , . Inflammation, Cancer And 15- Lipoxygenase-1 - How Hot Is The Link? , London BioNat. , University of East London , March 12th 2013., 2013 Poster, 2013

Frankish N. and Sheridan H, 6-(Methylamino)hexane-1,2,3,4,5-pentanol 4-(((1S,2S)-1-Hydroxy-2,3-dihydro-1H,1'H-[2,2-biinden]-2-yl)methyl)benzoate (PH46A): A Novel Small Molecule With Efficacy In Murine Models Of Colitis, Journal of Medicinal Chemistry, 55, 2012, p5497 - 5505 Journal Article, 2012 DOI

Helen Sheridan, Liselotte Krenn, Renwang Jiang, Ian Sutherland, Svetlana Ignatova, Andreas Marmann, Xinmiao Liang, Jandirk Sendker, The potential of metabolic fingerprinting as a tool for the modernisation of TCM preparations, Journal of Ethnopharmacology, 140, (3), 2012, p482-491 Journal Article, 2012 DOI TARA - Full Text

Frampton C. S., Zhang T., Scalabrino G. A., Frankish N. and Sheridan H., (1S)-1-Phenyl ethanaminium 4-{[(1S,2S)-1-hydroxy-2,3-dihydro-1H,1′H-[2,2′-biinden]-2-yl] methyl} benzoate,, Acta Crystallographica. Section C, 2012, po323 - o326. Journal Article, 2012 DOI

Ta o Zha ng , Tom McCabe , Bartosz Marzec, Neil Frankish and Helen, N -Cyclopentyl- N -(3-oxo-2,3-dihy dro-1 H -inden-1-yl)acetamid, Acta Crystallographica, E68, 2012, p958- Journal Article, 2012 DOI

Sheridan H, Nestor C, O'Driscoll L, Hook I., Isolation, structure elucidation, and cytotoxic evaluation of furanonaphthoquinones from in vitro plantlets and cultures of Streptocarpus dunnii., J Nat Prod., 71, (1), 2011, p82 - 85 Journal Article, 2011 DOI TARA - Full Text URL

Sheridan, H. , Nestor, C., O'Driscoll, L., Hook, I., Isolation, structure elucidation, and cytotoxic evaluation of furanonaphthoquinones from in vitro plantlets and cultures of Streptocarpus dunnii, Journal of Natural Products, 74, (1), 2011, p82 - 85 Journal Article, 2011 DOI

Jandirk Sendker, Andreas Marmann, Liselotte Krenn, Helen Sheridan, Ian Sutherland, Svetlana Ignatova, Peter Proksch, Monique Simmonds, Robert Verpoorte, Alberto Dias, Valérian Bunel, You-Ping Zhu, Comprehensive report on the methodology used in the analysis of 'priority list preparations': Deliverable 2.10 of WP2 (FP7 GP-TCM) to European Commission, EU COmmission Brussels, EU, October, 2011, 1-24 Report, 2011

Frankish, N. de Sousa Menezes, F. Mills, C. Sheridan, H., Enhancement of insulin release from the beta-cell line INS-1 by an ethanolic extract of Bauhinia variegata and its major constituent roseoside, Planta Med, 76, (10), 2010, p995-7 Journal Article, 2010 DOI

H. Sheridan, N. H. Frankish, BRA101, A NOVEL SMALL MOLECULE WITH PROFOUND EFFICACY IN MURINE DSS-COLITIS, Gut, Gastro 2009, London, 21-25 November 2009, 58, (Suppl II), 2009, ppA454 Meeting Abstract, 2009

Sheridan H, Walsh JJ, Cogan C, Jordan M, McCabe T, Passante E, Frankish NH, Diastereoisomers of 2-Benzyl-2, 3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol: Potent anti-inflammatory agents, Bioorganic & Medicinal Chemistry Letters, 19, 2009, p5927 - 5930 Journal Article, 2009 DOI

E Passante, C Ehrhardt, H Sheridan, N Frankish, RBL-2H3 cells are an imprecise model for mast cell mediator release, Inflamm Res, 58, (9), 2009, p611-618 Journal Article, 2009 DOI

Sheridan, H. Walsh, J. J. Jordan, M. Cogan, C. Frankish, N, A series of 1, 2-coupled indane dimers with mast cell stabilisation and smooth muscle relaxation properties, Eur J Med Chem, 44, (12), 2009, p5018-22 Journal Article, 2009

Passante, E. Ehrhardt, C. Sheridan, H. Frankish, N., Toll-like receptors and RBL-2H3 mast cells, Inflamm Res, 58 , (Suppl 1), 2009, p11-2 Journal Article, 2009 DOI

SHERIDAN H, HOOK I, NESTOR C, ET AL, INHIBITION OF LFA-1 MEDIATED T-CELL MOTILITY BY NAPHTHOQUINONES , PLANTA MEDICA , 74 , (11 ), 2008, p1383 - 1387 Journal Article, 2008

Sheridan, H, Title, Bioorganic & medicinal Chemistry, 16 , 2008, p248 - 254 Journal Article, 2008

H Sheridan, I Hook, J Coppins, C Nestor, C Ehrhardt, N Frankish, Inhibition of LFA-1 mediated T-cell motility by naphthoquinones, Planta Med, 74, (11), 2008, p1383-1387 Journal Article, 2008 DOI

Minker C, O' Meara J, Visdal-Johnsen L, Hook I, Lobstein A , Sheridan H and Frankish N. , In vivo and in vitro evaluation of the anti-inflammatory activity of seven Plectranthus species. , Planta. Med., 73, 2007, pP074 - P074 Journal Article, 2007

J.Coppins, I. Hook, C. Nestor, H. Sheridan, N. Frankish, C. Ehrhardt., Inhibition of LFA-1 mediated T-cell motility by naphthoquinones, Royal Academy of Medicine in Ireland, Winter meeting, Dublin City University, 2007, 2007 Conference Paper, 2007

Fábio de Sousa Menezes, Andréa Barreto Mattos Minto, Halliny Siqueira Ruela, Ricardo Machado Kuster, Helen Sheridan, Neil Frankish, Hypoglycemic activity of two Brazilian Bauhinia species: Bauhiniaforfi cata L. and Bauhinia monandra Kurz., Brazilian Journal of Pharmacognosy, 17, ((1)), 2007, p8 - 13 Journal Article, 2007

H.Sheridan, N. Frankish and R. Farrell, Investigation into the mast cell stabilizing activity of nature identical and synthetic indanones, J. Pharmacy and Pharmacology, 56, (11), 2004, p1423 Journal Article, 2004

A.L. Simplício, J.F. Gilmer, N. Frankish, H. Sheridan, J.J. Walsh and J.M. Clancy, Ionisation characteristics and elimination rates of some aminoindanones determined by capillary electrophoresis, Journal of Chromatography A, 1045, (1-2), 2004, p233 - 238 Journal Article, 2004

I. Hook, S. Ryan and H. Sheridan, Biotransformation of aliphatic and aromatic ketones, including several monoterpenoid ketones and their derivatives by five species of marine micro-algae, Phytochemistry, 63, 2003, p31 - 36 Journal Article, 2003

Hook I, Ryan S, Sheridan H. , Biotransformation of aliphatic and aromatic ketones, including several monoterpenoid ketones and their derivatives by five species of marine microalgae, Phytochemistry, 63, (1), 2003, p31 - 36 Journal Article, 2003 DOI

Transgenic Leontopodium (Edelweiss) in, Y.P.S. Bajaj , Biotechnology in Agriculture and Forestry, Berlin, Heidelberg, Springer-Verlag, 2001, pp221-236. , [Hook I, Sheridan H.] Book Chapter, 2001

Essential oil production by transformed roots of Leontopodium alpinum Cass in, editor(s)Y.P.S. Bajaj , Biotechnology in Agriculture and forestry, "Transgenic crops lll" vol 48, Springer Verlag, 2001, pp221 - 236, [I. Hook and H. Sheridan] Book Chapter, 2001

Comer, N., Grey, A.I., Hook, I.L., James, P., Sheridan, H., Erratum: Sesquiterpenes from Leontopodium alpinum (Phytochemistry (1999) 50 (1057-1060) PII: S0031942298006256) , 2000, - 551 Miscellaneous, 2000

Hook I, Ryan S, Sheridan H. , Biotransformation of aromatic aldehydes by five species of marine microalgae, Phytochemistry, 51, (5), 1999, p621 - 627 Journal Article, 1999 DOI

Farrell, R., Frankish, N.H.., & Sheridan, H., Synthesis and antispasmodic activity of analogues of Natural pterosins, European Journal of Medicinal Chemistry, 34, 1999, p953 - 966 Journal Article, 1999

Comey N, Grey A, Hook I, James P, Sheridan H. , Sesquiterpenes from Leontopodium alpinum., Phytochemistry, 50, (6), 1999, p1057 - 1060 Journal Article, 1999 DOI

SHERIDAN, H, FRANKISH, N, FARRELL, R, SMOOTH MUSCLE RELAXANT ACTIVITY OF PTEROSIN Z AND RELATED COMPOUNDS, PLANTA MEDICA, 65, 1999, 271 - 272 Miscellaneous, 1999

HOOK, IL, RYAN, S, SHERIDAN, H, BIOTRANSFORMATION OF AROMATIC ALDEHYDES BY FIVE SPECIES OF MARINE MICROALGAE, PHYTOCHEMISTRY, 51, 1999, p621 - 627 Journal Article, 1999

SHERIDAN, H, FRANKISH, N, FARRELL, R, SYNTHESIS AND ANTISPASMODIC ACTIVITY OF ANALOGUES OF NATURAL PTEROSINS, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 34, 1999, p953 - 966 Journal Article, 1999

H. Sheridan, I. Hook and S. Ryan, Biotransformation of aromatic aldehydes by five species of marine microalgae, Phytochemistry, 51, 1999, p621 - 627 Journal Article, 1999

SHERIDAN, H, CANNING, AM, NOVEL RADICINOL DERIVATIVES FROM LONG-TERM CULTURES OF ALTERNARIA CHRYSANTHEMI, JOURNAL OF NATURAL PRODUCTS, 62, 1999, p1568 - 1569 Journal Article, 1999

Sheridan, H., Frankish, N. H. & Farrell, R, Smooth muscle relaxant activity of pterosin Z and related compounds, Planta Medica, 65, 1999, p271 - 272 Journal Article, 1999

Comey N, Hook I, Sheridan H, Walsh J. , Isolation of (S)-(-)-2,3-dihydro-2,6-dimethyl - 4H-benzopyran-4-one from roots of Leontopodium alpinum, Journal Of Natural Products (Lloydia) , 60, (2), 1997, p148-149 Journal Article, 1997 DOI

Comey N, Sheridan H, Hook I, Influence of inulin, culture medium and light on the growth and essential oil content of Edelweiss hairy roots., Proceedings of the 27th ISEO Meeting, 27th ISEO Meeting, Vienna, Allured Publishing Corporation, 1997, pp116-119 Conference Paper, 1997

FARRELL, R, KELLEHER, F, SHERIDAN, H, SYNTHESIS OF FERN SESQUITERPENE PTEROSIN Z VIA A NOVEL PALLADIUM-CATALYZED ROUTE, JOURNAL OF NATURAL PRODUCTS, 59, 1996, p446 - 447 Journal Article, 1996

Hook, I., & Comey, N. & Sheridan, H., Essential oil of Edelweiss, Leontopodium alpinum, 25th International Symposium on Essential Oils, Grasse., 1994 Conference Paper, 1994

"Papaver bracteatum", Lindley (Giant Scarlet Poppy) In vitro production of benzophenanthridine alkaloids in, editor(s)Y.P.S. Bajaj , Biotechnology of Medicinal and Aromatic Plants Part VII, Springer Verlag, 1994, pp346 - 365, [I. Hook, R. Lecky and H. Sheridan] Book Chapter, 1994

N. Comey, I. Hook and H. Sheridan, Enhancement of anthocyanin production in cell cultures and hairy roots of L. alpinum, Planta medica, 58, (1), 1992 Journal Article, 1992

Comey, N., Hook, I., Sheridan, H., Enhancement of anthocyanin production in cell cultures and hairy roots of Leontopodium alpinum , Planta Medica , 58, ((7 SUPPL.)), 1992, A605-A606 Journal Article, 1992

HOOK, I, SHERIDAN, H, WILSON, G, VOLATILE METABOLITES FROM SUSPENSION-CULTURES OF TARAXACUM-OFFICINALE, PHYTOCHEMISTRY, 30, 1992, p3977 - 3979 Journal Article, 1992

H. Sheridan, A. M. Canning and P. James, Stereoselective reduction of radicinin by liquid cultures of Alterneria longipes, J. Nat. Prod., 55, (7), 1992, p986 Journal Article, 1992

SHERIDAN, H, BHANDARI, P, CATHIN-6-ONE FROM THE ROOT BARK OF PHELLODENDRON-CHINENSE, PLANTA MEDICA, 58, 1992, 299 - 299 Miscellaneous, 1992

Canning A-M, Hook I, Sheridan H. , Bisradicinin: a novel dimmer elicited in cultures of Alternaria chrysanthemi, Journal Of Natural Products (Lloydia) , 55, (4), 1992, p487 - 490. Journal Article, 1992

H. Sheridan, R. Lecky and I. Hook, Enhancement of dihydrosanguinarine production by suspension cultures of Papaver bracteatum 1. Medium modification, J. Nat. Prod., 55, (10), 1992, p1513 Journal Article, 1992

H.Sheridan, A. M. Canning, I. Hook, P. James and D. Kelly, Bis-Radicinin: a novel dimer elicited in cultures of Alternaria chrysanthemi, J. Nat. Prod., 55, (4), 1992, p487 Journal Article, 1992

Lecky R, Hook I, Sheridan H., Enhancement of dihydrosanguinarine production in suspension cultures of Papaver bracteatum, I Medium modifications, Journal Of Natural Products (Lloydia) , 55, (10), 1992, p1513 - 1517 Journal Article, 1992

J. Baldwin, M. Bradley, N.Turner, R. Adlington, A. Pitt and H. Sheridan, α-L-_-Aminoadipoyl-L-cysteinyl-D-allylglycine, and eight deuterated analogues, substrates for the investigation of the mechanism of action of isopenicillin N synthetase, Tetrahedron, 47, (38), 1991, p8203 - 8222 Journal Article, 1991

Hook I, Sheridan H, Wilson G., Volatile metabolites from suspension cultures of Taraxacum officinale, Phytochemistry , 30, (12), 1991, p3977 - 3979 Journal Article, 1991 DOI

I. Hook, G. Wilson and H.Sheridan, Volatile metabolites from suspension cultures of Taraxacum officinale, Phytochemistry, 30, (12), 1991, p3977 Journal Article, 1991

BHANDARI, P, SHERIDAN, H, PRENYLATED FLAVONOIDS OF PHELLODENDRON-CHINENSE, PROCEEDINGS OF THE ROYAL IRISH ACADEMY SECTION B-BIOLOGICAL GEOLOGICAL AND CHEMICAL SCIENCE, 89, 1990, p91 - 96 Journal Article, 1990

H Sheridan, S Lemon, N Frankish, P Mcardle, T Higgins, JP James, P Bhandari , Synthesis and Antispasmodic Activity of Nature Identical Substituted Indanes and Analogues, European Journal of Medicinal Chemistry, 25, (7), 1990, p603 - 608 Journal Article, 1990

Hook I, Lecky R, McKenna B, Sheridan H., Biotransformation of linalyl acetate by suspension cultures of Papaver bracteatum, Phytochemistry, 29, (7), 1990, p2143 - 2144 Journal Article, 1990 DOI

Hook, I., Sheridan, H., Wilson, G., Volatile metabolites with 'apple' odour from suspension cultures of Taraxacum officinale , Planta Medica, 56, (6), 1990, p627-628 Journal Article, 1990 DOI

HENNESSY, D, HOOK, I, SHERIDAN, H, MCGEE, A, HYDROXYCINNAMIC ACID-ESTERS FROM CELL-SUSPENSION CULTURES AND PLANTS OF LEONTOPODIUM-ALPINUM, PHYTOCHEMISTRY, 28, 1989, p489 - 490 Journal Article, 1989

HOOK, I, SHERIDAN, H, WILSON, G, ALKALOIDS OF CELL-CULTURES DERIVED FROM STRAINS OF PAPAVER-BRACTEATUM, PHYTOCHEMISTRY, 27, 1988, p2137 - 2141 Journal Article, 1988

Neoflavanoids in, editor(s)J.B. Harborne and T.J. Mabry , Flavanoids: Advances in Research. Vol. 2, Chapman and Hall, 1988, pp211 - 232, [D.M.X. Donnelly and H. Sheridan] Book Chapter, 1988

Hook I, Sheridan H, Wilson G., Alkaloids of cell cultures derived from strains of Papaver bracteatum, Phytochemistry, 27, (7), 1988, p2137 - 2141 Journal Article, 1988 DOI

Dervilla MX Donnelly, Joseph O'Reilly, Judith Polonsky, M Helen Sheridan, In vitro production and biosynthesis of fomajorin D and S by Fomes annosus (Fr.) Cooke, Journal of the Chemical Society, Perkin Transactions 1, 1987, p1869-1872 Journal Article, 1987

Hook, I., Hennessy, D. & Sheridan, H., Tissue culture of L. alpinum, Gesellschaft fur Arzneipflanzeforschung,, Leiden, 1987 Conference Paper, 1987

D. Hennessy, I. Hook and H. Sheridan, Hydroxycinnamic esters in tissue cultures of "Leontopodium alpinum", Pharmaceutisch Weekblad Scientific Ed., 21, 9, (4), 1987, p217 Journal Article, 1987

H. Sheridan and D.M.X. Donnelly, Anthraquinones from Trichoderma polysporum, Phytochemistry, 25, (10), 1986, p2302 Journal Article, 1986

H. Sheridan and D.M.X. Donnelly, Biosynthesis of Fomajorin D". Incorporations of [1- 13 C], [2- 13 C] and [1, 2- 13 C 2 ]-acetates", J.C.S. Chem. Commun., 1983, p615 Journal Article, 1983

Non-Peer-Reviewed Publications

Helen Sheridan , Exploration of the feasibility of setting up the Trinity (or Irish) - Natural Product Foundation (Trinity-NPF of I-NPF) within TCD., CF-2017-0569Y. , Enterprise Ireland, 2017 Report, 2017

Shanahan, F., Michael heinrich, Sasse, A, Sheridan, H., Traditional Medicinal Knowledge in Ireland in the 1930s - Exploring Botanical Treatments. , 58th Annual Meeting of the Society of Economic Botany. L, Braganca, Portugal, 5th June 2017, edited by Conference Committee , 2017 Conference Paper, 2017

Neil Frankish and helen Sheridan, 'Compounds for use in the treatment of inflammatory Bowel Disease', USP, 9,586,885 B2, 2017, Venantius Ltd. Patent, 2017 URL

Frankish N, Sheridan H , 'Compounds for use in the treatment of autoimmune inflammatory disease;.', European patent office, 2864279 B1, 2016, Venantius Ltd. Patent, 2016 URL

Shanahan, F., Sasse, A, Sheridan, H. , An Ethnomedicinal Study of Traditional Plant Remedies of Co. Wexford, Ireland in the 1930s. , 38th All Ireland Schools of Pharmacy Research Conference. , Royal College of Surgeons, Dublin 2. , 21st March 2016, 1, 2016, P1- Conference Paper, 2016

Helen Sheridan and Ciara Smyth, Identification of extracts (and compounds) that could be derived from new plant species, grown in Ireland. An overview of species, market and potential partners who have processing experience, Enterprise ireland 1V-2012-3242., 2014 Report, 2014

Nazir, I., Rahman, N., Chan, K., Frankish, N., Sheridan, H, Ethnobotanical Study of Antidiabetic Plants of Cholistan Desert, District Bahawalpur, Pakistan, London BioNat, University of East London. UK, March 12th 2013., 2013 Poster, 2013

Neil Frankish and Helen Sheridan, Trino Therapeutics Ltd, 2011 Campus Company, 2011 URL

Jandirk Sendker, Andreas Marmann, Liselotte Krenn, Helen Sheridan, Ian Sutherland, Svetlana Ignatova, Peter Proksch, Monique Simmonds, Robert Verpoorte, Alberto Dias, Valérian Bunel, You-Ping Zhu , Deliverable 2.10 of WP2 (FP7 GP-TCM) to European Commission., 2011/10/17, 2011 Dataset, 2011 URL

E Passante, C Ehrhardt, H Sheridan, N Frankish, Effect of novel indanes on the degranulation of rat basophilic leukemia mast cells (RBL-2H3), FASEB J, Experimental Biology Meeting 2007, Washington, DC, 28.04.-02.05.2007, 21, (5), 2007, pp574.9 Meeting Abstract, 2007

H. Sheridan, Indane compounds and their pharmaceutical use, 2002, US6433021 Patent, 2002

H. Sheridan, Indane dimer compounds with smooth muscle relaxing and/or mast cell stabilizing and/or anti-inflammatory activity, 2002, US-09/092,903, EP-96942551 Patent, 2002

H. Sheridan, Indane dimer compounds and their pharmaceutical use; respiratory and anti-inflammatory, 2002, PCT/IE 96/00080. US-09/093,060, EP-96942550 Patent, 2002

H. Sheridan, Indane compounds with smooth muscle relaxing and/or mast cell stabilizing and/or anti-inflammatory activity, 2002, US-09/092.902, EP-96942552 Patent, 2002

H. Sheridan, Indane dimer compounds with smooth muscle relaxing and/or mast cell stabilising and/or anti-inflammatory activity, 2002, US6423752 Patent, 2002

Hook, I., Comey, N. & Sheridan, H., Phytochemical evaluation of roots from cultivated L alpinum, Irish Botanists Meeting, University College Dublin, 2001 Conference Paper, 2001

Hook, I., Comey, N. & Sheridan, H., Effect of inulin as carbon source on growth and essential oil content of Edelweiss hairy roots, 27th International Symposium on Essential Oils, Vienna, Austria, 1996 Conference Paper, 1996

Hook, I., Comey, N., James, P. & Sheridan, H., A 2,3- dihydrochromone from the essential oil of edelweiss, Royal Society of Chemistry (TCD Meeting) Drugs from Natural Products. , Trinity College Dublin, 1994 Conference Paper, 1994

Hook, I., Comey, N. & Sheridan, H., Essential oil from roots of Edelweiss, Leontopodium alpinum, 23rd International Symposium on Essential Oils, Ayr, Scotland, 1992 Conference Paper, 1992

Hook, I. Ryan, S. & Sheridan, H., Biotransformation of exogenous organic substrates by marine microalgae, European Marine Biology Symposium, Trinity College Dublin, 1992 Conference Paper, 1992

Hook, I., Sheridan, H. & Waldren, S., Preliminary phytochemical evaluation of Nesocodon mauritianus, Irish Botanists Meeting, University College Dublin, 1991 Conference Paper, 1991

Hook, I. & Sheridan, H., Tissue culture and micropropagation of the fern Onychium japonicum, Plant Biotechnology-Dublin Group meeting , Maynooth, Ireland, 1991 Conference Paper, 1991

Hook, I., Sheridan, H. & Wilson, G., Production of volatile metabolites by tissue cultures of Taraxacum officinale, Gesellschaft fur Arzneipflanzeforschung, Bonn, 1990 Conference Paper, 1990

Hook, I., Lecky, R. & Sheridan, H., Biotransformation of exogenously applied terpenes by cell suspension culture of P bracteatum, Irish Botanists Meeting , Trinity College Dublin, 1989 Conference Paper, 1989

Hook, I., Lecky, R. & Sheridan, H., Biotransformation of substrates by plant cell cultures, Plant Biotechnology - Dublin Group meeting , Trinity College Dublin, 1988 Conference Paper, 1988

Hook, I., Lecky, R. & Sheridan, H., Biotransformation of exogenously applied substrates by cell suspension cultures of P bracteatum, SEB International Symposium, King's College London, Phytochemical Society of Europe, 1988 Conference Paper, 1988

Research Expertise

Description

My research has always been multidisciplinary built on collaboration with pharmacologists, molecular biologists, biotechnologists and botanists, and is recognised at a national and inter-national level. I believe interdisciplinary research is the key requirement for Novel Drug Discovery, where a range of expertise is required to bring therapeutic discoveries from concept to execution. My post-graduate students have benefitted from this approach, learning early in the process, to work in a team with joint, or multiple supervisors, at the interface of many areas of expertise. I am not afraid to lead in this area, and believe that multi-component therapeutics from natural sources will be in use clinically, globally, in my lifetime. This is why I have engaged with the International, Multidisciplinary TCM Consortium establishing good practice (GP-TCM) and gold standards for quality, safety and efficacy of these complex medicines, as determined by 2004/24/EC. Ireland and TCD need to be involved in the critical mass of this complex Drug Discovery platform. One of my core research and teaching beliefs is that 'it is at the interface of disciplines and expertise that new ideas and creativity emerge'. Due to my research led teaching in Natural Products Chemistry, the interdisciplinary nature of this area is constantly underlined at all levels. . Multidisciplinary approach to drug discovery and development. . The use of plants and cell cultures (plant, fungal and animal), for the discovery of novel bio-active materials. . Preparation of novel anti-inflammatory, anticancer, and immunomodulatory compounds by chemical and biological means. . Traditional Chinese Medicine (TCM). Overview the best practice methodology, recommend applications, and future directions for metabolic profiling, component analysis and purification of secondary metabolites in preparations utilised in Traditional Chinese Medicine. . Traditional Herbal Medicines. Collaborative analysis of Bioactive Brazilian and Pakastini plant species. . Co-founder of Trino Therapeutics (Formerly Pharmatrin ltd), a TCD campus company whose activities are centered on drug discovery/development. . Finding new therapies targeted at diseases with unmet clinical need. . Drug discovery from the natural world, inspired by Ethnopharmacology . Drug discovery and optimised production:- plants; fungi; marine species. Use of biotechnology to modify biosynthesis and to generate biomass . Utilising metabolomic techniques to establish best practice for the determination of quality, safety and efficacy of herbal medicines for human and veterinary use. . Global health in a Development context: Impact on Health. (Rwanda, Malawi, Kenya).

Projects

  • Title
    • Novel indanes as potential therapies for auto-immune disease
  • Summary
    • Novel indane compounds for the treatment of IBD. From Discovery to Phase 1 Human Trials.
  • Funding Agency
    • Wellcome Trust; Venture capital; Trino Therapeutics Ltd
  • Date From
    • 1999
  • Date To
    • December 2016
  • Title
    • Investigation into Mechanism of action of PH46A
  • Summary
    • Using Molecular biology and High resolution NMR to investigate molecular mechanism of action of the anti inflammatory clinical candidate PH46A
  • Funding Agency
    • Trino Therapeutics Ltd (Industry)
  • Date From
    • December 2015
  • Date To
    • December 2016
  • Title
    • A novel indane scaffold with potential anti-inflammatory agents.
  • Summary
    • Inflammatory bowel disease (IBD) consists of two major forms, Crohn's disease (CD) and ulcerative colitis (UC). Both chronic inflammatory disorders follow a complex interaction of multiple factors in the pathogenesis n IBD. During the last two decades, development of new IBD drugs has expanded the therapeutic options for IBD patients. However, the number of failed therapies especially biologic drugs is noticeably high. There is still a clear gap in addressing this unmet need to improve the treatment of IBD. Development of small molecule drugs (SMDs) have recently resurfaced with new therapeutic agents at various clinical development stages. The discovery of PH46A, a novel first in class, dimeric indane with two chiral centres originated from this research group and has recently completed a Phase I, single ascending dose double-blind, randomized, placebo-controlled study for the treatment of IBD. The scaffold of PH46A incorporates the indane skeleton and is the N-glucamine salt of a single enantiomer PH46 of this novel drug. The current study focusses on two themes: (1) The pharmacological evaluation of PH46 to define a clearer understanding of the mechanism of its molecular action. (2) In addition, we have designed an exciting new indane scaffold. Pharmacological evaluations to characterise the structural activity relationships (SARs) of this group of novel indanes in in vitro and in vivo models have resulted in the discovery of a NOVEL group of molecules with potent IL6 inhibitory properties. These molecules are undergoing further evaluation.
  • Funding Agency
    • Trino Therapeutics Ltd (Industry)
  • Date From
    • 2015
  • Date To
    • 2017
  • Title
    • Traditional Chinese medicine research in the post-genomic era: Good practice,priorities, challenges and opportunities
  • Summary
    • P-TCM is the 1st EU-funded Coordination Action consortium dedicated to tradi-tional Chinese medicine (TCM) research. This paper aims to summarise the objectives, structure andactivities of the consortium andintroduces the position of the consortium regarding good practice,priorities, challenges and opportunities in TCM research. Serving as the introductory paper for the GP-TCM Journal of Ethnopharmacology special issue, this paper describes the roadmap of this special issueand reports how the main outputs of the ten GP-TCM work packages are integrated, and have led toconsortium-wide conclusions
  • Funding Agency
    • EU
  • Date From
    • 2008
  • Date To
    • 2012
  • Title
    • Effect of novel indanes on mast cell function
  • Summary
    • Novel synthetic indanes will be investigated on mast cell function and degrnaulation using harvested peritoneal mast cells, and mast cell lines such as RBL-3H3 and LAD2. Mediators studied will include histamine, cytokines etc.
  • Funding Agency
    • Enterprise Ireland and Trino Therapeutics Ltd
  • Date From
    • 2005
  • Date To
    • 2008
  • Title
    • Novel neuroprotective agents for the treatment of Parkinsons disease and other neurodegenerative disorders
  • Summary
    • Parkinsons disease, with worldwide distribution, is a neurodegenerative disorder with symptoms of tremor, akinesia and rigidity. As part of an ongoing study we have identified a series of compounds with neuroprotective and neuroregenerative properties. We are investigating these molecules as a novel disease-modifying therapy for this important class of diseases
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2008
  • Date To
    • 2009

Keywords

ALTERNATIVE MEDICINE; Antiinflammatory drugs; Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis); Biotransformation; Chemical Biology; Development of drugs for malaria, Cancer and inflammatory diseases; Drug discovery; Fungi; Herbal medicine; In Vitro Testing, Trial Methods; Indanes, indanones, muscel, nast cell stabilisation, immunosuppressants; Inflammation; Inflammatory Bowel Disease; Medicinal plants; Multiple Sclerosis; Natural Product Chemistry; Organic chemistry; Over-the-Counter Drugs; Pharmacognosy; Phytochemical and pharmacological evaluations of native and foreign plants; Phytomedicines; Plant and algal cell monocultures; Secondary plant metabolism; The use of cell cultures for the discovery of novel drugs; Traditional and Indigenous health systems in developing countries; Traditional Chinese Medicine

Recognition

Representations

Appointed to the Health Products Regulatory Authority (HPRA) Herbal Medicines Sub-Committee 2006 to date

Irish Medicines Board Traditional Herbal Medicinal Products Ad Hoc sub-committee. 2003 - 2006

Youth Science committee of the Royal Dublin Society 1990-1992

Appointed external examiner to taught postgraduate masters programmes at the School of Pharmacy. University College London. 2014-2017

Awards and Honours

Department of Education Post Doctoral Fellowship (UCD). 1984-1985

"1851 Overseas Traveling Scholarship". 1983-1984

French Government research Award - CNRS. Gif-Sur-Yvette 1983

RIA Travelling award 1990

NBST Young Researcher award with Dr. Hector Rubelcava (UCD) 1979

Travel awards: British Council 1991

Wellcome Trust Strategic Translation Award (co-PI) 2013


Last updated 9 September 2016 by School of Pharmacy & Pharmaceutical Sciences (Email).