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Carsten Ehrhardt
Associate Professor, Pharmacy

Biography

Dr. Carsten Ehrhardt is Associate Professor in Pharmaceutics and Pharmaceutical Technology at the School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin. In addition, he is holding the position of Adjunct Associate Professor in the School of Pharmacy, University of Southern California. He was elected Fellow of Trinity College Dublin in 2013. Carsten has obtained his Ph.D. degree in Biopharmaceutics from Saarland University in 2003. His research is focused on lung drug disposition, pulmonary epithelial transport and molecular origins of airways disease. He has edited 1 book and (co-)authored 81 peer-reviewed publications, 11 book chapters and more than 230 abstracts and conference proceedings. Carsten has given over 120 invited oral presentations at research institutions, international conferences and workshops. He is a member of Gesellschaft für Wehrmedizin und Wehrpharmazie (VdSO), Deutsche Pharmazeutische Gesellschaft (DPhG), American Association of Pharmaceutical Scientists (AAPS), International Society for Aerosols in Medicine (ISAM), American Physiological Society (APS) and Japanese Society for the Study of Xenobiotics (JSSX). Carsten is the proud recipient of honours and awards from DPhG, APS and Galenus Foundation. He actively serves on the Editorial Boards of the American Journal of Physiology - Lung Cellular and Molecular Physiology, Drug Delivery Letters, Journal of Aerosol Medicine and Pulmonary Drug Delivery, Journal of Pharmaceutical Sciences and European Journal of Pharmaceutics and Biopharmaceutics.

Publications and Further Research Outputs

Peer-Reviewed Publications

S Nickel, MA Selo, J Fallack, H Huwer, N Schneider-Daum, CM Lehr, C Ehrhardt, Expression and activity of breast cancer resistance protein (BCRP) in human distal lung epithelial cells in vitro, Pharm Res, 2017 Journal Article, 2017 DOI

HJ Gukasyan, T Uchiyama, KJ Kim, C Ehrhardt, SK Wu, Z Borok, VHL Lee, ED Crandall, Oligopeptide transport in rat lung alveolar epithelial cells is mediated by Pept2, Pharm Res, 2017 Journal Article, 2017 DOI

C Ehrhardt, P Bäckman, W Couet, C Edwards, B Forbes, M Fridén, M Gumbleton, KI Hosoya, Y Kato, T Nakanishi, M Takano, T Terasaki, R Yumoto(ed.), Current progress toward a better understanding of drug disposition within the lungs: summary proceedings of the 1st Workshop on Drug Transporters in the Lungs, J Pharm Sci, Dublin, Ireland, 106, (9), 22-23/09/2016, 2017, 2234 - 2244 p Proceedings of a Conference, 2017 DOI

European Journal of Pharmaceutics and Biopharmaceutics, Amsterdam, The Netherlands, Elsevier Science, [eds.], 2017 Editorial Board, 2017

X Hu, FF Yang, CY Liu, C Ehrhardt, YH Liao, In vitro uptake and transport studies of PEG-PLGA polymeric micelles in respiratory epithelial cells, Eur J Pharm Biopharm, 114, 2017, p29-37 Journal Article, 2017 DOI

W de Kruif, C Ehrhardt, Inhalation delivery of complex drugs - the next steps, Curr Opin Pharmacol, 36, 2017, p52-57 Review Article, 2017

Y Tega, C Yuzurihara, Y Kubo, SI Akanuma, C Ehrhardt, KI Hosoya, Functional expression of nicotine influx transporter in A549 human alveolar epithelial cells, Drug Metab Pharmacokinet, 31, (1), 2016, p99-101 Journal Article, 2016 DOI

Tewes, F, Gobbo, OL, Ehrhardt, C, Healy, AM, Amorphous calcium carbonate based-microparticles for peptide pulmonary delivery, ACS Applied materials and interfaces, 8, (2), 2016, p1164-1175 Journal Article, 2016 DOI TARA - Full Text

S Nickel, CG Clerkin, MA Selo, C Ehrhardt, Transport mechanisms at the pulmonary mucosa: implications for drug delivery, Expert Opin Drug Deliv, 13, (5), 2016, p667-690 Review Article, 2016 DOI

Zelikin AN, Ehrhardt C, Healy AM, Materials and methods for delivery of biological drugs, Nature Chemistry, 8, (11), 2016, p997-1007 Review Article, 2016 DOI

MS Holmes, JN Seheult, P O'Connell, S D'Arcy, C Ehrhardt, AM Healy, RW Costello, RB Reilly, An acoustic based method to detect and quantify the effect of exhalation into a dry powder inhaler, J Aerosol Med Pulm Drug Deliv, 28, (4), 2015, p247-253 Journal Article, 2015 DOI

JJ Salomon, JC Gausterer, T Yahara, KI Hosoya H Huwer, M Hittinger, N Daum-Schneider, CM Lehr, C Ehrhardt, Organic cation transporter function in different in vitro models of human lung epithelium, Eur J Pharm Sci, 80, 2015, p82-88 Journal Article, 2015 DOI

M Takano, N Sugimoto, C Ehrhardt, R Yumoto, Functional expression of PEPT2 in the human distal lung epithelial cell line NCl-H441, Pharm Res, 32, (12), 2015, p3916-3926 Journal Article, 2015 DOI

JJ Salomon, Y Hagos, S Petzke, A Kühne, JC Gausterer, KI Hosoya, C Ehrhardt, Beta-2 adrenergic-agonists are substrates and inhibitors of human organic cation transporter 1, Mol Pharm, 12, (8), 2015, p2633-2641 Journal Article, 2015 DOI

Amaro MI, Tewes F, Gobbo O, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Formulation, stability and pharmacokinetics of sugar-based salmon calcitonin-loaded nanoporous/nanoparticulate microparticles (NPMPs) for inhalation, International Journal of Pharmaceutics, 483, (1-2), 2015, p6-18 Journal Article, 2015 TARA - Full Text DOI

American Journal of Physiology - Lung Cellular and Molecular Physiology , Bethesda, MD, American Physiological Society, 2015 Editorial Board, 2015

Journal of Aerosol Medicine and Pulmonary Drug Delivery, Rochelle, NY, Mary Ann Liebert, Inc., 2015 Editorial Board, 2015

E Schwagerus, S Sladek, ST Buckley, N Armas-Capote, D Alvarez de la Rosa, BJ Harvey, H Fischer, B Illek, H Huwer, N Daum, CM Lehr, C Ehrhardt, Expression and function of the epithelial sodium channel δ-subunit in human respiratory epithelial cells in vitro, Pflug Arch Eur J Phy, 467, (11), 2015, p2257-2273 Journal Article, 2015 DOI

JJ Salomon, VE Muchitsch, JC Gausterer, E Schwagerus, H Huwer, N Daum, CM Lehr, C Ehrhardt, The cell line NCI-H441 is a useful in vitro model for transport studies of human distal lung epithelial barrier, Mol Pharm, 11, (3), 2014, p995-1006 Journal Article, 2014 DOI

J Swaminathan, C Ehrhardt, Effect of lyophilisation on liposomal systems for the delivery of salmon calcitonin (sCT), J Liposome Res, 24, (4), 2014, p297-303 Journal Article, 2014 DOI TARA - Full Text

Journal of Pharmaceutical Sciences, New York, NY, Elsevier Science, [Member of the Scientific Advisory Board], 2014 Editorial Board, 2014

X Hu, FF Yang, LH Quan, CY Liu, XM Liu, C Ehrhardt, YH Liao, Pulmonary delivered polymeric micelles - pharmacokinetic evaluation and biodistribution studies, Eur J Pharm Biopharm, 88, (3), 2014, p1064-1075 Journal Article, 2014 TARA - Full Text DOI

JJ Salomon, C Ehrhardt, KI Hosoya, The verapamil transporter in human alveolar epithelial cells (A549) does not interact with β2-receptor agonists, Drug Metabolism and Pharmacokinetics, 29, (1), 2014, p101-104 Journal Article, 2014 TARA - Full Text DOI

F Tewes, C Ehrhardt, AM Healy, Superparamagnetic iron oxide nanoparticles (SPIONs)-loaded Trojan microparticles for targeted aerosol delivery to the lung, Eur J Pharm Biopharm, 86, (1), 2014, p98-104 Journal Article, 2014 DOI TARA - Full Text

JN Seheult, P O'Connell, I Sulaiman, KC Tee, T Bholah, E MacHale, S D'Arcy, MS Holmes, G Crispino-O'Connell, RB Reilly, D Bergin, E Reeves, C Ehrhardt, AM Healy, RW Costello, An acoustic method for monitoring aerosol delivery from a DiskusTM dry powder inhaler, Pharm Res, 31, (10), 2014, p2735-2747 Journal Article, 2014 DOI

Swaminathan J, Gobbo OL, Tewes F, Healy AM, Ehrhardt C, Encapsulation into PEG-liposomes does not improve the bioavailability of pulmonary delivered salmon calcitonin, Journal of Aerosol Medicine and Pulmonary Drug Delivery, 27, (1), 2014, p1-11 Journal Article, 2014 DOI

C Ehrhardt, Why do we know so little about absorption pathways in the lung?, Inhalation, 8, (2), 2014, p27-28 Journal Article, 2014 TARA - Full Text

Tewes F, Paluch KJ, Tajber L, Gulati K, Kalantri D, Ehrhardt C, Healy AM, Steroid/mucokinetic hybrid nanoporous microparticles for pulmonary drug delivery, European Journal of Pharmaceutics and Biopharmaceutics, 85, (3), 2013, p604 - 613 Journal Article, 2013 TARA - Full Text DOI

E Paszko, GM Vaz, C Ehrhardt, MO Senge, Transferrin conjugation does not increase the efficiency of liposomal Foscan during in vitro photodynamic therapy of oesophageal cancer, European Journal of Pharmaceutical Sciences, 48, (1-2), 2013, p202-210 Journal Article, 2013 DOI TARA - Full Text

JJ Salomon, P Galeron, N Schulte, PR Morow, D Severynse-Stevens, H Huwer, N Daum, CM Lehr, AJ Hickey, C Ehrhardt, Biopharmaceutical in vitro characterisation of CPZEN-45, a candidate compound for inhalation therapy of tuberculosis, Therapeutic Delivery, 4, (8), 2013, p915-923 Journal Article, 2013 DOI

N Chadderton, A Palfi, S Millington-Ward, O Gobbo, N Overlack, M Carrigan, M O'Reilly, M Campbell, C Ehrhardt, U Wolfrum, P Humphries, PF Kenna, GJ Farrar, Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy, Eur J Hum Genet, 21, (1), 2013, p62-68 Journal Article, 2013 DOI

B Zhou, ST Buckley, V Patel, Y Liu, J Luo, MS Krishnaveni, M Ivan, L DeMaio, KJ Kim, C Ehrhardt, ED Crandall, Z Borok, Troglitazone attenuates TGF-β1-induced EMT in alveolar epithelial cells via a PPARγ-independent mechanism, PLoS ONE, 6, (7), 2012, pe38827 Journal Article, 2012 TARA - Full Text DOI

JJ Salomon, C Ehrhardt, Regional distribution of organic cation transporters in human lung: possible therapeutic implications in aerosol therapy, Respiratory Drug Delivery, Respiratory Drug Delivery 12, Phoenix, AZ, 13-17/05/2012, 1, 2012, pp73-80 Conference Paper, 2012

OL Gobbo, M Zurek, F Tewes, C Ehrhardt, Y Crémillieux, Manganese: a new contrast agent for lung imaging?, Contrast Media Mol I, 7, (6), 2012, p542-546 Journal Article, 2012 DOI

Baginski L, Gobbo OL, Tewes F, Salomon JJ, Healy AM, Bakowsky U, Ehrhardt C, In vitro and in vivo characterisation of PEG-lipid based micellar complexes of salmon calcitonin for pulmonary delivery, Pharm Res, 29, (6), 2012, p1425-1434 Journal Article, 2012 DOI

F Májer, JJ Salomon, R Sharma, SV Etzbach, MNM Najib, R Keaveny, A Long, J Wang, C Ehrhardt, JF Gilmer, New fluorescent bile acids: Synthesis, chemical characterization, and disastereoselective uptake by Caco-2 cells of 3-deoxy 3-NBD-amino deoxycholic and ursodeoxycholic acid, Bioorg Med Chem, 20, (5), 2012, p1767-1778 Journal Article, 2012 DOI TARA - Full Text

MM Gaspar, A Radomska, OL Gobbo, MW Radomski, C Ehrhardt, Targeted delivery of transferrin-conjugated liposomes to an orthotopic model of lung cancer in nude rats, J Aerosol Med Pulm Drug Deliv, 25, (6), 2012, p310-318 Journal Article, 2012 DOI

G Jenkins, A Blanchard, Z Borok, P Bradding, C Ehrhardt, A Fisher, N Hirani, S Johnson, M Königshoff, TM Maher, A Millar, H Parfrey, C Scotton, T Tetley, D Thickett, P Wolters, In search of the fibrotic epithelial cell: opportunities for a collaborative network, Throrax, 67, (2), 2012, p179-182 Review, 2012 DOI

ST Buckley, C Medina, AM Davies, C Ehrhardt, Cytoskeletal re-arrangement in TGF-beta1-induced alveolar epithelial-mesenchymal transition studied by atomic force microscopy and high-content analysis, Nanomed - Nanotechnol Biol Med, 8, (3), 2012, p355-364 Journal Article, 2012 DOI TARA - Full Text

L DeMaio, ST Buckley, P Flodby, A Banfalvi, MS Krishnaveni, Y Xing, C Ehrhardt, P Minoo, ED Crandall, Z Borok, Transforming growth factor-β (TGF-β1) type I receptor mediates induction of epithelial-mesenchymal transition by type I collagen independent of TGF-β ligands, J Pathol, 226, (4), 2012, p633-644 Journal Article, 2012 DOI

Baginski L, Tewes F, Buckley ST, Healy AM, Bakowsky U, Ehrhardt C, Investigations on the fate of inhaled salmon calcitonin at the respiratory epithelial barrier, Pharmaceutical Research, 29, (1), 2012, p332-341 Journal Article, 2012 DOI

J Swaminathan, C Ehrhardt, Liposomal delivery of proteins and peptides, Expert Opin Drug Deliv, 9, (12), 2012, p1489-503 Review Article, 2012 DOI

JJ Salomon, C Ehrhardt, Organic cation transporters in the blood-air barrier: Expression and implications for pulmonary drug delivery, Ther Deliv, 3, (6), 2012, p735-747 Review Article, 2012 DOI

JJ Salomon, S Endter, G Tachon, F Falson, ST Buckley, C Ehrhardt, Transport of the fluorescent organic cation 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP+) in human respiratory epithelial cells, Eur J Pharm Biopharm, 81, (2), 2012, p351-359 Journal Article, 2012 DOI TARA - Full Text

Tewes F, Gobbo OL, Amaro MI, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Evaluation of HPβCD-PEG microparticles for salmon calcitonin administration via pulmonary delivery, Molecular Pharmaceutics, 8, (5), 2011, p1887 - 1898 Journal Article, 2011 DOI

C Ehrhardt, C Medina, AM Davies, ST Buckley, Novel tools for investigations of cytoskeletal re-arrangement during alveolar epithelial-mesenchymal transition, FASEB J, Experimental Biology Meeting 2011, Washington, DC, 09-13/04/2011, 25, 2011, pp856.2 Conference Paper, 2011

E Paszko, C Ehrhardt, MO Senge, DP Kelleher, JV Reynolds, Nanodrug applications in photodynamic therapy, Photodiagnosis Photodyn Ther , 8, 2011, p14-29 Review Article, 2011 DOI

C Ehrhardt, C Medina, AM Davies, ST Buckley, Using atomic force microscopy and high-content analysis for investigations into cytoskeletal re-arrangement during TGF-β1-induced alveolar epithelial-mesenchymal transition, Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society 2011, Denver, CO, 13-18/05/2011, 183, 2011, ppA3501 Conference Paper, 2011

In vitro cell culture models for evaluating controlled release pulmonary drug delivery in, editor(s)HDC Smyth, AJ Hickey , Controlled Pulmonary Drug Delivery, New York, Springer, 2011, pp417-442 , [ST Buckley, KJ Kim, C Ehrhardt] Book Chapter, 2011

C Ehrhardt, C Medina, AM Davies, ST Buckley, The receptor for advanced glycation end-products (RAGE) interacts with focal adhesion molecules in epithelial-mesenchymal transition (EMT) of alveolar epithelial cells, Am J Respir Crit Care Med , eeting of the American Thoracic Society 2011, Denver, CO, 13-18/05/2011, 183, 2011, ppA3502 Conference Paper, 2011

L Baginski, G Tachon, F Falson, JS Patton, U Bakowsky, C Ehrhardt, RT-PCR analysis of proteolytic enzymes in cultures of human respiratory epithelial cells, J Aerosol Med Pulm Drug Deliv, 24, (2), 2011, p89-101 Journal Article, 2011 DOI

Liposomes for pulmonary drug delivery in, editor(s)HDC Smyth, AJ Hickey , Controlled Pulmonary Drug Delivery, New York, Springer, 2011, pp313-334 , [J Swaminathan, C Ehrhardt] Book Chapter, 2011

ST Buckley, AM Davies, C Ehrhardt, Atomic force microscopy (AFM) and high-content analysis (HCA) - two innovative technologies for dissecting the relationship between epithelial-mesenchymal transition (EMT)-related morphological and structural alterations and cell mechanical properties, Methods Mol Biol , 784, 2011, p197-208 Review, 2011

ST Buckley, C Medina, M Kasper, C Ehrhardt, Interplay between the receptor for advanced glycation end-products (RAGE), CD44 and focal adhesion molecules in epithelial-mesenchymal transition of alveolar epithelial cells, Am J Physiol Lung Cell Mol Physiol, 300, (4), 2011, pL548-L559 Journal Article, 2011 TARA - Full Text DOI

JJ Salomon, C Ehrhardt, Nanoparticles attenuate P-glycoprotein/MDR1 function in A549 human alveolar epithelial cells, Eur J Pharm Biopharm, 77, (3), 2011, p392-397 Journal Article, 2011 DOI TARA - Full Text

C Ehrhardt, C Medina, ST Buckley, Interaction of RAGE with focal adhesion molecules during alveolar epithelial-mesenchymal transition, FASEB J, Experimental Biology Meeting 2011, Washington, DC, 09-13/04/2011, 25, 2011, pp865.1 Conference Paper, 2011

Paszko E, Ehrhardt C, Senge MO, Kelleher DP, Reynolds JV, Nanodrug applications in photodynamic therapy., Photodiagnosis and photodynamic therapy, 8, (1), 2011, p14-29 Journal Article, 2011 TARA - Full Text DOI

J Sitterberg, A Özcetin, C Ehrhardt, U Bakowsky, Utilising atomic force microscopy for the characterisation of nanoscale drug delivery systems, Eur J Pharm Biopharm, 74, (1), 2010, p2-13 Review, 2010 DOI TARA - Full Text

JS Patton, JD Brain, LA Davies, J Fiegel, M Gumbleton, KJ Kim, M Sakagami, R Vanbever, C Ehrhardt, The particle has landed - characterizing the fate of inhaled pharmaceuticals, J Aerosol Med Pulm Drug Deliv, 23, (S2), 2010, pS71-S87 Review Article, 2010 DOI TARA - Full Text

ST Buckley, C Ehrhardt, The receptor for advanced glycation end-products (RAGE) and the lung, J Biomed Biotechnol, 2010, 2010, p917108 Review Article, 2010 TARA - Full Text DOI

Tewes F, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Development and characterisation of soluble polymeric particles for pulmonary peptide delivery, European Journal of Pharmaceutical Sciences, 41, (2), 2010, p337 - 352 Journal Article, 2010 DOI TARA - Full Text

ST Buckley, C Medina, C Ehrhardt, Differential susceptibility to epithelial-mesenchymal transition (EMT) of alveolar, bronchial and intestinal epithelial cells in vitro and the effect of angiotensin II receptor inhibition, Cell Tissue Res, 342, (1), 2010, p39-51 Journal Article, 2010 DOI

P Stasiak, M Sznitowska, C Ehrhardt, M Juzwa, A Kowalczyk, P Grieb, In vivo assessment of parenteral formulations of oligo(3-hydroxybutyric acid) conjugates with the model compound ibuprofen, AAPS PharmSciTech, 11, (4), 2010, p1636-1641 Journal Article, 2010 TARA - Full Text DOI

Drug Delivery Letters, Saif Zone, Sharjah, U.A.E., Bentham Science Publishers, 2010 Editorial Board, 2010

ST Buckley, C Medina, C Ehrhardt, RAGE and ERM proteins in EMT of human alveolar epithelial cells, FASEB J, Experimental Biology Meeting 2010, Anaheim, CA, 24-28/04/2010, 24, 2010, pp612.21 Conference Paper, 2010

J Sitterberg, MM Gaspar, C Ehrhardt, U Bakowsky, Atomic force microscopy for the characterization of proteoliposomes, Methods Mol Biol , 606, 2010, p351-361 Review, 2010 DOI

ST Buckley, C Medina, C Ehrhardt, Investigations into the role of RAGE and ERM proteins in EMT of human alveolar epithelial cells, Acta Physiologica, Joint Meeting of the Scandinavian and German Physiological Societies, København, Denmark, 27-30/3/2010, 198, (S677), 2010, pp146 - 147 Conference Paper, 2010

ST Buckley, C Medina, C Ehrhardt, A role for RAGE and ERM proteins in EMT of human alveolar epithelial cells, Am J Respir Crit Care Med , Annual Meeting of the American Thoracic Society 2010, New Orleans, LA, 14-19/05/2010, 181, (1), 2010, ppA1234 Conference Paper, 2010

MM Gaspar, O Gobbo, C Ehrhardt, Generation of liposome aerosols with the Aeroneb Pro and the AeroProbe nebulisers, J Liposome Res, 20, (1), 2010, p55-61 Journal Article, 2010 DOI

ST Buckley, C Medina, C Ehrhardt, Characterisation of the role of inflammatory cytokines in EMT and cell migration in alveolar epithelial cells, FASEB J, Experimental Biology Meeting 2009, New Orleans, LA, 18-22/04/2009, 23, 2009, pp997.2 Conference Paper, 2009

ST Buckley, C Medina, C Ehrhardt, Characterisation of the role of inflammatory cytokines in EMT and cell migration in alveolar epithelial cells, Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society 2009, San Diego, CA, 15-20/05/2009, 179, (1), 2009, ppA5298 Conference Paper, 2009

ST Buckley, C Medina, C Ehrhardt, Assessment of the role of inflammatory cytokines in EMT and cell migration in alveolar epithelial cells, Eur Respir J, European Respiratory Society Annual Congress 2009, Wien, Austria, 12-16/09/2009, 22, (S53), 2009, pp582 Conference Paper, 2009

P Stasiak, C Ehrhardt, M Juzwa, M Sznitowska, Characterisation of a novel conjugate of ibuprofen with 3-hydroxybutyric acid oligomers, J Pharm Pharmacol, 61, 2009, p1119-1124 Journal Article, 2009 DOI

E Passante, C Ehrhardt, H Sheridan, N Frankish, RBL-2H3 cells are an imprecise model for mast cell mediator release, Inflamm Res, 58, (9), 2009, p611-618 Journal Article, 2009 DOI

P Doolan, M Clynes, S Kennedy, JP Mehta, S Germano, C Ehrhardt, J Crown, L O'Driscoll, TMEM25, REPS2 and Meis 1: Favourable prognostic and predictive biomarkers for breast cancer, Tumor Biol, 30, (4), 2009, p200-209 Journal Article, 2009 DOI URL

ST Buckley, C Medina, C Ehrhardt, Effect of TGF-β1 and inflammatory cytokines on EMT and cell migration in alveolar epithelial cells, Acta Physiol , 88th Annual Meeting of the German Physiological Society, Giessen, Germany, 22-25/03/2009, 195, (S669), 2009, pp14 Conference Paper, 2009

S Endter, D Francombe, C Ehrhardt, M Gumbleton, RT-PCR analysis of ABC - SLC- and SLCO-drug transporters in human lung epithelial cell models, J Pharm Pharmacol, 61, 2009, p583-591 Journal Article, 2009 DOI

L Horálková, A Radziwon, S Endter, R Andersen, R Koslowski, MW Radomski, P Dole al, C Ehrhardt., Characterisation of the R3/1 cell line as an alveolar epithelial cell model for drug disposition studies., Eur J Pharm Sci, 36, (4-5), 2009, p444-450 Journal Article, 2009 DOI

ST Buckley, C Medina, C Ehrhardt, The role of the receptor for advanced glycation end products (RAGE) in epithelial-mesenchymal transition in the lung: a potential therapeutic target, AAPS J, 23rd Annual Meeting of the AAPS, Los Angeles, CA, 08-12/11/2009, 11, (S2), 2009, ppW5006 Conference Paper, 2009

In vitro models of the bronchial epithelium in, editor(s)C Ehrhardt, KJ Kim , Drug Absorption Studies - In Situ, In Vitro and In Silico Models, New York, Springer, 2008, pp258 - 282, [C Ehrhardt, B Forbes, KJ Kim] Book Chapter, 2008

JL Sporty, L Horálková, C Ehrhardt, In vitro cell culture models for the assessment of pulmonary drug disposition, Expert Opin Drug Metab Toxicol. Expert Opin Drug Metab Toxicol, 4, (4), 2008, p333-345 Review, 2008 DOI

H Sheridan, I Hook, J Coppins, C Nestor, C Ehrhardt, N Frankish, Inhibition of LFA-1 mediated T-cell motility by naphthoquinones, Planta Med, 74, (11), 2008, p1383-1387 Journal Article, 2008 DOI

In vitro models of the alveolar epithelial barrier in, editor(s)C Ehrhardt, KJ Kim , Drug Absorption Studies - In Situ, In Vitro and In Silico Models, New York, Springer, 2008, pp235 - 257, [C Ehrhardt, M Laue, KJ Kim] Book Chapter, 2008

S Endter, C Ehrhardt, Drug disposition in the lung - recent advantages in understanding the role of drug transporters, Respiratory Drug Delivery, Respiratory Drug Delivery 2008, Scottsdale, AZ, 11-15/05/2008, 11, (1), 2008, pp65-72 Conference Paper, 2008

H Bakowsky, T Richter, C Kneuer, D Hoekstra, U Rothe, C Ehrhardt, U Bakowsky, Adhesion characteristics and stability assessment of lectin-modified liposomes for site-specific drug delivery, Biochim Biophys Acta - Biomembranes, 1778, (1), 2008, p242-249 Journal Article, 2008 DOI TARA - Full Text

M Gaspar, U Bakowsky, C Ehrhardt, Inhaled liposomes - current strategies and future challenges, J Biomed Nanotechnol, 4, (3), 2008, p245-257 Review, 2008 DOI

J Schäfer, J Sitterberg, C Ehrhardt, MNV Ravi Kumar, U Bakowsky, A new drug vehicle - lipid coated biodegradable nanoparticles, Adv Sci Technol, 57, 2008, p148-153 Journal Article, 2008

C Ehrhardt, KJ Kim , Drug Absorption Studies - In Situ, In Vitro and In Silico Models, 1, New York, Springer, 2008, 1 - 698pp Book, 2008

U Becker, C Ehrhardt, M Schneider, Leon Muys, Dorothea Groß, Klaus Eschmann, UF Schaefer, CM Lehr, Comparative evaluation of corneal epithelial cell cultures for assessing ocular permeability, Altern Lab Anim, 36, (1), 2008, p33-44 Journal Article, 2008

S Anabousi, U Bakowsky, C Ehrhardt, In vitro studies on liposomal systems for the inhalation treatment of lung cancer, J Aerosol Med , 16th Congress of the International Society for Aerosols in Medicine, Tours, France, 16.-20.06.2007, 20, (2), 2007, pp175-176 Conference Paper, 2007

A Steimer, H Franke, Eleonore Haltner-Ukomado, M Laue, C Ehrhardt, CM Lehr, Monolayers of porcine alveolar epithelial cells in primary culture as an in vitro model for drug absorption studies, Eur J Pharm Biopharm, 66, (3), 2007, p372-382 Journal Article, 2007 DOI

S Endter, U Becker, N Daum, H Huwer, CM Lehr, M Gumbleton, C Ehrhardt, P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers, Cell Tissue Res, 328, (1), 2007, p77-84 Journal Article, 2007 DOI

U Becker, C Ehrhardt, N Daum, C Baldes, UF Schaefer, K Rupprecht, KJ Kim, CM Lehr, Expression of ABC-transporters in human corneal tissue and the transformed cell line, HCE-T, J Ocul Pharmacol Ther, 23, (2), 2007, p172-181 Journal Article, 2007 DOI

N Demling, C Ehrhardt, M Kasper, M Laue, L Knels, EP Rieber, Promotion of cell adherence and spreading: a novel function of RAGE, the highly selective differentiation marker of alveolar epithelial type I cells, Cell Tissue Res, 323, (3), 2006, p475 - 488 Journal Article, 2006 DOI

Kneuer, C., Ehrhardt, C., Radomski, M.W., Bakowsky, U. , Selectins - potential pharmacological targets? , Drug Discovery Today, 11, (21-22), 2006, p1034-1040 Review, 2006 URL DOI

M Bur, H Huwer, CM Lehr, N Hagen, M Guldbrandt, KJ Kim, C Ehrhardt, Assessment of protein transport rates across primary human alveolar epithelial cell monolayers, Eur J Pharm Sci, 28, (3), 2006, p196-203 Journal Article, 2006 DOI

C Kneuer, C Ehrhardt, H Bakowsky, MNV Ravi Kumar, V Oberle, CM Lehr, D Hoekstra, U Bakowsky, The influence of physicochemical parameters on the efficacy of non-viral DNA transfection complexes: A comparative study, J Nanosci Nanotechnol, 6, (9-10), 2006, p2776-2782 Journal Article, 2006 DOI

S Anabousi, U Bakowsky, M Schneider, H Huwer, CM Lehr, C Ehrhardt, In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for the inhalation therapy of lung cancer, Eur J Pharm Sci, 29, (5), 2006, p367 - 374 Journal Article, 2006 DOI

S Anabousi, E Kleemann, U Bakowsky, T Kissel, T Schmehl, T Gessler, W Seeger, CM Lehr, C Ehrhardt, Effect of PEGylation on the stability of liposomes during nebulisation and in lung surfactant, J Nanosci Nanotechnol, 6, (9-10), 2006, p3010-3016 Journal Article, 2006 DOI

G Sharma, S Anabousi, C Ehrhardt, MNV Ravi Kumar, Liposomes as targeted drug delivery systems in the treatment of breast cancer, J Drug Target, 14, (5), 2006, p301-310 Review, 2006 DOI

C Ehrhardt, EM Collnot, C Baldes, M Laue, KJ Kim, CM Lehr, Towards an in vitro model of cystic fibrosis small airway epithelium: Characterisation of the human bronchial epithelial cell line CFBE41o - Cell Tissue Res, 323, (3), 2006, p405 - 415 Journal Article, 2006 DOI

S Anabousi, M Laue, CM Lehr, U Bakowsky, C Ehrhardt, Assessing transferrin modification of liposomes by atomic force microscopy and transmission electron microscopy, Eur J Pharm Biopharm, 60, (2), 2005, p295 - 303 Journal Article, 2005 DOI

KJ Kim, Z Borok, C Ehrhardt, BC Willis, CM Lehr, ED Crandall, Estimation of paracellular conductance of primary rat alveolar epithelial cell monolayers, J Appl Physiol, 98, (1), 2005, p138 - 143 Journal Article, 2005 DOI

B Forbes, C Ehrhardt, Human respiratory epithelial cell culture for drug delivery application, Eur J Pharm Biopharm, 60, (2), 2005, p193-205 Review, 2005 DOI

C Ehrhardt, KJ Kim, CM Lehr, Isolation and culture of human alveolar epithelial cells, Methods Mol Med, 107, 2005, p207-216 Review, 2005 DOI

C Ehrhardt, C Kneuer, C Bies, CM Lehr, KJ Kim, U Bakowsky, Salbutamol is actively absorbed across human respiratory epithelial cell layers, Pulm Pharmacol Ther, 18, (3), 2005, p165 - 170 Journal Article, 2005 DOI

Adhesion molecule-modified cardiovascular prostheses: characterization of cellular adhesion in a cell culture model and by cellular force spectroscopy in, editor(s)W Possart , Adhesion: current research and applications, Weinheim,Germany, Wiley-VCH, 2005, pp159 - 174, [U Bakowsky, C Ehrhardt, C Loehbach, P Li, C Kneuer, D Jahn, D Hoekstra, CM Lehr] Book Chapter, 2005

U Becker, C Ehrhardt, UF Schaefer, HJ Gukasyan, KJ Kim, VHL Lee, CM Lehr, Tissue distribution of moxaverine-hydrochloride in the rabbit eye and plasma, J Ocul Pharmcol Ther, 21, (3), 2005, p210 - 216 Journal Article, 2005 DOI

C Ehrhardt, The lung in a box - can pulmonary PK really be predicted from cell culture models?, Eur J Pharm Sci, EUFEPS 2004, Bruxelles, Belgium, 17.-20.10.2004, 23, (S1), 2004, ppS26 - S27 Conference Paper, 2004

P Li, C Ehrhardt, C Loehbach, CM Lehr, U Bakowsky, Tissue engineering, surface coating and pharmaceutical nanotechnology, Proceedings of the International School on Advanced Material Science and Technology, Smart materials and Nanotechnologies V, Jesi, Italy, 26.-29.08.2003, edited by A Lodini, F Rustichelli , 5, 2004, pp26 - 41 Conference Paper, 2004

G Abraham, C Kneuer, C Ehrhardt, W Honscha, FR Ungemach, Expression of functional β2-adreneric receptors in lung epithelial cell lines 16HBE14o - Calu-3 and A549, Biochim Biophys Acta, 1691, (2-3), 2004, p169 - 179 Journal Article, 2004 DOI

Toward improved particle characterization in the lung: impingement of large porous particles on lung epithelial cell monolayers in, editor(s)G Scheuch , Aerosole in der Inhalationstherapie VIII, München, dustriTBmed, 2004, pp87 - 93, [C Ehrhardt, J Fiegel, U Bakowsky, UF Schaefer, J Hanes, CM Lehr] Book Chapter, 2004

C Ehrhardt, C Kneuer, U Bakowsky, Selectins - an emerging target for drug delivery, Adv Drug Deliv Rev, 56, (4), 2004, p527-549 Review, 2004 DOI

C Ehrhardt, C Kneuer, M Laue, UF Schaefer, KJ Kim, CM Lehr, 16HBE14o- human bronchial epithelial cell layers express P-glycoprotein, lung resistance-related protein and caveolin-1, Pharm Res, 20, (4), 2003, p545 - 551 Journal Article, 2003 DOI

J Fiegel, C Ehrhardt, UF Schaefer, CM Lehr, J Hanes, Large porous particle impingement on lung epithelial cell monolayers - Toward improved particle characterization in the lung, Pharm Res, 20, (5), 2003, p788 - 796 Journal Article, 2003 DOI

CM Lehr, S Fuchs, K Roemer, M Laue, UF Schaefer, C Ehrhardt, Cell culture models of alveolar and airway mucosa, Proc VIIth Conference on Nasal and Pulm Drug Del, Conference VII on Nasal and Pulmonary Drug Delivery, Barcelona, Spain, 15.-17.09.2003, 2003, pp24 - 26 Conference Paper, 2003

C Ehrhardt, C Kneuer, J Fiegel, J Hanes, UF Schaefer, KJ Kim, CM Lehr, Influence of apical fluid volume on the development of functional intercellular junctions in the human epithelial cell line 16HBE14o-: implications for the use of this cell line as an in vitro model for bronchial drug absorption studies, Cell Tissue Res, 308, (3), 2002, p391 - 400 Journal Article, 2002 DOI

Bronchial epithelial cell cultures in, editor(s)CM Lehr , Cell culture models of biological barriers, London, Taylor & Francis, 2002, pp211 - 227, [C Meaney, BI Florea, C Ehrhardt, UF Schaefer, CM Lehr, HE Junginger, G Borchard] Book Chapter, 2002

C Ehrhardt, J Fiegel, S Fuchs, R Abu-Dahab, UF Schaefer, J Hanes, CM Lehr, Drug absorption by the respiratory mucosa - cell culture models and particulate drug carriers, J Aerosol Med, 15, (2), 2002, p131-139 Review, 2002 DOI

Arzneistoffabsorption durch die Lungenschleimhaut - Zellkulturmodelle und partikuläre Arzneistoffträger in, editor(s)G Scheuch , Aerosole in der Inhalationstherapie VI, München, dustriTBmed, 2002, pp23 - 38, [C Ehrhardt, S Fuchs, R Abu-Dahab, UF Schaefer, CM Lehr] Book Chapter, 2002

Non-Peer-Reviewed Publications

C Ehrhardt, In vitro and ex vivo models to study inhalation biopharmaceutics - are we there yet? , Inhalation Asia 2017, Macau, China, 15/09/2017, 2017 Invited Talk, 2017

C Ehrhardt, Organic cation transporters in the lung, Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, 05/05/2017, 2017 Invited Talk, 2017

C Ehrhardt, Anatomy and cell physiology of the human lungs and in vitro and ex vivo models to study pulmonary drug disposition, 4th Pulmonary Drug Delivery Workshop, Istanbul, Turkey, 20/09/2017, 2017 Invited Talk, 2017

C Ehrhardt, Ergothioneine, OCTN1 and COPD, 36th Western Epithelial Biology Society Meeting, Avila Beach, CA, 04/03/2017, 2017 Invited Talk, 2017

MA Selo, S Nickel, J Fallack, H Huwer, N Schneider-Daum, CM Lehr, C Ehrhardt, Determination of expression and activity of breast cancer resistance protein (BCRP/ABCG2) in human lung alveolar epithelial barrier in vitro, J Aerosol Med Pulm Drug Deliv, 21st Congress of the International Society for Aerosols in Medicine, Santa Fe, NM, 03-06/06/2017, 30, (3), 2017 Oral Presentation, 2017

C Ehrhardt, Organic cation transporter function in different in vitro lung epithelial models: impact on delivery of pharmaceuticals and chemicals., 53rd Congress of the European Societies of Toxicology (EUROTOX 2017), Bratislava, Slovakia, 10/09/2017, 2017 Invited Talk, 2017

C Ehrhardt, Ayca Yildiz-Pekoz, 4th Pulmonary Drug Delivery Workshop, 19-21/2017, 2017, Istanbul, Turkey Meetings /Conferences Organised, 2017

C Ehrhardt, Innovative Formulierungen für die Inhalationstherapie mit Biopharmazeutika, Institut für Pharmazeutische Technologie, Technische Universität Braunschweig, Germany, 10/01/2017, 2017 Invited Talk, 2017

C Ehrhardt, Transport and efflux systems at the air-blood-barrier, 11th International Conference and Workshop on Biological Barriers, Saarbrücken, Germany, 08/03/2016, 2016 Invited Talk, 2016

C Ehrhardt, Biopharmazie der Lunge - Über das Schicksal inhalierter Arzneistoffe, Department für Pharmazeutische Technologie und Biopharmazie, Universität Wien, Wien, Austria, 10/06/2016, 2016 Invited Talk, 2016

C Ehrhardt, Pharmacokinetic and pathophysiological roles of transporters in the lung, Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan, 12/10/2016, 2016 Invited Talk, 2016

S Nickel, MA Selo, CG Clerkin, BN Talbot, JJ Walsh, JB Lewis, PR Reynolds, Y Kato, N Nakamichi, C Ehrhardt, Ergothioneine protects lung epithelial cells from tobacco smoke-induced oxidative damage in vitro and in vivo, Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society 2016, San Francisco, CA, 13-18/05/2016, 193, 2016, ppA7514 Meeting Abstract, 2016

S Nickel, MA Selo, CG Clerkin, Y Kato, PR Reynolds, C Ehrhardt, Ergothioneine up-regulates anti-oxidant enzymes and thus protects from tobacco smoke-related damage, Physiology 2016 - Joint Meeting of the American Physiological Society and The Physiological Society, Dublin, Ireland, 29-31/07/2016, 2016 Meeting Abstract, 2016

C Ehrhardt, Organic cation transporters in the lungs - their role in drug disposition and as drug targets, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil, 19/08/2016, 2016 Invited Talk, 2016

C Ehrhardt, CG Clerkin, MA Selo, S Nickel, Protective effect of OCTN1-mediated ergothioneine uptake in lung epithelial cells in vitro and in vivo, AAPS/ITC Joint Workshop on Drug Transporters, Baltimore, MD, 18-20/04/2016, 2016, ppM1040 Meeting Abstract, 2016

C Ehrhardt, Drug Transporters in the Lung, PhD Course on Biological Membranes, Drug Targets and Absorption Barriers, Copenhagen, Denmark, 01/11/2016, 2016 Invited Talk, 2016

C Ehrhardt, Involvement of membrane transporters in pulmonary drug disposition and their role in COPD, Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto, Japan, 01/06.2016, 2016 Invited Talk, 2016

C Ehrhardt, Protective role of ergothioneine from tobacco smoke-induced oxidative stress in vitro and in vivo, Experimental Biology Meeting 2016, San Diego, CA, 04/04/2016, 2016 Oral Presentation, 2016

C Ehrhardt, Einfluss von Transporterproteinen auf die Arzneistoffverteilung in der Lunge, XIX. Deutsches Aerosol Therapie Seminar, Schloss Waldeck, Germany, 05/11/2016, 2016 Invited Talk, 2016

C Ehrhardt, CG Clerkin, MA Selo, J Fallack, S Nickel, Human distal lung epithelial cells express functional MRP1 and BCRP in vitro, AAPS/ITC Joint Workshop on Drug Transporters, Baltimore, MD, 18-20/04/2016, 2016, ppM1003 Meeting Abstract, 2016

C Ehrhardt, Mechanisms of drug disposition in the lung, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil, 01/09/2016, 2016 Invited Talk, 2016

C Ehrhardt, Membrane transporters in lung epithelial barrier, University of Southern California, School of Pharmacy, Los Angeles, CA, 01/04/2016, 2016 Invited Talk, 2016

C Ehrhardt, Interaction of organic cation transporters with bronchodilators in vitro, ex vivo and in vivo, 1st Workshop on Drug Transporters in the Lungs, Trinity College Dublin, Dublin, Ireland, 22/09/2016, 2016 Invited Talk, 2016

C Ehrhardt, 1st Workshop on Drug Transporters in the Lungs, 22-23/09/2016, 2016, Trinity College Dublin, Dublin, Ireland Meetings /Conferences Organised, 2016

C Ehrhardt, Cell culture models of the air-blood barrier, 1st Workshop on Drug Transporters in the Lungs, Trinity College Dublin, Dublin, Ireland, 22/09/2016, 2016 Invited Talk, 2016

C Ehrhardt, Drug transporters in the lungs - How do they contribute to pulmonary drug disposition? , Laboratory of Pharmaceutics, Osaka University of Pharmaceutical Sciences, Osaka, Japan, 03/06/2016, 2016 Invited Talk, 2016

S Nickel, MA Selo, CG Clerkin, BN Talbot, JJ Walsh, JB Lewis, DC Milner, PR Reynolds, Y Kato, N Nakamichi, C Ehrhardt, Ergothioneine protects lung epithelial cells from tobacco smoke-induced oxidative damage in vitro and in vivo, 15th Symposium of the Flight Attendant Medical Research Institute, Miami, FL, 23-25/05/2016, 2016 Meeting Abstract, 2016

C Ehrhardt, In vitro, ex vivo and in vivo models of the lungs, DNA-TRAP Workshop on Drug Development to Cross Biological Barriers, University of East Anglia, Norwich, UK, 30/06/2016, 2016 Invited Talk, 2016

C Ehrhardt, The role of drug transporters in inhalation biopharmaceutics, 18th International Pharmaceutical Technology Symposium-IPTS 2016, Antalya, Turkey, 19/09/2016, 2016 Invited Talk, 2016

C Ehrhardt, In vitro, ex vivo and in vivo evidence for drug transporter interactions in lung drug disposition , Department of Pharmaceutics and Therapeutics, Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan, 31/05/2016, 2016 Invited Talk, 2016

C Ehrhardt, MA Selo, CG Clerkin, BN Talbot, JJ Walsh, JB Lewis, PR Reynolds, Y Kato, N Nakamichi, S Nickel, Protective role of ergothioneine from tobacco smoke-induced oxidative stress in vitro and in vivo, FASEB J, Experimental Biology Meeting 2016, San Diego, CA, Experimental Biology, 30, (4), 2016, pp982.1 Meeting Abstract, 2016

MA Selo, M Richter, J Fallack, N Schneider-Daum, CM Lehr, S Nickel, C Ehrhardt, Multidrug resistance-associated protein 1 (MRP1) expression and activity in human distal lung epithelial cells, AAPS J, 30th Annual Meeting of the AAPS, Denver, CO, 13-17/11/2016, 18, (S2), 2016, pp05W0400 Meeting Abstract, 2016

C Ehrhardt, Inhalation Biopharmaceutics - Do Transporters Matter in the Lung? , 29th Annual Meeting of the AAPS, Orlando, FL, 29/10/2015, 2015 Invited Talk, 2015

C Ehrhardt, Recent advances in drug transporter research in the lungs, Department of Pharmaceutics and Therapeutics, Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan, 09/11/2015, 2015 Invited Talk, 2015

C Ehrhardt, Drug transporters in the lung and it their relevance for pulmonary drug disposition, Universitetet i Tromsø, Institutt for farmasi, Tromsø, Norway, 19/03/2015, 2015 Invited Talk, 2015

C Ehrhardt, The role of drug transporters in inhalation biopharmaceutics, University of Toyama. Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan, 13/04/2015, 2015 Invited Talk, 2015

C Ehrhardt, Drug transporters in the lung - expression and interactions with inhaled medicines, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, 15/04/2015, 2015 Invited Talk, 2015

VE Muchitsch, C Ehrhardt, NCI-H441 human bronchiolar epithelial cells functionally express P-glycoprotein and multidrug resistance-related protein-1, AAPS/ITC Joint Workshop on Drug Transporters, Baltimore, MD, 20-22/04/2015, 2015, ppM1002 Meeting Abstract, 2015

S Nickel, MA Selo, CG Clerkin, PR Reynolds, Y Kato, N Nakamichi, BN Talbot, JJ Walsh, C Ehrhardt, OCTN1-mediated uptake of ergothioneine protects from tobacco smoke-induced oxidative damage, 30th Annual Meeting of the Japanese Society for the Study of Xenobiotics, Tokyo, Japan, 12-14/11/2105, 2015, pp326 Meeting Abstract, 2015

S Nickel, MA Selo, CG Clerkin, M Meinhardt, C Ehrhardt, Studies on the functional expression of MRP1 and BCRP in lung epithelial cells in vitro, AAPS J, 29th Annual Meeting of the AAPS, Orlando, FL, 25-29/10/2015, 17, (S2), 2015, ppW5247 Meeting Abstract, 2015

C Ehrhardt, OCTN1-mediated ergothioneine uptake protects lung epithelial cells from tobacco smoke-induced damage, Experimental Biology Meeting 2015, Boston, MA, 31/03/2015, 2015 Invited Talk, 2015

S Nickel, MA Selo, CG Clerkin, JJ Salomon, M Ortiz, E Richert, BN Talbot, JJ Walsh, C Ehrhardt, Ergothioneine protects lung epithelial cells from tobacco smoke-induced oxidative damage, 3rd COST BM1201 Conference on the Early Origins of Chronic Lung Disease, Stockholm, Sweden, 15-16/06/2015, 2015 Meeting Abstract, 2015

C Ehrhardt, OCTN1-mediated uptake of ergothioneine protects from tobacco smoke-induced oxidative damage, 30th Annual Meeting of the Japanese Society for the Study of Xenobiotics, Tokyo, Japan, 2015 Oral Presentation, 2015

C Ehrhardt, The best of the rest - transporters in non-traditional biological barriers, 25-29/10/2015, In:29th Annual Meeting of the American Association of Pharmaceutical Scientists, 2015, Orlando, FL Meetings /Conferences Organised, 2015

C Ehrhardt, Arzneistoffabsorption in der Lunge - mehr als nur Diffusion, Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany, 24/03/2015, 2015 Invited Talk, 2015

C Ehrhardt, S Nickel, MA Selo, CG Clerkin, JJ Salomon, B Talbot, JJ Walsh, OCTN1-mediated ergothioneine uptake protects lung epithelial cells from tobacco smoke-induced damage, FASEB J, Experimental Biology Meeting 2015, Boston, MA, 28/03-01/04/2015, 29, 2015, pp970.7 Meeting Abstract, 2015

JJ Salomon, C Ehrhardt, Organic cation transporter function in different in vitro models of human lung epithelium, AAPS/ITC Joint Workshop on Drug Transporters, Baltimore, MD, 20-22/04/2015, 2015, ppM1001 Meeting Abstract, 2015

S Nickel, MA Selo, CG Clerkin, JJ Salomon, BN Talbot, JJ Walsh, C Ehrhardt, Ergothioneine uptake by OCTN1 protects lung epithelial cells from tobacco smoke-induced damage, Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society 2015, Denver, CO, 15-20/05/2015, 191, 2015, ppA2048 Meeting Abstract, 2015

C Ehrhardt, The impact of membrane transporters on drug absorption from the lungs, AstraZeneca, Mölndal, Sweden, 25/03/2015, 2015 Invited Talk, 2015

C Ehrhardt, SH Park, JJ Salomon, S Micallef, Tobacco smoke-induced oxidative stress response is attenuated by OCTN1-mediated ergothioneine uptake in vitro, Drug Metab Rev, 19th North American ISSX/29th JSSX Meeting, San Francisco, CA, 19-23/10/2014, 47, (Suppl 1), 2015, pp297 Meeting Abstract, 2015

VE Muchitsch, C Ehrhardt, P-glycoprotein and multidrug resistance-related protein 1 are functionally expressed in the human distal lung epithelial cell line NCI-H441, J Aerosol Med Pulm Drug Deliv, 20th Congress of the International Society for Aerosols in Medicine, München, Germany, 30/05-03/06/2015, 28, (3), 2015, ppA27 Meeting Abstract, 2015

M Ortiz, MA Martins, A Pohlmann, A Bernardi, S Guterres, C Ehrhardt, Dry powders inhalers from budesonide loaded lipid-core nanocapsules for asthma treatment: development and toxicity evaluation, J Aerosol Med Pulm Drug Deliv, 20th Congress of the International Society for Aerosols in Medicine, München, Germany, 30/05-03/06/2015, 28, (3), 2015, ppA25 Meeting Abstract, 2015

C Ehrhardt, 2nd Workshop on Pulmonary Drug Delivery, 16-18/09/2015, 2015, Trinity College Dublin Meetings /Conferences Organised, 2015

C Ehrhardt, Ergothioneine protects lung epithelial cells from tobacco smoke-induced oxidative damage, 14th Symposium of the Flight Attendant Medical Research Institute, Miami, FL, 15/05/2015, 2015 Invited Talk, 2015

S Nickel, MA Selo, CG Clerkin, M Meinhardt, C Ehrhardt, Expression and activity of MRP1 and BCRP in lung epithelial cells in vitro, 30th Annual Meeting of the Japanese Society for the Study of Xenobiotics, Tokyo, Japan, 12-14/11/2015, 2015, pp290 Meeting Abstract, 2015

C Ehrhardt, In vitro, ex vivo and in vivo models for pulmonary drug disposition studies, AstraZeneca, Mölndal, Sweden, 25/03/2015, 2015 Invited Talk, 2015

C Ehrhardt, Importance of Aerosol Drug Distribution I: Drug Uptake: What are the Cellular Targets and Their Locations in the Respiratory Tract? , 20th Congress of the International Society for Aerosols in Medicine, München, Germany, 30/05/2015, 2015 Invited Talk, 2015

C Ehrhardt, Transporter-Effekte bei der Arzneistoffabsorption in der Lunge, Abteilung Pharmazeutische Technologie, Ruprecht-Karls-Universität, Heidelberg, Germany, 22/07/2014, 2014 Invited Talk, 2014

S Micallef, SH Park, JJ. Salomon, C Ehrhardt, Tobacco smoke-induced oxidative stress response in respiratory epithelial cells is attenuated by OCTN1-mediated ergothioneine uptake, AAPS J, 28th Annual Meeting of the AAPS, San Diego, CA, 02-06/11/2014, 16, (2), 2014, ppR6331 Meeting Abstract, 2014

C Ehrhardt, In vitro models of human distal lung and their application in pulmonary drug disposition research, Graduate School of Health, University of Technology, Sydney, Sydney, NSW, Australia, 09/04/2014, 2014 Invited Talk, 2014

C Ehrhardt, Spielen Arzneistofftransporter im Lungenepithel eine biopharmazeutische Rolle?, Institut für Pharmazeutische Technologie, Technische Universität Braunschweig, Braunschweig, Germany, 18/06/2014, 2014 Invited Talk, 2014

C Ehrhardt, The Physiology and Pharmacology of Drug Transporters in the Lung, Institute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, TU Dresden, Germany, 25/09/2014, 2014 Invited Talk, 2014

C Ehrhardt, Biopharmazie der Lunge - Spielen Arzneistofftransporter eine Rolle?, Institut für Pharmazeutische Technologie, Goethe-Universität, Frankfurt am Main, Germany, 04/06/2014, 2014 Invited Talk, 2014

C Ehrhardt, In vitro, ex vivo and in vivo models of pulmonary drug disposition, SF Nano Workshop on Tools and Models for Translation of Advanced Drug Delivery Systems, Porto, Portugal, 03/10/2014, 2014 Invited Talk, 2014

C Ehrhardt, Anatomy and cell physiology of the human lungs, ISPE Turkey Affiliate Pulmonary Drug Delivery Workshop, Istanbul, Turkey, 09/05/2014, 2014 Invited Talk, 2014

VE Muchitsch, JC Gausterer, JJ Salomon, C Ehrhardt, Human bronchiolar epithelial cells functionally express P-glycoprotein and multidrug resistance-related protein-1, FASEB J, Experimental Biology Meeting 2014, San Diego, CA, 26-30/04/2014, 28, 2014, pp1064.11 Meeting Abstract, 2014

C Ehrhardt, Wo geht's lang? Wege der Arzneistoffabsorption in der Lunge, Institut für Pharmazeutische Technologie und Biopharmazie, Philipps-Universität, Marburg, Germany, 02/09/2014, 2014 Invited Talk, 2014

C Ehrhardt, Drug disposition in the lung - what we do know and what we don't, Department of Physiology & Developmental Biology, Brigham Young University, Provo, UT, 15/05/2014, 2014 Invited Talk, 2014

C Ehrhardt, A probable association between the ergothioneine transporter, OCTN1 and COPD, 33rd West Coast Salt and Water Club Meeting, Avila Beach, CA, 08/03/2014, 2014 Invited Talk, 2014

C Ehrhardt, Drug Transport(ers) in the Lung: Challenges in Drug Development, Woolcock Institute of Medical Research, Sydney, NSW, Australia, 11/09/2014, 2014 Invited Talk, 2014

R Yumoto, N Sugimoto, Y Sasaki, C Yamamoto, J Nagai, C Ehrhardt, M Takano, Expression and function of a peptide transporter PEPT2 in alveolar epithelial cells in culture, 5th FIP Pharmaceutical Sciences World Congress, Melbourne, VIC, Australia, 13-16/04/2014, 2014 Meeting Abstract, 2014

C Ehrhardt, 33rd West Coast Salt and Water Club Meeting, 07-08/03/2014, 2014, Avila Beach, CA Meetings /Conferences Organised, 2014

C Ehrhardt, The many unknowns of pulmonary drug disposition, Institut für Pharmazie, Freie Universität Berlin, Berlin, Germany, 18/07/2014, 2014 Invited Talk, 2014

C Ehrhardt, MRP1 is functionally expressed in human distal lung epithelial cells, Göttinger Transportertage, Göttingen, Germany, 24/11/2013, 2013 Invited Talk, 2013

C Ehrhardt, Y Hagos, JJ Salomon, Beta-2 agonists are inhibitors but not substrates of organic cation transporters, Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society 2013, Philadelphia, PA, 17-22/05/2013, 187, 2013, ppA1890 Meeting Abstract, 2013

C Ehrhardt, JJ Salomon, Human lung epithelial cells functionally express organic cation/carnitine transporters (OCT/Ns) in vitro, AAPS Workshop on Drug Transporters in ADME: From the Bench to the Bedside, Bethesda, MD, 17-20/03/2012, 2013, ppM1005 Meeting Abstract, 2013

C Ehrhardt, Characterisation of HCI-H441 cells as an in vitro model of small airways epithelial barrier, Inhalation Asia 2013, Hong Kong, China, 26-28/06/2013, 2013 Invited Talk, 2013

C Ehrhardt, Y Hagos, JJ Salomon, Organic cation transporters in the lung are inhibited by β2-agonists, AAPS Workshop on Drug Transporters in ADME: From the Bench to the Bedside, Bethesda, MD, 17-20/03/2012, 2013, ppM1004 Meeting Abstract, 2013

C Ehrhardt, Transporter proteins in the lung epithelium, 2nd Galenus Workshop on Pulmonary Drug Delivery, Trinity College Dublin, 18-20/09/2013, 2013 Invited Talk, 2013

C Ehrhardt, Do drug transporter proteins in the lung interfere with pulmonary drug disposition? , Department of Pharmaceutics and Therapeutics, Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan, 07/10/2013, 2013 Invited Talk, 2013

C Ehrhardt, Do drug transporters influence the disposition of inhaled drugs?, Drug Delivery to the Lungs 24, Edinburgh, Scotland, UK, 12/12/2013, 2013 Invited Talk, 2013

C Ehrhardt, VE Muchitsch, F Gabor, JJ Salomon, Human bronchiolar epithelial cells functionally express P-glycoprotein and multidrug resistance-related protein-1, 28th Annual Meeting of the Japanese Society for the Study of Xenobiotics, Tokyo, Japan, 09-11/10/2013, 2013, pp2-B-O9-3 Meeting Abstract, 2013

C Ehrhardt, JC Gausterer, E Schwagerus, JJ Salomon, Characterisation of H441 cells as an in vitro model of distal lung epithelial barrier, FASEB J, Experimental Biology Meeting 2013, Boston, MA, 20-24/04/2014, 27, 2013, pp722.1 Meeting Abstract, 2013

JJ Salomon, Y Hagos, C Ehrhardt, Beta-2 receptor agonists are selective inhibitors of organic cation transporter 1 in respiratory epithelial cells, Inhalation Asia 2013, Hong Kong, China, 26-28/06/2013, 2013, pp42 Meeting Abstract, 2013

C Ehrhardt, Human bronchiolar epithelial cells functionally express P-glycoprotein and multidrug resistance-related protein-1, 28th Annual Meeting of the Japanese Society for the Study of Xenobiotics, Tokyo, Japan, 09-11/10/2013, 2013 Oral Presentation, 2013

JJ Salomon, Y Hagos, C Ehrhardt, Beta-2-receptor agonists inhibit but are not transported by organic cation transporters, J Aerosol Med Pulm Drug Deliv , 19th Congress of International Society for Aerosols in Medicine, Chapel Hill, NC, 06-10/04/2013, 26, (2), 2013, ppA40 Meeting Abstract, 2013

JJ Salomon, JC Gausterer, E Schwagerus, C Ehrhardt, Characterisation of HCI-H441 cells as an in vitro model of small airways epithelial barrier, Inhalation Asia 2013, Hong Kong, China, 26-28/06/2013, 2013, pp33 Meeting Abstract, 2013

C Ehrhardt, Drug transport across the epithelial barrier: Is it all just diffusion?, 19th Congress of International Society for Aerosols in Medicine, Chapel Hill, NC, 09/04/2013, 2013 Invited Talk, 2013

C Ehrhardt, Anatomy and cell physiology of the respiratory tract, 2nd Galenus Workshop on Pulmonary Drug Delivery, Trinity College Dublin, 18-20/09/2013, 2013 Invited Talk, 2013

JJ Salomon, JC Gausterer, E Schwagerus, C Ehrhardt, Characterisation of NCI-H441 cells as an in vitro model of human distal lung epithelium, J Aerosol Med Pulm Drug Deliv, 19th Congress of International Society for Aerosols in Medicine, Chapel Hill, NC, 06-10/04/2013, 26, (2), 2013, ppA40 Meeting Abstract, 2013

C Ehrhardt, In vitro models of human respiratory epithelial barriers and their application in biopharmaceutical studies, Chiesi Pharmaceutici, Parma, Italy, 19/06/2013, 2013 Invited Talk, 2013

C Ehrhardt, Drug Transporters in the Lung - Advances and Challenges, School of Pharmacy, Chinese University of Hong Kong, Hong Kong, China, 25/06/2013, 2013 Invited Talk, 2013

C Ehrhardt, Drug transport across the epithelial barrier: Is it all just diffusion?, J Aerosol Med Pulm Drug Deliv, 19th Congress of International Society for Aerosols in Medicine, Chapel Hill, NC, 06-10/04/2013, 26, (2), 2013, ppA10 Meeting Abstract, 2013

C Ehrhardt, 2nd Galenus Workshop on Pulmonary Drug Delivery, 18-20/09/2013, 2013, Trinity College Dublin Meetings /Conferences Organised, 2013

C Ehrhardt, Drug transporters in the lung - are they relevant for pulmonary drug disposition? , Pharmazentrum der Universität Wien, Austria, 31/05/2012, 2012 Invited Talk, 2012

C Ehrhardt, Characterisation of an in vitro model for biopharmaceutical studies of distal lung epithelial barrier: NCI-H441, 27th Annual Meeting of the Japanese Society for the Study of Xenobiotics, Chiba, Japan, 20-22/11/2012, 2012 Oral Presentation, 2012

JJ Salomon, JC Gausterer, E Schwagerus, F Gabor, C Ehrhardt, H441 - A useful in vitro model for biopharmaceutical studies of alveolar epithelial barrier, AAPS J, 26th Annual Meeting of the AAPS, Chicago, IL, 14-18/10/2012, 14, (S2), 2012, ppM1065 Meeting Abstract, 2012

N Chadderton, A Palfi, S Millington-Ward, O Gobbo, N Overlack, M Carrigan, M O'Reilly, M Campbell, C Ehrhardt, U Wolfrum, P Humphries, PF Kenna, GJ Farrar, Intravitreal delivery of AAV-NDI1 for the treatment of Leber Hereditary Optic Neuropathy, Hum Gene Ther, Retina 2011 - Fighting Blindness, Dublin, Ireland, 11-12/11/2011, 23, (10), 2012, ppA55-A56 Meeting Abstract, 2012

JJ Salomon, Y Hagos, C Ehrhardt, Beta-2 agonists are specific inhibitors but not substrates of organic cation transporters in the lung, Drug Delivery to the Lungs 23, Edinburgh, Scotland, UK, 05-07/12/2012, 2012, pp322-325 Meeting Abstract, 2012

E Schwagerus, B Illek, H Fischer, C Ehrhardt, Functional expression of epithelial sodium channel delta subunit in human respiratory epithelial cells in vitro, Am J Respir Crit Care Med , Annual Meeting of the American Thoracic Society 2012, San Francisco, CA, 18-23/05/2012, 185, 2012, ppA3528 Meeting Abstract, 2012

C Ehrhardt, Interactions between organic cation transporters and inhaled medicines, 31st West Coast Salt and Water Club Meeting, Cambria, CA, 10/03/2012, 2012 Invited Talk, 2012

JJ Salomon, Y Hagos, C Ehrhardt, Interaction of β2-receptor agonists with organic cation transporters in respiratory epithelia, AAPS J, 26th Annual Meeting of the AAPS, Chicago, IL, 14-18/10/2012, 14, (S2), 2012, ppM1064 Meeting Abstract, 2012

JJ Salomon, C Ehrhardt, Functional expression of organic cation/carnitine transporters (OCT/Ns) in lung epithelial barrier in vitro, AAPS J, 26th Annual Meeting of the AAPS, Chicago, IL, 14-18/10/2012, 14, (S2), 2012, ppM1063 Meeting Abstract, 2012

JJ Salomon, P Galeron, N Schulte, PR Morow, D Severynse-Stevens, AJ Hickey, C Ehrhardt, In vitro permeability studies of a novel inhaled antibiotic (CPZEN-45) for the treatment of tuberculosis, AAPS J, 26th Annual Meeting of the AAPS, Chicago, IL, 14-18/10/2012, 14, (S2), 2012, ppT2024 Meeting Abstract, 2012

E Schwagerus, B Illek, H Fischer, C Ehrhardt, Studies on the functional expression of epithelial sodium channel delta subunit (δ-ENaC) in human respiratory epithelial cells in vitro, FASEB J, Experimental Biology Meeting 2012, San Diego, CA, 21-25/04/2012, 26, 2012, pp696.1 Meeting Abstract, 2012

C Ehrhardt, Drug transporters in the lung - expression and role in pulmonary drug disposition, Ph.D. Course on Biological Membranes, Drug Targets and Absorption Barriers, Copenhagen, Denmark, 23/11/2012, 2012 Invited Talk, 2012

C Ehrhardt, Delta-ENaC expression and function in the airways, 31st West Coast Salt and Water Club Meeting, Cambria, CA, 10/03/2012, 2012 Invited Talk, 2012

C Ehrhardt, Regional distribution of organic cation transporters in human lung epithelial cells: Possible implications for aerosol therapy, Respiratory Drug Delivery 2012, Phoenix, AZ, 14/05/2012, 2012 Invited Talk, 2012

JJ Salomon, C Ehrhardt, Understanding the pathways of organic cation transport at the respiratory epithelial barrier, Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society 2012, San Francisco, CA, 18-23/05/2012, 185, 2012, ppA3529 Meeting Abstract, 2012

JJ Salomon, Y Hagos, C Ehrhardt, Beta-2-receptor agonists are inhibitors but not substrates of putative organic cation transporters, 27th Annual Meeting of the Japanese Society for the Study of Xenobiotics, Chiba, Japan, 20-22/11/2012, 2012, pp221 Meeting Abstract, 2012

C Ehrhardt, Beta-2-receptor agonists are inhibitors but not substrates of putative organic cation transporters, 27th Annual Meeting of the Japanese Society for the Study of Xenobiotics, Chiba, Japan, 20-22/11/2012, 2012 Oral Presentation, 2012

JJ Salomon, C Ehrhardt, Transport of organic cations across human bronchial and bronchiolar epithelial barriers in vitro, FASEB J, Experimental Biology Meeting 2012, San Diego, CA, 21-25/04/2012, 26, 2012, pp694.9 Meeting Abstract, 2012

C Ehrhardt, Drug Transporters in the Lung - Fact or Fiction? , 2012 Drug Delivery Symposium honouring Prof. Vincent H. L. Lee, Aurora, CO, 14/06/2012, 2012 Invited Talk, 2012

C Ehrhardt, Drug transporter research in the lungs - Past, present and future, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan, 19/11/2012, 2012 Invited Talk, 2012

JJ Salomon, JC Gausterer, E Schwagerus, F Gabor, C Ehrhardt, Characterisation of an in vitro model for biopharmaceutical studies of distal lung epithelial barrier: NCI-H441, 27th Annual Meeting of the Japanese Society for the Study of Xenobiotics, Chiba, Japan, 20-22/11/2012, 2012, pp220 Meeting Abstract, 2012

JJ Salomon, KI Hosoya, C Ehrhardt, Competitive inhibition of [14C]-TEA uptake in A549 cell monolayers by formoterol and salbutamol, FASEB J, Experimental Biology Meeting 2011, Washington, DC, 09-13/04/2011, 25, 2011, pp1015.2 Meeting Abstract, 2011

L DeMaio, ST Buckley, P Flodby, A Banfalvi, MS Krishnaveni, Y Xing, C Ehrhardt, P Minoo, ED Crandall, Z Borok, Induction of epithelial-mesenchymal transition (EMT) in alveolar epithelial cells (AEC) by type I collagen (Col1) involves signaling via transforming growth factor-β type I receptor (TβRI), Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society 2011, Denver, CO, 13-18/05/2011, 183, 2011, ppA2709 Meeting Abstract, 2011

JJ Salomon, S Endter, ST Buckley, C Ehrhardt, Translocation pathways of 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP+) across human respiratory epithelial cell monolayers, AAPS Workshop on Drug Transporters in ADME: From the Bench to the Bedside, Bethesda, MD, 14-16/03/2011, 2011, ppW3019 Meeting Abstract, 2011

C Ehrhardt, Expression of membrane transport proteins in the lung, 26th Annual Meeting of the Japanese Society for the Study of Xenobiotics, Hiroshima, Japan, 16/11/2011, 2011 Invited Talk, 2011

C Ehrhardt, Nanoparticles in pulmonary drug delivery: Applications in lung cancer & gene delivery, 18th Congress of International Society for Aerosols in Medicine, Rotterdam, NL, 20/06/2011, 2011 Invited Talk, 2011

C Ehrhardt, Do drug transporters in the lung have an impact on respiratory drug disposition? , Medical University of Vienna, Department of Pathophysiology, Vienna, Austria, 30/09/2011, 2011 Invited Talk, 2011

C Ehrhardt, Atomic force microscopy (AFM) and high content analysis (HCA) as novel tools to quantify alveolar EMT, 30th West Coast Salt and Water Club Meeting, Morro Bay, CA, 12/03/2011, 2011 Invited Talk, 2011

JJ Salomon, KI Hosoya, C Ehrhardt, Drug transporters in the respiratory mucosa: expression and interplay with β-receptor agonists, Drug Delivery to the Lungs 22, Edinburgh, Scotland, UK, 07-09/12/2011, 2011, pp61-64 Meeting Abstract, 2011

JJ Salomon, S Endter, ST Buckley, C Ehrhardt, Uptake pathways for 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP+) in human respiratory epithelial cell monolayers, AAPS J, 25th Annual Meeting of the AAPS, Washington, DC, 23-27/10/2011, 13, (S2), 2011, ppT2121 Meeting Abstract, 2011

JJ Salomon, M Tachikawa, KI Hosoya, C Ehrhardt, Beta-agonists interfere with the transport of organic cations across the human alveolar epithelial barrier, AAPS Workshop on Drug Transporters in ADME: From the Bench to the Bedside, Bethesda, MD, 14-16/03/2011, 2011, ppW3018 Meeting Abstract, 2011

V Patel, ST Buckley, MS Krishnaveni, M Ivan, L DeMaio, ED Crandall, C Ehrhardt, Z Borok, Troglitazone attenuates TGF-β1-induced epithelial-mesenchymal transition (EMT) in alveolar epithelial cells (AEC) through peroxisome proliferator activated receptor γ (PPARγ) receptor-independent mechanisms, Am J Respir Crit Care Med , Annual Meeting of the American Thoracic Society 2011, Denver, CO, 13-18/05/2011, 183, 2011, ppA3508 Meeting Abstract, 2011

E Schwagerus, ST Buckley, C Ehrhardt, Studies on the activity of the delta-ENaC in human respiratory epithelial cell lines, FASB J, Experimental Biology Meeting 2011, Washington, DC, 09-13/04/2011, 25, 2011, pp659.1 Meeting Abstract, 2011

JJ Salomon, KI Hosoya, C Ehrhardt, Expression of membrane transport proteins in the lung, 26th Annual Meeting of the Japanese Society for the Study of Xenobiotics, Hiroshima, Japan, 16-18/11/2011, 2011, pp244 Meeting Abstract, 2011

JJ Salomon, T Yahara, KI Hosoya, C Ehrhardt, Characterisation of organic cation/carnitine transporters in human alveolar epithelial cell monolayers (A549), Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society 2011, Denver, CO, 13-18/05/2011, 183, 2011, ppA4237 Meeting Abstract, 2011

JJ Salomon, KI Hosoya, C Ehrhardt, Involvement of organic cation transporters (OCTs) in β2-agonist uptake at the human respiratory epithelial barrier, AAPS J, 25th Annual Meeting of the AAPS, Washington, DC, 23-27/10/2011, 13, (S2), 2011, ppT2120 Meeting Abstract, 2011

F Tewes, L Tajber, C Ehrhardt, AM Healy, Formulation of colistin-ambroxol microparticles for passive targeting of lung infections, AAPS J, 25th Annual Meeting of the AAPS, Washington, DC, 23-27/11/2011, 13, (S2), 2011, ppM1046 Meeting Abstract, 2011

JJ Salomon, S Etzbach, F Májer, JF Gilmer, CM Lehr, C Ehrhardt, Fluorescent bile acids for the assessment of organic anionic transporting polypeptide (OATP) function, AAPS J, 25th Annual Meeting of the AAPS, Washington, DC, 23-27/10/2011, 13, (S2), 2011, ppT2119 Meeting Abstract, 2011

JJ Salomon, T Yahara, KI Hosoya, C Ehrhardt, Activity assessment of organic cation/carnitine transporters in A549 alveolar epithelial cells, FASEB J, Experimental Biology Meeting 2011, Washington, DC, 09-13/04/2011, 25, 2011, pp1015.1 Meeting Abstract, 2011

S Etzbach, JJ Salomon, F Májer, MN Mohd Najib, CM Lehr, JF Gilmer, C Ehrhardt, Fluorescence-labelled bile acids as novel tools to measure organic anionic transporting polypeptide (OATP) function, AAPS Workshop on Drug Transporters in ADME: From the Bench to the Bedside, Bethesda, MD, 14-16/03/2011, 2011, ppW3020 Meeting Abstract, 2011

J Swaminathan, C Ehrhardt, Salmon calcitonin delivery via the lung using liposomal carriers, AAPS J, 25th Annual Meeting of the AAPS, Washington, DC, 23-27/10/2011, 13, (S2), 2011, ppT2068 Meeting Abstract, 2011

C Ehrhardt, Understanding absorption across the pulmonary mucosa, Informa's Inhalation Drug Development, London, UK, 13/10/2011, 2011 Invited Talk, 2011

JJ Salomon, KI Hosoya, C Ehrhardt, Impact of β2-agonists on transcellular pathways of organic cations at the human alveolar epithelial barrier, 26th Annual Meeting of the Japanese Society for the Study of Xenobiotics, Hiroshima, Japan, 16-18/11/2011, 2011, pp220 Meeting Abstract, 2011

F Tewes, M Zurek, C Ehrhardt, Y Crémillieux, OL Gobbo, Manganese: A new contrast agent for lung imaging?, AAPS J, 25th Annual Meeting of the AAPS, Washington, DC, 23-27/10/2011, 13, (S2), 2011, ppT2069 Meeting Abstract, 2011

E Schwagerus, ST Buckley, C Ehrhardt, Expression and function of the epithelial sodium channel delta subunit in human respiratory, Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society 2011, Denver, CO, 13-18/05/2011, 183, 2011, ppA4229 Meeting Abstract, 2011

JJ Salomon, KI Hosoya, C Ehrhardt, Formoterol and salbutamol are competitive inhibitors of [14C]-TEA uptake in A549 cell monolayers, Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society 2011, Denver, CO, 13-18/05/2011, 183, 2011, ppA4238 Meeting Abstract, 2011

JJ Salomon, C Ehrhardt, Nanoparticles attenuate P-glycoprotein function in A549 cells, FASEB J, Experimental Biology Meeting 2010, Anaheim, CA, 24-28/04/2010, 24, 2010, pp758.1 Meeting Abstract, 2010

C Ehrhardt, Culturing alveolar type II epithelial cells from human tissue specimens, BRU/GSK Epithelial Cells in Idiopathic Pulmonary Fibrosis Workshop, Nottingham, UK, 15/10/2010, 2010 Invited Talk, 2010

ST Buckley, V Patel, MS Krishnaveni, ED Crandall, C Ehrhardt, Z Borok, Troglitazone attenuates TGF-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells, AAPS J, 24th Annual Meeting of the AAPS, New Orleans, 14-18/11/2010, 12, (S2), 2010, ppW4438 Meeting Abstract, 2010

L Baginski, ST Buckley, U Bakowsky, C Ehrhardt, Stability of salmon calcitonin against trypsin, chymotrypsin and neutrophil elastase in human lung epithelial cells, Sci Pharm, 8th Central European Symposium on Pharmaceutical Technology, Graz, Austria, 16-18/09/2010, 78, (3), 2010, pp720 Meeting Abstract, 2010 TARA - Full Text URL

JJ Salomon, C Ehrhardt, A functional and toxicological evaluation of latex nanoparticles: Effect on P-glycoprotein function in A549 cells, AAPS J, 24th Annual Meeting of the AAPS, New Orleans, LA, 14-18/11/2010, 12, (S2), 2010, ppM1216 Meeting Abstract, 2010

J Swaminathan, C Ehrhardt, Salmon calcitonin delivery via the lung using liposomal carriers, AAPS J, 24th Annual Meeting of the AAPS, New Orleans, New Orleans, LA, 24th Annual Meeting , 12, (S2), 2010, ppW2029 Meeting Abstract, 2010

E Schwagerus, ST Buckley, C Ehrhardt, ENaC delta-subunit is functionally expressed in human respiratory epithelial cells, Am J Respir Crit Care Med , Annual Meeting of the American Thoracic Society 2010,, New Orleans, LA, 14-19/05/2010, 181, (1), 2010, ppA6454 Meeting Abstract, 2010

C Ehrhardt, Pulmonary drug delivery and inhalation biopharmaceutics, Advanced Delivery Strategies for Pharmaceutics and Cosmetics, Lyon, France, 07/10/2010, 2010 Invited Talk, 2010

L Baginski, ST Buckley, U Bakowsky, C Ehrhardt, Stability of inhaled salmon calcitonin against trypsin, chymotrypsin and neutrophil elastase, AAPS J, 24th Annual Meeting of the AAPS, New Orleans, LA, 14-18/11/2010, 12, (S2), 2010, ppW2026 Meeting Abstract, 2010

C Ehrhardt, Drug disposition in the lung - how in vitro models can help optimising inhalation therapy, Universität Basel, Departement Pharmazeutische Wissenschaften, Basel, Switzerland, 16/08/2010, 2010 Invited Talk, 2010

L Baginski, U Bakowsky, C Ehrhardt, Stability of inhaled salmon calcitonin at the respiratory epithelial barrier, Am J Respir Crit Care Med , Annual Meeting of the American Thoracic Society 2010, New Orleans, LA, 14-19/05/2010, 181, (1), 2010, pp3622 Meeting Abstract, 2010

J Swaminathan, C Ehrhardt, Formulation and in-vitro characterisation of liposomal systems for salmon calcitonin (sCT) delivery to the lung, Drug Delivery to the Lungs 21, Edinburgh, Scotland, UK, 08-10/12/2010, 2010, pp327-330 Meeting Abstract, 2010

E Schwagerus, ST Buckley, C Ehrhardt, Functional expression of the epithelial sodium channel delta subunit in human respiratory epithelial cells, FASEB J, Experimental Biology Meeting 2010, Anaheim, CA, 24-28/04/2010, 24, 2010, pp611.14 Meeting Abstract, 2010

C Ehrhardt, Expression of drug transporter proteins in human respiratory epithelial barrier, University of Toyama. Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan, 28/01/2010 , 2010 Invited Talk, 2010

C Ehrhardt, Surface modified liposomes for targeted aerosol delivery to lung tumours, 8th International Conference and Workshop on Biological Barriers - In Vitro Tools, Nanotoxicology and Nanomedicine, Saarbrücken, Germany, 22/03/2010, 2010 Invited Talk, 2010

C Ehrhardt, S Endter, G Tachon, M Gumbleton, Organic cation transporter expression and activity in human respiratory epithelial cells, Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society 2009, San Diego, CA, 15-20/05/2009, 179, (1), 2009, ppA4939 Meeting Abstract, 2009

C Ehrhardt, Absorption mechanisms for biopharmaceuticals across respiratory epithelium, 1000 Years of Pharmaceutical Aerosols, Reykjavik, Iceland, 02/10/2009, 2009 Invited Talk, 2009

JJ Salomon, S Endter, C Ehrhardt, Organic cation transporters are functionally expressed in human respiratory epithelial cells, AAPS J, 23rd Annual Meeting of the AAPS, Los Angeles, CA, 08-12/11/2009, 11, (S2), 2009, ppW5134 Meeting Abstract, 2009

L Baginski, GC Boutsikaris, C Ehrhardt, The role of epithelial proteases in the pulmonary absorption of calcitonin, AAPS J, 23rd Annual Meeting of the AAPS, Los Angeles, CA, 08-12/11/2009, 11, (S2), 2009, ppT3103 Meeting Abstract, 2009

J Swaminathan, MM Gaspar, C Ehrhardt, Characterisation of liposome aerosols generated with the AeroProbe nebulisation catheter, DDL Proceedings, Drug Delivery to the Lungs 20, Edinburgh, UK, 09-11/12/2009, 2009, pp76-79 Meeting Abstract, 2009

C Ehrhardt, G Tachon, S Endter, Organic cation transporter expression and function in human pulmonary epithelial cells, FASEB J, Experimental Biology Meeting 2009, New Orleans, LA, 18-22/04/2009, 23, 2009, pp748.6 Meeting Abstract, 2009

E Passante, C Ehrhardt, H Sheridan, N Frankish, Toll-like receptors and RBL-2H3 mast cells, Inflamm Res, 37th Annual Meeting of the European Histamine Release Society, Stockholm, Sweden, 07-10/05/2008, 58, (S1), 2009, pp11-12 Meeting Abstract, 2009

C Ehrhardt, S Endter, G Tachon, M Gumbleton, Expression and activity of organic cation transporter in human respiratory epithelial cells, J Aerosol Med Pulm Drug Deliv, 17th Congress of the International Society for Aerosols in Medicine, Monterey, CA, 10-14/05/2009, 22, (2), 2009, pp198 Meeting Abstract, 2009

C Ehrhardt, Development of liposome aerosols for (lung)cancer therapy by inhalation, University of Southern California, School of Pharmacy, Los Angeles, CA, 27/03/2009, 2009 Invited Talk, 2009

L Baginski, G Tachon, C Ehrhardt, Investigations on peptidases expression pattern in respiratory epithelial cells, Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society 2009, San Diego, CA, 15-20/05/2009, 179, (1), 2009, ppA4969 Meeting Abstract, 2009

C Ehrhardt, The use of in vitro epithelial cell culture models for pulmonary delivery, 1st SFI Irish Drug Delivery Research Network (IDDRN) Cluster Conference - Optimising Drug Delivery, Dublin, 19/08/2009, 2009 Invited Talk, 2009

C Ehrhardt, The role of RAGE in epithelial-mesenchymal transition in the human alveolus, 28th West Coast Salt and Water Club Meeting, Morro Bay, CA, 14/03/2009, 2009 Invited Talk, 2009

J Swaminathan, MM Gaspar, C Ehrhardt, Characterisation of liposome aerosols generated with new generation nebulisers, AAPS J, 23rd Annual Meeting of the AAPS, Los Angeles, CA, 08-12/11/2009, 11, (S2), 2009, ppR6396 Meeting Abstract, 2009

L Baginski, GC Boutsikaris, G Tachon, C Ehrhardt, Peptidases expression patterns in respiratory epithelial cells, J Aerosol Med Pulm Drug Deliv, 17th Congress of the International Society for Aerosols in Medicine, Monterey, CA, 10-14/05/2009, 22, (2), 2009, pp195 Meeting Abstract, 2009

MM Gaspar, A Radomska, O Gobbo, MW Radomski, C Ehrhardt, Effect of inhaled anti-cancer liposomes in an orthotopic lung cancer model in the nude rat, J Aerosol Med Pulm Drug Deliv, 17th Congress of the International Society for Aerosols in Medicine, Monerey, CA, 10-14/05/2009, 22, (2), 2009, pp190 Meeting Abstract, 2009

P Stasiak, S Endter, C Ehrhardt, M Sznitowska, In Vitro studies of a novel ibuprofen 3-hydroxybutyric acid conjugate, Proc Intern Symp Control Rel Bioact Mat , 35th Annual Meeting of the Controlled Release Society, New York, NY, 12-16/07/2008, 35, (1), 2008, pp786 Meeting Abstract, 2008

P Stasiak, C Ehrhardt, M Sznitowska, Ibuprofen 3-hydroxybutyric acid oligomer conjugates - physicochemical characterisation and cytotoxicity studies, 19th International Symposium on Pharmaceutical and Biomedical Analysis, Gdańsk, Poland, 08-12/6/2008, 2008, pp150 Meeting Abstract, 2008

E Passante, C Ehrhardt, H Sheridan, N Frankish, In vitro inhibition of rat basophilic leukaemia mast cell (RBL-2H3) degranulation by novel indane compounds. , Inflamm Res, 36th Annual Meeting of the European Histamine Release Society, Firenze, Italy, 09.-12.05.2007, 57, (S1), 2008, ppS01-S02 Meeting Abstract, 2008

C Ehrhardt, Drug disposition in the lung - recent advantages in understanding the role of drug transporters, Respiratory Drug Delivery 2008, Scottsdale, AZ, 12/05/2008, 2008 Invited Talk, 2008

P Stasiak, C Ehrhardt, M Sznitowska, Biopharmaceutical evaluation of a conjugate of ibuprofen with 3-hydroxybutyric acid oligomers, 7th International Conference on Biological Barriers and Nanomedicine -Advanced Drug Delivery and Predictive non vivo Testing Technologies, Saarbrücken, Germany, 20-29/02/2008, 2008 Meeting Abstract, 2008

MM Gaspar, C Ehrhardt, Influence of nebulization on physicochemical properties of liposomes., Respiratory Drug Delivery, Respiratory Drug Delivery 2008, Scottsdale, AZ, 11-15/05/2008, 11, (3), 2008, pp771-774 Meeting Abstract, 2008

S Endter, M Gumbleton, C Ehrhardt, Charaterisation of organic cation transporters in human respiratory epithelial cells, 2nd International Symposium "Cellular Delivery of Therapeutic Macromolecules 2008", Cardiff, UK, 22-25/6/2008, 2008, pp80 Meeting Abstract, 2008

L Baginski, C Ehrhardt, Comparison of peptidases expression in Calu-3 and Caco-2 cells by RT-PCR, AAPS J, 22nd Annual Meeting of the AAPS, Atlanta, GA, 16-20/11/2008, 10, (S2), 2008, ppW5272 Meeting Abstract, 2008

MM Gaspar, C Ehrhardt, Physicochemical characterisation of liposomes for aerosol delivery, Proc Intern Symp Control Rel Bioact Mat, 35th Annual Meeting of the Controlled Release Society, New York, NY, 12-16/07/2008, 35, (1), 2008, pp774 Meeting Abstract, 2008

L Horálková, S Endter, R Andersen, R Koslowski, C Ehrhardt, Characterization of the R3/1 cell line as a type I alveolar epithelial cell model for biopharmaceutical studies., Respiratory Drug Delivery, Respiratory Drug Delivery 2008, Scottsdale, AZ, 11-15/05/2008, 11, (3), 2008, pp775-778 Meeting Abstract, 2008

C Ehrhardt, Liposome aerosols in (lung)cancer therapy, 4th International Intensive Course and Workshop on Nanomedicines - Nanoparticulates for Drug Delivery, Patras, Greece, 16/09/2008, 2008 Invited Talk, 2008

C Ehrhardt, M Gumbleton, S Endter, Analysis of mRNA for ABC - SLC- and SLCO-transporter in human respiratory epithelial cells, FASEB J, Experimental Biology Meeting 2009, San Diego, CA, 05-09/04/2008, 22, 2008, pp918.6 Meeting Abstract, 2008

M Gaspar, U Bakowsky, C Ehrhardt, Aerosolised liposomes: influence of physicochemical properties and nebulisation device, AAPS J, 22nd Annual Meeting of the AAPS, Atlanta, GA, 16-20/11/2008, 10, (S2), 2008, ppT2163 Meeting Abstract, 2008

P Stasiak, M Sznitowska, C Ehrhardt, Ibuprofen-3-hydroxybutyric acid oligomer conjugates for drug delivery applications, AAPS J, 22nd Annual Meeting of the AAPS, Atlanta, GA, 16-20/11/2008, 10, (S2), 2008, ppM1168 Meeting Abstract, 2008

P Stasiak, M Sznitowska, C Ehrhardt, Caco-2 cell monolayer studies of ibuprofen - oligo (3-hydroxybutyric acid) conjugates, 2nd International Symposium "Cellular Delivery of Therapeutic Macromolecules 2008", Cardiff, UK, 22-25/6/2008, 2008, pp82 Meeting Abstract, 2008

MM Gaspar, F de Sousa Menezes, MW Radomski, C Ehrhardt, Effects of liposomal surface charge on human platelet aggregation, Proc Intern Symp Control Rel Bioact Mat, 35th Annual Meeting of the Controlled Release Society, New York, NY, 12-16/07/2008, 35, (1), 2008, pp748 Meeting Abstract, 2008

L Horálková, S Endter, R Koslowski, C Ehrhardt, The rat alveolar epithelial type I-like cell line R3/1 - Characterisation as an in vitro model for drug disposition, Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society 2008, Toronto, Canada, 16-21/05/2008, 177, 2008, ppA197 Meeting Abstract, 2008

S Endter, M Gumbleton, C Ehrhardt, Expression analysis of ABC - SLC- and SLCO-transporter mRNA in human respiratory epithelial cells, Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society 2008, Toronto, Canada, 16-21/05/2008, 177, 2008, ppA204 Meeting Abstract, 2008

L Horálková, S Endter, R Andersen, R Koslowski, C Ehrhardt, R3/1 alveolar epithelial cells - characterisation of a new in vitro model for pulmonary drug disposition, 2nd International Symposium "Cellular Delivery of Therapeutic Macromolecules 2008", Cardiff, UK, 22-25/6/2008, 2008, pp77 Meeting Abstract, 2008

C Ehrhardt, S Endter, R Andersen, R Koslowski, L Horálková, The R3/1 alveolar epithelial type I like cell line - Characterisation as an in vitro model for drug disposition, FASEB J, Experimental Biology Meeting 2009, San Diego, CA, 05-09/04/2008, 22, 2008, pp762.5 Meeting Abstract, 2008

L Baginski, C Ehrhardt, Investigation of mRNA expression of proteolytic enzymes in Calu-3 bronchial epithelial cells, 2nd International Symposium "Cellular Delivery of Therapeutic Macromolecules 2008", Cardiff, UK, 22-25/6/2008, 2008, pp78 Meeting Abstract, 2008

M Gaspar, F de Sousa Menezes, MW Radomski, C Ehrhardt, Effect of liposomal systems on human platelet aggregation, AAPS J, 22nd Annual Meeting of the AAPS, Atlanta, GA, 16-20/11/2008, 10, (S2), 2008, ppT2107 Meeting Abstract, 2008

L Horálková, S Endter, P Dole al, C Ehrhardt, Characterisation of the rat alveolar type I-like epithelial cell line R3/1 as an in vitro absorption model, 3rd Pharmaceutical Sciences World Congress, Amsterdam, The Netherlands, 19.-25.04.2007, 2007, pp51 Meeting Abstract, 2007

L Horálková, S Endter, R Koslowski, C Ehrhardt, Characterisation of the rat alveolar epithelial type I-like cell line R3/1 for use as an in vitro model of pulmonary drug disposition, Drug Delivery to the Lungs 18, Edinburgh, UK, 12.-14.12.2007, 2007, pp141-143 Meeting Abstract, 2007

S Endter, M Gumbleton, C Ehrhardt, RT-PCR analysis of ABC- and SLC-transporter expression in human respiratory epithelial cells, AAPS Workshop Drug Transporters in ADME: From the Bench to the Bedside, Bethesda, MD, 05.-07.03.2007, 2007, ppM1028 Meeting Abstract, 2007

C Ehrhardt, Symposium on the Fluid Bed Coating of Micro Pellets, 26.-27.09.2007, 2007, Dublin, Ireland Meetings /Conferences Organised, 2007

L Horálková, S Endter, P Dole al, C Ehrhardt, The rat alveolar type I-like epithelial cell line R3/1 as an in vitro model for pulmonary drug disposition, AAPS J, 2007 AAPS National Biotechnology Conference, San Diego, CA, 24.-27.06.2007, 9, (S1), 2007, ppT2073 Meeting Abstract, 2007

C Ehrhardt, 5th Thematic Network Meeting of the Galenos Marie Curie Early Research Training Programme of the 6th Framework, 08.-11.09.2007, 2007, Dublin, Ireland Meetings /Conferences Organised, 2007

E Passante, S Endter, MH Tindal, MR Pankratz, NH Frankish, C Ehrhardt, Albuterol is net absorbed across human bronchial epithelial cell layers in an enantiomer-dependent fashion, FASEB J, Experimental Biology Meeting 2007, Washington, DC, 28.04.-02.05.2007, 21, (5), 2007, pp881.2 Meeting Abstract, 2007

S Endter, M Gumbleton, C Ehrhardt, Characterisation of ABC- and SLC-transporter mRNA transcripts in human respiratory epithelial cells, AAPS J, 2007 AAPS National Biotechnology Conference, San Diego, CA, 24.-27.06.2007, 9, (S1), 2007, ppT2072 Meeting Abstract, 2007

E Passante, C Ehrhardt, H Sheridan, N Frankish, Effect of novel indanes on the degranulation of rat basophilic leukemia mast cells (RBL-2H3), FASEB J, Experimental Biology Meeting 2007, Washington, DC, 28.04.-02.05.2007, 21, (5), 2007, pp574.9 Meeting Abstract, 2007

C Ehrhardt, Monolayers of human alveolar epithelial cells as tools in biomedical research, California Pacific Medical Center Research Institute, San Francisco, CA, 18.05.2007, 2007 Invited Talk, 2007

U Becker, C Ehrhardt, UF Schaefer, CM Lehr, Comparison and evaluation of different models of the corneal epithelium with focus on ocular drug delivery, 3rd Pharmaceutical World Sciences Congress, Amsterdam, The Netherlands, 19.-25.4.2007, 2007, pp31 Meeting Abstract, 2007

S Endter, M Gumbleton, C Ehrhardt, Expression of ABC- and SLC-transporter mRNA transcripts in human lung epithelial cells, AAPS J, 21st Annual Meeting of the AAPS, San Diego, CA, 11.-15.11.2007, 9, (S2), 2007, ppM2016 Meeting Abstract, 2007

J Coppins, I Hook, C Nestor, H Sheridan, C Ehrhardt, N Frankish, Inhibition of LFA-1 mediated T-Cell motility by Naphthoquinones, Royal Academy of Medicine in Ireland, Biomedical Sciences Section, Winter Meeting 2007, Dublin, Ireland , 11.01.2007 , 2007 Meeting Abstract, 2007

S Endter, E Passante, MH Tindal, MR Pankratz, NH Frankish, C Ehrhardt, Albuterol but not formoterol shows enantiomer-dependent net absorption across human bronchial epithelial cell layers, Am J Respir Crit Care Med , Annual Meeting of the American Thoracic Society 2007, San Franscisco, CA, 18.-23.05.2007, 175, 2007, ppA751 Meeting Abstract, 2007

S Endter, M Gumbleton, C Ehrhardt, Qualitative analysis of mRNA transcripts for ABC- SLC- and SLCO-transporter in human respiratory epithelial cells, Drug Delivery to the Lungs 18, Edinburgh, 12.-14.12.2007, 2007, pp200-201 Meeting Abstract, 2007

C Ehrhardt, Active drug transport in the lung, 11. Active drug transport in the lung. 04.10.2007, APS Inhalation and Biopharmaceutics Symposium - Biopharmaceutics of Inhaled Drug Delivery, London, UK, 04.10.2007, 2007 Invited Talk, 2007

L Horálková, S Endter, P Dole al, C Ehrhardt, Characterisation of the rat alveolar epithelial cell line R3/1 as an in vitro model for drug disposition studies, AAPS J, 21st Annual Meeting of the AAPS, San Diego, CA, 11.-15.11.2007, 9, (S2), 2007, ppM1216 Meeting Abstract, 2007

J O'Meara, J Coppins, C Ehrhardt, I Hook, N Frankish, H Sheridan, F de Sousa Menezes, Phytochemical and pharmacological evaluation of aqueous extracts of seven Plectranthus species. , 50th Anniversary Meeting of the Phytochemical Society of Europe, Cambridge, UK, 11.-14.04.2007, 2007 Meeting Abstract, 2007

J O'Meara, L Visdal Johnsen, C Ehrhardt, J Coppins, N Frankish, H Kelleher, Y Li, F de Sousa Menezes, Bioactivity guided fractionation of Isodon yunnanensis Handel-Mazzetti, using A549 human alveolar epithelial lung cancer cell line, 50th Anniversary Meeting of the Phytochemical Society of Europe, Cambridge, UK, 11.-14.04.2007, 2007 Meeting Abstract, 2007

S Endter, M Gumbleton, P Buckland, CM Lehr, C Ehrhardt, RT-PCR analysis of PEPT1, PEPT2, OCT2, OCTN2 and OATP in human lung epithelial cell cultures, 3rd Pharmaceutical World Sciences Congress, Amsterdam, The Netherlands, 19.-25.4.2007, 2007, pp50 Meeting Abstract, 2007

U Becker, C Ehrhardt, UF Schaefer, KW Ruprecht, CM Lehr, Proteins of the multi-drug resistance in human corneal tissue, 6th International Conference and Workshop on Cell Culture and in vitro Models for Drug Absorption and Delivery, Saarbrücken, Germany, 01.03.-10.03.2006, 2006 Meeting Abstract, 2006

C Ehrhardt, M Bur, N Hagen, M Guldbrandt, H Huwer, CM Lehr, KJ Kim, Net absorption of serum proteins across primary human alveolar epithelial cell (hAEpC) monolayers., FASEB J, Experimental Biology Meeting 2006, San Francisco, CA, 01.-05.04.2006, 20, (5), 2006, ppA1438 Meeting Abstract, 2006

C Ehrhardt, Human alveolar epithelial cells in primary culture as a tool for physiological studies, University College Cork, Department of Physiology, Cork, Ireland, 11.12.2006, 2006 Invited Talk, 2006

C Ehrhardt, In vitro models of the lung, 3rd Socrates Intensive Programme: Innovative Therapeutics - From Molecules to Medicines, Athens, Greece, 05.07.2006, 2006 Invited Talk, 2006

C Ehrhardt, C Kneuer, C Baldes, KJ Kim, CM Lehr, Albuterol is net absorbed across human alveolar epithelial cell monolayers, Proc Am Thor Soc , Annual Meeting of the American Thoracic Society 2006, San Diego, CA, 19.-24.05.2006, 3, 2006, ppA761 Meeting Abstract, 2006

C Ehrhardt, Drug absorption across human respiratory epithelial barriers, Pfizer, La Jolla, CA, 11.08.2006, 2006 Invited Talk, 2006

S Endter, CM Lehr, P Buckland, M Gumbleton, C Ehrhardt. , Expression of drug transporter mRNA in human lung epithelial cell models, 6th International Conference and Workshop on Cell Culture and in vitro Models for Drug Absorption and Delivery, Saarbrücken, Germany, 01.03.-10.03.2006, 2006 Meeting Abstract, 2006

C Ehrhardt, Prediction of pulmonary pharmacokinetics using in vitro models of the lung, 3rd Socrates Intensive Programme: Innovative Therapeutics - From Molecules to Medicines, Athens, Greece, 05.07.2006, 2006 Invited Talk, 2006

C Ehrhardt, Drug absorption across human bronchial and alveolar epithelial barriers, University of Southern California, Los Angeles, CA, 03.08.2006, 2006 Invited Talk, 2006

S Anabousi, E Kleemann, U Bakowsky, CM Lehr, C Ehrhardt, Transferrin-modified liposomes for inhalation therapy of lung can, Proc Intern Symp Control Rel Bioact Mat, 33rd Annual Meeting of the Controlled Release Society, Wien, Austria, 22.-26.07.2006, 33, (1), 2006, pp35 Meeting Abstract, 2006

C Ehrhardt, Drug absorption across human lung alveolar epithelial barrier, Nektar Therapeutics, San Carlos, CA, 31.07.2006, 2006 Invited Talk, 2006

C Ehrhardt, Drug delivery across pulmonary biological barriers, 8th International Symposium on Pharmaceutical Sciences, Ankara, Turkey, 13.06.2006, 2006 Invited Talk, 2006

S Anabousi, U Bakowsky, E Kleemann, CM Lehr, C Ehrhardt, Liposomal drug carrier systems for inhalation therapy of lung cancer, AAPS J, 20th Annual Meeting of the AAPS, San Antonio, TX, 28.10.-02.11.2006, 8, (S2), 2006, ppT2099 Meeting Abstract, 2006

C Kneuer, MNV Ravi Kumar, CM Lehr, T Kissel, C Ehrhardt, U Bakowsky, Novel nanoscale drug delivery systems, Proc BioNanoMaT, Bioinspired Nanomaterials for Medicine and Technologies, Marl, Germany, 23.-24.11.2005, 2005, pp45 Meeting Abstract, 2005

C Ehrhardt, Cell culture models of biological barriers - lung epithelium, Proc Intern Symp Control Rel Bioact Mat, 32nd Annual Meeting of the Controlled Release Society, Miami Beach, FL, 18.-22.06.2005, 32, (1), 2005, pp130 Meeting Abstract, 2005

S Anabousi, CM Lehr, C Ehrhardt, Binding and uptake of transferring-modified liposomes in lung epithelial cells, Proc CRS German Chapter Annual Meeting, CRS German Chapter Annual Meeting, Marburg, Germany, 15.03.2005, 2005, pp17 Meeting Abstract, 2005

U Becker, C Ehrhardt, UF Schaefer, KW Rupprecht, CM Lehr, Proteins of the multi-drug resistance in human corneal tissue, Proc Association for Research in Vision and Ophthalmology Annual Meeting, Association for Research in Vision and Ophthalmology Annual Meeting 2005, Fort Lauderdale, FL, 01.-05.05.2005, 2005, pp113 Meeting Abstract, 2005

C Ehrhardt, Drug absorption and metabolism in the lung - the impact of cell-based in vitro models, Jordan University, Amman, Jordan, 25.07.2005, 2005 Invited Talk, 2005

C Ehrhardt, Drug absorption via the respiratory tract - challenges and opportunities, Jordan University, Amman, Jordan, 19.07.2005, 2005 Invited Talk, 2005

C Ehrhardt, Net absorption of albuterol across bronchial epithelial cell layers, Sepracor Scientific Research Forum, Boston, MA, 30.09.2005, 2005 Invited Talk, 2005

C Ehrhardt , Cell culture models of biological barriers - lung epithelium, 32nd Annual meeting of the Controlled Release Society, Miami Beach, FL, 22.06.2005, 2005 Invited Talk, 2005

C Ehrhardt, Liposomal Drug Delivery - new strategies for the treatment of cancer and inflammation, Jordan University, Amman, Jordan, 26.07.2005, 2005 Invited Talk, 2005

C Ehrhardt , Human alveolar epithelial cell monolayers in primary culture for drug absorption and metabolism studies, Novo Nordisk A/S, Målov, Denmark, 29.04.2005, 2005 Invited Talk, 2005

S Anabousi, CM Lehr, C Ehrhardt, Transferrin-modified liposomes for treatment of lung cancer - binding and uptake studies using human lung epithelial cells, 17th Mountain/Sea Liposome Workshop, Oberjoch, Germany, 04.-08.04.2005, 2005 Meeting Abstract, 2005

S Endter, C Ehrhardt, CM Lehr, P Buckland, M Gumbleton, RT-PCR analysis of drug transporters in human lung epithelial cell models, AAPS J, 19th Annual Meeting of the AAPS, Nashville, TN, 06.11.-10.11.2005, 7, (S2), 2005, ppR6244 Meeting Abstract, 2005

M Bur, CM Lehr, N Hagen, M Guldbrandt, C Ehrhardt, Assessment of protein transport rates across human alveolar epithelial cell layers, AAPS J, 19th Annual Meeting of the AAPS, Nashville, TN, 06.11.-10.11.2005, 7, (S2), 2005, ppT2142 Meeting Abstract, 2005

C Ehrhardt, Pulmonary drug delivery, 7th ULLA Summer School, Uppsala, Sweden, 08.07.2005, 2005 Invited Talk, 2005

N Demling, C Ehrhardt, M Kasper, M Laue, L Knels, KJ Kim, EP Rieber, RAGE, a marker for human alveolar type I cells promotes cell adhesion, FASEB J, Experimental Biology Meeting 2005 and XXXV International Congress of Physiological Sciences, San Diego, CA, 02.-06.04.2005, 19, (5), 2005, ppA1294 Meeting Abstract, 2005

S Anabousi, CM Lehr, C Ehrhardt, Design of transferrin-modified liposomes: binding and uptake in lung cancer cells, Proc Intern Symp Control Rel Bioact Mat, 32nd Annual Meeting of the Controlled Release Society, Miami Beach, FL, 18.-22.06.2005, 32, (1), 2005, pp290 Meeting Abstract, 2005

C Ehrhardt , The lung in a box - can pulmonary PK really be predicted from cell culture models?, EUFEPS 2004, Bruxelles, Belgium, 20.10.2004, 2004 Invited Talk, 2004

C Ehrhardt, EM Collnot, C Bies, UF Schaefer, KJ Kim, CM Lehr, Characterisation of the human cell line CFBE41o- as an in vitro model of cystic fibrotic bronchial epithelium, FASEB J, Experimental Biology Meeting 2004, Washington, DC, 17.-21.04.2004, 18, (5), 2004, ppA1052 Meeting Abstract, 2004

U Becker, C Ehrhardt, UF Schaefer, HJ Gukasyan, KJ. Kim, VHL Lee, CM Lehr, Determination of the tissue distribution of moxaverine-hydrochloride with special focus on the posterior compartments of the eye, Proc CRS German Chapter Annual Meeting, CRS German Chapter Annual Meeting, Heidelberg, Germany, 02.04.2004, 2004, pp17 Meeting Abstract, 2004

EM Collnot, C Bies, J Hyatt, L Navarro, K Edgar, UF Schaefer, C Ehrhardt, CM Lehr, Inhibition of P-glycoprotein by TPGS: influence of the PEG-chain length, AAPS J, Annual Meeting of the AAPS, Baltimore, MD, 07.-11.11.2004, 2004, ppT2234 Meeting Abstract, 2004

U Bakowsky, C Kneuer, C Ehrhardt, RK Majeti, H Bakowsky, Selectins - an emerging target for site specific drug delivery, Proc Int Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nürnberg, Germany, edited by 15.-18.03.2004 , 2004, pp757 - 758 Meeting Abstract, 2004

U Becker, C Ehrhardt, UF Schaefer, HJ Gukasyan, KJ. Kim, VHL Lee, CM Lehr, Targeting a topically administered drug to posterior compartments of the eye, Proc Int Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nürnberg, Germany, 15.-18.03.2004, 2004, pp857 - 858 Meeting Abstract, 2004

S Anabousi, U Bakowsky, UF Schaefer, CM Lehr, C Ehrhardt, Preparation and characterisation of DSPE-PEG-maleimide-modified liposomes for conjugation with receptor ligands for cell specific targeting, Proc Int Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nürnberg, Germany, 15.-18.03.2004, 2004, pp787 - 788 Meeting Abstract, 2004

U Bakowsky, C Loehbach, C Ehrhardt, D Hoekstra, CM Lehr, Characterization of adhesion forces between living human endothelial cells and protein-coated implant surfaces by scanning force microscopy, 7th European Adhesion Conference - EURADH 2004, Freiburg, Germany, 05.-09.09.2004 , 2004 Meeting Abstract, 2004

S Anabousi, U Bakowsky, M Laue, CM Lehr, C Ehrhardt, AFM as a novel tool to verify the presence of transferrin on liposomal surfaces, AAPS J, 18th Annual meeting of the AAPS, Baltimore, MD, 07.-11.11.2004, 2004, ppT3263 Meeting Abstract, 2004

EM Collnot, C Ehrhardt, C Bies, UF Schaefer CM Lehr, The human bronchial epithelial cell line CFBE41o- as an in vitro model for cystic fibrosis studies, Arch Pharm Pharm Med Chem, DPhG Jahrestagung und Joint-Meeting 2004, Regensburg, Germany, 07.-09.10.2004, 337, 2004 Meeting Abstract, 2004

S Anabousi, U Bakowsky, M Laue, CM Lehr, C Ehrhardt, Atomic force microscopy and transmission electron microscopy are novel tools used for verification of transferrin modification of liposomes, Proc CRS German Chapter Annual Meeting, CRS German Chapter Annual Meeting, Heidelberg, Germany, 02.04.2004, 2004, pp16 Meeting Abstract, 2004

C Ehrhardt, C Kneuer, RK Majeti, H Bakowsky, C Olbrich, D Hoekstra, CM Lehr, U Bakowsky, Modern pharmaceutical-relevant non-viral gene transfection systems, German Bunsen Society for Physical Chemistry Annual Meeting, Dresden, Germany, 20.-22.05.2004, 2004 Meeting Abstract, 2004

M Bur, C Ehrhardt, KJ Kim, CM Lehr, Bioelectric properties of primary cultured tight monolayers of human alveolar epithelial cells (hAEpC), Arch Pharm Pharm Med Chem, DPhG Jahrestagung und Joint-Meeting 2004, Regensburg, Germany, 07.-09.10.2004, 337, 2004 Meeting Abstract, 2004

H Bakowsky, C Ehrhardt, C Kneuer, U Rothe, U Bakowsky, Antiadhesive surface coatings generated by covalent coupling of monomolecular tetraetherlipid films, German Bunsen Society for Physical Chemistry Annual Meeting, Dresden, Germany, 20.-22.05.2004 , 2004 Meeting Abstract, 2004

M Bur, C Ehrhardt, KJ Kim, CM Lehr, Bioelectric properties of primary cultured tight monolayers of human alveolar epithelial cells, IX. Deutsches Aerosol Therapie Seminar, Nürnberg, Germany, 12.-13.11.2004, 2004 Meeting Abstract, 2004

EM Collnot, C Ehrhardt, C Bies, UF Schaefer, CM Lehr, Towards an in vitro model of cystic fibrosis epithelium: the human bronchial epithelial cell line CFBE41o - AAPS J, 18th Annual Meeting of the AAPS, Baltimore, MD, 07.-11.11.2004, 2004, ppW4270 Meeting Abstract, 2004

U Rothe, C Ehrhardt, H Bakowsky, C Kneuer, MNV Ravi Kumar, U Bakowsky, Selectins - an emerging target for site specific drug delivery, Proc Intern Symp Control Rel Bioact Mat, 31st Annual Meeting of the Controlled Release Society, Honolulu, HI, 12.-16.06.2004, 31, (1), 2004 Meeting Abstract, 2004

H Bakowsky, C Ehrhardt, C Kneuer, U Rothe, U Bakowsky, PEG-modified immunoliposomes for site-specific selectin targeting, Proc CRS German Chapter Annual Meeting, CRS German Chapter Annual Meeting, Heidelberg, Germany, 02.04.2004, 2004, pp7 Meeting Abstract, 2004

C Ehrhardt, M Bur, UF Schaefer, CM Lehr, KJ Kim, Bioelectric properties of primary cultured tight monolayers of human alveolar epithelial cells (hAEpC), FASEB J, Experimental Biology Meeting 2004, Washington, DC, 17.-21.04.2004, 18, (4), 2004, ppA723 Meeting Abstract, 2004

U Becker, C Ehrhardt, UF Schaefer, HJ Gukasyan, KJ. Kim, VHL Lee, CM Lehr, Tissue distribution and relative bioavailability of ocularly-administered moxaverine-HCl, Proc Association for Research in Vision and Ophthalmology Annual Meeting, Association for Research in Vision and Ophthalmology Annual Meeting, Fort Lauderdale, FL, 25.-29.04.2004, 2004, pp165 Meeting Abstract, 2004

H Bakowsky C Ehrhardt, C Kneuer, D Hoekstra, U Bakowsky, Surface-modified liposomes: stability and specific binding properties, German Bunsen Society for Physical Chemistry Annual Meeting, Dresden, Germany, 20.-22.05.2004 , 2004 Meeting Abstract, 2004

C Ehrhardt , Cell culture models of the human airway and alveolar epithelium, 5th International Conference and Workshop on Cell Culture and In Vitro Models for Drug Absorption and Delivery, Saarbrücken, Germany, 01.03.2004, 2004 Invited Talk, 2004

C Ehrhardt , Verwendung von Zellkulturen des Lungenepithels als in vitro Modelle in der biopharmazeutischen Forschung, Symphatol Meeting, Saarbrücken, Germany, 14.05.2004, 2004 Invited Talk, 2004

C Ehrhardt, M Bur, CM Lehr, U Bakowsky, KJ Kim, Tight monolayers of human alveolar epithelial cells in primary culture: bioelectric properties, Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society, Orlando, FL, 21.-26.05.2004, 169, (7), 2004, ppA670 Meeting Abstract, 2004

C Ehrhardt , Zellkultursysteme als Werkzeug zur Vorhersage der Arzneistoffabsorption, Zentrales Institut des Sanitätsdienstes der Bundeswehr, Kiel, Germany, 24.03.2004, 2004 Invited Talk, 2004

C Ehrhardt, E Collnot, C Bies, UF Schaefer, CM Lehr, Characterisation of the human cell line CFBE41o- as an in vitro model of cystic fibrotic bronchial epithelium, Am J Respir Crit Care Med, Annual Meeting of the American Thoracic Society, Orlando, FL, 21.-26.05.2004, 169, (7), 2004, ppA387 Meeting Abstract, 2004

C Ehrhardt , Cell culture models of the human airway and alveolar epithelium, Seminars in Molecular Medicine, Royal College of Surgeon in Ireland, Dublin, Ireland, 10.09.2004, 2004 Invited Talk, 2004

C Ehrhardt, J Fiegel, U Bakowsky, UF Schaefer, J Hanes, CM Lehr, Microparticle impingement on lung epithelial cell monolayers: Toward improved particle characterisation in the lung, VIII. Deutsches Aerosol Therapie Seminar, Marburg, Germany, 14.-15.11.2003, 2003 Meeting Abstract, 2003

S Anabousi, U Bakowsky, U Schaefer, CM Lehr, C Ehrhardt, Design of DSPE-PEG-maleimide-modified liposomes for specific conjugation with transferrin, Proc 3rd Int Course Liposome Technol, 3rd International Galenos Intensive Course and Workshop on Liposome Technology and Applications in Therapeutics, Patras, Greece, 01.-11.09.2003, 2003, pp163 Meeting Abstract, 2003

C Ehrhardt , Nanoparticles as carrier systems for drug delivery and gene therapy, 5th Course on Smart Materials and Nanotechnology, Università Politecnica delle Marche, Jesi (AN), Italy, 29.08.2003, 2003 Invited Talk, 2003

C Ehrhardt , Drug transport across the epithelium, 5th GUIDE/UIPS Course on Drug Delivery and Targetin, Rijksuniversiteit Groningen, Groningen, The Netherlands, 24.11.2003, 2003 Invited Talk, 2003

C Ehrhardt, C Bies, H Stumpf, C Kneuer, UF Schaefer, KJ Kim, CM Lehr, Net active absorption of salbutamol across human respiratory epithelial cell layers may occur via hOCT, Proc CRS German Chapter Annual Meeting, CRS German Chapter Annual Meeting, München, Germany, 04.04.2003, 2003, pp36 Meeting Abstract, 2003

C Ehrhardt, C Bies, H Stumpf, C Kneuer, UF Schaefer, KJ Kim, CM Lehr, Net active absorption of salbutamol across human respiratory epithelial cell layers may occur via hOCT, VIII. Deutsches Aerosol Therapie Seminar, Marburg, Germany, 14.-15.11.2003, 2003 Meeting Abstract, 2003

C Ehrhardt , In vitro Transportstudien über Epithelzellen der Lunge: Eine Methode zur Aufklärung von Absorptionsprozessen pulmonal applizierter Arzneistoffe, DPhG Doktorandentagung, Düsseldorf, Germany, 09.03.2003, 2003 Invited Talk, 2003

C Ehrhardt , Entwicklung und Charakterisierung von in vitro Modellen zur Arzneistoffabsorption und Partikel-Zell-Interaktion basierend auf Epithelzellkulturen der humanen Lunge, Institut für Inhalationsbiologie, GSF, München, Germany, 04.11.2003, 2003 Invited Talk, 2003

C Ehrhardt, C Bies, H Stumpf, C Kneuer, UF Schaefer, KJ Kim, CM Lehr, Active absorption of salbutamol across human respiratory epithelial cell layers, J Aerosol Med, International Society for Aerosols in Medicine 2003, Baltimore, MD, 14.-18.06.2003, 16, (2), 2003, pp214 Meeting Abstract, 2003

C Ehrhardt, C Bies, H Stumpf, C Kneuer, UF Schaefer, KJ Kim, CM Lehr, Salbutamol is actively absorbed across human respiratory epithelial cell layers, Proc Intern Symp Control Rel Bioact Mat, 30th Annual Meeting of the Controlled Release Society, Glasgow, United Kingdom, 19.-23.07.2003, 30, (1), 2003, pp95 Meeting Abstract, 2003

C Ehrhardt , The use of respiratory epithelial cell models for drug absorption studies, Trinity College, Dublin, Ireland, 25.07.2003, 2003 Invited Talk, 2003

U Bakowsky, C Loehbach, C Kneuer, C Ehrhardt, D Hoekstra, CM Lehr, Determination of adhesion forces between nanosensors modified with living cells and protein-coated surfaces by scanning force microscopy, Proc Intern Symp Control Rel Bioact Mat, 30th Annual Meeting of the Controlled Release Society, Glasgow, United Kingdom, 19.-23.07.2003, 30, (1), 2003, pp787 Meeting Abstract, 2003

U Bakowsky, C Loehbach, C Kneuer, C Ehrhardt, D Hoekstra, CM Lehr, The determination of adhesion forces between living cells and proteins by using scanning force microscopy, Proc CRS German Chapter Annual Meeting, CRS German Chapter Annual Meeting, München, Germany, 04.04.2003, 2003, pp37 Meeting Abstract, 2003

C Ehrhardt, CM Lehr, Z Borok, ED Crandall, KJ Kim, Relative total ion conductance of the paracellular pathway in primary rat alveolar epithelial cells (AEC) monolayers, FASEB J, Experimental Biology Meeting 2003, San Diego, CA, 11.-15.04.2003, 17, (4), 2003, ppA85 Meeting Abstract, 2003

C Ehrhardt , Development of in vitro models for studies on drug absorption and drug carrier-cell interactions based on human respiratory epithelial cells, Johns Hopkins University, Baltimore, MD, 22.08.2002, 2002 Invited Talk, 2002

C Ehrhardt , Insulintherapie im Wandel: Von injizierten zum inhalativen Hormon, Zentrales Institut des Sanitätsdienstes der Bundeswehr, Kiel, Germany, 26.10.2002, 2002 Invited Talk, 2002

U Bakowsky, H Bakowsky, G Bendas, U Rothe, C Ehrhardt, CM Lehr, D Hoekstra, The morphology dependence of the selectin/glycolipid recognition in lateral structured supported model membranes, Proc Nanobiotec II, Nanobiotec II, Marburg, Germany, 21.-25.09.2002, 2002, pp16 Meeting Abstract, 2002

C Ehrhardt, J Fiegel, UF Schaefer, J Hanes CM Lehr, Calu-3 bronchial epithelial cell monolayers to study drug release and absorption from aerosol particles in vitro, Proc 4th World Meeting ADRITELF/APGI/APV, 4th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Firenze, Italy, 08.-11.04.2002, 2002, pp1009 - 1010 Meeting Abstract, 2002

C Ehrhardt, J Moebius, UF Schaefer, CM Lehr, Calu-3: Characterisation of an human bronchial cell line as an in vitro model for drug absorption in the upper airways, Proc 4th Workshop on Cell Culture and In Vitro Models for Drug Absorption and Delivery, 4th Workshop on Cell Culture and In Vitro Models for Drug Absorption and Delivery, Saarbrücken, Germany, 20.02.-01.03.2002, 2002 Meeting Abstract, 2002

C Ehrhardt, UF Schaefer, CM Lehr, Human alveolar epithelial cell monolayers in primary culture as an in vitro model for drug absorption studies, Proc 4th GPEN Meeting, 4th GPEN Meeting, Ann Arbor, MI, 06.-08.11.2002, 2002, pp37 Meeting Abstract, 2002

U Bakowsky, H Bakowsky, C Kneuer, G Bendas, U Rothe, C Ehrhardt, CM Lehr, D Hoekstra, On the dependence of membrane morphology from selectin/glycolipid recognition properties, Arch Pharm Pharm Med Chem, Annual Meeting of the DPhG, Berlin, Germany, 09.-12.10.2002, 335, (S1), 2002, pp50 Meeting Abstract, 2002

C Ehrhardt, UF Schaefer, CM Lehr, Human alveolar epithelial cell monolayers in primary culture as an in vitro model for drug absorption studies, AAPS Pharm Sci, 16th Annual Meeting of the AAPS, Toronto, Canada, 10.-14.11.2002, 4, 2002, ppR6144 Meeting Abstract, 2002

J Fiegel, C Ehrhardt, CM Lehr, J Hanes, An in vitro method to characterize therapeutic aerosol particulates using lung epithelial cell monolayers, Proc Am Inst Chem Eng, Annual Meeting of the AIChE, Reno, NV, 04.-09.11.2001, 2001 Meeting Abstract, 2001

C Ehrhardt, B Amro, C Kneuer, UF Schaefer, KJ Kim, CM Lehr, Characterisation of the bronchial epithelial cell line 16HBE14o- as an in vitro model for drug absorption: expression of P-glycoprotein, LRP-56 and caveolin-1, Proc Intern Symp Control Rel Bioact Mat, 28th Annual Meeting of the Controlled Release Society, San Diego, CA, 23.-27.06.2001, 28, (1), 2001, pp203 Meeting Abstract, 2001

J Moebius, C Ehrhardt, I Erler, UF Schaefer, CM Lehr, The epithelial cancer cell line Calu-3: Characterisation as an in vitro model for drug absorption in the upper airways, Arch Pharm Pharm Med Chem, 3rd European Graduate Student Meeting, Frankfurt, Germany, 23.-25.02.2001, 334, (S1), 2001, pp13 Meeting Abstract, 2001

C Ehrhardt, S Fuchs, UF Schaefer, CM Lehr, Comparative evaluation of in vitro test systems for pulmonary drug delivery based on airway epithelial cell lines and human alveolar epithelial cells (hAEpC) in primary culture, ALTEX, 9. Österreichischer internationaler Kongreß über Ersatz- und Ergänzungsmethoden zu Tierversuchen in der biomedizinischen Forschung, Linz, Austria, 24.-26.09.2000, 18, (1), 2001, pp66 Meeting Abstract, 2001

J Fiegel, C Ehrhardt, CM Lehr, J Hanes, Air-interfaced lung epithelial cell monolayers for characterization of large light polymer aerosols, Ann Biomed Eng, Biomedical Engineering Society's Conference, Durham, NC, 04.-07.10.2001, 29, (S1), 2001, ppS141 Meeting Abstract, 2001

C Ehrhardt, Bronchial epithelial cell culture as an in vitro model for drug absorption, Johns Hopkins University, Baltimore, MD, 28.08.2001, 2001 Invited Talk, 2001

C Ehrhardt, C Kneuer, UF Schaefer, CM Lehr, Development of an in vitro model for drug absorption based on the bronchial epithelial cell line 16HBE14o - Proc CRS German Chapter Annual Meeting, Saarbrücken, Germany, 02.02.2001, 2001, pp4 Meeting Abstract, 2001

C Ehrhardt, J Neumannová, UF Schaefer, CM Lehr, Human alveolar epithelial cell (hAEpC) monolayers in primary culture as an in vitro model for drug transport, Eur J Pharm Sci, 6th European Congress of Pharmaceutical Sciences, EUFEPS 2000, Budapest, Hungary, 16.-19.09.2000, 11, (S1), 2000, ppS90 Meeting Abstract, 2000

C Ehrhardt, The lung as a target for drug delivery: cell culture models as in vitro test systems, University of Malta, Msida, Malta, 27.10.2000, 2000 Invited Talk, 2000

S Fuchs, C Ehrhardt, J Neumannová, UF Schaefer, CM Lehr, Human alveolar epithelial cell monolayers in primary culture - characterisation and drug transport, Proc Aerosols and Health, Aerosols and Health, Karlsruhe, Germany, 28.-29.06.2000, 2000, pp12 Meeting Abstract, 2000

Research Expertise

Description

I have established an international reputation in the field of Pulmonary Biopharmaceutics. The scientific aim of my work is to describe the behaviour of drugs following their administration to the lung as inhaled aerosols, i.e. lung drug disposition and pulmonary epithelial transport. Moreover, I have developed a keen interest in the molecular origins of lung disease. Over the last 20 years, the incidence of lung-related diseases and the morbidity due to these conditions is increasing at more than 5% per year. With 1 in 7 people in Ireland having an undiagnosed lung condition and Ireland having the third highest death rate from lung disease in Europe, causing 1 in 5 deaths, the potential impact of my work becomes clear. In my lab we primarily employ pre-clinical models. We have established organotypic in vitro, ex vivo and experimental in vivo models, which allow a wide array of discovery and development studies. Inter alia, we have been credited with pioneering the development of primary cultures of human alveolar epithelial cells. The expertise of my laboratory includes techniques from the areas of pharmaceutics, pharmacokinetics, pharmacology, electrophysiology, cell and molecular biology and immunocytochemistry. The unique combination of cell physiological basis and pharmaceutical application has led to numerous research collaborations, nationally and internationally, as well as to a continuous stream of visiting researchers to my laboratory. At the moment, we are involved in a number of international, multidisciplinary, translational studies into the role that drug transporters play in the pathogenesis of lung diseases. In this context, we are studying, e.g. the role of ergothioneine and its physiological transporter OCTN1 in the development and progression of tobacco-related chronic obstructive pulmonary disease (COPD). This study brings together researcher from TCD, St. James's Hospital, Brigham Young University, University of Kanazawa and University Medical Center Groningen and is financially supported by a Clinical Investigator Award from the Flight Attendant Medical Research Institute (FAMRI). My lab continuously publishes in in high ranking peer-reviewed journals in the subject areas of Pharmaceutics, Pharmacology and Physiology. One of the highlights of our endeavours so far was the invitation to publish a review article in Nature Chemistry (Zelikin et al. 2016). Another of our publications (Paszko et al. 2011) achieved highly cited paper status according to Essential Science Indicators, i.e. it has received enough citations to place it in the top 1% of its academic field based on a highly cited threshold for the field and publication year. Chapters from Drug Absorption Studies, a book edited by me and published by Springer in 2008, were downloaded >65,000 times, placing it in the top 25% most downloaded eBooks in the relevant eBook Collection in 2016. My total research grant income as PI amounts to more than 2.5 million euros, of which >440,000 euros were secured in the last three years. In addition, I am involved as co-PI in a number of international collaborations, e.g. a TÜBITAK grant with Dr Ayca Yıldız Peköz from Istanbul University and a Lung Foundation Netherlands grant with Dr Irene Heijink from the University of Groningen. To maintain the momentum, I have recently submitted an SFI CDA proposal in collaboration with Dr Andrej Budanov (School of Biochemistry and Immunology) and another TÜBITAK grant with Dr. Peköz. I am also in advanced stages of discussions about an EI Innovation Partnership Programme submission with Mylan Ltd.

Keywords

AEROSOL; ALVEOLAR EPITHELIAL-CELLS; ALVEOLAR EPITHELIUM; Asthma, Cystic Fibrosis, obstructive airways, interstitial lung diseases, pulmonary fibrosis; Biomedical sciences; Biopharmaceutical aspects of drug delivery systems; BRONCHIAL EPITHELIUM; Cell and tissue development; Drug development and evaluation; IN VITRO MODEL; In vitro testing, trial methods; IN-VITRO CULTURE; INHALATION; LIPOSOMES; LUNG ; Membrane transport, structure and dynamics; Physiological and physiochemical barriers to drug absorption; Physiology; Respiratory System

Recognition

Representations

Member, Board of Examiners in Pharmaceutical Technology 2002 - 2011

Local Co-ordinator, Marie-Curie Early Stage Training (EST) Network "Galenos EuroPhD in Advanced Drug Delivery" 2006 - 2010

Adjunct Assistant Professor, Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 2008 - present

Professor Invité, Laboratoire de Pharmacie Galénique Industrielle, Faculté de Pharmacie, Université Claude Bernard Lyon 1, Lyon, France 2010 - July 2014

Chair, Drug Delivery: Emerging Therapies Networking Group, International Society for Aerosols in Medicine 2011 - 2013

Member, Management Committee, COST Action BM1201: Developmental Origins of Chronic Lung Disease 2012 - 2016

Chair, Imaging, Modeling, and Physiology of Aerosols in the Lung, International Society for Aerosols in Medicine 2013 - 2015

Member, Management Committee, COST Action MP1404: Simulation and pharmaceutical technologies for advanced patient-tailored inhaled medicines (SimInhale) 2014 - 2018

Vice-Leader, WG5: Toxicity, Risk Assessment and Regulation, COST Action MP1404: Simulation and pharmaceutical technologies for advanced patient-tailored inhaled medicines (SimInhale) 2014 - 2018

Member, Council, Western Epithelial Biology Society (formerly West Coast Salt and Water Club) 2015 - present

Member, Editorial Board, Journal of Aerosol Medicine and Pulmonary Drug Delivery 2015 - present

Member, Editorial Board, American Journal of Physiology - Lung Cellular and Molecular Physiology 2015 - present

Member, Awards Committee, International Society for Aerosols in Medicine 2015 - present

Member, Editorial Board, European Journal of Pharmaceutics and Biopharmaceutics 2017 - present

Awards and Honours

International Research Collaboration Award, University of Sydney 2013

Fellowship, Trinity College Dublin 2013

Galenus Support Award 2012, Galenus Privatstiftung 2012

Galenus Support Award 2011, Galenus Privatstiftung 2011

Galenus Support Award 2010, Galenus Privatstiftung 2010

Galenus Support Award 2009, Galenus Privatstiftung 2009

Galenus Support Award 2008, Galenus Privatstiftung 2008

Galenus Support Award 2007, Galenus Privatstiftung 2007

Travel grant from the DFG to attend the Experimental Biology Meeting, Washington, DC, USA 2004

Poster Award at the 8th German Seminar on Aerosol Therapy, Marburg, Germany 2003

Recognition Award for Meritorious Research by a Young Investigator, American Physiological Society 2003

Travel grant from the CRS to attend the 30th Annual Meeting of the CRS, Glasgow, UK 2003

"Förderung der wissenschaftlichen Nachwuchses" Fellowship from the DPhG 2002

Travel grant from the Nagai Foundation to attend the 28th Annual Meeting of the CRS, San Diego, CA, USA 2001

Travel grant from the DPhG to attend the 6th European Congress of Pharmaceutical Sciences - EUFEPS 2000, Budapest, Hungary 2000

Memberships

Gesellschaft für Wehrmedizin und Wehrpharmazie, VdSO 1997 – Present

Deutsche Pharmazeutische Gesellschaft, DPhG 2000 – Present

American Association of Pharmaceutical Scientists, AAPS 2002 – Present

International Society for Aerosols in Medicine, ISAM 2003 – Present

American Physiological Society, APS 2006 – Present

Japanese Society for the Study of Xenobiotics, JSSX 2015 – Present


Last updated 9 September 2016 by School of Pharmacy & Pharmaceutical Sciences (Email).