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Andrew Harkin
Associate Professor in Pharmacology, Pharmacy
Deputy Director of TCIN, Trinity Inst. of Neurosciences (TCIN)

RESEARCH INTERESTS

Andrew Harkin is Associate Professor of Pharmacology in The School of Pharmacy & Pharmaceutical Sciences in Trinity College Dublin and a principle investigator in Trinity College Institute of Neuroscience. He leads a neuropsychopharmacology research group which is focused on bridging neuroscience to the pharmacological treatment of psychiatric and neurological disorders.
Current research interests include (1) bidirectional nervous system immune interactions, the role of inflammation in the pathogenesis, and potential of anti-inflammatory agents in treating, psychiatric disorders and (2) targeting the N-methyl-D-aspartic acid (NMDA) receptor and the NMDA-nitric oxide-cGMP intra-neuronal signalling in stress related psychiatric disorders.

FINANCIAL SUPPORT

Assoc. Prof. Harkin’s research program is currently funded by the European Commission (Framework 7 - Brain Imaging Return to Health [r’birth] Marie Curie International Training Network) and the Programme for Research in Third Level Institutions in Ireland (PRTLI) under the auspices of the Higher Education Authority (HEA). The group collaborates widely with a variety of academic and industrial partners on fundamental and clinical projects.

Biography

Andrew Harkin is Associate Professor of Pharmacology in The School of Pharmacy & Pharmaceutical Sciences in Trinity College Dublin and a principle investigator in Trinity College Institute of Neuroscience. He leads a neuropsychopharmacology research group which is focused on bridging neuroscience to the pharmacological treatment of psychiatric and neurological disorders. Current research interests include- - bidirectional nervous system immune interactions, the role of inflammation in the pathogenesis, and potential of anti-inflammatory agents in treating, psychiatric disorders. - targeting the N-methyl-D-aspartic acid (NMDA) receptor and the NMDA-nitric oxide-cGMP intra-neuronal signalling in stress related psychiatric disorders. Professor Harkin's research program is funded by the European Commission (Framework 7), Science Foundation Ireland, the Irish Health Research Board and the Irish Research Council for Science Engineering and Technology, His group collaborates widely with a variety of academic and industrial partners on fundamental and clinical projects.

Publications and Further Research Outputs

Peer-Reviewed Publications

Griffin, E.W., Yssel, J.D., O Neill, E., Ryan, K.J., Boyle, N., Harper, P., Harkin, A. and Connor, T., The beta2-adrenoceptor agonist clenbuterol reduces the neuroinflammatory response, neutrophil infiltration and apoptosis following intra-striatal IL-1β administration to rats, Immunopharmacology and Immunotoxicology, 2018, p1-8 Journal Article, 2018 DOI

Yssel, J.D., O'Neill, E., Nolan, Y.M., Connor, T.J., Harkin, A., Treatment with the noradrenaline re-uptake inhibitor atomoxetine alone and in combination with the alpha2-adrenoceptor antagonist idazoxan attenuates loss of dopamine and associated motor deficits in the LPS inflammatory rat model of Parkinson's disease, Brain, Behavior, and Immunity, 69, 2018, p456-469 Journal Article, 2018 DOI

Abautret-Daly Á, Dempsey E, Riestra S, de Francisco-García R, Parra-Blanco A, Rodrigo L, Medina C, Connor TJ, Harkin A., Association between psychological measures with inflammatory and disease related markers of inflammatory bowel disease, International Journal of Psychiatry & Clinical Practice, 21, (3), 2017, p221 - 230 Journal Article, 2017 DOI

McIntosh A.L, Gormley S, Tozzi L, Frodl T, Harkin A, Recent advances in translational magnetic resonance imaging in animal models of stress and depression, Frontiers in Cellular Neuroscience, 11, 2017, p00150- Journal Article, 2017 TARA - Full Text URL DOI

Doolin, K., Farrell, C., Tozzi, L., Harkin, A., Frodl, T., O Keane, V., Diurnal hypothalamic-pituitary-adrenal axis measures and inflammatory marker correlates in major depressive disorder, International Journal of Molecular Sciences, 18, (10), 2017 Journal Article, 2017 DOI

Abautret-Daly Á, Dempsey E, Riestra S, de Francisco-García R, Parra-Blanco A, Rodrigo L, Medina C, Connor TJ, Harkin A., Gut-brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease, Acta Neuropsychiatr, 2017, p1 - 22 Review Article, 2017 DOI

Abautret-Daly, Ã ., Dempsey, E., Parra-Blanco, A., Medina, C., Harkin, A., Gut brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease, Acta Neuropsychiatrica, 2017, p1-22 Journal Article, 2017 DOI

Tropea, D. and Harkin, A., Biology of Brain Disorders, Frontiers in Cellular Neuroscience - e collection, Frontiers Media SA academic publisher, 2017 Book, 2017 DOI

O'Farrell K, Fagan E, Connor T.J, Harkin A, Inhibition of the kynurenine pathway protects against reactive microglial-associated reductions in the complexity of primary cortical neurons, European Journal of Pharmacology, 810, 2017, p163 - 173 Journal Article, 2017 DOI URL

Sherwin E, Gigliucci V, Harkin A, Regional specific modulation of neuronal activation associated with nitric oxide synthase inhibitors in an animal model of antidepressant activity, Behavioural Brain Research, 316, 2017, p18 - 28 Journal Article, 2017 DOI URL

Sherwin, E., Lennon, A., Harkin, A., Regional specific modulation of stress-induced neuronal activation associated with the PSD95/NOS Interaction Inhibitor ZL006 in the Wistar Kyoto rat, International Journal of Neuropsychopharmacology, 20, (10), 2017, p833-843 Journal Article, 2017 DOI

O'Farrell, K., Harkin, A., Stress-related regulation of the kynurenine pathway: Relevance to neuropsychiatric and degenerative disorders, Neuropharmacology, (112), 2017, p307 - 323 Journal Article, 2017 DOI TARA - Full Text

Maria N.I, van Helden-Meeuwsen C.G, Brkic Z, Paulissen S.M.J, Steenwijk E.C, Dalm V.A, van Daele P.L, Martin van Hagen P, Kroese F.G.M, van Roon J.A.G, Harkin A, Dik W.A, Drexhage H.A, Lubberts E, Versnel M.A, Association of Increased Treg Cell Levels With Elevated Indoleamine 2,3-Dioxygenase Activity and an Imbalanced Kynurenine Pathway in Interferon-Positive Primary Sjogren's Syndrome, Arthritis and Rheumatology, 68, (7), 2016, p1688 - 1699 Journal Article, 2016 DOI URL

McGuiness B, Gibney S.M, Beumer W, Versnel M.A, Sillaber I, Harkin A, Drexhage H.A, Exaggerated increases in microglia proliferation, brain inflammatory response and sickness behaviour upon lipopolysaccharide stimulation in non-obese diabetic mice, NeuroImmunoModulation, 23, (3), 2016, p137 - 150 Journal Article, 2016 URL DOI

Novel Targets in the Glutamate and Nitric Oxide Neurotransmitter Systems for the Treatment of Depression in, editor(s) , Systems Neuroscience in Depression, 2016, pp81-113 , [O'Toole, E., Doucet, M.V., Sherwin, E., Harkin, A.] Book Chapter, 2016 DOI

O'Neill E, Kwok B, Day J.S, Connor T.J, Harkin A, Amitriptyline protects against TNF-alpha induced atrophy and reduction in synaptic markers via a Trk-dependent mechanism, Pharmacology Research and Perspectives, 4, (2), 2016 Journal Article, 2016 URL DOI

Finnegan M, Ryan K, Shanahan E, Harkin A, Daly L, McLoughlin DM, Ketamine for depression relapse prevention following electroconvulsive therapy: protocol for a randomised pilot trial (the KEEP-WELL trial)., Pilot and Feasibility Studies, 2016 Journal Article, 2016

Gormley, S., Rouine, J., McIntosh, A., Kerskens, C., Harkin, A., Glial fibrillary acidic protein (GFAP) immunoreactivity correlates with cortical perfusion parameters determined by bolus tracking arterial spin labelling (bt-ASL) magnetic resonance (MR) imaging in the Wistar Kyoto rat, Physiology and Behavior, 160, 2016, p66-79 Journal Article, 2016 DOI

Hughes M.M, Connor T.J, Harkin A, Stress-Related Immune Markers in Depression: Implications for Treatment, International Journal of Neuropsychopharmacology, 19, (6), 2016, p1 - 19 Journal Article, 2016 TARA - Full Text URL DOI

Ryan K.M, Griffin à .W, Ryan K.J, Tanveer R, Vanattou-Saifoudine N, McNamee E.N, Fallon E, Heffernan S, Harkin A, Connor T.J, Clenbuterol activates the central IL-1 system via the β2-adrenoceptor without provoking inflammatory response related behaviours in rats, Brain, Behavior, and Immunity, 56, 2016, p114 - 129 Journal Article, 2016 DOI URL

Murray, C., Griffin, E.W., O'Loughlin, E., (...), Harkin, A., Cunningham, C., Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I: C, Brain, Behavior, and Immunity, 48, 2015, 274-286 Journal Article, 2015 TARA - Full Text

Morgese, M.G., Colaianna, M., Mhillaj, E., Zotti, M., Schiavone, S., D'Antonio, P., Harkin, A., Gigliucci, V., Campolongo, P., Trezza, V., De Stradis, A., Tucci, P., Cuomo, V., Trabace, L., Soluble beta amyloid evokes alteration in brain norepinephrine levels: Role of nitric oxide and interleukin-1, Frontiers in Neuroscience, 9, (NOV), 2015, p2015 Journal Article, 2015 TARA - Full Text DOI

Dempsey, E., Abautret-Daly, A., Medina, C., Docherty, N., Harkin A., Central neuroinflammation in inflammatory bowel disease: evidence for a central increase in iNOS in an animal model of colitis, European Neuropsychopharmacology, 25, 2015, ppS47-S47 Poster, 2015

Inflammation in the pathogenesis of depression in, editor(s)Nicola Woodroofe, Sandra Amor , Neuroinflammation and CNS Disorders, United Kingdom, Wiley Blackwell, 2015, pp261 - 288, [Thomas J. Connor and Andrew Harkin] Book Chapter, 2015

Rodent Models of Stress-Induced Depression: The link between stress and immune system related changes in, editor(s)Norbert Muller, Aye-Mu Myint, Markus J Schwarz , Immunology and Psychiatry; from basic research to therapeutic interventions, Switzerland, Springer, 2015, pp33 - 62, [McGuinness B, Harkin A] Book Chapter, 2015

Rouine J, Kelly ME, Jennings-Murphy C, Duffy P, Gorman I, Gormley S, Kerskens CM, Harkin A, Investigation of the mechanisms mediating MDMA "Ecstasy"-induced increases in cerebro-cortical perfusion determined by btASL MRI., Psychopharmacology, 232, (9), 2015, p1501-1513 Journal Article, 2015 DOI

Doucet MV, O'Toole E, Connor T, Harkin A, Small molecule inhibitors at the PSD-95/nNOS interface protect against glutamate-induced neuornal atrophy in primary cortical neurons, Neuroscience, 301, 2015, p421 - 438 Journal Article, 2015

Frodl T, Carballedo A, Frey EM, O'Keane V, Skokauskas N, Morris D, Gill M, Hughes MM, Harkin A, Connor T, Expression of glucocorticoid inducible genes is associated with reductions in cornu ammonis and dentate gyrus volumes in patients with major depressive disorder., Development and psychopathology, 26, (4 Pt 2), 2014, p1209-17 Journal Article, 2014 DOI TARA - Full Text

Cuartero MI, Ballesteros I, de la Parra J, Harkin A, Abautret-Daly A, Sherwin E, Fernandez-Salguero P, Corbi AL, Lizasoain I, Moro MA, L-kynurenine/aryl hydrocarbon receptor pathway mediates brain damage after experimental stroke, Circulation, 130, (23), 2014, p2040 - 2051 Journal Article, 2014

Harkin A, Muscling in on Depression, New England Journal of Medicine, 371, (24), 2014 Review, 2014

Gibney S, Fagan EM, Waldron AM, O'Byrne J, Connor TJ, Harkin A , Inhibition of stress-induced heaptic tryptophan 2,3 di-oxygenase exhibits antidepressant activity in an animal model of depressive behaviour, International Journal of Neuropsychopharmacology, 17, (6), 2014, p917 - 928 Journal Article, 2014

Gigliucci V, Gormley S, Gibney S, Rouine J, Kerskens C, Connor TJ, Harkin A, Characterisation of the antidepressant properties of nitric oxide synthase inhibitors in the olfactory bulcectomised rat model of depression, European Neuropsychopharmacology, 24, (8), 2014, p1349 - 1361 Journal Article, 2014 DOI

O'Donovan S*, Dalton VS*, Harkin A, McLoughlin DM; * joint first author, Effects of brief pulse and ultrabrief pulse electroconvulsive stimulation on rodent brain and behaviour in the corticosterone model of depression. , International Journal of Neuropsychopharmacology. DOI: 10.1017/S1461145714000500, 17, (9), 2014, p1477 - 1486 Journal Article, 2014 DOI

Ryan KJ, Griffin E, Yssel JD, Ryan KM, McNamee EN, Harkin A, Connor TJ, Stimulation of central ß2-adrenoceptors suppresses NFkB activity in rat brain: A role for IkB., Neurochemistry international, 63, (5), 2013, p368-378 Journal Article, 2013

Pertl, M.M., Hevey, D., Boyle, N.T., Hughes, M.M., Collier, S., O'Dwyer, A.M., Harkin, A., Kennedy, M.J., & Connor, T.J., C-reactive prtoein predicts fatigue independently of depression in breast cancer patients prior to chemotherapy, Brain Behaviour and Immunity, 34, 2013, p108 - 119 Journal Article, 2013 DOI

Gigliucci V, O'Dowd G, Casey S, Egan D, Gibney S, Harkin A, Ketamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism., Psychopharmacology, 228, (1), 2013, p157-66 Journal Article, 2013

Rouine J, Gobbo OL, Campbell M, Gigliucci V, Ogden I, McHugh Smith K, Duffy P, Behan B, Byrne D, Kelly ME, Blau CW, Kerskens CM, Harkin A, MDMA 'ecstasy' increases cerebral cortical perfusion determined by bolus-tracking arterial spin labelling (btASL) MRI., British journal of pharmacology, 169, (5), 2013, p974-87 Journal Article, 2013

Gibney SM, McGuinness B, Prendergast C, Harkin A, Connor TJ, Poly I:C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression., Brain, behavior, and immunity, 28, 2013, p170-81 Journal Article, 2013

Doucet MV, Levine H, Dev KK, Harkin A, Small-Molecule Inhibitors at the PSD-95/nNOS Interface have Antidepressant-Like Properties in Mice., Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38, (8), 2013, p1575-1584 Journal Article, 2013 DOI

Day JS, O'Neill E, Cawley C, Aretz NK, Kilroy D, Gibney SM, Harkin A, Connor TJ, Noradrenaline acting on astrocytic ß2-adrenoceptors induces neurite outgrowth in primary cortical neurons., Neuropharmacology, 77C, 2013, p234-248 Journal Article, 2013 DOI

Vanattou-Saifoudine N, Behan B, Harkin A, Dopamine D1 receptor mediated intracellular responses in the hypothalamus after co-administration of caffeine with MDMA, Basic and Clinical Pharmacology and Toxicology, 110, 2012, p283 - 289 Journal Article, 2012

Hughes MM, Carballedo A, McLoughlin DM, Amico F, Harkin A, Frodl T, Connor TJ, Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation, Brain Behavior and Immunity, 26, 2012, p979 - 987 Journal Article, 2012

Vanattou-Saifoudine N, McNamara R, Harkin A, Caffeine provokes adverse interactions with MDMA ("Ecstasy") and related psychostimulants: mechanisms and mediators, British Journal of Pharmacology, 2012, pEpub ahead of print Journal Article, 2012

Doucet MV, Harkin A, Dev KK, The PSD-95/nNOS Complex: New Drugs for Depression?, Pharmacology & Therapeutics, 133, 2012, p218 - 229 Journal Article, 2012 TARA - Full Text

Hughes MM, Carballedo A, McLoughlin DM, Amico F, Harkin A, Frodl T, Connor TJ, Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation., Brain, behavior, and immunity, 26, (6), 2012, p979-987 Journal Article, 2012 DOI

Beumer W, Gibney SM, Drexhage RC, Pont-Lezica L, Doorduin J, Klein HC, Steiner J, Connor TJ, Harkin A, Versnel MA, Drexhage HA, The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes., Journal of leukocyte biology, 92, (5), 2012, p959-75 Journal Article, 2012

Doucet MV, Harkin A, Dev KK, The PSD-95/nNOS complex: New drugs for depression?, Pharmacology and Therapeutics, 133, (2), 2012, p218-29 Journal Article, 2012 DOI

Natacha Vanattou-Saïfoudine, Anna Gossen, Andrew Harkin, A role for adenosine A1 receptor blockade in the ability of caffeine to promote MDMA "Ecstasy"-induced striatal dopamine release , European Journal of Pharmacology , 650, (1), 2011, p220-228 Journal Article, 2011 TARA - Full Text

Vanattou-Saïfoudine N, McNamara R, Harkin A, Caffeine promotes dopamine D(1) receptor-mediated body temperature, heart rate and behavioural responses to MDMA ('ecstasy')., Psychopharmacology, 211, (1), 2010, p15-25 Journal Article, 2010 DOI

Vanattou-Saifoudine N, McNamara R, Harkin A., Mechanisms mediating the ability of caffeine to influence MDMA ("Ecstasy")-induced hyperthermia in rats. , British Journal of Pharmacology, 160, 2010, p860 - 877 Journal Article, 2010

Gigliucci V, Buckley KN, Nunan J, O'Shea K, Harkin A, A role for serotonin in the antidepressant activity of N(G)-Nitro-L-arginine, in the rat forced swimming test., Pharmacology, biochemistry, and behavior, 94, (4), 2010, p524-533 Journal Article, 2010 DOI

J.B. O'Sullivan, K.M. Ryan, A. Harkin and T.J. Connor, Noradrenaline reuptake inhibitors inhibit expression of chemokines IP-10 and RANTES and cell adhesion molecules VCAM-1 and ICAM-1 in the CNS following a systemic inflammatory challenge, Journal of Neuroimmunology, 220, (1-2), 2010, p34 - 42 Journal Article, 2010 DOI

L.C. Gleeson, K.J. Ryan, E.W. Griffin, T.J. Connor and A. Harkin, The beta2-adrenoceptor agonist clenbuterol elicits neuroprotective, anti-inflammatory and neurotrophic actions in the kainic acid model of excitotoxicity , Brain Behavior and Immunity, 24, (8), 2010, p1354 - 1361 Journal Article, 2010 DOI

O'Sullivan JB, Ryan KM, Harkin A, Connor TJ, Noradrenaline reuptake inhibitors inhibit expression of chemokines IP-10 and RANTES and cell adhesion molecules VCAM-1 and ICAM-1 in the CNS following a systemic inflammatory challenge., Journal of neuroimmunology, 220, (1-2), 2010, p34-42 Journal Article, 2010 DOI

E.N. McNamee, E.W. Griffin, K.M. Ryan, K.J. Ryan, S. Heffernan, A. Harkin and T.J. Connor, Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex, Neuropharmacology, 59, (1-2), 2010, p37 - 48 Journal Article, 2010 TARA - Full Text

E.N. McNamee, K.M. Ryan, E.W. Griffin, R.E. González-Reyes, K.J. Ryan, A. Harkin and T.J. Connor, Noradrenaline acting at central beta-adrenoceptors induces interleukin-10 and suppressor of cytokine signaling-3 expression in rat brain: Implications for neurodegeneration, Brain Behavior and Immunity, 24, (4), 2010, p660 - 671 Journal Article, 2010 DOI

J.B. O'Sullivan, K.M. Ryan, N.M. Curtin, A. Harkin and T.J. Connor, Noradrenaline reuptake inhibitors limit neuroinflammation in rat cortex following a systemic inflammatory challenge: implications for depression and neurodegeneration., International Journal of Neuropsychopharmacology , 12, (5), 2009, p687 - 699 Journal Article, 2009 DOI TARA - Full Text

Valentina Gigliucci, Kathleen Niamh Buckley, John Nunan, Karen O'Shea and Andrew Harkin, A role for serotonin in the antidepressant activity of NG Nitro-L-arginine in the rat forced swimming test, Pharmacology Biochemistry and Behavior, 2009 Journal Article, 2009 TARA - Full Text DOI

T.J. Connor, N. Starr, J.B. O'Sullivan and A. Harkin, Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-gamma?, Neuroscience Letters, 441, (1), 2008, p29 - 34 Journal Article, 2008 DOI

Harkin, A., MDMA (Ecstasy) induced 5-HT loss; implications for depressive and anxiety disorders, International Journal of Neuropsychopharmacology, 26th CINP Congress, Munich, Germany, 2008, 11, (S1), 2008, pp14,S.09.05- Oral Presentation, 2008

M. Roche, E. Shanahan, A. Harkin, J.P. Kelly, Trans-species assessment of antidepressant activity in a rodent model of depression, Pharmacological Reports, 60, (3), 2008, p404 - 408 Journal Article, 2008 URL

Harkin, A., The predisposing influence of recreational drug use to neuropsychiatric disorders, 2008, In:26th CINP World Congress, 2008, Munich, Germany Meetings /Conferences Organised, 2008

S. Durkin, A. Prendergast, A. Harkin, Reduced efficacy of fluoxetine following MDMA ("Ecstasy")-induced serotonin loss in rats, Progress in Neuropsychopharmacology and Biological Psychiatry, 32, (8), 2008, p1894 - 1901 Journal Article, 2008 DOI

M.R. Garland, B. Hallahan, M. McNamara, P.A. Carney, H. Grimes, J.R. Hibbeln, A. Harkin, R.M. Conroy , Lipids and essential fatty acids in patients presenting with self-harm., British Journal of Psychiatry , 190, 2007, p112 - 117 Journal Article, 2007 DOI

M. Roche, A. Harkin, J.P. Kelly, Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate and neuronal activation in the olfactory bulbectomised rat, Neuropsychopharmacology, 32, (6), 2007, p1312-1320 Journal Article, 2007 DOI

R. McNamara, M. Maginn, A. Harkin, Caffeine induces a profound and persistent tachycardia in response to MDMA ("Ecstasy") administration, European Journal of Pharmacology, 555, (2-3), 2007, p194 - 198 Journal Article, 2007 DOI

R. McNamara, A. Kerans, B. O'Neill and A. Harkin, Caffeine promotes hyperthermia and serotonergic loss following co-administration of the substituted amphetamines, MDMA ("Ecstasy") and MDA ("Love") , Neuropharmacology, 50, (1), 2006, p69 - 80 Journal Article, 2006 DOI

Zueger M, Urani A, Chourbaji S, Zacher C, Roche M, Harkin A, Gass P., Olfactory bulbectomy in mice induces alterations in exploratory behavior, Neuroscience letters, 374, (2), 2005, p142 - 146 Journal Article, 2005 DOI

T.J. Connor, C. Brewer, J.P. Kelly and A. Harkin, Acute stress suppresses pro-inflammatory cytokines TNF-alpha and IL-1beta independent of a catecholamine-driven increase in IL-10 production. , Journal of Neuroimmunology , 159, (1-2), 2005, p119 - 128 Journal Article, 2005 DOI

T.J. Connor, A. Harkin and J.P. Kelly , Methylenedioxymethamphetamine (MDMA; "Ecstasy") suppresses production of the pro-inflammatory cytokine tumor necrosis factor-alpha independent of a beta-adrenoceptor mediated increase in interleukin-10. , Journal of Pharmacology and Experimental Therapeutics , 312, (1), 2005, p134 - 143 Journal Article, 2005 DOI

Connole L, Harkin A, Maginn M, Adenosine A(1) receptor blockade mimics caffeine's attenuation of ethanol-induced motor incoordination, Basic and Clinical Pharmacology and Toxicology, 95, (6), 2004, p299 - 304 Journal Article, 2004 DOI

A. Harkin, T.J. Connor, M.P. Burns and J.P. Kelly, Nitric oxide synthase inhibitors augment the effects of serotonin re-uptake inhibitors in the forced swimming test., European Neuropsychopharmacology, 14, (4), 2004, p274 - 281 Journal Article, 2004 DOI

A. Harkin, J.P. Kelly, Leonard B.E. , A review of the relevance and validity of olfactory bulbectomy as a model of depression, Clinical Neurscience Research, 3, (4), 2003, p253 - 262 Journal Article, 2003 DOI

A. Harkin, J.M. O'Donnell, J.P. Kelly, A combined and comparative study of physiologic and behavioural parameters in a systemic toxicity test, Contemporary Topics in Laboratory Animal Science , 42, (2), 2003, p30 - 37 Journal Article, 2003 URL

A. Harkin, T.J. Connor, M. Walsh, St. John, N. and J.P. Kelly, Serotonergic mediation of the antidepressant-like effects of nitric oxide synthase inhibitors, Neuropharmacology, 44, (5), 2003, p616 - 623 Journal Article, 2003 DOI

A. Harkin, M.J. Hynes, E. Masterson, J.P. Kelly, J.M. O' Donnell and T.J. Connor, A toxicokinetic study of nickel-induced immunosuppression in rats. Immunopharmacol, Immunopharmacology and Immunotoxicology, 25, (4), 2003, p655 - 670 Journal Article, 2003 DOI

A. Harkin, E. Shanahan, J.P. Kelly and T.J. Connor , Methylenendioxyamphetamine produces serotonin nerve terminal loss and diminished behavioural and neurochemical responses to the antidepressant fluoxetine., European Journal of Neuroscience, 18, (4), 2003, p1021 - 1027 Journal Article, 2003 DOI

A. Harkin, J.M. O'Donnell, J.P. Kelly, A study of VitalView for behavioural and physiological monitoring in laboratory rats, Physiology & Behavior, 77, (1), 2002, p65 - 77 Journal Article, 2002 DOI

A. Harkin, D.D. Houlihan, J.P. Kelly, Reduction in preference for saccharin by repeated unpredictable stress in mice and its prevention by imipramine, Journal of Psychopharmacology, 16, (2), 2002, p115 - 123 Journal Article, 2002 URL

A. Harkin, T.J. Connor, J.M. O' Donnell and J.P. Kelly, Physiological and behavioral responses to stress: What does a rat find stressful ? , Lab Animal , 31, (4), 2002, p42 - 50 Journal Article, 2002

A. Harkin, T.J. Connor, J. Mulrooney, J.P. Kelly and B.E. Leonard, Prior exposure to methylenedioxyamphetamine (MDA) induces serotonergic loss and changes in spontaneous exploratory and amphetamine-induced behaviours in rats, Life Science, 68, (12), 2001, p1367 - 1382 Journal Article, 2001 DOI

A. Harkin, K. Morris, J.P. Kelly, J.M. O'Donnell, B.E. Leonard, Modulation of MK-801-induced behaviour by noradrenergic agents in mice, Psychopharmacology, 154, (2), 2001, p177 - 188 Journal Article, 2001 DOI

T.J. Connor, M.C. Dennedy, A. Harkin and J.P. Kelly, Methylenedioxymethamphetamine-induced suppression of interleukin-1β and tumour necrosis factor-α is not mediated by serotonin, European Journal of Pharmacology, 418, (1-2), 2001, p147 - 152 Journal Article, 2001 DOI

A. Harkin, R. Nally, J.P. Kelly, B.E. Leonard , Effects of reboxetine and sertraline treatments alone and in combination on the binding properties of cortical NMDA and beta1-adrenergic receptors in an animal model of depression, Journal of Neural Transmission, 107, (10), 2000, p1213 - 1227 Journal Article, 2000 DOI

T.J. Connor, P. Kelliher, Y. Shen, A. Harkin, J.P. Kelly and B.E. Leonard, Effect of Subchronic Antidepressant Treatments on Behavioral, Neurochemical, and Endocrine Changes in the Forced-Swim Test, Pharmacology Biochemistry and Behavior, 65, (4), 2000, p591 - 597 Journal Article, 2000 DOI

A. Harkin, J.P. Kelly, J. Frawley, J.M. O'Donnell, B.E. Leonard, Test conditions influence the response to a drug challenge in rodents., Pharmacology Biochemistry and Behavior, 65, (3), 2000, p389 - 398 Journal Article, 2000 DOI

A. Harkin, G. Nowak, I.A. Paul, Noradrenergic lesion antagonizes desipramine-induced adaptation of NMDA receptors, European Journal of Pharmacology, 389, (2-3), 2000, p187 - 192 Journal Article, 2000 DOI

T.J. Connor, A. Harkin, J.P. Kelly and B.E. Leonard, Olfactory bulbectomy provokes a suppression of interleukin-1beta and tumour necrosis factor-alpha production following an in vivo challenge with lipopolysaccharide: Effect of chronic desipramine treatment, Neuroimmunomodulation, 7, (1), 2000, p27 - 35 Journal Article, 2000 DOI

P. Kelliher, T.J. Connor, A. Harkin, C. Sanchez, J.P. Kelly and B.E. Leonard, Varying responses to the rat forced swim test under diurnal and nocturnal conditions, Physiology & Behavior, 69, (4-5), 2000, p531 - 539 Journal Article, 2000 DOI

A. Harkin, J.F. Cryan, M. Naughton, J.P. Kelly, B.E. Leonard , Characterization of D-fenfluramine-induced hypothermia: evidence for multiple sites of action, European Journal of Pharmacology, 390, (3), 2000, p275 - 285 Journal Article, 2000 DOI

A.M. Redmond, A. Harkin, J.P. Kelly, B.E. Leonard , Effects of acute and chronic antidepressant administration on phencyclidine induced locomotor hyperactivity, European Neuropsychopharmacology, 9, (1-2), 1999, p165 - 170 Journal Article, 1999 DOI

T.J. Connor, P. Kelliher, A. Harkin, J.P. Kelly and B.E. Leonard, Reboxetine attenuates forced swim test-induced behavioural and neurochemical alterations in the rat, European Journal of Pharmacology, 379, (2-3), 1999, p125 - 133 Journal Article, 1999 DOI

A. Harkin, J.P. Kelly, M. McNamara, T.J. Connor, K. Dredge, A. Redmond, B.E. Leonard, Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression, European Journal of Pharmacology, 364, (2-3), 1999, p123 - 132 Journal Article, 1999 DOI

D.G. Healy, A. Harkin, J.F. Cryan, J.P. Kelly, B.E. Leonard, Metyrapone displays antidepressant-like properties in preclinical paradigms, Psychopharmacology, 145, (3), 1999, p303 - 308 Journal Article, 1999 DOI

A. Harkin, K.H. Bruce, B. Craft, I.A. Paul , Nitric oxide synthase inhibitors have antidepressant-like properties in mice. 1. Acute treatments are active in the forced swim test, European Journal of Pharmacology, 372, (2), 1999, p207 - 213 Journal Article, 1999 DOI

C.J. Faherty, A. Harkin, B.E. Leonard , The functional sensitisation of sigma receptors following chronic selective serotonin reuptake inhibitor treatment, European Journal of Pharmacology, 346, (1), 1998, p15 - 21 Journal Article, 1998 DOI

I. De Souza, J.P. Kelly, A. Harkin, B.E. Leonard , An appraisal of the pharmacological and toxicological effects of a single oral administration of 3,4-methylenedioxymethamphetamine (MDMA) in the rat, Pharmacology & Toxicology, 80, (5), 1997, p207 - 210 Journal Article, 1997 DOI

Harkin, A., Molecules and Mental Illness, Review of Molecules and Mental Illness, by Samuel H. Barondes , Human Psychopharmacology, 11, 1996, p72 Review, 1996

A. Harkin, J.P. Kelly, B.E. Leonard , Single or repeated administration of selective serotonin reuptake inhibitors fail to modulate apomorphine-induced responses in the rat., J. Serotonin Res, 3, 1996, p49 - 58 Journal Article, 1996

A. Harkin, J.P. Kelly, B.E. Leonard , The comparative effects of long-term administration of sertraline, paroxetine, citalopram, fluoxetine and amitryptyline on monoamine content in rat brain, J. Serotonin Res, 2, 1995, p181 - 190 Journal Article, 1995

Non-Peer-Reviewed Publications

Doolin, K., Harkin, A., Frodl, T., O'Keane, V. , Relationship between hippocampal subfield volumes and cortisol awakening response parameters in Major Depressive Disorder, European Neuropsychopharmacology, 30th ECNP Congress , Paris, France, 2017, 27, (4), 2017, ppS521-- Poster, 2017

Doolin, K., Frodl, T., Harkin, A., O'Keane, V., Altered circulating kynurenine pathway expression in pregnant women and perinatal depression., World Psychiatric Association, World Congress of Psychiatry, Berlin, Germany, 2017, 2017 Poster, 2017

Doolin, K., Harkin, A., O'Keane, V., Significant relationships between wakening cortisol concentrations, inflammatory cytokines and suicidality in first presentation depressives, European Neuropsychopharmacology, 29th ECNP Congress, Vienna, Austria, 2016, 26, (3), 2016, pps109- Published Abstract, 2016

Dempsey, E., McIntosh, A., Kerskens, C., Harkin, A., Behavioural alterations associated with a change in brain relaxometry in an animal model of inflammatory bowel disease, Young Neuroscientists Symposium, Trinity College Dublin, 2016, 2016 Poster, 2016

Doolin, K., Harkin, A., O'Keane, V., Tryptophan pathway depletion and hyperactivity of the HPA axis in major depressive disorder, Trinity College Health Science Faculty Research Day, Dublin, September, 2016, 2016 Poster, 2016

David, J., McIntosh, A., Harkin, A., L-alpha aminoadipic acid induced glial ablation in the prelimbic corex induces depressive and anxiety like behaviour in mice, Journal of Psychopharmacology, British Association for Psychopharmacology Annual Meeting, Brighton, UK, 2016, 30, (8), 2016, ppa64-- Poster, 2016

David, J., McIntosh, A., Harkin, A., L-alphaaminoadipic acid provokes a reduction of astrocytes in the pre-limbic cortex and depressive like behaviour in mice, ECNP Workshop for Junior Scientists, Nice, France, 2016 Poster, 2016

Doolin, K., Harkin, A., O'Keane, V., An investigation of kynurenine pathway activation and inflammatory cytokines in first presentation depression, CINP thematic meeting Stress Inflammation and Depression, Dublin, June, 2015, 2015 Poster, 2015

Sherwin, E., Lennon, A., Harkin, A., Regional specific modulation of neuronal activation associated with the antidepressant like properties of targeting the NMDAR PSD95 NOS pathway in the Wistar Kyoto rat., Journal of Psychopharmacology, British Association for Psychopharmacology, Bristol, UK, 2015, 2015 Meeting Abstract, 2015

O'Toole, E., McIntosh, A., Doucet, M., Harkin, A., Small moleculae inhibitors at the PSD-95/NOS interface protect against glutamate induced neuronal atrophy in primary cortical neurons, Journal of Psychopharmacology, British Association for Psychopharmacology, Bristol, UK, July, 2015, 2015 Meeting Abstract, 2015

Dempsey, E., Abautret-Daly, A., Medina, C., Harkin, A., Evidence for behavioural and central molecular changes in an animal model of inflammatory bowel disease, CINP Thematic Meeting on Stress, Inflammation and Depression, Dublin, 2015 Poster, 2015

Yssel, J., Connor, T., Harkin, A., Anti inflammatory actions of noradrenergic agents as a target to prevent neurodegeneration in Parkinson's disease, Neurodegenerative Diseases, 12th International Conference on Alzheimer's and Parkinson's diseases, Nice, France, 2015, 15, (1), 2015, pp1286- Meeting Abstract, 2015

Dempsey, E., Downing, J., Abautret-Daly, A., Medina, C., Harkin, A., Evidence for central molecular changes and changes to neuronal activity in an animal model of inflammatory bowel disease, European Neuropsychopharmacology, 28th ECNP Congress , Amsterdam, The Netherlands, 2015, 25, (3), 2015, pps107- Poster, 2015

David, J., McIntosh, A., Harkin, A., L-alpha amnoadipic acid provokes a reduction in astroglial GFAP expression in the prelimbic cortex and induces anhedonia and depressive-like behaviours in mice, ICVS - Life and Health Sciences Research Institute, Braga, Portugal, 2015, 2015 Poster, 2015

O'Neill, E., Day, J.S., Cunningham K., Connor, T.J., Harkin, A., Investigating the role of astrocyte adrenoceptors in protection against amyloid beta induced neuronal atrophy, Biochemical Society/British Neuroscience Association; Astrocytes in Health and Neurodegenerative Disease, London, UK, April, 2014, 2014 Poster, 2014

O'Toole, E., Doucet, M., Harkin, A., Astrocytic ablation by L alpha amino adipic acid (L AAA) reduces measures of neuronal complexity in vitro; rescue by gliotrophins?, Joint Biochemical Society and British Neuroscience Association, Astrocytes in Health and Disease Conference, University College London, April, 2014, 2014 Poster, 2014

O'Toole, E., Harkin, A., Astrocytic dysfunction induced by L alpha aminoapidic acid (L AAA) reduces measures of neuronal complexity; resuce by NMDA receptor antagonists, International Society of Neuroimmunology, Mainz, Germany, November, 2014, 2014 Meeting Abstract, 2014

O'Neill, E., Day, J.S., Connor, T.J., Harkin, A., Noradrenaline mediated protection against TNF alpha induced neuronal atrophy, International Society for Neuroimmunology Congress, Mainz, Germany, 2014, 2014 Poster, 2014

Yssel, J.D., Connor, T.J., Harkin, A., The anti inflammatory actions of noradrenergic agents as a target ot prevent neurodegeneration in Parkinon's disease, 36th All Ireland Schools of Pharmacy Conference, Trinity College Dublin, April 2014, 2014 Poster, 2014

Yssel, J.D., Connor, T.J., Harkin, A., Pharmacological enhancement of noradrenaline as a target to limit neuroinflammation in Parkinson's disease, Irish Journal of Medical Science, Royal Academy of Medicine in Ireland, University College Dublin, June, 2014, 2014 Meeting Abstract, 2014

Gormely, S., Kersken, C., Harkin, A., Reduced cortical astroglial cell numbers coupled to reduced cortical cerebral blood perfusion in a genetically predisposed model of depression as assessed by magnetic resonance bolus tracking arterial spin labelling (MR-btASL)., Brain Behavior and Immunity, Annual meeting of the Psychoneuroimmunology Research Society, Philadelphia, USA, 2014, 40, (e31), 2014 Published Abstract, 2014

Gormley, S., Kerskens, C., Harkin, A., Strain related differences in behaviour and neuroimaging markers in the Wistar and WIstar Kyoto rat are associated with altered astroglial cell number, Journal of Psychopharmacology, British Association for Psychopharmacology Annual meeting, Cambridge, UK, 2014, 28, (8), 2014, ppTC32- Published Abstract, 2014

Sherwin, E., Gormley, S., McGuinness, B., Harkin A., Enhnaced glucocorticoid sensitivity coupled with reduced microglial activation in a genetically predisposed animal model of depression, Brain Behavior and Immunity, Annual meeting of the PNIRS, Philadelphia, USA, 2014, 40, (e31), 2014 Meeting Abstract, 2014

Dempsey, E., Abautret-Daly, A., Medina, C., Docherty, N., Harkin, A. , iNOS as a mediator of central inflammation in an animal model of inflammatory bowel disease, Gut Brain Axis European Conference on Microbiology and Immunology (EUCMI), Berlin, Germany, 2014, 2014 Poster, 2014

Yssel, J., Connor, T., Harkin, A., The anti inflammatory actions of noradrenergic agents as a target to prevent neurodegeneration in Parkinson's disease, Journal of Neuroimmunology , 12th International Congress of Neuroimmunology, Mainz, Germany, 2014, 275, (1-2), 2014, pp122 - 123 Meeting Abstract, 2014

O'Neill, E., Kwok, B., Connor, T.J., Harkin, A., Amitriptyline and nortriptyline have neurotrophic effects on neuornal complexity mediated via a Trk/MAPK/PI3K pathway , Irish Journal of Medical Science, Royal Academy of Medicine in Ireland, Biomedical Sciences Section, Dublin, June, 2014, 2014 Meeting Abstract, 2014

Sherwin, E., Gigliucci, V., Harkin, A., Regional specific modulation of neuornal activation associated with the antidepressant-like properties of nitric oxide synthase inhibitors, Journal of Psychopharmacology, British Association for Psychopharmacology Annual Meeting, Cambridge, UK, 2014, 2014 Meeting Abstract, 2014

O'Toole, E., Doucet, M., Harkin, A., Small molecule inhibitors at the PSD96 NOS interface protect against glutamate induced neuronal atrophy in primary cortical neurons, Irish Journal of Medical Science, Royal Academy of Medicine in Ireland, Biomedical Sciences Section, University College Dublin, 2014, 2014 Meeting Abstract, 2014

Sherwin, E., Gormley, S., McGuinness B., Harkin, A. , Enhanced glucocorticoid sensitivity coupled with reduced microglial activation in a genetically predisposed animal model of depression, Brain Behavior and Immunity, Psychoneuroimmunology Reseach Society Annual Meeting, Philadelphia, USA, 2014, 40, 2014, ppe31- Meeting Abstract, 2014

O'Neill, E., Kwok, B., Harkin, A., Connor, T.J., Amitriptyline acting on Trk receptors protects against cytokine induced neuronal atrophy, Neuroscience Ireland & Irish Area Section Biochemical Society meeting, University College Cork, September, 2013, 2013 Poster, 2013

McGuinness, B., O'Farrell, K., Harkin, A., Connor, T.J., Systemic administation of IL-6 induces time dependent IL-6 related signalling in the brain, 8th Annual meeting of Neuroscience Ireland, September 2013, 2013 Poster, 2013

Yssel, J.D., Kelly, M., Connor, T.J., Nolan, Y., Harkin, A., Characterisation of a novel rat model of Parkinson's disease, combining intrastriatal 6-hydroxydopamine and intranigral lipopolysaccharide, Young Life Scientist (Cell Signalling) Symposium, University College Cork, September 2013, 2013 Poster, 2013

O'Toole, E., Doucet, M., Harkin, A., Astrocytic ablation by L alpha aminoadipic acid (L AAA) reduces measures of neuronal complexity in vitro, Neuroscience Ireland/Irish Area Section Biochemical Society Joint Meeting, University College Cork, 2013, 2013 Poster, 2013

Yssel, J.D., Kelly, M., Connor, T.J., Nolan, Y., Harkin, A., Characterisation of a novel rat model of Parkinson's disease, combining intrastriatal 6-hydroxydopamine and intranigral lipopolyscaaharide, Neuroscience Ireland, University College Cork, September 2013, 2013 Poster, 2013

Fagan, E.M., Gibney, S.M., Harkin, A., Connor, T.J. , IFN gamma reduces neuronal viability via BV-2 microglia , Brain Behavior and Immunity, 18th Annual meeting of Psychoneuroimmunology Reseach Society, Stockholm, Sweden, 2013, 2013 Meeting Abstract, 2013

Gormley, S., Mulkerrins, L., Kerskens, C., Harkin A., Reduced hippocampal volume and a region specific decrease in cortical perfusion as determined by high resolution MRI in a putative animal model of depression, 8th annual meeting of Neuroscience Ireland, University College Cork, September 2013, 2013 Poster, 2013

Harkin, A., Curtin, N.M., Mills, K.H.G., Boyle, N.T., Connor, T.J., Neuroimmune mechanisms underlying stress-induced immunosuppression, Abstracts of the IBNS, International Behavioral Neuroscience Society Annual Meeting, Dublin, June, 2013, 22, 2013, pp63 - 64 Oral Presentation, 2013

McGuinness, B., Gibney, S., Harkin, A., Connor, T.J., Exaggerated behavioural and HPA axis responses to stress in the non-obese diabetic (NOD) mouse, Abstracts of the IBNS , 22nd Annual Meeting of the International Behavioral Neuroscience Society, Dublin, June, 2013, 22, 2013 Poster, 2013

Fagan, E., Harkin, A., Connor, T.J., The serotonin transporter and monoamine oxidase A as novel pharmacological targets to inhibit microglial activation, Brain Behavior and Immunity, 18th Annual Meeting of the Psychoneuroimmunology Reseach Society, Stockholm, Sweden, 2013, 2013 Meeting Abstract, 2013

McGuinness, B., Gibney, S., Harkin, A., Connor, T.J., Stressor-induced IL-6 production and signalling: divergence in responses between the periphery and CNS, 22nd International Behavioural Neuroscience Society, Dublin, June, 2013, 2013 Poster, 2013

Sherwin, E., Gormley, S., Connor, T., Harkin, A., An investigation of stress induced glucocorticoid sensitivity and activation of the kynurenine pathway in Wistar Kyoto rats, 8th Annual Meeting of Neuroscience Ireland, University College Cork, 2013, 2013 Poster, 2013

Doucet, M., Levine, H., Dev, K.K., Harkin, A., Small molecule inhibitors at the PSD95 NOS interface have antidepressant like properties in mice, Irish Journal of Medical Science, Royal Academy of Medicine in Ireland, Biomedical Sciences Section, Summer meeting, University College Cork, 2013, 2013 Meeting Abstract, 2013

Sherwin, E., Gigliucci, V., Mannion, D., Harkin, A., Nitric oxide synthase inhibitors modulate regional patterns of stress induced neuronal activation assessed by C FOS immunohistochemical analysis, 8th Annual Meeting of Neuroscience Ireland, University College Cork, 2013, 2013 Poster, 2013

Gormley, S., GIgliucci, V., Gibney, S., Rouine, J., Kerskens, C., Harkin, A., An investigation into volumetric and cerebral perfusion changes in an animal model of depression using high resolution anatomical and perfusion weighted MRI, EURON workshop Drugs and the Brain: an update in psychopharmacology from experimental to clinic, Braga, Portugal, 2012, 2012 Poster, 2012

Abautret Daly, A., Murphy, N., Docherty N., Medina, C., Connor, T.J., Harkin, A., Behavioural changes in the dextran sodium sulfate model of colitis are associated with long term systemic and central induction of inducible nitric oxide synthase in Wistar rats, Neuroscience Ireland Annual meeting, Dublin, 2012, 2012 Poster, 2012

Abautret Daly, A., Medina, C., Connor, T.J., Harkin, A., Altered peripheral circualting and central tryptophan concentrations in the dextran sodium sulfate model of colitis in Wistar rats, Neuroscience Ireland Annual meeting, Dublin, 2012, 2012 Poster, 2012

O'Neill, E., Day, J.S., Connor, T.J., Noradrenaline acting on glial cells prevents cytokine induced reduction in neuronal complexity, Neuroscience Ireland Annual Meeting, Dublin, September 2012, 2012 Poster, 2012

Doucet, M., Harkin, A., Dev, K.K., Regulation of nNOS function using lentiviral-mediated gene delivery, European Graduate School of Neuroscience (EURON), Braga, Portugal, 2012, 2012 Poster, 2012

Gormley, S., Harkin, A., Animal models of depression: preclinical approaches to develop new and improved antidepressant treatments, Assessment of rodent behaviour; methods and rationale. An international course organsied by FPDP Pharmacy and Biocenter Finland, Helsinki, Finland, August, 2012, 2012 Oral Presentation, 2012

McGuinness, B., Gibney, S., Harkin, A., Connor, T.J., Increased anxiety and stress sensitivity and evidence of glucocorticoid resisatnce in non-obese diabetic (NOD) mice, EURON Workshop - Drugs and the brain: update in psychopharmacology from experiemental to clinic, Braga, Portugal, April 2012, 2012 Poster, 2012

Gormley, S., Mackay, E., Scott, C., Kerskens, C., Harkin, A., Glial ablation in the prefrontal cortex is assocaited with depressive and anxiety like behavior and cortical perfusion changes in male Wistar rats, 7th Annual meeting of Neuroscience Ireland, RCSI Dublin, 2012, 2012 Poster, 2012

McGuinness, B., Gibney, S.M., Harkin, A., Connor, T.J., The effects of stress on IL-6 production and signalling in a mouse model, 7th Annual meeting of Neuroscience Ireland, RCSI Dublin, September 2012, 2012 Poster, 2012

Gormley, S., GIgliucci, V., Gibney, S., Rouine, J., Kerskens, C., Harkin, A., An investigation into volumetric and cerebral perfusion changes in an animal model of depression using high resolution anatomical and perfusion weighted MRI, EURON workshop Drugs and the Brain: an update in psychopharmacology from experimental to clinic, Braga, Portugal, 2012, 2012 Poster, 2012

Fagan, E.M., Harkin, A., Connor, T.J., The serotonin transporter and monoamine oxidase A as novel pharmacological targets to inhibit microglial activation, European Graduate School of Neuroscience (EURON), Braga, Portugal, 2012, 2012 Poster, 2012

Gormley, S., Kerskens, C., Harkin, A. , Reduced hippocampal volume in the Wistar Kyoto rat as determined by high resolution anatomical MRI is assocaited with depressive and anxiety related behaviours, 22nd Annual meeting of the International Behavioral Neuroscience Society, Dublin, 2012, 2012 Poster, 2012

Fagan, E.M., Gibney, S., Harkin, A., Connor, T.J., IFN gamma reduces neuronal viability via kynurenine pathway activation in BV-2 microglia, 6th Annual Neuroscience Ireland meeting, NUI Maynooth, 2011, 2011 Poster, 2011

Rouine, J., Jennings Murphy, C., Kerskens, C., Harkin A. , Serotonin related changes to cerebral blood flow and cerebral blood volume determined by bolus tracking arterial spin labelling magnetic resonance imaging, Journal of Psychopharmacology, British Association for Psychopharmacology Summer meeting, Harrogate, UK, 2011, 25, (8), 2011, ppS3, A58- Meeting Abstract, 2011

Doucet, M., Harkin, A., Dev, K.K., The PSD95 nNOS interface as a new target for treating depression, Irish Journal of Medical Science, Royal Academy of Medicine in Ireland, Biomedical Sciences Section, Summer meeting, Dublin, 2011, 2011 Meeting Abstract, 2011

Gigliucci, V., Gibney, S., Casey, S., Egan, D., Harkin, A., An assessment of the antidpressant like activity of ketamine in a rodent model of depression related behaviour unresponsive to conventional antidepressants, Anxiety and Depression , Washington DC, USA, 2011, 2011 Poster, 2011

Doucet, M., Harkin, A., Dev, K.K. , Regulating nNOS function using lentiviral mediated gene delivery, 8th International Brain Research Organization (IBRO) World Congress of Neuroscience, Florence, Italy, 2011, 2011 Meeting Abstract, 2011

Gigliucci, V., Gibney S., Casey, S., Harkin, A., Combination of stress and central 5-HT depletion promotes a depression lreated phenotype in a putative model of treatment resistant depression, Journal of Psychopharmacology, British Association for Psychopharmacology, Harrogate, UK, 2011, 25, (8), 2011, ppA23- Meeting Abstract, 2011

Abautret, A., Medina, C., Connor, T.J., Harkin, A., Evidence of dperession and anxiety related behavioural disturbances in an animal model of inflammatory bowel disease, 6th Euron Workshop, Drugs and the Brain; Update in Psychopharmacology, Braga, Portugal, 2010, 2010 Poster, 2010

Gigliucci, G., Buckley, K.N., Nunan, J., O'Shea, K., Harkin, A., A role for serotonin in the antidepressant activity of NG Nitro L Arginine in the rat forced swimming test, Journal of Psychopharmacology, British Association for Psychopharmacology, Harrogate, UK, 2010, 24, (3), 2010, ppA39- Meeting Abstract, 2010

Rouine, J., Byrne, D., Behan, B., Kelly, M., Blau, C., Gobbo, O., Kerskens, C., Harkin, A., Methylenedioxymethamphetamine (MDMA; Ecstasy) induced alterations in cerebral blood perfusion determined by arterial spin labelling coupled to magnetic resonance imaging, FENS abstracts, 7th Forum of European Neuroscience, Amsterdam, The Netherlands, 2010, 5, 2010, pp0.59.29- Meeting Abstract, 2010

Rouine, J., Byrne, D., Behan, B., Kelly, M, Blau, C., Gobbo, O., Kerskens, C., Harkin, A., Cortical blood perfusion following MDMA (Ecstasy) administration in rats determined by spin labelling of arterial water coupled to magnetic resonance imaging, Journal of Psychopharmacology, British Association for Psychopharmacology Summer meeting, Harrogate, UK, 2010, 24, (8), 2010, ppS3, A37- Meeting Abstract, 2010

Abautret Daly, A., Medina, C., Connor, T.J., Harkin, A., Behavioural disturbances observed in experimental colitis are associated with activation of the kynurenine pathway and expression of hepatic tryptophan 2,3 dioxygenase, Brain Behavior and Immunity, Psychoneuroimmunology Research Society meeting, Dublin, 2010, 24, (1), 2010, ppS50- Meeting Abstract, 2010

Abautret Daly, A., Medina, C., Connor, T.J., Harkin, A., Evidence of depression and anxiety related behavioural disturbances associated with activation of the kynurenine pathway and expression of hepatic tryptophan 2,3 dioxyenase in an animal model of inflammatory bowel disease, FENS Abstracts, 7th Forum of European Neuroscience, Amsterdam, The Netherlands, 2010, 5, 2010, pp050.1- Meeting Abstract, 2010

Beumer, W., Abautret Daly, A., van Helden Meeuwsen, C.G., Harkin, A., Drexhage, H., Versnel, M.A., The NOD mouse model for immune induced depressive like behavior, Brain Behavior and Immunity, Psychoneuroimmunology Research Society meeting, Dublin, 2010, 24, (1), 2010, ppS50-51- Meeting Abstract, 2010

Abautret Daly, A., Medina, C., Connor, T.J., Harkin, A., Anxiety related behaviour in an animal model of experimental colitis is associated with a long term systemic and central inflammatory response, Brain Behaviour and Immunity, Psychoneuroimmunology Research Society meeting, Dublin, 2010, 24, (S1), 2010, ppS55- Meeting Abstract, 2010

Rouine, J., Behan, B., Blau, C., Gobbo, O., Kerskens, C., Harkin, A., Perfusion magnetic resonance imaging using spin labeling of arterial water show increased cortical blood flow following methylenedioxymethamphetamine (MDMA; ecstasy) administration to rats, Irish Journal of Medical Science, Royal Academy of Medicine in Ireland, Biomedical Sciences Section Summer meeting, Trinity College Dublin, 2010, 179, (3), 2010, ppS108- Meeting Abstract, 2010

Gleeson, L.C., Harkin, A., Inhibitors of noradrenaline transport exacerbate excitotoxin-induced hippocampal apoptosis., BNA abstracts, British Neuroscience Association Annual meeting, Liverpool, UK, 2009, 2009 Meeting Abstract, 2009

McNamee, E.N., Tanveer, R., Ryan, K.M., Griffin, E., O'Sullivan, J.B., Harkin, A., Connor, T.J., The beta2 adrenoceptor agonist clenbuterol induces IL-1 receptor antagonist and IL-1 type II receptor expression in rat brain in vivo: Imlications ofr CNS inflammation, European Journal of Neurology, 13th Congress of European Federation of Neurological Societies, Florence, Italy, 2009, 16, (3), 2009, pp573- Meeting Abstract, 2009

Vannatou Saifoudine, A., Gossen, A., McNamara, R., Harkin, A. , Caffeine exacerbates the acute toxivity of MDMA (Ecstasy): A role for dopamine, BNA meeting abstracts, British Neuroscience Association Annual meeting, Liverpool, UK, 2009, 2009 Meeting Abstract, 2009

Harkin A., Tryptophan and the kynurenine pathway in mood disorders, Invited lecture, Ludwig Maximillian University, January, 2009 Invited Talk, 2009

Vanattou Saifoudine N., Gossen, A., Harkin, A., Effect of caffeine on MDMA (Ecstasy) induced dopamine release from superfused striatal and hypothalamic tissue slices; a role for adenosine A1 receptors, Meeting abstracts, Neuroscience Ireland, Dublin, 2009, 2009 Meeting Abstract, 2009

Ryan, K.M., Harkin, A., Connor, T.J. , A systemic LPS challenge does not alter central beta2 adrenoceptor expression or responsiveness, Brain Behavior and Immunity, Psychoneuroimmunology Research Society meeting, Colorado, USA, 2009, 23, (2), 2009, pp54 - 55 Meeting Abstract, 2009

Ryan, K.M., Mahfoud, O.K., Jones, R.S., Harkin, A., Connor, T.J., The beta2 adrenoceptor agonist clenbuterol activates astrocytes and reduces amyloid beta concentrations and RAGE expression in rat cortex and hippocampus, Glia, 9th European Meeting on Glia in Health and Disease, Paris, France, 2009, 57, 2009, ppS106- Meeting Abstract, 2009

Gleeson, L.C., Connor, T.J., Harkin, A., Noradrenaline reuptake inhibition influences neuroinflammatory and degenerative changes associated with the excitotoxin kainic acid, Brain Behavior and Immunity, Psychoneuroimmunology Research Society meeting, Colorado, USA, 2009, 23, (2), 2009, ppS38- Meeting Abstract, 2009

Harkin, A., The inflammatory response system as an antidepressant target in animal models of depression, MOODINFLAME EU 6th framework cosortium meeting, ERASMUS MC, Rotterdam, The Netherlands, November, 2008, 2008 Oral Presentation, 2008

Harkin, A., Testing drug effects on depression and aggression: preclinical approaches to develop new and improved antidepressant treatments, Training programme on behavioural assessment of rodent disease models , University of Kuopio, Finland, 2008, Finnish Graduate School of Neuroscience Invited Talk, 2008

Vanattou-Saifoudine, N., Harkin, A., A lethal combination of caffeine and MDMA (Ecstasy) is reproduced with D-amphetamine and D-fenfluramine, Journal of Psychopharmacology, British Association for Psychopharmacology Summer meeting, Harrogate, UK, 2008, 22, (5), 2008, ppA65, TF05- Meeting Abstract, 2008

McNamee, E.N., Gonzalez, R., Harkin, A., Connor, T.J., Enhancing central noradrenergic tone promotes IL-10 production and signalling in the CNS via beta adrenoceptor activation, Journal of Neuroimmunology, International Neuroimmunology Symposium, Dublin, 2008, 197, 2008, pp163- Meeting Abstract, 2008

Harkin, A., The role of glutamate in depression and antidepressant action, Invited lecture series, St. Ita's Psychiatric Hospital Portrane , 2008 Invited Talk, 2008

Harkin, A., Role of glutamate neuronal transmission in depression and antidepressant action, Danish Society for Biological Psychiatry Annual meeting, University of Aarhus, Denmark, September, 2008, 2008 Invited Talk, 2008

Gleeson, L., Harkin, A., Dexamethasone suppresses inflammatory and apoptotic response but not seizures or neuronal cell loss in response to kainic acid, Journal of Psychopharmacology, British Association for Psychopharmacology Summer meeting, Harrogate, UK, 2008, 22, (5), 2008, ppA57, TC09- Meeting Abstract, 2008

Ryan, K.M., Guaghran, J., McNamee, E.N., O'Sullivan, J.B., Harkin, A., Connor, T.J. , The beta2 adrenoceptor agonist clenbuterol elicits antiinflammatory actions in rat brain, Journal of Neuroimmunology, International Neuroimmunology Symposium, Dublin, 2008, 197, 2008, pp175- Meeting Abstract, 2008

McNamee, E.N., Gonzalez-Reyes, R.E., Harkin, A., Connor, T.J. , Enhancing central noradrenergic tone induces IL-10 production and signalling in rat brain: A role for beta adrenoceptor activation, Brain Behavior and Immunity, Psychoneuroimmunology Research Society meeting, Madison, Winconsin, USA, 2008, 21, (S1), 2008, pp40- Meeting Abstract, 2008

Vanattou Saifoudine N., Harkin, A., A lethal combination of caffine and MDMA (Ecstasy) is reproduced with D-amphetamine and D-fenfluramine, Irish Journal of Medical Science, Royal Academy of Medicine in Ireland, Biomedical Sciences Section Summer meeting, Dundalk, 2008, 2008 Meeting Abstract, 2008

Vanattou Saifoudine, N., Harkin, A., Caffeine exacerbates the hyperthermic response to MDMA (Ecstasy): Role of dopamine, European Neuropsychopharmacology, ECNP Workshop for Young Scientists, Nice, France, 2008, 2008 Meeting Abstract, 2008

McNamee, E.N., Harkin, A., Connor, T.J. , Beta2 adrenoceptor activation induces expression of IL-1ra and the IL1R(II) in vivo; implications for CNS inflammation, European Neuropsychopharmacology, ECNP workshop of Neuropscyhopharmacology, Nice, France, 2007, 17, (S1), 2007, ppS35-36- Meeting Abstract, 2007

Harkin, A., Experimenting with Ecstasy - cautionary lessons from laboratory studies, TCIN focused meeting on drug abuse in Ireland, Dublin, 2007 Invited Talk, 2007

Harkin, A., Improving translational animal models of depression, SMi conference on Depression and Anxiety, London, 2007 Invited Talk, 2007

O'Sullivan, JB, Ryan, K.M., Gaughran, J., McNamee, E.N., Harkin, A., Connor, T.J. , Noradrenergic enhancers inhibit expression of the inflammatory chemokines RANTES and IL-10 in the CNS, Brain Behaviour and Immunity, Psychoneuroimmunology Research Society meeting, Arcachon, France, 2007, 21, 2007, ppe29- Meeting Abstract, 2007

Connor, T.J., Starr, N.J., Harkin, A. , Systemic inflammation alters expression of the kynurenine pathway enzymes indolamine 2,3 dioxygenase and kynurenine 3-monooxygenase in rat brain, Brain Behavior and Immunity, Psychoneuroimmunology Research Society meeting,, Arcachon, France, 2007, 21, 2007, ppe8- Meeting Abstract, 2007

Durkin, S., Ryan, R., Harkin, A., Prior exposure to MDMA (ecstasy) induces serotonergic loss and a reduced neurochemical response to the antidepressant fluoxetine, International Journal of Neuropsychopharmacology, 25th CINP Congress, Chicago, USA, 2006, 9, (S211), 2006, ppP.02.175- Meeting Abstract, 2006

McNamara, R., Harkin, A., Physiological response to 3,4 methylenedioxymethamphetamine (MDMA;Ecstasy) is profoundly altered by caffeine , Irish Journal of Medical Science, Royal Irish Academy of Medicine in Ireland, Biomedical Sciences section, Winter meeting, RCSI Dublin, 2005, 174, (1), 2005, ppp20- Meeting Abstract, 2005

Roche, M., Harkin, A., Kelly, J.P., Altered physiological responses to stress in the olfactory bulbecomised rat; normalisation by chronic fluoxetine treatment, European Neuropsychopharmacology, 18th ECNP Congress, Amsterdam, The Netherlands, 2005, 15, (S3), 2005, ppS326- Meeting Abstract, 2005

McNamara, R., Kerans, A., Cooney, E., Harkin, A., Caffeine exacerbates 3,4 methylenedioxymethamphetmiane (MDMA) induced toxicity; a role for phosphodiesterase inhibition, Journal of Psychopharmacology, British Association for Psychopharmacology Summer meeting, Harrogate, UK, 2005, 19, (4), 2005, ppMD24- Meeting Abstract, 2005

Diamond, M., Kelly, J.P., Connor, T.J., Harkin, A., Immunomodulatory properties of haemodialysis membranes, polarization of a Th2 T cell cytokine response, Irish Journal of Medical Science, Royal Academy of Medicine in Ireland Biomedical Sciences Section, NUI Galway, 2005, 174, (2), 2005, ppes4; 25- Meeting Abstract, 2005

Harkin, A., Connor, T., Abuse of MDMA (Ecstasy): a predisposing factor to depression?, The Irish Scientist, 12, 2004, p93- Journal Article, 2004

Harkin, A., Prendergast, A., Connor, T.J., Methylenedioxymethamphetamine produces serotonn nerve terminal loss and diminsihed behavioural and neurochemical responses to th antidepressant fluoxetine, International Journal of Neuropsychopharmacology, 24th CINP Congress, Paris, France, 2004, 7, (S1), 2004, ppP.02.031- Meeting Abstract, 2004

McNamara, R., Harkin, A., Dopamine mediates the exacerbation by caffeine of methylenedioxymethamphetamine (MDMA; Ecstasy) induced hyperthermia in the rat., Irish Journal of Medical Science, Royal Irish Academy of Medicine in Ireland Biomedical Sciences section, Summer meeting, University of Ulster Jordanstown, 2004, 172, (2), 2004, pp11- Meeting Abstract, 2004

Harkin, A., Prendergast, A., Connor, T.J., Prior exposure to methylenedioxymethamphetamine results in reduced responsiveness to the serotonin reuptake inhibitor fluoxetine: Behavioural and neurochemcial evidence, FENS Abstracts, 4th Forum of European Neuroscience, Lisbon, Portugal, 2004, 2, 2004, ppA230.8- Meeting Abstract, 2004

Roche, M., Shanahan, E., Harkin, A., Kellu, J.P., Chronic imipramine treatment reverses olfactory bulbectomy induced hyperactivity in three rodent species, European Neuropsychopharmacology, 17th ECNP Congress, Stockholm, Sweden, 2004, 14, (S3), 2004, ppS207- Meeting Abstract, 2004

McNamara, R., Harkin, A., Caffeine alters the body temperature response and long-term serotonin loss induced by MDMA (Ecstasy) and it's metabolite MDA in the rat, Fundamental and Clinical Pharmacology , 4th Federation of European Pharmacological Societies (EPHAR) Congress, Porto, Portugal, 2004, 18, (S1), 2004, pp115- Meeting Abstract, 2004

Roche, M., Harkin, A., Kelly, J.P., Fluoxetine attenuates open field induced neuronal cFOS expression in a regionally dependent manner in the olfactory bulbectomised rat , FENS abstracts, 4th Forum of European Neuroscience, Lisbon, Portugal, 2004, 2, 2004, ppA234.8- Meeting Abstract, 2004

Connor, T.J., O'Mahony, S., Kelly, J.P., Harkin, A. , Elevation of synaptic serotonin suppresses proinflammatory cytokine production in response to an in vivo immune challenge, Irish Journal of Medical Science, Royal Academy of Medicine in Ireland, Biomedical Sciences section, Winter meeting, University College Dublin, 2003, 172, (S2), 2003, pp23- Meeting Abstract, 2003

Connor, T.J., Harkin, A., Kelly, J.P., Methylenediocymethamphetamine (MDMA; Ecstasy) increases LPS induced IL10 production via beta adrenoceptor activation, European Cytokine Network, International Cytokine Society meeting, Dublin, (14), 2003, pp47- Meeting Abstract, 2003

Connor, T.J., Brewer, C., Harkin, A., Kelly, J.P., Acute stress promotes an immunosuppressive cytokine phenotype: a role for catecholamines, Brain Behavior and Immunity, Psychoneuroimmunolgy Research Society meeting, Florida, USA, 2003, 17, 2003, pp168- Meeting Abstract, 2003

Harkin, A., Hynes, M.J., Masterson, E., Kelly, J.P., O'Donnell, J.M., Connor, T.J., A toxicokinetic study of nickel induced immunosuppression, Irish Journal of Medical Science, Royal Academy of Medicine in Ireland Biomedical Sciences section, Winter meeting, University College Dublin, 2003, 172, (2), 2003, pp23- Meeting Abstract, 2003

Harkin, A., Shanahan, E., Kelly, J.P., Connor, T.J, Diminished behavioural and neurochemcial responses to fluoxetine following prior treatment with methylenedioxymethamphetamine, Journal of Psychopharmacology, British Association for psychopharmacology, Cambridge, UK, 2003, 17, (A34), 2003, ppC14- Meeting Abstract, 2003

Connor, T.J., Brewer, C., Harkin, A., Kelly, J.P., Acute stress suppresses TNFalpha independent of increase IL10 production, Brain Behavior and Immunity, Psychoneuroimmunology Research Society meeting, Florida, USA, 2003, 27, 2003, pp168- Meeting Abstract, 2003

Connor, T.J., Brewer, C., Harkin, A., Kelly, J.P., Acute stress promotes an immunosuppressive/anti inflammatory cytokine phenotype in rats, European Cytokine Network, International Cytokine Society meeting , Dublin, 2003, 14, 2003, pp86- Meeting Abstract, 2003

Harkin, A., Walsh, M., Connor, T.J., Kelly, J.P , Serotonergic mediation of the antidepressant like effects of nitric oxide synthase inhibitors in the rat forced swimming test, FENS abstracts, 3rd Forum of European Neuroscience, Paris, France, 2002, 1, 2002, ppA175.14- Meeting Abstract, 2002

Harkin, A., O'Donnell. J.M., Kelly, J.P., Physiological and behavoural monitoring in rats in response to pharmacological agents and laboratory stressors with battery free telemetry, British Journal of Pharmacology, British Pharmacological Society Winter meeting, Imperial College London, 2002, 135, (S), 2002, pp214P- Meeting Abstract, 2002

Harkin, A., Stress; a precipitating factor in animal models of depression, EURON workshop on Psychopharmacology, Maastricht, The Netherlands, 2002, European Graduate School of Neuroscience Invited Talk, 2002

Harkin, A., Houlihan, D., O'Connor, R., O'Donnell, J.M., Kelly, J.P., Reduction in preference for saccharin by repeated unpredictable mild stress in mice and its prevention but not restoration by impramine, Journal of Psychopharmacology, British Association for Psychopharmacology Summer meeting, Harrogate, UK, 2001, S15, (3), 2001, ppD5- Meeting Abstract, 2001

Harkin, A., Bioradiotelemetry; measurement of physiology with behaviour in small laboratory animals, International Bioradiotelemetry meeting, University of Utrecht, The Netherlands, 2001 Invited Talk, 2001

Connor, T.J., Harkin, A., Kelly, J.P. , An assessment of dexamethasone sensitivity in the olfactory bulbectomized rat model of depression, World Journal of Biological Psychiatry, 7th World Congress of Biological Psychiatry, Berlin, Germany, 2001, 2, (1S), 2001, pp48- Meeting Abstract, 2001

Connor, T.J., Dennedy, M.C., Harkin, A., Kelly, J.P., Serotonin release does not mediate the immunosuppressive effects of methylenedioxymethamphetmaine (MDMA; Ecstasy), Brain Behavior and Immunity, Psychoneuroimmunology Research Society meeting, Utrecht, The Netherlands, 2001, 15, 2001, pp143- Meeting Abstract, 2001

Harkin, A., Lawlor, A., Kelly, J.P., O'Donnell, J.M., Investigation of a new method for physiological and behavioural monitoring of laboratory animals by telemetry, Conference proceedings , 3rd International Conference on Methods and Techniques in Behavioural Research, Nijmegen, The Netherlands, 2000, 2001, pp124 - 125 Meeting Abstract, 2001

Harkin, A., Connor, T.J., St. John, N., Walsh, M., O'Donnell, J.M., Kelly, J.P., Nitric oxide synthase inhbitors produce antidepressant like activity in the rat forced swim test, Society for Neuroscience Abstracts, 31st Society for Neuroscience meeting, San Diego, 2001, 27, 2001, pp502- Meeting Abstract, 2001

Kelly, J.P., Harkin, A., Moore, N.A., Leonard, B.E., Effect of olanzapine in the olfactory bulbectomized rat model of depression, World Jounral of Biological Psychiatry, 7th World Congress of Biological Psychiatry, Berlin, Germany, 2001, 2, (1S), 2001, pp35- Meeting Abstract, 2001

Raducan, I., Harkin, A., Corcoran, P., Kelly, J.P., O'Donnell, J.M., Portable telemetric data logging for collection and management of observational data, Irish Journal of Medical Science, Royal Academy of Medicine in Ireland, NUI Galway, 2000, 169, (4), 2000, pp362- Meeting Abstract, 2000

Harkin, A., Connor, T.J., Reilly, H., Mulrooney, J., Kelly, J.P., Leonard, B.E., Long term behavioural and neurochemical changes following methylendioxyamphetamine administration to rats, International Journal of Neuropsychopharmacology, 22nd CINP Congress, Brussels, Belgium, 2000, 3, 2000, ppS201- Meeting Abstract, 2000

Harkin, A., Keenan, M., Leonard, B.E., Kelly, J.P., Desipramine attenuates olfactory bulbectomy induced hyperactivity in rats assessed by video image analysis, Journal of Psychopharmacology, British Association for Psychopharmacology Summer meeting, Cambridge, UK, 2000, S14, 2000, pp14- Meeting Abstract, 2000

Connor, T.J., Harkin, A., Kelly, J.P., Leonard, B.E., Olfactory bulbectomy suppresses IL1beta and TNFalpha production in response to an in vivo challnege with lipopolysaccharide: effect of chronic desipramine treatment, International Journal of Neuropsychopharmacology, 22nd CINP Congress, Brussels, Belgium, 2000, 3, 2000, pps306- Meeting Abstract, 2000

Houlihan, D., Harkin, A., Kelly, J.P., O'Donnell, J.M., Behavioural effects of chronic mild stress in mice, Irish Journal of Medical Science, Royal Irish Academy of Medicine in Ireland Biomedical Sciences Section Summer meeting, NUI Galway, 2000, 169, 2000, pp361- Meeting Abstract, 2000

Nally, R., Harkin, A., Kelly, J.P., Leonard, B.E., Chronic desipramine treatment alters the behavioural effects of the strychnine insensitive glycine site agonist 1-aminocyclopropanecarboxylic acid in mice, Journal of Psychopharmacology, British Association for Psychopharmacology Summer meeting, Cambridge, UK, 2000, S14, (3), 2000, pp9- Meeting Abstract, 2000

Harkin, A., Burns, M., Connor, T.J., Kelly, J.P., Leonard, B.E., Nitro-l-arginine attenuate forced swim test induced behavioural and neurochemical changes in the rat, Society for Neuroscience abstracts, 20th Society for Neuroscience meeting, New Orleans, USA, 2000, 26, 2000, pp1272- Meeting Abstract, 2000

Harkin, A., Burns, M., Connor, T.J., Kelly, J.P., Leonard, B.E., Nitro-l-arginine attenuates forced swim test induced behavioural and neurochemical changes in the rat, Society for Neuroscience abstracts, 20th Society for Neuroscience meeting, New Orleans, USA, 2000, 26, 2000, pp1272- Meeting Abstract, 2000

Dennedy, M.C., Connor, T.J., Harkin, A., Kelly, J.P., O'Donnell, J.M., Does serotonin mediate the immnosuppressive effects of methylenedioxymethamphetamine and fenfluramine in rats?, Irish Journal of Medical Science, Royal Academy of Medicine in Ireland Biomedical Sciences Section Summer meeting, NUI Galway, 2000, 169, 2000, pp360- Meeting Abstract, 2000

Harkin, A., Kelly, J.P., O'Donnell, J.M., New method for physiological and behavioural monitoring of laboratory animals by telemetry, Irish Journal of Medical Science, Royal Academy of Medicine in Ireland, NUI Galway, 2000, 164, (4), 2000, pp362- Meeting Abstract, 2000

Harkin, A., Morris, K., Kelly, J.P., O'Donnell, J.M., Leonard, B.E., Modulation of MK-801 response by noradrenergic agents in mice, European Journal of Neuroscience, 2nd Forum of European Neuroscience, Brighton, UK, 2000, 12, (s11), 2000, pp396- Meeting Abstract, 2000

Connor, T.J., Harkin, A., Kelly, J.P., Leonard, B.E., Fenfluramine induced immunosuppression is not dependent on its serotonin releasing properties, Brain Behavior and Immunity, Psychoneuroimmunology Research Society meeting, North Carolina, USA, 2000, 14, 2000, pp86 - 87 Meeting Abstract, 2000

Brennan, R., Harkin, A., Molloy, P., Kelly, J.P., O'Donnell, J.M., Development of an automated monitoring system for evaluating behaivour in laboratory rodents, Irish Journal of Medical Science, Royal Academy of Medicine in Ireland, Summer meeting, NUI Galway, 2000, 169, (4), 2000, pp362- Meeting Abstract, 2000

Connor, T.J., Kelliher, P., Harkin, A., Kelly, J.P., Leonard, B.E., Reboxetine attenuates forced swim test induced behavioural and neurochemical alterations in the rat., European Neuropsychopharmacology, 11th ECNP Congress, London, UK, 1999, 9, (5), 1999, pp242- Meeting Abstract, 1999

Harkin, A., Burns, M., Kelly, J.P., Leonard, B.E., Nitro-l-arginine, a nitric oxide synthase inhibitor, potentiates the action of imipramine in an acute stress paradigm in mice, Behavioural Pharmacology, First joint meeting of the Behavioural Pharmacology Society and European Behavioural Pharmacology Society, Boston, USA, 1999, 10, 1999, pp43- Meeting Abstract, 1999

McNamara, M., Kelly, J.P., Harkin, A., Dredge, K., Redmond, A., Connor, T., Leonard, B.E., Activity and onset of action of reboxetine alone and in combination with sertraline in an animal model of depression, International Journal of Neuropsychopharmacology, 21st CINP congress (The International College of Neuropsychopharmacology), Glasgow, Scotland, 1998, 2, (S1), 1999, pp149- Meeting Abstract, 1999

Harkin, A., Naughton, M., Cryan, J., Kelly, J.P., Leonard, B.E., Differential modification of fenfluramine-induced serotonergic responses by acute and chronic sertraline and fluoxetine adminsitration to rats. , European Neuropsychopharmacology, 11th ECNP congress, London, UK, 1999, 9, 1999, pp242- Meeting Abstract, 1999

Harkin, A., Kelly, J.P., Frawley, J., Morris, K., Burns, M., Leonard, B.E., Test conditions influence response to drug challenge in rodents, Fundamental and Clinical Pharmacology, 2nd European Congress of Pharmacology, Budapest, Hungary, 1999, 13, 1999, pp273- Meeting Abstract, 1999

Harkin, A., Kelly, J.P., Redmond, A.M., Leonard, B.E. , Behavioural interactions of antiderpessant with the non-competitive NMDA receptor antagonists MK-801 and phencyclidine, International Journal of Neuropsychopharmacology, 21st CINP meeting, Glasgow, Scotland, 1998, 2, (1), 1998, pp182 - 183 Meeting Abstract, 1998

Connor, T.J., Kelliher, P., Shen, Y., Harkin, A., Kelly, J.P., Leonard, B.E., Effect of chronic antidepressant treatment on behavioural, neurochemical and endocrine changes following forced swim test exposure, European Neuropsychopharmacology, 11th European College of Neuropsychopharmacology Congress, Paris, France, 1998, 8, (s2), 1998, pp194- Meeting Abstract, 1998

Kelleher, P., Harkin, A., Connor, T.J., Sanchez, C., Kelly, J.P., Leonard, B.E. , Circadian alterations in the rat forced swim test, Behavioural Pharmacology, European Behavioural Pharmacology Society (EBPS) meeting, Brno, Czech Republic, 1998, 9, (1), 1998, pp49- Meeting Abstract, 1998

Connor, T.J., Kelliher, P., Shen, Y., Harkin, A., Kelly, J.P., Leonard, B.E., Effect of chronic antidepressant treatment on behavioural, neurochemical and endocrine changes following forced swim test exposure, European Neuropsychopharmacology, 10th European College of Neuropsychopharmacology Congress, Paris, France, 1998, 8, (s2), 1998, pp194- Meeting Abstract, 1998

Harkin, A., Kelly, J.P., Nsimba, S., Leonard, B.E., Lessons from an apomorphine challenge test in rats, Behavioural Pharmacology, EBPS meeting, Brno, Czech Republic, 1998, 9, 1998, pp42- Meeting Abstract, 1998

Harkin, A., Kelly, J.P., Leonard, B.E. , The effects of reboxetine in some preclinical tests predictive of antidepressant activity., Journal of Psychopharmacology, British Association for Psychopharmacology Summer meeting, Cambridge, UK, 1997, S11, 1997, pp155- Meeting Abstract, 1997

Harkin, A., English, J.A., Hemphill, K., Craft, B., Paul, I.A., Nitric oxide synthase inhibitors have antidpressant properties, Society for Neuroscience Abstracts, 27th Annual meeting, Society for Neuroscience, New Orleans, USA, 1997, 1997, pp1757- Meeting Abstract, 1997

Healy, D., Harkin A., Kelly J.P., Leonard, B.E., Exhibition of an antidepressant-like profile with an antiglucocorticoid drug in animal tests, Journal of Psychopharmacology, British Association for Psychopharmacology Summer meeting, Cambridge, UK, 1997, S11, 1997, pp156- Meeting Abstract, 1997

Regan, C., Redmond, A., Harkin, A., Kelly, A., Leonard, B.E. , Comparative behavioural response to MK-801 and PCP in male rats, Irish Journal of Medical Science, Royal Academy of Medicine in Ireland Summer meeting, Queen's University Belfast, 1997, 166, 1997, pp166- Meeting Abstract, 1997

Harkin, A., Kelly, J.P., Leonard, B.E., The comparative effects of long term adminstration of sertraline, paroxetine, citalopram, fluoxetine and amitriptyline on monoamine content in rat brain, Irish Journal of Medical Science, Royal Academy of Medicine in Ireland Biomedical Sciences Section Winter meeting, Trinity College Dublin, 1996, 165, 1996, pp311- Meeting Abstract, 1996

Harkin A., Kelly, JP, Leonard, BE, A comparative assessment of aopmorphine induced effects in the rat under difference experimental conditions, Irish Journal of Medical Science, Royal Academy of Medicine in Ireland Summer meeting, National University of Ireland Galway, 1995, 165, (3), 1995, pp229- Meeting Abstract, 1995

Research Expertise

Description

My research falls within the remit of Neuropsychopharmacology, a discipline that links basic neuroscience to the pharmacological treatment of psychiatric and neurological disease. Selected examples of projects in these areas are outlined below: 1. Marie Curie Initial Training Networks (ITN): FP7-PEOPLE-2012-ITN Brain Imaging Return to Health "reBIRTH" see http://www.rbirth.eu/). The r'BIRTH consortium is a Marie Curie Initial Training Network that gathers experts on molecular mechanisms of age-associated pathologies including neurodegeneration and depression. They work together to identify stress-regulated molecules provoking neuronal atrophy and hindering neurogenesis (birth of new neurons), and monitor the consequences of these processes in human brain that contribute to cognitive decline and increased depressive and anxiety disorders associated with ageing. The work is funded by the European Commission (FP7) under the sub-programme PEOPLE (Marie Curie Actions). 16 early stage researchers will be trained in the topics of the programme i.e. molecular imaging (MRI), proteomics, immunotechnology, high content screening, molecular neuroscience, neuropharmacology and patient studies. The training is provided by seven universities, two private companies and one non-profit research organisation from 7 European countries. 2. Early diagnosis, treatment and prevention of mood disorders targeting the activated inflammatory response system [Acronym: MOODINFLAME] Our research group is funded under EU FP7 as part of a collaborative, large-scale research project entitled "Early diagnosis, treatment and prevention of mood disorders targeting the activated inflammatory response system. [Acronym: MOODINFLAME]. A consortium of 14 European Universities/Research Institutes and 4 SMEs have come together for this project with the overall objective of developing biomarker tests for mood disorder patients based on an activated inflammatory response system (IRS) and inflammation-mediated disturbances in tryptophan metabolism. As part of this programme patients are treated with drugs to counteract the consequences of an activated IRS/disturbed metabolism of tryptophan. The project leads to an enhanced understanding of the pathogenesis of inflammation-related mood disorders, and of the mechanism of anti-inflammatory drugs and drugs targeting tryptophan metabolism in treating depressive behaviour. 3. Neuronal nitric oxide synthase (nNOS): a novel target for antidepressant action. Inhibition of NMDA-R has shown considerable promise as a drug target to produce new antidepressants that work faster, and are more effective than existing antidepressants. We hypothesise that targeting signalling events down-stream of NMDA-R may provide a more viable approach. nNOS is a down stream target of NMDA-R. We have published a number of original papers demonstrating that 1) NOS inhibitors have antidepressant properties 2) such properties are dependent on endogenous serotonin and 3) NOS inhibitors can augment the effects of conventional antidepressants in preclinical models. Currently our research is assessing the efficacy of nNOS inhibitors as novel antidepressant agents. A future aim is to determine if uncoupling the NMDA-R from nNOS can elicit antidepressant actions. This work is funded by the Health research board.

Projects

  • Title
    • Brain Imaging Return to Health
  • Summary
    • Marie Curie Initial Training Networks (ITN): FP7-PEOPLE-2012-ITN Brain Imaging Return to Health "reBIRTH" (see http://www.rbirth.eu/) The r'BIRTH consortium is a Marie Curie Initial Training Network that gathers experts on molecular mechanisms of age-associated pathologies including neurodegeneration and depression. They work together to identify stress-regulated molecules provoking neuronal atrophy and hindering neurogenesis, and monitor the consequences of these processes in human brain. At the cellular level, diminished birth of new neurons (neurogenesis) contributes to cognitive decline and increased depressive and anxiety disorders that are associated with ageing. The work is funded by the European Commission (FP7) under the sub-programme PEOPLE (Marie Curie Actions). 16 early stage researchers will be trained in the topics of the programme i.e. molecular imaging (MRI), proteomics, immunotechnology, high content screening, molecular neuroscience, neuropharmacology and patient studies. The training is provided by seven universities, two private companies and one non-profit research organisation from 7 European countries.
  • Funding Agency
    • European Commission
  • Date From
    • 2014
  • Date To
    • 2018
  • Title
    • Early diagnosis, treatment and prevention of mood disorders targeting the activated inflammatory response system.
  • Summary
    • [Acronym: MOODINFLAME] 2008-2013. A collaborative, large-scale focused research project entitled "Early diagnosis, treatment and prevention of mood disorders targeting the activated inflammatory response system. [Acronym: MOODINFLAME]. A consortium of 14 European Universities/Research Institutes and 4 SMEs have come together for this project with the overall objective of developing biomarker tests for mood disorder patients based on an activated inflammatory response system (IRS) and inflammation-mediated disturbances in tryptophan metabolism. As part of this programme patients are treated with drugs to counteract the consequences of an activated IRS/disturbed metabolism of tryptophan. The project leads to an enhanced understanding of the pathogenesis of inflammation-related mood disorders, and of the mechanism of anti-inflammatory drugs and drugs targeting tryptophan metabolism in treating depressive behaviour.
  • Funding Agency
    • EU 7th Framework
  • Date From
    • 2008
  • Date To
    • 2012
  • Title
    • Neuronal nitric oxide synthase: A novel target for antidepressant activity
  • Summary
    • Inhibition of N-methyl-D-aspartic acid receptors (NMDA-R) has shown considerable promise as a drug target to produce new antidepressants that work faster, and are more effective than existing antidepressants. However, targeting NMDA-R directly is problematic due to adverse effects. We hypothesise that targeting signalling events down-stream of NMDA-R may provide a more viable approach. nNOS is a down stream target of NMDA-R. We have published a number of original papers demonstrating that 1) NOS inhibitors have antidepressant properties 2) such properties are dependent on endogenous serotonin and 3) NOS inhibitors can augment the effects of conventional antidepressants in preclinical models. Currently our research is assessing the efficacy of nNOS inhibitors as novel antidepressant agents. A future aim is to determine if uncoupling the NMDA-R from nNOS can elicit antidepressant actions.
  • Funding Agency
    • Health Research Board
  • Date From
    • 2008
  • Date To
    • 2012
  • Title
    • Caffeine exacerbates the acute toxicity of 3,4 methylenedioxymethamphetamine (MDMA; "Ecstasy"): A role for dopamine ?
  • Summary
    • Co-administration of caffeine profoundly enhances the acute toxicity of MDMA. This project will elucidate the mechanism underlying a potentially serious drug interaction between caffeine and MDMA and clarify risks associated with the concurrent consumption of caffeine with other drugs which increase dopaminergic transmission.
  • Funding Agency
    • Health Research Board
  • Date From
    • 2006
  • Date To
    • 2009
  • Title
    • Caffeine promotes hyperthermia and serotonergic loss following co-administration of the substituted amphetamines, MDMA
  • Summary
    • The project determined the effect of caffeine co-administration on the core body temperature response and long-term serotonin (5-HT) loss induced by methylenedioxymethamphetamine (MDMA; "Ecstasy") and its metabolite methylenedioxyamphetamine (MDA; "Love"). Caffeine promotes hyperthermia, tachycardia and long-term central serotonin loss associated with MDMA and MDA. This is a serious drug interaction, which could have important acute and long-term health consequences for recreational drug users.
  • Funding Agency
    • Irish Research Council for Science Engineering and Technology
  • Date From
    • 2003
  • Date To
    • 2006

Keywords

Addiction and substance abuse; Animal Research Policy; Depression; Emotional, behavioural and cognitive disorders; Ethics/Values in Science and Technology; Histology; Histology, Cytochemistry, Histochemistry; Imaging Techniques; In vitro testing, trial methods; MDMA ("Ecstasy"); Medicine; Neurobiology; Neurochemistry and neuropharmacology; Neurodegeneration; Neuroimaging; Neuroimmunology; Neuropharmacology; Neuroplasticity; Neuroscience; Neurotoxicity; PHARMACODYNAMICS; PHARMACOKINETIC; PHARMACOLOGICAL CHARACTERIZATION; PHARMACOLOGICAL EVIDENCE; PHARMACOLOGICAL TREATMENT; PHARMACOLOGY; Physiology; Psychiatry; Stress Response, Neuroanatomy

Recognition

Awards and Honours

Health Research Board career development fellowship 2002

CINP Young Investigator Award. 2004

Fellowship Trinity College Dublin 2011

Memberships

Psychoneuroimmunology Research Society 2010 – present

Collegium Internationale Neuro-Psychopharmacologicum 2003 – present

British Pharmacological Society 2003 – present

British Association for Psychopharmacology 1997 – present

Neuroscience Ireland 2012 – Present